Displaying drugs 376 - 400 of 1182 in total
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Approved
Investigational
Matched Synonyms: … Black lead ... Stove black ... C.i. pigment black 10 …
Ondansetron
A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
Having been developed in the 1980s by GlaxoSmithKline and approved by the US FDA since January 1991, ondansetron has...
Approved
Withdrawn
Matched Description: … cisplatin, and has reported anxiolytic and neuroleptic properties. ... Commonly formulated as oral tablets, orally disintegrating tablets (ODT), and injections, and available ... ondansetron has demonstrated a long history of use and efficacy. …
Matched Categories: … Antiemetics and Antinauseants …
Matched Products: … Ondansetron Hydrochloride and Dextrose ... Ondansetron and Dextrose ... Ondansetron hydrochloride and dextrose …
Matched Categories: … Antiemetics and Antinauseants …
Matched Products: … Ondansetron Hydrochloride and Dextrose ... Ondansetron and Dextrose ... Ondansetron hydrochloride and dextrose …
Magaldrate
Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market.
Approved
Withdrawn
Matched Synonyms: … Aluminium magnesium hydroxide sulfate hydrate ... Aluminum magnesium hydroxide sulfate hydrate ... Aluminum magnesium hydroxide sulphate hydrate …
Matched Description: … Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and …
Matched Categories: … Aluminum and magnesium containing antacids ... Alimentary Tract and Metabolism ... magaldrate and antiflatulents ... Magnesium Compounds …
Matched Description: … Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and …
Matched Categories: … Aluminum and magnesium containing antacids ... Alimentary Tract and Metabolism ... magaldrate and antiflatulents ... Magnesium Compounds …
Darunavir
Darunavir is a protease inhibitor used with other HIV protease inhibitor drugs as well as ritonavir for the effective management of HIV-1 infection. As a second-generation protease inhibitor, darunavir is designed to combat resistance to standard HIV therapy.[A2278,A2281] It was initially approved by the FDA in 2006. Darunavir is being...
Approved
Matched Description: … [A191682] Clinical trials are underway and are expected to conclude in August 2020.[L12066] …
Matched Categories: … darunavir and cobicistat ... darunavir and ritonavir ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics ... emtricitabine, tenofovir alafenamide, darunavir and cobicistat …
Matched Products: … Darunavir 600 and 800 mg …
Matched Categories: … darunavir and cobicistat ... darunavir and ritonavir ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics ... emtricitabine, tenofovir alafenamide, darunavir and cobicistat …
Matched Products: … Darunavir 600 and 800 mg …
Echinacea purpurea flowering top
Approved
Experimental
Matched Synonyms: … Brauneria purpurea flowering top ... Purple coneflower flowering top ... Rudbeckia purpurea flowering top …
Matched Name: … Echinacea purpurea flowering top …
Matched Name: … Echinacea purpurea flowering top …
Epimedium grandiflorum top
Epimedium grandiflorum top is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Experimental
Matched Synonyms: … Epimedium Grandiflorum Leaf/stem ... Barrenwort Top ... Epimedium Macranthum Top …
Matched Name: … Epimedium grandiflorum top …
Matched Description: … Epimedium grandiflorum top is a plant/plant extract used in some OTC (over-the-counter) products. …
Matched Name: … Epimedium grandiflorum top …
Matched Description: … Epimedium grandiflorum top is a plant/plant extract used in some OTC (over-the-counter) products. …
Ginkgo biloba leaf oil
Ginkgo biloba leaf oil is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Experimental
Matched Synonyms: … Common Ginkgo Leaf Oil ... Common Ginkgo Leaf Water ... Ginkgo Biloba Leaf Water …
Matched Name: … Ginkgo biloba leaf oil …
Matched Description: … Ginkgo biloba leaf oil is a plant/plant extract used in some OTC (over-the-counter) products. …
Matched Name: … Ginkgo biloba leaf oil …
Matched Description: … Ginkgo biloba leaf oil is a plant/plant extract used in some OTC (over-the-counter) products. …
Black cohosh
Black cohosh (Actaea racemosa or Cimicifuga racemosa), a member of the buttercup family, is a perennial plant which native to North America. Historical names for this plant include snakeroot, black bugbane, rattleweed, macrotys, and rheumatism weed. Black cohosh has a long history of use. Native Americans used it for its...
