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Displaying drugs 326 - 350 of 15136 in total

Maralixibat

Maralixibat (also known as SHP625, LUM001, and lopixibat) is an ileal bile acid transporter inhibitor, like odevixibat.[A236823,A239249,L38834] Maralixibat is indicated for the treatment of cholestatic pruritus in patients with Alagille syndrome. Previously, patients with cholestatic pruritus associated with Alagille syndrome were treated with antihistamines, rifampin, ursodeoxycholic acid, cholestyramine, naltrexone, and...
Approved
Investigational
Matched Description: … Maralixibat (also known as SHP625, LUM001, and lopixibat) is an ileal bile acid transporter inhibitor ... pruritus associated with Alagille syndrome were treated with antihistamines, [rifampin], [ursodeoxycholic acid ... ], [cholestyramine], [naltrexone], and [sertraline] alone or in combination. …
Matched Categories: … Bile and Liver Therapy ... Alimentary Tract and Metabolism ... Ileal bile acid transport inhibitor ... Ileal Bile Acid Transporter Inhibitor …

Latanoprostene bunod

Latanoprostene Bunod has been used in trials studying the treatment of Glaucoma, Ocular Hypertension, Open-Angle Glaucoma, Open Angle Glaucoma, and Intraocular Pressure. As of November 2, 2017 the FDA approved Bausch + Lomb's Vyzulta (latanoprostene bunod opthalmic solution), 0.024% for the indication of reducing intraocular pressure in patients with open-angle...
Approved
Investigational
Matched Description: … In comparison, both latanoprost and latanoprostene bunod contain a latanoprost acid backbone. ... proposed dual mechanism of action that stems from both its prostaglandin F2-alpha analog latanoprost acid ... metabolite and its ability to donate NO for proposed tissue/cell relaxation effects. …
Matched Categories: … Antiglaucoma Preparations and Miotics …

Phenoxyethanol

Phenoxyethanol is a colorless liquid with a pleasant odor. It is a glycol ether used as a perfume fixative, insect repellent, antiseptic, solvent, preservative, and also as an anesthetic in fish aquaculture. Phenoxyethanol is an ether alcohol with aromatic properties. It is both naturally found and manufactured synthetically. Demonstrating antimicrobial...
Approved
Matched Description: … It is produced by reacting phenol (EU) and ethylene oxide (EU) at a high temperature and pressure. ... It has also been used in vaccines and shown to inactivate bacteria, and several types of yeast [A32838 ... a low water solubility and evaporation rate. …
Matched Mixtures name: … Puricia Sanitizing Wipes (Citrus) …

Dextropropoxyphene

Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the market in Europe...
Approved
Illicit
Investigational
Withdrawn
Matched Description: … It displays antitussive and local anaesthetic actions. ... been withdrawn from the market in Europe and the United States. ... Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. …
Matched Mixtures name: … Propoxyphene and Acetaminophen ... Propoxyphene and Acetaminophen ... Propoxyphene and Acetaminophen …

Tazobactam

Tazobactam is an antibiotic of the beta-lactamase inhibitor class that prevents the breakdown of other antibiotics by beta-lactamase enzyme producing organisms. It is combined with Piperacillin and Ceftolozane for the treatment of a variety of bacterial infections. Piperacillin-tazobactam was initially approved by the FDA in 1994, and ceftolozane-tazobactam was approved...
Approved
Matched Iupac: … 4,4,7-trioxo-3-[(1H-1,2,3-triazol-1-yl)methyl]-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid …
Matched Description: … It is combined with [Piperacillin] and [Ceftolozane] for the treatment of a variety of bacterial infections ... ventilator-associated bacterial pneumonia, which are significant causes of morbidity and mortality in ... , ceftolozane-tazobactam was approved by the FDA for treating hospital-acquired bacterial pneumonia and …
Matched Mixtures name: … Piperacillin and Tazobactam ... Piperacillin and Tazobactam ... Piperacillin and Tazobactam …

Chlordiazepoxide

An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal.
Approved
Illicit
Investigational
Matched Description: … An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. …
Matched Mixtures name: … Chlordiazepoxide and Amitriptyline Hydrochloride ... Chlordiazepoxide and Amitriptyline HCl ... Chlordiazepoxide and Amitriptyline HCl …
Matched Categories: … Hypnotics and Sedatives ... Benzodiazepines and benzodiazepine derivatives ... Nucleic Acids, Nucleotides, and Nucleosides …

