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Cyanocobalamin Co-60 is an analog of Vitamin B12 labeled with Co60. Cyanocobalamin Co-60 was used for the diagnosis of pernicious anemia, but now it is withdrawn from the market in the US for unknown reasons.
Approved
Withdrawn
Matched Synonyms: … Cyanocobalamin (60Co) ... Cyanocobalamin Co 60 ... Cyanocobalamine (60 Co) …
Matched Name: … Cyanocobalamin Co-60 …
Matched Description: … Cyanocobalamin Co-60 is an analog of Vitamin B12 labeled with Co60. ... Cyanocobalamin Co-60 was used for the diagnosis of pernicious anemia, but now it is withdrawn from the …
Experimental
Matched Synonyms: … Chondroitinsulfuric acid type B ... Chondroitin sulfate B ... Dermatan 4-sulfate
Matched Name: … Dermatan sulfate
Matched Salts name: … Dermatan sulfate sodium
Matched Categories: … Blood and Blood Forming Organs ... dermatan sulfate
Ibandronate, or BM 21.0955, is a third generation, nitrogen containing bisphosphonate similar to zoledronic acid, minodronic acid, and risedronic acid.[A203111,A203138] It is used to prevent and treat postmenopausal osteoporosis.[L13805,L13808] Ibandronate was first described in the literature in 1993 as a treatment for bone loss in dogs. Ibandronate was granted FDA...
Approved
Investigational
Matched Synonyms: … Ibandronic acid
Matched Iupac: … {1-hydroxy-3-[methyl(pentyl)amino]-1-phosphonopropyl}phosphonic acid
Matched Description: … ], [minodronic acid], and [risedronic acid]. ... [A203111,A203138] It is used to prevent and treat postmenopausal osteoporosis. ... Ibandronate, or BM 21.0955, is a third generation, nitrogen containing bisphosphonate similar to [zoledronic acid
Matched Mixtures name: … IBONE D® ... IBONE D 30000 ... IBONE D 30000 …
Matched Salts name: … Ibandronate sodium
Matched Categories: … ibandronic acid and colecalciferol ... Drugs Affecting Bone Structure and Mineralization ... ibandronic acid
Matched Products: … Ibandronate Sodium ... ACIDO IBANDRONICO DOC GENERICI ... Ibandronate sodium
Experimental
Matched Synonyms: … Dihydrogen sulfate ... Dihydrogen sulphate ... Acide sulfurique …
Matched Name: … Sulfuric acid
Matched Iupac: … sulfuric acid
Matched Categories: … Acids ... Sulfur Acids ... Acids, Noncarboxylic …
Docetaxel is a clinically well established anti-mitotic chemotherapy medication used for the treatment of different types of cancer, including breast, ovarian, and non-small cell lung cancer. Docetaxel is a complex diterpenoid molecule and a semisynthetic analogue of paclitaxel.[A259676,L46466] Docetaxel reversibly binds to microtubulin with high affinity in a 1:1 stoichiometric...
Approved
Investigational
Matched Synonyms: … Docetaxel anhydrous
Matched Description: … chemotherapy medication used for the treatment of different types of cancer, including breast, ovarian, and ... Docetaxel is a complex diterpenoid molecule and a semisynthetic analogue of [paclitaxel]. ... microtubulin with high affinity in a 1:1 stoichiometric ratio, allowing it to prevent cell division and
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … Oncotaxel Concentrate and solvent for solution for infusion 40 mg/ ml ... Docetaxel Anhydrous ... Docetaxel anhydrous
DHEA sulfate is the major steroid of the fetal adrenal. DHEA-S is the principal adrenal androgen and is secreted together with cortisol under the control of ACTH and prolactin. DHEA-S is elevated with hyperprolactinemia.
Investigational
Matched Synonyms: … Androst-5-en-17-on-3beta-yl sulfuric acid ... DHEA sulfate ... DHEA sulphate
Matched Name: … Prasterone sulfate
Matched Iupac: … -1H,2H,3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-yl]oxidanesulfonic acid
Matched Description: … DHEA sulfate is the major steroid of the fetal adrenal. ... ACTH and prolactin. ... DHEA-S is the principal adrenal androgen and is secreted together with cortisol under the control of …
Matched Salts name: … Prasterone sodium sulfate anhydrous
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Chondroitin sulfate is a glycosaminoglycan considered as a symptomatic slow-acting drug for osteoarthritis (SYSADOA). The SYSADOA status suggested a pain relief and increased joint mobility after a relative long regular administration, as well as a long-lasting effect after the end of the treatment. Chondroitin sulfate is composed of alternating 1,3-N-acetyl-β-d-galactosamine...