Experimental
Matched Synonyms: … Black cohosh ... Black snakeroot …
Matched Name: … Black cohosh …
Matched Description: … Black cohosh (_Actaea racemosa_ or _Cimicifuga racemosa_), a member of the buttercup family, is a perennial ... Historical names for this plant include snakeroot, black bugbane, rattleweed, macrotys, and rheumatism ... Black cohosh has a long history of use. …
Matched Categories: … Herbs and Natural Products ... Genito Urinary System and Sex Hormones …
Matched Products: … Black Cohosh Tablet ... Black Cohosh Root Powder …
Matched Name: … Black cohosh …
Matched Description: … Black cohosh (_Actaea racemosa_ or _Cimicifuga racemosa_), a member of the buttercup family, is a perennial ... Historical names for this plant include snakeroot, black bugbane, rattleweed, macrotys, and rheumatism ... Black cohosh has a long history of use. …
Matched Categories: … Herbs and Natural Products ... Genito Urinary System and Sex Hormones …
Matched Products: … Black Cohosh Tablet ... Black Cohosh Root Powder …
Levonorgestrel
Levonorgestrel (LNG) is a synthetic progestogen similar to Progesterone used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of these devices...
Approved
Investigational
Matched Description: … Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone ... Some of these devices are known as Jaydess, Kyleena, and Mirena. ... [A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as …
Matched Mixtures name: … Levonorgestrel and Ethinyl Estradiol and Ethinyl Estradiol ... Levonorgestrel and Ethinyl Estradiol and Ethinyl Estradiol ... Levonorgestrel and Ethinyl Estradoil …
Matched Categories: … Combination Contraceptives (with Estrogen and derivatives) ... Genito Urinary System and Sex Hormones ... levonorgestrel and estrogen ... levonorgestrel and estrogen ... levonorgestrel and ethinylestradiol …
Matched Products: … ONE-AND-ONE …
Matched Mixtures name: … Levonorgestrel and Ethinyl Estradiol and Ethinyl Estradiol ... Levonorgestrel and Ethinyl Estradiol and Ethinyl Estradiol ... Levonorgestrel and Ethinyl Estradoil …
Matched Categories: … Combination Contraceptives (with Estrogen and derivatives) ... Genito Urinary System and Sex Hormones ... levonorgestrel and estrogen ... levonorgestrel and estrogen ... levonorgestrel and ethinylestradiol …
Matched Products: … ONE-AND-ONE …
Zinc sulfate
Zinc sulfate is the inorganic compound with the formula ZnSO4 and historically known as "white vitriol". It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.
