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Displaying drugs 3026 - 3050 of 9627 in total
Clonidine
Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors. This activity is useful for the treatment of hypertension, severe pain, and ADHD.[L7237,L7240,L7243,L7246]
Clonidine was granted FDA approval on 3 September 1974.
Approved
Matched Description: … Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors. ... [A180559] This activity is useful for the treatment of hypertension, severe pain, and ADHD. …
Ceritinib
Ceritinib is used for the treatment of adults with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) following failure (secondary to resistance or intolerance) of prior crizotinib therapy. About 4% of patients with NSCLC have a chromosomal rearrangement that generates a fusion gene between EML4 (echinoderm microtubule-associated protein-like...
Approved
Matched Description: … of the downstream signaling protein STAT3, and proliferation of ALK-dependent cancer cells. ... Ceritinib is used for the treatment of adults with anaplastic lymphoma kinase (ALK)-positive metastatic ... non-small cell lung cancer (NSCLC) following failure (secondary to resistance or intolerance) of prior …
Amlodipine
Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called dihydropyridine calcium channel blockers. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial depression and cardiac conduction abnormalities...
Approved
Matched Description: … The option for single daily dosing of amlodipine is an attractive feature of this drug [FDA label]. ... Amlodipine is commonly used in the treatment of high blood pressure and angina. ... Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of …
Matched Mixtures name: … AMVAL(R) 10/80 MG TABLETAS …
Matched Mixtures name: … AMVAL(R) 10/80 MG TABLETAS …
Molindone
An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate...
Approved
Matched Description: … the aggressive type of undersocialized conduct disorder. ... indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of ... electrophysiologic data from animals indicate that molindone has certain characteristics that resemble those of …
Ponatinib
Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012.
Approved
Investigational
Matched Description: … tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of …
Siponimod
Siponimod, also known as Mayzent, by Novartis, is a new drug formulated for the management of Multiple Sclerosis (MS). It was approved by the FDA on March 26, 2019 and by Health Canada on February 20, 2020. This drug is considered a sphingosine-1-phosphate (S1P) receptor modulator and is thought to...
Approved
Investigational
Matched Description: … [L5801] MS is one of the most common causes of neurological disability in young adults and is found to ... 20 to 40, often the most productive years of life. ... , disrupting communication between the brain and other parts of the body. …
Polymyxin B
Polymyxin B was discovered in the 1940s . They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes . Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic[A176426,FDA Label]. All gram-positive bacteria, fungi, and the gram-negative cocci,...
Approved
Vet approved
Matched Description: … It is appropriate for treatment of infections of the urinary tract, meninges, and blood stream, caused ... by susceptible strains of _Pseudomonas aeruginosa_[FDA Label]. ... They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes …
Velmanase alfa
Velmanase alfa is a recombinant human lysosomal alpha-mannosidase developed for enzyme replacement therapy to treat alpha-mannosidosis. Alpha-mannosidosis is a rare autosomal recessive lysosomal storage disorder. Patients with alpha-mannosidosis have a genetic mutation that causes a deficiency in the lysosomal enzyme alpha-mannosidase, which is an enzyme responsible for breaking down complex...
Approved
Investigational
Matched Description: … The resulting accumulation of sugars in the body leads to an array of clinical manifestations leading ... alpha-mannosidase for the treatment of alpha-mannosidosis. ... Commission in March 2018 under the market name Lamzede [L39754] as the first human recombinant form of …
Puccinia graminis
Puccinia graminis is a fungus which can provoke allergic reactions. Puccinia graminis extract is used in allergenic testing.
Approved
Sequoia sempervirens pollen
Sequoia sempervirens pollen is the pollen of the Sequoia sempervirens plant. Sequoia sempervirens pollen is mainly used in allergenic testing.
Approved
Matched Description: … Sequoia sempervirens pollen is the pollen of the Sequoia sempervirens plant. …
Lumasiran
Lumasiran is a small interfering RNA used in the treatment of primary hyperoxaluria type 1 (PH1). This condition, caused by a deficiency in the enzyme alanine-glyoxylate aminotransferase, leads to an accumulation of oxalate, causing calcium crystal formation. These patients experience frequent kidney stones, nephrocalcinosis, and renal failure. Oxlumo, producted by...
Approved
Investigational
Matched Description: … of crystallization, [pyridoxine], and renal transplant. ... Lumasiran is a small interfering RNA used in the treatment of primary hyperoxaluria type 1 (PH1). ... caused by a deficiency in the enzyme alanine-glyoxylate aminotransferase, leads to an accumulation of …
Netilmicin
Netilmicin is a semisynthetic 1-N-ethyl derivative of sisomycin, an aminoglycoside antibiotic with action similar to gentamicin, but less ear and kidney toxicity. Netilmicin inhibits protein synthesis in susceptible organisms by binding to the bacterial 30S ribosomal subunit and interfering with mRNA binding and the acceptor tRNA site. The bactericidal effect...
Approved
Investigational
Matched Description: … The bactericidal effect of netilmiicin is not fully understood. ... Netilmicin is a semisynthetic 1-N-ethyl derivative of sisomycin, an aminoglycoside antibiotic with action …
Ganciclovir
An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
Approved
Investigational
Matched Description: … An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. …
Nirmatrelvir
Nirmatrelvir (PF-07321332) is an orally bioavailable 3C-like protease (3CLPRO) inhibitor that is the subject of clinical trial NCT04756531. 3CLPRO is responsible for cleaving polyproteins 1a and 1ab of SARS-CoV-2. Without the activity of the SARS-CoV-2 3CLPRO, nonstructural proteins (including proteases) cannot be released to perform their functions, inhibiting viral replication.[A234224,A234229,A234234]...