Approved
Investigational
Nutraceutical
Matched Synonyms: … Chondroitin sulfates ... Condroitín sulfato
Matched Name: … Chondroitin sulfate
Matched Description: … Chondroitin sulfate is composed of alternating 1,3-N-acetyl-β-d-galactosamine and 1,4-β-d-glucuronic ... acid units which bear 4-O- and/or 6-O-sulfations at the N-acetylgalactosamine units disposed of in specific ... [A32063] Chondroitin sulfate is sold as an OTC dietary supplement in North America and it is a prescription …
Matched Mixtures name: … Blackmores Joint Formula with Glucosamine and Chondroitin ... GLUCOSAMINE HYDROCHLORIDE 500 MG CHONDROITIN SULFATE 400 MG TABLETS ... Glucosamine Sulfate, Chondroitin Sulfate, Ibuprofen …
Matched Salts name: … Chondroitin sulfate sodium (bovine) ... Chondroitin sulfate sodium (shark) ... Chondroitin sulfate sodium (chicken) ... Chondroitin sulfate sodium (porcine) ... Chondroitin sulfate (bovine) …
Matched Categories: … chondroitin sulfate ... Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids …
Matched Products: … Chondroitin Sulfate 400mg ... Chondroitin sulphate 500mg tablets ... Gold Life® BioFlex Chondroitin Sulphate Capsule 400mg …
Alpha-tocopherol is the primary form of vitamin E that is preferentially used by the human body to meet appropriate dietary requirements. In particular, the RRR-alpha-tocopherol (or sometimes called the d-alpha-tocopherol stereoisomer) stereoisomer is considered the natural formation of alpha-tocopherol and generally exhibits the greatest bioavailability out of all of the...
Approved
Nutraceutical
Vet approved
Matched Synonyms: … alpha-tocopheryl acetate, D- ... D-alpha tocopheryl acetate ... D-alpha-Tocopheryl acetate …
Matched Name: … D-alpha-Tocopherol acetate …
Matched Description: … is considered the natural formation of alpha-tocopherol and generally exhibits the greatest bioavailability ... In particular, the RRR-alpha-tocopherol (or sometimes called the d-alpha-tocopherol stereoisomer) stereoisomer ... At the moment however, there exists a lack of formal data and evidence to support any such additional …
Matched Mixtures name: … Kordel"s Bio-Liquid Women"s Multi With Fish Oil Vegicap ... Folet DHA ... Multi Vitamin and Mineral vitamin …
Matched Categories: … Diet, Food, and Nutrition ... Tocopherols
Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from Micromonospora purpurea in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234354] Gentamicin is effective against both gram-positive and gram-negative organisms but is particularly useful for the treatment...
Approved
Vet approved
Matched Description: … , low cost, and availability. ... Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea ... [A234339,A234354] Gentamicin is effective against both gram-positive and gram-negative organisms but …
Matched Mixtures name: … Gentamicin Sulfate In 0.9% Sodium Chloride Injection ... Garasone Ophthalmic and Otic Solution ... DEXORYL EAR DROPS OILY SUSPENSION …
Matched Salts name: … Gentamicin sulfate
Matched Categories: … Ophthalmological and Otological Preparations ... alpha-Galactosidase, antagonists & inhibitors …
Matched Products: … Gentamicin Sulfate In Sodium Chloride ... Gentamicin Sulfate in Sodium Chloride ... INYECCION DE SULFATO DE GENTAMICINA ISOTONICA 1.6 MG/ ML …
Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically prior to ocular surgery to prevent or reduce intraoperative miosis....
Approved
Investigational
Matched Synonyms: … 3-fluoro-4-phenylhydratropic acid ... (±)-2-fluoro-α-methyl-4-biphenylacetic acid ... 2-(2-fluorobiphenyl-4-yl)propanoic acid
Matched Iupac: … 2-{2-fluoro-[1,1'-biphenyl]-4-yl}propanoic acid
Matched Description: … Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic ... and analgesic activity. ... Flurbiprofen is structurally and pharmacologically related to fenoprofen, ibuprofen, and ketoprofen. …
Matched Mixtures name: … MAJEZIK DUO %5 + %0.25 TOPIKAL JEL, 50 G ... MERDEX DUO %5 + %0.25 TOPIKAL JEL, 30 G ... MERDEX DUO %5 + %0.25 TOPIKAL JEL, 50 G …
Matched Salts name: … Flurbiprofen sodium
Matched Categories: … Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids ... Topical Products for Joint and Muscular Pain ... Acids, Acyclic ... Carboxylic Acids
Matched Products: … Strepsils MaxPro Honey and Lemon lozenges 8.75mg ... Flurbiprofen Sodium ... FLURBIPROFENE DOC
Nickel sulfate is used in allergenic testing.