Approved
Investigational
Matched Synonyms: … Zinc sulphate ... Zinc sulfate anhydrous ... Zinc sulfate (anhydrous) …
Matched Name: … Zinc sulfate …
Matched Iupac: … zinc(2+) sulfate …
Matched Description: … Zinc sulfate is the inorganic compound with the formula ZnSO4 and historically known as "white vitriol …
Matched Mixtures name: … Calcium and Magnesium W Zinc Tab ... Prenatal Vitamin and Mineral Supplement ... Multiple Vitamins and Minerals …
Matched Salts name: … Zinc sulfate heptahydrate ... Zinc sulfate hexahydrate ... Zinc sulfate monohydrate …
Matched Categories: … Alimentary Tract and Metabolism ... Sulfates ... Blood and Blood Forming Organs ... Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use ... Blood Substitutes and Perfusion Solutions …
Matched Products: … ZINC SULFATE HEPTAHYDRATE ... Anu-aide - Ont Top 0.5% ... Zinc Sulfate …
Matched Name: … Zinc sulfate …
Matched Iupac: … zinc(2+) sulfate …
Matched Description: … Zinc sulfate is the inorganic compound with the formula ZnSO4 and historically known as "white vitriol …
Matched Mixtures name: … Calcium and Magnesium W Zinc Tab ... Prenatal Vitamin and Mineral Supplement ... Multiple Vitamins and Minerals …
Matched Salts name: … Zinc sulfate heptahydrate ... Zinc sulfate hexahydrate ... Zinc sulfate monohydrate …
Matched Categories: … Alimentary Tract and Metabolism ... Sulfates ... Blood and Blood Forming Organs ... Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use ... Blood Substitutes and Perfusion Solutions …
Matched Products: … ZINC SULFATE HEPTAHYDRATE ... Anu-aide - Ont Top 0.5% ... Zinc Sulfate …
Olea europaea leaf
Experimental
Matched Synonyms: … Olive leaf ... Common olive leaf ... Olea sativa leaf …
Matched Name: … Olea europaea leaf …
Matched Name: … Olea europaea leaf …
Sodium lauryl sulfate
Sodium Lauryl Sulfate (SLS) is an anionic surfactant naturally derived from coconut and/or palm kernel oil. It usually consists of a mixture of sodium alkyl sulfates, mainly the lauryl. SLS lowers surface tension of aqueous solutions and is used as fat emulsifier, wetting agent, and detergent in cosmetics, pharmaceuticals and...
Experimental
Matched Synonyms: … Sodium dodecyl sulfate ... Sodium lauryl sulfate ... Sodium dodecyl sulphate …
Matched Name: … Sodium lauryl sulfate …
Matched Iupac: … sodium dodecyl sulfate …
Matched Description: … Sodium Lauryl Sulfate (SLS) is an anionic surfactant naturally derived from coconut and/or palm kernel ... It usually consists of a mixture of sodium alkyl sulfates, mainly the lauryl. ... SLS lowers surface tension of aqueous solutions and is used as fat emulsifier, wetting agent, and detergent …
Matched Name: … Sodium lauryl sulfate …
Matched Iupac: … sodium dodecyl sulfate …
Matched Description: … Sodium Lauryl Sulfate (SLS) is an anionic surfactant naturally derived from coconut and/or palm kernel ... It usually consists of a mixture of sodium alkyl sulfates, mainly the lauryl. ... SLS lowers surface tension of aqueous solutions and is used as fat emulsifier, wetting agent, and detergent …
Chlorhexidine
Chlorhexidine is a broad-spectrum antimicrobial biguanide used as a topical antiseptic and in dental practice for the treatment of inflammatory dental conditions caused by microorganisms. It is one of the most common skin and mucous membrane antiseptic agents in use today. The molecule itself is a cationic bis-guanide consisting of...