Oxycodone

Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. It is currently indicated as an immediate release product for moderate to severe pain and as an extended release product for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period.[Label] The first oxycodone...
Approved
Illicit
Investigational
Matched Description: … [A178696] It is currently indicated as an immediate release product for moderate to severe pain and as …
Matched Mixtures name: … Oxycodone and Aspirin ... Oxycodone and Aspirin ... Oxycodone and Acetaminophen …
Matched Categories: … oxycodone and acetylsalicylic acid ... oxycodone and naloxone ... oxycodone and ibuprofen ... oxycodone and naltrexone ... oxycodone and paracetamol …

Misoprostol

Misoprostol is a prostaglandin analog used to reduce the risk of NSAID related ulcers, manage miscarriages, prevent post partum hemorrhage, and also for first trimester abortions.[L7616,L7619,A181589,A181583,A181697] The stimulation of prostaglandin receptors in the stomach reduces gastric acid secretion, while stimulating these receptors in the uterus and cervix can increase the...
Approved
Matched Description: … ,A181589,A181583,A181697] The stimulation of prostaglandin receptors in the stomach reduces gastric acid ... secretion, while stimulating these receptors in the uterus and cervix can increase the strength and ... frequency of contractions and decrease cervical tone. …
Matched Mixtures name: … Diclofenac Sodium and Misoprostol ... Diclofenac Sodium and Misoprostol ... Diclofenac Sodium and Misoprostol …
Matched Categories: … Drugs for Acid Related Disorders ... naproxen and misoprostol ... Alimentary Tract and Metabolism ... Genito Urinary System and Sex Hormones ... Antiinflammatory and Antirheumatic Products …

Norgestimate

Norgestimate was first described in the literature in 1977. It was developed by Ortho Pharmaceutical Corporation as part of an effort to develop new hormonal contraceptives with reduced adverse effects. It is commonly formulated with ethinylestradiol as a combined oral contraceptive that can also be used to treat moderate acne...
Approved
Investigational
Matched Mixtures name: … Norgestimate and Ethinyl Estradiol ... Norgestimate and Ethinyl Estradiol ... Norgestimate and Ethinyl Estradiol …
Matched Categories: … norgestimate and estrogen ... norgestimate and ethinylestradiol ... norgestimate and ethinylestradiol ... Genito Urinary System and Sex Hormones ... Combination Contraceptives (with Estrogen and derivatives) …

Amitriptyline

Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties.
Approved
Matched Mixtures name: … Perphenazine and Amitriptyline Hydrochloride ... Perphenazine and Amitriptyline Hydrochloride ... Chlordiazepoxide and Amitriptyline HCl …
Matched Categories: … Medications that increase serum magnesium ... amitriptyline and psycholeptics ... Tricyclics and Other Norepinephrine-reuptake Inhibitors …

Olanzapine

Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug interactions. Olanzapine very closely resembles clozapine and only differs by...
Approved
Investigational
Matched Description: … and the absence of a chloride moiety. ... [A176996] The second-generation antipsychotics were introduced in the 90s and quickly gained traction ... [T554] It was discovered by scientists at Eli Lilly and approved to be marketed in the US in 1996. …
Matched Mixtures name: … Olanzapine and Fluoxetine ... Olanzapine and Fluoxetine ... Olanzapine and Fluoxetine …
Matched Categories: … olanzapine and samidorphan ... Diazepines, Oxazepines, Thiazepines and Oxepines …

Amikacin

Amikacin is a semi-synthetic aminoglycoside antibiotic that is derived from kanamycin A.[FDA label] Amikacin is synthesized by acylation with the l-(-)-γ-amino-α-hydroxybutyryl side chain at the C-1 amino group of the deoxystreptamine moiety of kanamycin A. Amikacin's unique property is that it exerts activity against more resistant gram-negative bacilli such as...
Approved
Investigational
Vet approved
Matched Description: … of breath and the coughing up of blood. ... some Mycobacterium (M. avium-intracellulare, M. chelonae, and M. fortuitum)[L4680]. ... that it exerts activity against more resistant gram-negative bacilli such as Acinetobacter baumanii and …
Matched Categories: … cefepime and amikacin ... Medications that reduce magnesium levels …