Approved
Experimental
Matched Synonyms: … Nickel sulphate ... Nickel sulfate(1:1) ... nickel(II) sulfate
Matched Name: … Nickel sulfate
Matched Iupac: … nickel(2+) sulfate
Matched Description: … Nickel sulfate is used in allergenic testing. …
Matched Mixtures name: … Milltrium Senior Vitamin and Mineral Supplement ... Multivitamins and Minerals Tablets ... Spectrum Performa Multivitamins and Minerals Tablets …
Matched Salts name: … Nickel sulfate hexahydrate …
Estrone sulfate (as estropipate) is a form of estrogen. It has several uses such as: alleviate symptoms of menopause as hormone replacement therapy, treatment some types of infertility, treatment of some conditions leading to underdevelopment of female sexual characteristics, treatment of vaginal atrophy, treatment of some types of breast cancer...
Approved
Matched Synonyms: … Estrone 3-sulfate ... Estrone sulphate ... Estrone-3-sulphate
Matched Name: … Estrone sulfate
Matched Iupac: … 11a-methyl-1-oxo-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-yl]oxidanesulfonic acid
Matched Description: … Estrone sulfate (as estropipate) is a form of estrogen. ... postmenopausal women), treatment of prostate cancer and prevention of osteoporosis. ... characteristics, treatment of vaginal atrophy, treatment of some types of breast cancer (particularly in men and
Matched Mixtures name: … Eemt D.S. ... Esterified Estrogens and Methyltestosterone ... Esterified Estrogens and Methyltestosterone …
Matched Salts name: … Estrone sodium sulfate ... Potassium estrone sulfate
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Since it's earliest discovery in salmon rine sperm heads in the late 1800's to its formal introduction via US FDA approval in 1939, protamine sulfate has occupied an important therapeutic niche as perhaps the only viable option for reversing the anticoagulant effect of heparin use for over 77 years [A174778,...
Approved
Matched Synonyms: … Protamine sulfate
Matched Name: … Protamine sulfate
Matched Description: … protamine sulfate, most substitutes possess similar and unacceptable adverse effects [A174778, A174781 ... kidney tissue damage, and anaphylactic reaction, amongst others [A174778, L5371]. ... reversal predominantly via the formation of an inactive complex between the anionic nature of heparin and
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … Protamine Sulfate ... PROTAMINE SULPHATE LEO ... Protamine Sulfate Injection USP …
Experimental
Matched Synonyms: … Cysteinyl-S-sulfonic acid ... Cysteine-S-sulfate ... Cysteine-S-sulfonate
Matched Iupac: … (2R)-2-amino-3-(sulfosulfanyl)propanoic acid
Matched Categories: … Amino Acids, Peptides, and Proteins ... Amino Acids ... Amino Acids, Neutral ... Amino Acids, Sulfur …
Trichloroacetate, or trichloroacetic acid, is a strong acid prepared by the reaction of chlorine with acetic acid in the presence of a suitable catalyst. In clinical chemistry and biochemistry, it is used as a precipitant of macromolecules including proteins, DNA and RNA. Trichloroacetate is also found in cosmetic treatments and...
Approved
Matched Description: … , DNA and RNA. ... In clinical chemistry and biochemistry, it is used as a precipitant of macromolecules including proteins ... Trichloroacetate is also found in cosmetic treatments and topical formulations as a cauterant, which …
Matched Salts name: … Trichloroacetic acid
Matched Categories: … Acids, Acyclic ... Carboxylic Acids ... Trichloroacetic Acid
Matched Products: … Trichloroacetic Acid 30% ... Trichloroacetic Acid 15% ... Trichloroacetic Acid 50% …
Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor...