Approved
Vet approved
Withdrawn
Matched Description: … Chlorhexidine is a broad-spectrum antimicrobial biguanide used as a topical antiseptic and in dental ... [L11512] It is one of the most common skin and mucous membrane antiseptic agents in use today. ... [A190417] The molecule itself is a cationic bis-guanide consisting of two 4-chlorophenyl rings and two …
Matched Mixtures name: … QCare Rx Oral Cleansing and Suctioning System, Q4 ... QCare Rx Oral Cleansing and Suctioning System ... Oral Cleansing and Suctioning System, q2 …
Matched Categories: … Alimentary Tract and Metabolism ... Biguanides and Amidines ... Antiseptics and Disinfectants ... Mouthwashes and Gargles ... Antiinfectives and Antiseptics for Local Oral Treatment …
Matched Products: … Foster and Thrive ... 3M AVAGARD 9232 ANTISEPTIC HAND AND BODY WASH CLORHEXIDINE GLUCONATE 2% W/W SOLUTION BOTTE . …
Matched Mixtures name: … QCare Rx Oral Cleansing and Suctioning System, Q4 ... QCare Rx Oral Cleansing and Suctioning System ... Oral Cleansing and Suctioning System, q2 …
Matched Categories: … Alimentary Tract and Metabolism ... Biguanides and Amidines ... Antiseptics and Disinfectants ... Mouthwashes and Gargles ... Antiinfectives and Antiseptics for Local Oral Treatment …
Matched Products: … Foster and Thrive ... 3M AVAGARD 9232 ANTISEPTIC HAND AND BODY WASH CLORHEXIDINE GLUCONATE 2% W/W SOLUTION BOTTE . …
Ginkgo biloba
Ginkgo biloba extract contains a group of terpene lactones (notably, ginkgolides and diterpenes) and ginkgo flavone glycosides (notably, ginkgetin, bilobetin, and sciadopitysin) that have antioxidant and vasoactive properties. Most of the studies that investigate the effect of ginkgo biloba use the standardized extract of Ginkgo biloba (EGb) 761 (EGb761), which...
Approved
Investigational
Nutraceutical
Matched Synonyms: … Common ginkgo leaf ... Ginkgo leaf ... Ginkgo biloba leaf …
Matched Description: … [A232379] _Ginkgo folium_, the leaf extract of _Ginkgo biloba_, is considered an anti-dementia drug by ... _Ginkgo biloba_ extract contains a group of terpene lactones (notably, ginkgolides and diterpenes) and ... ginkgo flavone glycosides (notably, ginkgetin, bilobetin, and sciadopitysin) that have antioxidant and …
Matched Mixtures name: … Bee Venom Wart And Tags Removal Treatment …
Matched Categories: … donepezil, memantine and Ginkgo folium …
Matched Description: … [A232379] _Ginkgo folium_, the leaf extract of _Ginkgo biloba_, is considered an anti-dementia drug by ... _Ginkgo biloba_ extract contains a group of terpene lactones (notably, ginkgolides and diterpenes) and ... ginkgo flavone glycosides (notably, ginkgetin, bilobetin, and sciadopitysin) that have antioxidant and …
Matched Mixtures name: … Bee Venom Wart And Tags Removal Treatment …
Matched Categories: … donepezil, memantine and Ginkgo folium …
Ocimum tenuiflorum top
Ocimum tenuiflorum top is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Approved
Experimental
Matched Synonyms: … Holy Basil Leaf/stem ... Tulsi Top ... Tulasi Top …
Matched Name: … Ocimum tenuiflorum top …
Matched Description: … Ocimum tenuiflorum top is a plant/plant extract used in some OTC (over-the-counter) products. …
Matched Name: … Ocimum tenuiflorum top …
Matched Description: … Ocimum tenuiflorum top is a plant/plant extract used in some OTC (over-the-counter) products. …
Codeine
The relief of pain (analgesia) is a primary goal for enhancing the quality of life of patients and for increasing the ability of patients to engage in day to day activities. Codeine, an opioid analgesic, was originally approved in the US in 1950 and is a drug used to decrease...
