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Displaying drugs 301 - 325 of 13884 in total

Estetrol

Naturally or synthetically produced steroid estrogens have a wide range of pharmaceutical uses ranging from hormonal contraception to the treatment of menopausal symptoms. Estetrol (E4) is a native estrogen occurring naturally during pregnancy, but can be synthesized from a plant source and used for contraception. It is more potent and...
Approved
Investigational
Matched Iupac: … (1R,2R,3R,3aS,3bR,9bS,11aS)-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthrene …
Matched Description: … from a plant source and used for contraception. ... [L33179] In Canada, Nextstellis was approved for use in March 2021; it was developed by Mithra and is ... The combination of drospirenone and estetrol offers a new choice with a favourable safety profile for …
Matched Categories: … Hormonal Contraceptives for Systemic Use …

Lesinurad

Lesinurad is an oral uric acid transporter 1 (URAT1) inhibitor indicated for the treatment of hyperuricemia associated with gout. It reduces serum uric acid concentration through the inhibition of URAT1, an enzyme responsible for reuptake of uric acid from the renal tubule, and OAT4, another uric acid transporter associated with...
Approved
Investigational
Matched Description: … uric acid levels with a xanthine oxidase inhibitor alone. ... Marketed as the product Zurampic, it is indicated for use in combination with a xanthine oxidase inhibitor ... In August 2017, a combination oral therapy consisting of lesinurad and [DB00437] was FDA-approved under …

Phenazopyridine

Phenazopyridine, also known as Pyridium, is a urinary tract analgesic used for the short-term management of urinary tract irritation and its associated unpleasant symptoms such as burning and pain during urination. In the USA, this drug was previously marked by Roche but has been discontinued by the FDA. It is...
Approved
Matched Description: … Phenazopyridine, also known as Pyridium, is a urinary tract analgesic used for the short-term management ... [L7832] It is still used in various parts of the world. ... In the USA, this drug was previously marked by Roche but has been discontinued by the FDA. …
Matched Mixtures name: … All-In-One UTI Emergency Kit …

Anthrax vaccine

Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to Bacillus anthracis. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsulated strain of Bacillus anthracis...
Approved
Matched Description: … Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high ... [L47526] It is considered one of the most likely agents to be used in a biological attack. ... for an Anthrax terrorist attack or for pre-exposure prophylaxis of personnel going to specific arenas …
Matched Products: … BioThrax (Anthrax Vaccine Adsorbed) Supension for Injection 50?g/dose (nominal) …

Acetylcarnitine

Acetylcarnitine is an investigational drug in the United states, Italy, United Kingdom, China, Israel, and Norway, and it is approved in Italy, Portugal, Argentina, Chile, Philippines, Australia, and India. Acetylcarnitine can be synthesized, but it is also naturally found in adequate amounts in healthy humans. In human plasma and tissues,...
Approved
Investigational
Matched Description: … Acetylcarnitine can be synthesized, but it is also naturally found in adequate amounts in healthy humans ... Acetylcarnitine is an investigational drug in the United states, Italy, United Kingdom, China, Israel ... , and Norway, and it is approved in Italy, Portugal, Argentina, Chile, Philippines, Australia, and India …
Matched Categories: … Psychostimulants, Agents Used for ADHD and Nootropics …

Glucagon

Glucagon is a 29 amino acid hormone used as a diagnostic aid in radiologic exams to temporarily inhibit the movement of the gastrointestinal tract and to treat severe hypoglycemia.[L7634,L7637,L7640,L7643,L8519] Glucagon raises blood sugar through activation of hepatic glucagon receptors, stimulating glycogenolysis and the release of glucose.[L7640,L7643] Glucagon was granted FDA...
Approved
Matched Description: … Glucagon is a 29 amino acid hormone used as a diagnostic aid in radiologic exams to temporarily inhibit …
Matched Products: … GLUCAGEN FOR INJECTION 1 mg/ml …

Perindopril

Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to...
Approved
Matched Description: … Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of ... It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration ... Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor …
Matched Mixtures name: … PERINDO/IN RAT T 5/1.25 ... PERINDO/IN RAT T 5/1.25 ... PERINDO IN 1A PHA4/1.25MG …
Matched Categories: … Antihypertensive Agents Indicated for Hypertension …

Diamorphine

Diamorphine (heroin) is a narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed) Internationally, diamorphine is controlled under...
Approved
Illicit
Investigational
Matched Description: … It is a controlled substance (opium derivative) listed in the U.S. ... However, under the name diamorphine, heroin is a legal prescription drug in the United Kingdom. ... Diamorphine (heroin) is a narcotic analgesic that may be habit-forming. …
Matched Categories: … Drugs Used in Opioid Dependence ... Drugs Used in Addictive Disorders …

Citalopram

Citalopram is an antidepressant belonging to the class of selective serotonin-reuptake inhibitors (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] Citalopram enhances serotonergic transmission through the...
Approved
Matched Description: … [A261316] Citalopram was approved by the FDA in 1998 for the treatment of depression in adults 18 ... metabolites among all SSRIs. ... It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing …
Matched Categories: … Monoamine Oxidase A Substrates ... Antidepressive Agents Indicated for Depression …