Ethynodiol diacetate

A synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive. Although etynodiol or ethynodiol are sometimes used as a synonym for ethynodiol diacetate, what is usually being referred to is actually ethynodiol diacetate and not ethynodiol (which is a separate drug that has never been...
Approved
Matched Description: … synonym for ethynodiol diacetate, what is usually being referred to is actually ethynodiol diacetate and …
Matched Mixtures name: … Ethynodiol Diacetate and Ethinyl Estradiol ... Ethynodiol Diacetate and Ethinyl Estradiol …
Matched Categories: … Genito Urinary System and Sex Hormones ... Sex Hormones and Modulators of the Genital System ... Combination Contraceptives (with Estrogen and derivatives) …

Emtricitabine

Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) indicated for the treatment of HIV infection in adults or combined with tenofovir alafenamide for the prevention of HIV-1 infection in high risk adolescents and adults. Emtricitabine is a cytidine analogue. The drug works by inhibiting HIV reverse transcriptase, preventing transcription of...
Approved
Investigational
Matched Description: … combined with [tenofovir alafenamide] for the prevention of HIV-1 infection in high risk adolescents and …
Matched Mixtures name: … Emtricitabine and Tenofovir Disoproxil Fumarate ... Emtricitabine and Tenofovir Disoproxil Fumarate ... Emtricitabine and Tenofovir Disoproxil Fumarate …
Matched Categories: … Nucleic Acid Synthesis Inhibitors ... tenofovir disoproxil and emtricitabine ... emtricitabine and tenofovir alafenamide ... Nucleic Acids, Nucleotides, and Nucleosides ... emtricitabine, tenofovir disoproxil and efavirenz …

Trandolapril

Trandolapril is a non-sulhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure...
Approved
Matched Iupac: … -[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-octahydro-1H-indole-2-carboxylic acid …
Matched Description: … ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS ... to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and ... stable patients with left ventricular dysfunction, as an adjunct treatment for congestive heart failure, and …
Matched Mixtures name: … Trandolapril and Verapamil Hydrochloride ... Trandolapril and Verapamil Hydrochloride ... Trandolapril and Verapamil Hydrochloride …
Matched Categories: … trandolapril and verapamil ... ACE Inhibitors and Calcium Channel Blockers …

Verapamil

Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes drugs...
Approved
Matched Description: … angina,[L8791] and was the first calcium channel antagonist to be introduced into therapy in the early ... phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and ... of the non-dihydropyridine class of calcium channel blockers, which includes drugs like [diltiazem] and …
Matched Mixtures name: … Trandolapril and Verapamil Hydrochloride ... Trandolapril and Verapamil Hydrochloride ... Trandolapril and Verapamil Hydrochloride …
Matched Categories: … Verapamil and analogues ... trandolapril and verapamil ... ACE Inhibitors and Calcium Channel Blockers …

Opium

Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was...
Approved
Illicit
Matched Description: … This plant is an integrant of the Papaveraceae family, and it is characterized by solitary leaves and ... Morphine is the most prevalent and principal alkaloid in opium, and it is responsible for most of the ... During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. …
Matched Mixtures name: … Belladonna and Opium ... Belladonna and Opium ... Belladonna and Opium …
Matched Categories: … Alimentary Tract and Metabolism …

Colchicine

Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as Colchicum autumnale, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events....
Approved
Matched Description: … [L8192] Colchicine is used in the treatment of gout flares and Familial Mediterranean fever,[L8138] and ... [L47591] It has also been investigated in other inflammatory and fibrotic conditions.[A183602] …
Matched Mixtures name: … Probenecid and Colchicine ... Probenecid and Colchicine ... Probenecid and Colchicine …
Matched Categories: … colchicine and probenecid ... Preparations With No Effect on Uric Acid Metabolism …

Drospirenone

Drospirenone is a synthetic progestin commonly found in the popular oral contraceptive, Yaz in combination with Ethinyl estradiol. Most recently, it was approved by both Health Canada and the FDA in combination with Estetrol as an oral contraceptive therapy.[L33199,L33174] Aside from its contraceptive effects, drospirenone is used with estrogens to...
Approved
Matched Description: … [L7973] Most recently, it was approved by both Health Canada and the FDA in combination with [Estetrol ... ,L33174] Aside from its contraceptive effects, drospirenone is used with estrogens to control acne and ... during the postpartum period, and this should be considered when assessing potential risks of hormonal …
Matched Mixtures name: … Drospirenone and Ethinyl Estradiol ... Drospirenone and Ethinyl Estradiol ... Drospirenone and Ethinyl Estradiol …
Matched Categories: … drospirenone and estetrol ... drospirenone and estrogen ... drospirenone and ethinylestradiol ... Genito Urinary System and Sex Hormones ... Sex Hormones and Modulators of the Genital System …