Approved
Illicit
Matched Description: … The relief of pain (analgesia) is a primary goal for enhancing the quality of life of patients and for ... agent, and is also recommended in certain diseases with incessant coughing. ... Codeine, an opioid analgesic, was originally approved in the US in 1950 and is a drug used to decrease …
Matched Mixtures name: … Acetaminophen and Codeine Phosphate ... Acetaminophen and Codeine Phosphate ... Acetaminophen and Codeine Phosphate …
Matched Salts name: … Codeine sulfate ... Codeine phosphate ... Codeine sulfate anhydrous ... Codeine phosphate hemihydrate …
Matched Categories: … Cough and Cold Preparations ... codeine and ibuprofen ... codeine and paracetamol ... Opium Alkaloids and Derivatives ... codeine and acetylsalicylic acid …
Matched Products: … Linctus Codeine Blanc ... Codeine Sulfate ... Codeine sulfate …
Matched Mixtures name: … Acetaminophen and Codeine Phosphate ... Acetaminophen and Codeine Phosphate ... Acetaminophen and Codeine Phosphate …
Matched Salts name: … Codeine sulfate ... Codeine phosphate ... Codeine sulfate anhydrous ... Codeine phosphate hemihydrate …
Matched Categories: … Cough and Cold Preparations ... codeine and ibuprofen ... codeine and paracetamol ... Opium Alkaloids and Derivatives ... codeine and acetylsalicylic acid …
Matched Products: … Linctus Codeine Blanc ... Codeine Sulfate ... Codeine sulfate …
Muparfostat
Muparfostat (PI-88) is a mixture of highly sulfated, monophosphorylated mannose oligosaccharides, derived from the extracellular phosphomannan of the yeast Pichia (Hansenula) holstii, with potential antiangiogenic activity.
Investigational
Matched Synonyms: … Mannopentaose phosphate sulfate ... Sulfated mannopentaose phosphate ... -D-MANNAN, (1->3)-, 6-(DIHYDROGEN PHOSPHATE) TRIS(HYDROGEN SULFATE) …
Matched Description: … Muparfostat (PI-88) is a mixture of highly sulfated, monophosphorylated mannose oligosaccharides, derived …
Matched Salts name: … Muparfostat sodium …
Matched Description: … Muparfostat (PI-88) is a mixture of highly sulfated, monophosphorylated mannose oligosaccharides, derived …
Matched Salts name: … Muparfostat sodium …
Sodium tetradecyl sulfate
An anionic surface-active agent used for its wetting properties in industry and used in medicine as an irritant and sclerosing agent for hemorrhoids and varicose veins.
Approved
Investigational
Matched Synonyms: … Sodium tetradecyl sulfate ... Tetradecyl sodium sulfate ... Sodium tetradecyl sulphate …
Matched Name: … Sodium tetradecyl sulfate …
Matched Iupac: … sodium 7-ethyl-2-methylundecan-4-yl sulfate …
Matched Description: … irritant and sclerosing agent for hemorrhoids and varicose veins. ... An anionic surface-active agent used for its wetting properties in industry and used in medicine as an …
Matched Categories: … sodium tetradecyl sulfate …
Matched Products: … Sodium Tetradecyl Sulfate …
Matched Name: … Sodium tetradecyl sulfate …
Matched Iupac: … sodium 7-ethyl-2-methylundecan-4-yl sulfate …
Matched Description: … irritant and sclerosing agent for hemorrhoids and varicose veins. ... An anionic surface-active agent used for its wetting properties in industry and used in medicine as an …
Matched Categories: … sodium tetradecyl sulfate …
Matched Products: … Sodium Tetradecyl Sulfate …
Tolevamer
Sodium polystyrene sulfonate is a medication used to treat abnormally high potassium levels. It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines. It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among others, HIV.