Resmetirom

Resmetirom is a thyroid hormone receptor-beta (THR-beta) agonist. On March 14, 2024, it was approved by the FDA as the first treatment of liver fibrosis due to noncirrhotic non-alcoholic steatohepatitis (NASH), which is a form of non-alcoholic fatty liver disease (NAFLD). Thyroid hormones directly regulate lipid metabolism in the liver;...
Approved
Investigational
Matched Description: … function, such as low serum thyroid hormone levels, is often observed in NAFLD. ... Resmetirom is a thyroid hormone receptor-beta (THR-beta) agonist. ... first treatment of liver fibrosis due to noncirrhotic non-alcoholic steatohepatitis (NASH), which is a …

Guselkumab

Guselkumab is a human immunoglobulin G1 lambda (IgG1λ) monoclonal antibody that selectively blocks interleukin-23. IL-23 is an inflammatory cytokine that activates the CD4+ T-helper (Th17) cell pathway to mediate the inflammatory cascade that induces psoriatic plaque formation . In clinical trials, guselkumab demonstrated improved skin clearance and symptomatic improvements in...
Approved
Investigational
Matched Description: … Guselkumab is a human immunoglobulin G1 lambda (IgG1λ) monoclonal antibody that selectively blocks interleukin ... market name Tremfya for the treatment of adult patients with moderate-to-severe plaque psoriasis. ... In clinical trials, guselkumab demonstrated improved skin clearance and symptomatic improvements in dermatological …
Matched Products: … TREMFYA SOLUTION FOR INJECTION IN PRE-FILLED PEN 100MG/ML ... TREMFYA SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE 100MG/1ML ... TREMFYA 100MG/ML SOLUTION FOR INJECTION …

Tixocortol

Tixocortol is a 21-thiol derivative of hydrocortisone classified as a class A corticosteroid. It is a synthetic steroid with topical anti-inflammatory properties without the systemic glucocorticoid and mineralocorticoid activities and toxicity.
Approved
Withdrawn
Matched Description: … Tixocortol is a 21-thiol derivative of hydrocortisone classified as a class A corticosteroid. ... It is a synthetic steroid with topical anti-inflammatory properties without the systemic glucocorticoid …

Levetiracetam

Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures stemming from epileptic disorders. It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated to other anti-epileptic drugs (AEDs).[L8606,L8600,L8615] Levetiracetam possesses a wide therapeutic index[L8615,A185918]...
Approved
Matched Description: … indexes and a propensity for involvement in drug interactions. ... It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated ... desirable choice over other AEDs, a class of drugs notorious for having generally narrow therapeutic …
Matched Products: … Levetiracetam in Sodium Chloride ... Keppra Concentrate for Solution for Infusion 100 mg/ml ... INTIRACETAM CONCENTRATE FOR SOLUTION FOR INFUSION 100MG/ML …

Drometrizole trisiloxane

Drometrizole trisiloxane is a photostable UVA and UVB light filter [A33069, L2780, L2781, L2782, L2783, F81]. The compound is a lipophilic benzotriazole derivative marketed as Meroxyl XL by L'Oreal, although sunscreens with drometrizole trisiloxane are currently only approved for use in the EU, Canada, Australia, and Japan, among other countries....
Approved
Matched Description: … with drometrizole trisiloxane are currently only approved for use in the EU, Canada, Australia, and ... Drometrizole trisiloxane is a photostable UVA and UVB light filter [A33069, L2780, L2781, L2782, L2783 ... The compound is a lipophilic benzotriazole derivative marketed as Meroxyl XL by L'Oreal, although sunscreens …
Matched Mixtures name: … Kiehls Activated Sun Protector Sunscreen SPF 50 For Face and Body For All Skin Types ... Kiehls Activated Sun Protector Sunscreen SPF 30 For Face and Body For All Skin Types ... Anthelios XL Melt-IN Cream …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Cholestyramine

Cholestyramine or colestyramine is a bile acid sequestrant. Bile acid sequestrants are polymeric compounds which serve as ion exchange resins. Cholestyramine resin is quite hydrophilic, but insoluble in water.
Approved
Investigational
Matched Description: … Cholestyramine or colestyramine is a bile acid sequestrant. ... Cholestyramine resin is quite hydrophilic, but insoluble in water. …
Matched Categories: … Compounds used in a research, industrial, or household setting ... Medications that reduce magnesium levels ... Hypolipidemic Agents Indicated for Hyperlipidemia ... Non-statin Hypolipidemic Agents Indicated for Hyperlipidemia …
Matched Products: … Cholestyramine Powder for Suspension ... Cholestyramine for Oral Suspension ... PHL-cholestyramine Powder for Suspension 400gm/can …

Dimethyl sulfoxide

A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during cryopreservation. Dimethyl sulfoxide shows a range of pharmacological activity including...
Approved
Vet approved
Matched Description: … Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application ... A highly polar organic liquid, that is used widely as a chemical solvent. ... Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation …
Matched Categories: … Compounds used in a research, industrial, or household setting ... Topical Products for Joint and Muscular Pain …