Approved
Investigational
Matched Description: … of being orally bioavailable. ... [L33354] 3CLPRO is responsible for cleaving polyproteins 1a and 1ab of SARS-CoV-2. ... 07321332) is an orally bioavailable 3C-like protease (3CLPRO) inhibitor that is the subject of …
Pimecrolimus
Pimecrolimus is an immunomodulating agent that was first marketed by Novartis under the trade name Elidel. It is now promoted in Canada by Galderma since early 2007. It is currently available as a topic cream used in the treatment of atopic dermatitis (eczema).
Approved
Investigational
Matched Description: … It is currently available as a topic cream used in the treatment of atopic dermatitis (eczema). …
Thrombomodulin Alfa
Thrombomodulin Alfa is a novel, recombinant and soluble thrombomodulin (ART-123). It is a human protein with both thrombin inhibiting and protein C stimulating activities, for the potential treatment of thromboembolism and blood clotting disorders, such as disseminated intravascular thromboembolism.
Approved
Investigational
Matched Description: … protein with both thrombin inhibiting and protein C stimulating activities, for the potential treatment of …
Ammonia
Ammonia is a naturally-occurring compound with a chemical formula NH3 and structure of trigonal pyramidal geometry. It is a colorless gas with a pungent smell, and become NH4, or ammonium ion, when in water. Although ammonia is used as a food additive in the anhydrous form and serves as a...
Approved
Matched Description: … Ammonia is a natural byproduct of biological and chemical reactions, including decomposition of organic ... It is proposed that human adults produce about 1000 mmol of ammonia daily, most of which undergoes excretion ... Ammonia is a naturally-occurring compound with a chemical formula NH3 and structure of trigonal pyramidal …
Ammonia N-13
Ammonia N 13 Injection, USP is a positron emitting radiopharmaceutical that is used for diagnostic purposes in conjunction with positron emission tomography (PET) imaging. The active ingredient, [13N] ammonia, has the molecular formula of 13NH3 with a molecular weight of 16.02.
Ammonia N 13 Injection, USP is used for imaging...
Approved
Matched Description: … The active ingredient, [13N] ammonia, has the molecular formula of 13NH3 with a molecular weight of 16.02 ... Ammonia N 13 Injection, USP is used for imaging of the myocardium under rest or pharmacologic stress …
Bosutinib
Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q11), resulting in a BCR-ABL fusion protein.[A6902,A261796,A261801] The first BCR-ABL inhibitor,...
Approved
Matched Description: … [A6901,A17961]
Bosutinib was first approved by the FDA in 2012 for the treatment of adult chronic, ... [L48436] On September 26, 2023, bosutinib was also approved by the FDA for the treatment of pediatric ... Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q11), resulting …
Copper
Copper is a transition metal and a trace element in the body. It is important to the function of many enzymes including cytochrome c oxidase, monoamine oxidase and superoxide dismutase [FDA Label]. Copper is commonly used in contraceptive intrauterine devices (IUD) .
Approved
Investigational
Matched Description: … It is important to the function of many enzymes including cytochrome c oxidase, monoamine oxidase and …
Matched Mixtures name: … Formula R Mineral Supplement …
Matched Mixtures name: … Formula R Mineral Supplement …
Betula nigra pollen
Betula nigra pollen is the pollen of the Betula nigra plant. Betula nigra pollen is mainly used in allergenic testing.
Approved
Matched Description: … Betula nigra pollen is the pollen of the Betula nigra plant. …
Ambrosia deltoidea pollen
Ambrosia deltoidea pollen is the pollen of the Ambrosia deltoidea plant. Ambrosia deltoidea pollen is mainly used in allergenic testing.
Approved
Matched Description: … Ambrosia deltoidea pollen is the pollen of the Ambrosia deltoidea plant. …
Bremelanotide
Bremelanotide is a 7 amino acid peptide used to treat hypoactive sexual desire disorder in premenopausal women. Bremelanotide does not interact with alcohol. The mechanism by which bremelanotide's action on receptors translates to a clinical effect is still unknown. Bremelanotide was first described in the literature in 2003 when it...
Approved
Investigational
Amisulpride
Amisulpride is a benzamide derivative and a dopamine receptor antagonist that selectively works on dopamine D2 and D3 receptors. As an antipsychotic agent, amisulpride alleviates both positive and negative symptoms of schizophrenia, and it exhibits antidepressant properties in patients with psychiatric disorders, dysthymia, and major depression. Amisulpride predominantly works in...
Approved
Investigational
Matched Description: … As an antipsychotic agent, amisulpride alleviates both positive and negative symptoms of schizophrenia ... [A6752, L32764] Oral tablets of amisulpride is used in European countries as a treatment for acute and ... A6755] Amisulpride predominantly works in the limbic system, which explains its relatively lower risk of …
Lornoxicam
Lornoxicam (chlortenoxicam) is a new nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic, anti-inflammatory and antipyretic properties. Lornoxicam differs from other oxicam compounds in its potent inhibition of prostaglandin biosynthesis, a property that explains the particularly pronounced efficacy of the drug. Lornoxicam is approved for use in Japan.
Approved
Investigational
Matched Description: … , a property that explains the particularly pronounced efficacy of the drug. ... Lornoxicam (chlortenoxicam) is a new nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class ... Lornoxicam differs from other oxicam compounds in its potent inhibition of prostaglandin biosynthesis …
Displaying drugs 3026 - 3050 of 9627 in total