Approved
Investigational
Matched Synonyms: … Polystyrene sulfonate …
Matched Description: … Sodium polystyrene sulfonate is a medication used to treat abnormally high potassium levels. ... It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines ... It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among …
Matched Salts name: … Tolevamer potassium sodium ... Tolevamer sodium …
Matched Categories: … Drugs for Treatment of Hyperkalemia and Hyperphosphatemia ... polystyrene sulfonate ... Potassium Binder ... Potassium-removing Agents ... Potassium Ion Exchange Activity …
Matched Products: … Sodium Polystyrene Sulfonate ... PMS-sodium Polystyrene Sulfonate ... Odan-sodium Polystyrene Sulfonate …
Matched Description: … Sodium polystyrene sulfonate is a medication used to treat abnormally high potassium levels. ... It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines ... It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among …
Matched Salts name: … Tolevamer potassium sodium ... Tolevamer sodium …
Matched Categories: … Drugs for Treatment of Hyperkalemia and Hyperphosphatemia ... polystyrene sulfonate ... Potassium Binder ... Potassium-removing Agents ... Potassium Ion Exchange Activity …
Matched Products: … Sodium Polystyrene Sulfonate ... PMS-sodium Polystyrene Sulfonate ... Odan-sodium Polystyrene Sulfonate …
Turnera diffusa leaf
Turnera diffusa leaf is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Experimental
Matched Synonyms: … Damiana Leaf ... Damiana Leaf Preparation ... Turnera Aphrodisiaca Leaf …
Matched Name: … Turnera diffusa leaf …
Matched Description: … Turnera diffusa leaf is a plant/plant extract used in some OTC (over-the-counter) products. …
Matched Name: … Turnera diffusa leaf …
Matched Description: … Turnera diffusa leaf is a plant/plant extract used in some OTC (over-the-counter) products. …
Lamivudine
A reverse transcriptase inhibitor and zalcitabine analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV).
Approved
Investigational
Matched Description: … A reverse transcriptase inhibitor and zalcitabine analog in which a sulfur atom replaces the 3' carbon ... It is used to treat Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV). …
Matched Mixtures name: … Abacavir Sulfate, Lamivudine and Zidovudine ... Lamivudine and Zidovudine ... Lamivudine and Zidovudine …
Matched Categories: … Medications that reduce magnesium levels ... lamivudine and abacavir ... stavudine and lamivudine ... zidovudine and lamivudine ... lamivudine and dolutegravir …
Matched Products: … Lamivudine and Zidovudine …
Matched Mixtures name: … Abacavir Sulfate, Lamivudine and Zidovudine ... Lamivudine and Zidovudine ... Lamivudine and Zidovudine …
Matched Categories: … Medications that reduce magnesium levels ... lamivudine and abacavir ... stavudine and lamivudine ... zidovudine and lamivudine ... lamivudine and dolutegravir …
Matched Products: … Lamivudine and Zidovudine …
Cinnamon leaf oil
Experimental
Matched Synonyms: … Cinnamomum zeylanicum leaf oil ... Cinnamomum verum leaf essential oil …
Matched Name: … Cinnamon leaf oil …
Matched Name: … Cinnamon leaf oil …
Alpinia officinarum leaf
Experimental
Matched Synonyms: … Alpinia officinarum leaf ... Chinese ginger leaf ... Chinese-ginger leaf …
Matched Name: … Alpinia officinarum leaf …
Matched Name: … Alpinia officinarum leaf …
Orthosiphon aristatus leaf
Approved
Experimental
Matched Synonyms: … Cat's whiskers leaf ... Java tea leaf ... Shen cha leaf …
Matched Name: … Orthosiphon aristatus leaf …
Matched Name: … Orthosiphon aristatus leaf …
Oxygen
Oxygen is an element displayed by the symbol O, and atomic number 8. It is an essential element for human survival. Decreased oxygen levels may be treated with medical oxygen therapy. Treatment with oxygen serves to increase blood oxygen levels and also exerts a secondary effect of decreasing blood flow...
Approved
Vet approved
Matched Description: … Oxygen is an element displayed by the symbol O, and atomic number 8. ... any disease that impairs the body's ability to take up and use gaseous oxygen. ... Treatment with oxygen serves to increase blood oxygen levels and also exerts a secondary effect of decreasing …
Matched Mixtures name: … Carbon Dioxide and Oxygen Mixture, Compressed, Oxidizing, N.O.S. …
Matched Products: … OSSIGENO FARMA GAS MEDICAL AND TECHNICAL GASES …
Matched Mixtures name: … Carbon Dioxide and Oxygen Mixture, Compressed, Oxidizing, N.O.S. …
Matched Products: … OSSIGENO FARMA GAS MEDICAL AND TECHNICAL GASES …
Displaying drugs 376 - 400 of 1182 in total