Approved
Investigational
Matched Synonyms: … Dimethyl fumarate ... Fumaric acid, dimethyl ester ... (E)-But-2-enedioic acid dimethyl ester …
Matched Name: … Dimethyl fumarate
Matched Description: … [L43752] Dimethyl fumarate is marketed under the brand name Tecfidera, and it was the third oral disease-modifying ... agent for multiple sclerosis approved by the FDA, following [fingolimod] and [teriflunomide]. ... It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate ( …
Matched Mixtures name: … Dimethyl Fumarate ... Dimethyl Fumarate ... Dimethyl Fumarate
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Fumarates ... Acids, Acyclic ... dimethyl fumarate ... Carboxylic Acids
Matched Products: … DIMETILFUMARATO BIOCON ... D-FUMARIC 240 CAPSULAS DE LIBERACIÓN RETARDADA 240 MG ... D-FUMARIC 120 CAPSULAS DE LIBERACION RETARDADA 120 MG …
Experimental
Investigational
Matched Synonyms: … Sulfuric acid ion(2-) ... Sulfate ... Sulfate(2-) …
Matched Name: … Sulfate ion …
Matched Iupac: … sulfate
Matched Categories: … Sulfates ... Sulfur Acids ... Sulfuric Acids
Cyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes. Colistin is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used orally.
Approved
Matched Description: … It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes …
Matched Mixtures name: … COLISTINA SULFATO+HIDROCORTISONA ACETATO+NEOMICINA SULFATO ... COLISTINA SULFATO+HIDROCORTISONA ACETATO+NEOMICINA SULFATO
Matched Salts name: … Colistin sulfate
Matched Categories: … Amino Acids, Peptides, and Proteins ... Alimentary Tract and Metabolism …
Matched Products: … COLISTIMETATO SODICO ALTAN ... YH Colistin Sulfate 10% w/w Granule ... Colistin Sulphate 10% w/w Oral Granules. …
Terbutaline was first synthesized in 1966 and described in the literature in the late 1960s and early 1970s. It is a selective beta-2 adrenergic agonist used as a bronchodilator in asthmatic patients.[A230333,L32093,L32098] Terbutaline was granted FDA approval on 25 March 1974.
Approved
Matched Description: … and early 1970s. ... Terbutaline was first synthesized in 1966[A230333] and described in the literature in the late 1960s …
Matched Salts name: … Terbutaline sulfate
Matched Products: … Terbutaline Sulfate ... TERBUTALINE SULFATE ... TERBUTALINA SULFATO 2.5 MG. TABLETAS …
Fenofibric acid is a lipid-lowering agent that is used in severe hypertriglyceridemia, primary hyperlipidemia, and mixed dyslipidemia. It works to decrease elevated low-density lipoprotein cholesterol, total cholesterol, triglycerides, apolipoprotein B, while increasing high-density lipoprotein cholesterol.[A32038,L12855] Due to its high hydrophilicity and poor absorption profile, prodrug ,fenofibrate, and other conjugated compounds...
Approved
Matched Name: … Fenofibric acid
Matched Iupac: … 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoic acid
Matched Description: … ], and other conjugated compounds of fenofibric acid, such as choline fenofibrate, have been developed ... [A32038,L12855] Due to its high hydrophilicity and poor absorption profile,[A32038] prodrug ,[fenofibrate ... , and mixed dyslipidemia. …
Matched Categories: … Peroxisome Proliferator Receptor alpha Agonist ... Acids, Acyclic ... Fibric Acids ... Carboxylic Acids
Matched Products: … Fenofibric Acid ... Fenofibric acid ... Fenofibric Acid Delayed-Release …
Any of a class of cerebroside sulfuric esters, they are found largely in the medullated nerve fibers and may accumulate in metachromatic leukodystrophy.
Experimental
Matched Synonyms: … 2-hydroxytetracosanoyl sulfatide ... 2-hydroxytetracosanoylgalactosylceramide sulfate
Matched Name: … Sulfatide
Matched Iupac: … -2-[(2R)-2-hydroxytetracosanamido]octadec-4-en-1-yl]oxy}-6-(hydroxymethyl)oxan-4-yl]oxidanesulfonic acid
Matched Description: … Any of a class of cerebroside sulfuric esters, they are found largely in the medullated nerve fibers and
Matched Categories: … Acidic Glycosphingolipids …
Ciprofloxacin is a second generation fluoroquinolone that has spawned many derivative antibiotics. It is formulated for oral, intravenous, intratympanic, ophthalmic, and otic administration for a number of bacterial infections.[L6469,L6472,L6475,L6478,L6481,L6484,L6487,L6490,L6493] The first ciprofloxacin containing product was FDA approved on 22 October 1987.