Pantethine

Pantethine is a naturally occurring compound synthesized in the body from pantothenic acid (vitamin B5) via addition of cysteamine. It consists of two molecules of pantetheine that form a dimer via disufide linkages, and acts as an intermediate in the production of Coenzyme A. Coenzyme A plays an essential role...
Approved
Investigational
Matched Description: … fatty acid oxidation, carbohydrate metabolism, pyruvate degradation, and amino acid catabolism [A27255 ... Pantethine is a naturally occurring compound synthesized in the body from pantothenic acid (vitamin B5 ... Pantethine is available as a dietary supplement for lowering blood cholesterol and triglycerides. …
Matched Categories: … Alimentary Tract and Metabolism …

Belladonna

Belladonna, also known as atropa belladonna or deadly nightshade, is a perennial herbaceous plant in the nightshade family Solanaceae. Its roots, leaves and fruits contain DB00424, DB00747, and mostly, DB00572. These alkaloids are naturally-occurring muscarinic antagonists. DB00572 is a non-selective muscarinic antagonist that is mainly used as an adjunct for...
Approved
Experimental
Matched Description: … Its roots, leaves and fruits contain [DB00424], [DB00747], and mostly, [DB00572]. ... Belladonna is a poisonous plant and belladonna intoxication from accidental ingestion may result in a ... severe anticholinergic syndrome, which is associated with both central and peripheral manifestations …
Matched Mixtures name: … Belladonna and Opium ... Belladonna and Opium ... Belladonna and Opium …

Hydralazine

Originally developed in the 1950s as a malaria treatment, hydralazine showed antihypertensive ability and was soon repurposed. Hydralazine is a hydrazine derivative vasodilator used alone or as adjunct therapy in the treatment of hypertension and only as adjunct therapy in the treatment of heart failure.[A186820,L8782,L8785] Hydralazine is no longer a...
Approved
Matched Description: … Originally developed in the 1950s as a malaria treatment, hydralazine showed antihypertensive ability and ... hydrazine derivative vasodilator used alone or as adjunct therapy in the treatment of hypertension and …
Matched Mixtures name: … Hydralazine HCl and Hydrochlorothiazide ... Hydralazine HCl and Hydrochlorothiazide ... Hydralazine HCl and Hydrochlorothiazide …
Matched Categories: … Medications that reduce magnesium levels ... hydralazine and diuretics ... Hydrazinophthalazine Derivatives and Diuretics …

Alfacalcidol

Alfacalcidol, or 1-alpha-hydroxycholecalciferol or 1-alpha-hydroxyvitamin D3, is a non-endogenous analogue of vitamin D. It plays an essential function in calcium homeostasis and bone metabolism. Alfacaldisol is activated by the enzyme 25-hydroxylase in the liver to mediate its effects in the body, or most importantly, the kidneys and bones. The pharmacological...
Approved
Nutraceutical
Matched Description: … malabsorptive rickets and osteomalacia, vitamin D-dependent rickets and osteomalacia, and hypophosphataemic ... vitamin D resistant rickets and osteomalacia. ... [A234044] It plays an essential function in calcium homeostasis and bone metabolism. …
Matched Categories: … alendronic acid and alfacalcidol, sequential ... Vitamin D and Analogues ... Alimentary Tract and Metabolism ... Drugs Affecting Bone Structure and Mineralization …

Vanadium

Approved
Experimental
Matched Mixtures name: … Chromium and Vanadium (combo) ... Revit Multi-vitamins and Minerals ... Multivitamins and Minerals for Men …
Matched Categories: … Diet, Food, and Nutrition …

Ciclopirox

Ciclopirox olamine (used in preparations called Batrafen, Loprox, Mycoster, Penlac and Stieprox) is a synthetic antifungal agent for topical dermatologic treatment of superficial mycoses. In particular, the agent is especially effective in treating Tinea versicolor.
Approved
Investigational
Matched Description: … Ciclopirox olamine (used in preparations called Batrafen, Loprox, Mycoster, Penlac and Stieprox) is a …
Matched Mixtures name: … Ciclopirox 0.77% / Salicylic Acid 2% ... Ciclopirox Olamine 1% / Salicylic Acid 2% ... Ciclopirox Olamine 0.77% / Clobetasol Propionate 0.05% / Salicylic Acid 3%. …
Matched Categories: … Vaginal Creams, Foams, and Jellies ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …
Displaying drugs 326 - 350 of 15136 in total