Turoctocog alfa pegol

Turoctocog alfa pegol is a pegylated version of turoctocog alfa. Novo Nordisk's brand name Esperoct (turoctocog alfa pegol, N8-GP) was approved by the US FDA on February 19, 2019. Fundamentally, the N8-GP moiety is identical to turoctocog alfa, a recombinant human clotting factor VIII (rFVIII) with a truncated B-domain made...
Approved
Matched Description: … A as it ultimately provides a less burdensome and more convenient dosing regimen for patients that is ... factor VIII replacement therapy in patients with factor VIII deficiency, or hemophilia A [F3649]. ... 40-kDa polyethylene glycol (PEG) group to a specific _O_-glycan in the truncated B-domain of the general …

Viltolarsen

Duchenne muscular dystrophy (DMD) is an X-linked recessive allelic disorder characterized by a lack of functional dystrophin protein, which leads to progressive ambulatory, pulmonary, and cardiac function and is invariably fatal. A related, albeit a less severe, form of muscular dystrophy known as Becker muscular dystrophy (BMD) is characterized by...
Approved
Investigational
Matched Description: … mutations allows for exon skipping, which retains a productive reading frame and results in the production ... dystrophin levels in skeletal muscle of patients treated with viltolarsen; this approval is contingent ... Viltolarsen is a phosphorodiamidate morpholino oligonucleotide (PMO); PMOs are oligonucleotides in which …

Busulfan

Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought...
Approved
Investigational
Matched Description: … It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), ... Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow ... It is not a structural analog of the nitrogen mustards. …
Matched Categories: … Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Matched Products: … Busulfan Kabi Injection 6mg/ml Concentrate for Solution for Infusion ... Busulfan for Injection ... CANBUSUL- Busulfan Injection 6 mg/ml Concentrate for Solution for Infusion …

Hydrocortisone acetate

Approved
Vet approved
Matched Iupac: … 1,10-dihydroxy-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a] …
Matched Mixtures name: … Alcortin A ... Alcortin A …
Matched Products: … Poli-A …

Bulevirtide

Hepatitis D is considered the most severe type of viral hepatitis and leads to the rapid development of cirrhosis, severe decompensation of liver function, and an increased risk of mortality.[A226340,L30235] Until recently, there have been extremely limited treatments available for Hepatitis D infection. Bulevirtide, also known as Hepcludex, is a...
Approved
Investigational
Matched Description: … [A226305] Bulevirtide, also known as Hepcludex, is a first-in-class entry inhibitor for the treatment ... It was first approved for use in the EU on May 28, 2020; bulevirtide has been granted PRIME scheme eligibility ... [A226340,L30235] Until recently, there have been extremely limited treatments available for Hepatitis …
Matched Categories: … Antivirals for Systemic Use ... Antiinfectives for Systemic Use …

Poliovirus type 3 antigen (formaldehyde inactivated)

Poliovirus type 3 antigen is a suspension of poliovirus Type 3 (Saukett) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 3. The vaccine contains purified and inactivated poliovirus type 3 that were...
Approved
Investigational
Matched Description: … Poliovirus type 3 antigen is a suspension of poliovirus Type 3 (Saukett) used in the active immunization ... of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused ... The vaccine contains purified and inactivated poliovirus type 3 that were grown from a continuous line …
Matched Mixtures name: … -POLIO SUSPENSION FOR INJECTION IN PRE-FILLED SYRINGE ... Hexaxim Suspension for Injection ... BOOSTRIX POLIO SUSPENSION FOR INJECTION …

Estradiol acetate

Estradiol acetate is a pro-drug ester of DB00783, a naturally occurring hormone that circulates endogenously within the human body. Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone. As a pro-drug of estradiol, estradiol acetate therefore has the same downstream...
Approved
Investigational
Vet approved
Matched Iupac: … (1S,3aS,3bR,9bS,11aS)-1-hydroxy-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthren …
Matched Description: … Estradiol acetate is commercially available as Femring, a vaginal ring used for the treatment of moderate ... Because of the difference in potency between estradiol and estrone, menopause (and a change in primary ... Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex …

Peginterferon beta-1a

Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years of...
Approved
Matched Description: … It was originally approved by the FDA in 2014 for subcutaneous use, and was approved for intramuscular ... Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system ... occur more frequently in women than in men. …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Fezolinetant

Vasomotor symptoms (VMS), more colloquially known as hot flashes or night sweats, are some of the most common symptoms in menopause. With a median duration of 7.4 years, vasomotor symptoms are also the most common reasons why women seek treatments for menopausal issues.[A259591,A259596] Although mostly considered a nuisance, vasomotor symptoms...
Approved
Investigational
Matched Iupac: … 5-[(8R)-7-(4-fluorobenzoyl)-8-methyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-3-yl]-3-methyl-1,2,4-thiadiazole …
Matched Description: … effective treatments for VMS by relieving symptoms in as many as 95% of menopausal women. ... [L46422] It was subsequently approved by the EMA in December 2023 for the same indication.[L50086] ... quality of life, as women with 7 or more moderate to severe VMS daily have reported a decline in sleep …
Displaying drugs 301 - 325 of 13884 in total