Approved
Investigational
Matched Synonyms: … 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid ... 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid ... 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
Matched Iupac: … 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
Matched Description: … [A178870] It is formulated for oral, intravenous, intratympanic, ophthalmic, and otic administration …
Matched Mixtures name: … Ciprofloxacin and Fluocinolone Acetonide ... Ciprofloxacin and Dexamethasone ... Ciprofloxacin and Dexamethasone …
Matched Salts name: … Ciprofloxacin hydrochloride
Matched Categories: … Drug-Related Side Effects and Adverse Reactions ... ciprofloxacin and tinidazole ... ciprofloxacin and ornidazole ... ciprofloxacin and metronidazole ... Metabolic Side Effects of Drugs and Substances …
Matched Products: … CIPROFLOXACIN HYDROCHLORIDE MONOHYDRATE ... Ciprofloxacin and Dextrose ... CILOXAN STERILE OPHTHALMIC AND OTIC SOLUTION 0.3% …
Carglumic acid is a drug used for the treatment of hyperammonemia in patients with a deficiency in N-acetyl glutamate synthase. This rare genetic disorder results in elevated blood levels of ammonia, which can eventually cross the blood–brain barrier and cause neurologic problems, cerebral edema, coma, and death. Carglumic acid was...
Approved
Matched Synonyms: … Acide carglumique ... Carglumic acid ... Acidum carglumicum …
Matched Name: … Carglumic acid
Matched Iupac: … (2S)-2-(carbamoylamino)pentanedioic acid
Matched Description: … Carglumic acid was approved by the U.S. Food and Drug Administration (FDA) on 18 March 2010. ... cause neurologic problems, cerebral edema, coma, and death. ... disorder results in elevated blood levels of ammonia, which can eventually cross the blood–brain barrier and
Matched Categories: … Amino Acids and Derivatives ... Amino Acids, Peptides, and Proteins ... Alimentary Tract and Metabolism ... Amino Acids, Acidic ... Amino Acids
Matched Products: … Carglumic Acid ... Carglumic acid ... ACIDO CARGLUMICO WAYMADE …
Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label] .
Approved
Matched Synonyms: … Alendronic acid ... Acido Alendronico ... Acide Alendronique …
Matched Name: … Alendronic acid
Matched Iupac: … (4-amino-1-hydroxy-1-phosphonobutyl)phosphonic acid
Matched Description: … osteoperosis and Paget's disease[FDA Label][A959,A203111]. ... Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of …
Matched Mixtures name: … Alendronate-cholecalciferol ... Alendronate-cholecalciferol ... Teva-alendronate/cholecalciferol
Matched Salts name: … Alendronate sodium anhydrous ... Alendronate sodium
Matched Categories: … alendronic acid and colecalciferol ... alendronic acid and alfacalcidol, sequential ... alendronic acid, calcium and colecalciferol, sequential ... Drugs Affecting Bone Structure and Mineralization ... alendronic acid
Matched Products: … Alendronate Sodium ... Ag-alendronate Sodium ... Jamp Alendronate Sodium
Hyaluronic acid (HA) is an anionic, nonsulfated glycosaminoglycan found in connective, epithelial, and neural tissues; it was first isolated in 1934. Karl Meyer and John Palmer obtained glycosaminoglycan (GAG) from the bovine eye, giving it the name “hyaluronic acid”. HA is involved in many important physiological processes, including but not...
Approved
Vet approved
Matched Name: … Hyaluronic acid
Matched Iupac: … 3R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy}-4,5-dihydroxyoxane-2-carboxylic acid
Matched Description: … Hyaluronic acid (HA) is an anionic, nonsulfated glycosaminoglycan found in connective, epithelial, and ... A popular use of hyaluronic acid in recent years is cosmetic injection due to its ability to minimize ... [A230133] Several preparations of hyaluronic acid have been approved by the FDA and are available in …
Matched Mixtures name: … Hyaluronic Acid 60mg and Lidocaine 2% PF ... Ascorbyl Palmitate 2% / Hyaluronic Acid Sodium Salt 0.2% / Niacinamide 5% / Tretinoin 0.025% ... Oil
Matched Salts name: … Hyaluronate sodium ... Sodium hyaluronate …
Matched Categories: … Preparations for Treatment of Wounds and Ulcers ... hyaluronic acid ... hyaluronic acid ... hyaluronic acid ... hyaluronic acid
Matched Products: … DERMAVISC DF (0.6% SODIUM HYALURONATE) ... C-eye Day ... Hyaluronic Acid Micro …
Displaying drugs 401 - 425 of 3998 in total