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Displaying drugs 401 - 425 of 14743 in total

Sunitinib

Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally available as an orally administered formulation....
Approved
Investigational
Matched Description: … In addition, sunitinib inhibits other RTKs including RET, CSF-1R, and flt3. ... agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and ... These include all platelet-derived growth factor receptors (PDGF-R) and vascular endothelial growth factor …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A7 Substrates with a Narrow Therapeutic Index …

Nisoldipine

Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction. Nisoldipine may be used in alone...
Approved
Matched Description: … of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contraction and ... Nisoldipine may be used in alone or in combination with other agents in the management of hypertension …
Matched Categories: … Calcium-Regulating Hormones and Agents ... Selective Calcium Channel Blockers With Mainly Vascular Effects …

Acetyldigitoxin

Cardioactive derivative of lanatoside A or of digitoxin used for fast digitalization in congestive heart failure.
Approved

Tolazoline

A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output. Tolazoline can interact to some degree with histamine, adrenergic, and cholinergic receptors, but the mechanisms of its therapeutic effects are not clear. It is used in treatment of persistent pulmonary hypertension of the newborn.
Approved
Vet approved
Matched Description: … Tolazoline can interact to some degree with histamine, adrenergic, and cholinergic receptors, but the ... A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output. …
Matched Categories: … Topical Products for Joint and Muscular Pain …

Febuxostat

Febuxostat is a non-purine xanthine oxidase (XO) inhibitor. In early 2008, febuxostat was granted marketing authorization by the European Commission for the treatment of chronic hyperuricemia and gout. In the following year, the FDA for approved febuxostat for use in the chronic management of hyperuricemia in adult patients with gout...
Approved
Matched Description: … gout and known cardiovascular disease treated with febuxostat, when compared to those treated with allopurinol ... Gout is closely associated with hyperuricemia. ... of febuxostat in patients with cardiovascular diseases. …

Sodium stibogluconate

Sodium stibogluconate is a medicine used to treat leishmaniasis and is only available for administration by injection. It belongs to the class of medicines known as the pentavalent antimonials. Sodium stibogluconate is sold in the UK as Pentostam (manufactured by GlaxoSmithKline). Widespread resistance has limited the utility of sodium stibogluconate,...
Approved
Investigational
Matched Description: … Sodium stibogluconate is a medicine used to treat leishmaniasis and is only available for administration ... Widespread resistance has limited the utility of sodium stibogluconate, and in many parts of the world …
Matched Categories: … Agents Against Leishmaniasis and Trypanosomiasis ... Antiparasitic Products, Insecticides and Repellents …

Nilvadipine

Nilvadipine is a calcium channel blocker (CCB) for the treatment of hypertension.
Approved
Investigational
Matched Categories: … Calcium-Regulating Hormones and Agents ... Selective Calcium Channel Blockers With Mainly Vascular Effects …

Technetium Tc-99m tetrofosmin

Technetium Tc-99m tetrofosmin is a drug used in nuclear myocardial perfusion imaging. The radioisotope, technetium-99m, is chelated by two 1,2-bis[di-(2-ethoxyethyl)phosphino]ethane ligands which belong to the group of diphosphines and which are referred to as tetrofosmin. It is a lipophilic technetium phosphine dioxo cation that was formulated into a freeze-dried kit...
Approved
Matched Description: … by two 1,2-bis[di-(2-ethoxyethyl)phosphino]ethane ligands which belong to the group of diphosphines and ... [A31592] Technetium Tc-99m tetrofosmin was developed by GE Healthcare and FDA approved on February 9, …
Matched Categories: … Indicators and Reagents …

Levamlodipine

Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of amlodipine, an antihypertensive medication. Levamlodipine belongs to the dihydropyridine group of calcium channel blockers. This medication was first marketed in Russia and India before being granted FDA approval. The names S-amlodipine and levamlodipine may be used interchangeably as both...
Approved
Investigational
Matched Description: … [L10833] This medication was first marketed in Russia and India before being granted FDA approval. ... [L1484] The names S-amlodipine and levamlodipine may be used interchangeably as both substances are the ... [L10833] As a racemic mixture, amlodipine contains (R) and (S)-amlodipine isomers, but only (S)-amlodipine …
Matched Categories: … Selective Calcium Channel Blockers With Mainly Vascular Effects …

Strontium ranelate

Strontium ranelate, a strontium (II) salt of ranelic acid, is a medication for osteoporosis. Some reports have shown that strontium ranelate can slow down the progression of osteoarthritis of the knee. This agent presents an atypical mechanism of action in which it increases deposition of new bone by osteoblasts and,...
Approved
Withdrawn
Matched Description: … was ultimately discontinued in 2016-2017 owing to an increased adverse cardiac effects profile along with ... intrinsic bone tissue quality and microarchitecture in osteoporosis by way of a number of cellular and ... increased risk of venous thromboembolism (VTE) and various life threatening allergic reactions. …
Matched Categories: … strontium ranelate and colecalciferol ... Drugs Affecting Bone Structure and Mineralization …

Ioxaglic acid

Ioxaglic acid is marketed as Hexabrix. This drug is an ionic tri-iodinated benzoate used as a low-osmolality contrast agent during diagnostic imaging procedures. Like other organic iodine compounds, ioxaglic acid blocks x-rays and is opaque in its appearance on x-ray film, improving the visualization of important structures and organs during...
Approved
Investigational
Matched Description: … Ioxaglic acid has a low osmolarity and is associated with fewer side effects compared to older contrast ... , arthrography, cholangiography, urography, and computed tomography [L1889]. ... Like other organic iodine compounds, ioxaglic acid blocks x-rays and is opaque in its appearance on x-ray …

Metrizoic acid

Metrizoic acid is a molecule used as a contrast medium. It present a higher risk of allergic reactions due to its high osmolality. Its approval has been discontinued by the FDA. One study in 1976 demonstrated that metrizoic acid, when used for cardiac angiography, was well tolerated. A total of...
Approved
Matched Description: … Seven cases of ventricular fibrillation, and 5 of significant bradycardia/asystole, were associated with ... With two exceptions, all complications occurred during injection of the right coronary artery. …

Tetrofosmin

Tetrofosmin was developed to overcome the non-target uptake of radioligands by the generation of hetero-atomic compounds. It presents a molecular formula of 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane. Tetrofosmin is part of the group of diphosphines. Tetrofosmin is used in conjunction with technetium Tc-99m as a radiopharmaceutical.
Approved
Matched Description: … Tetrofosmin is used in conjunction with technetium Tc-99m as a radiopharmaceutical.[A7788] …

Oftasceine

Oftasceine is also referred to as Fluorexon. It is used in ophthalmic solutions as a staining agent when fitting soft and hard lenses. It is a fluorescent dye or luminescent agent.
Approved
Matched Description: … It is used in ophthalmic solutions as a staining agent when fitting soft and hard lenses. …

Pentoxyverine

Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma-1 receptors, as well as kappa and mu-opioid receptors. The...
Approved
Investigational
Withdrawn
Matched Description: … It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and ... , anticonvulsant [A32717], and local anesthetic properties. ... Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic …
Matched Categories: … Cough and Cold Preparations …

Ethyl ferulate

Approved
Experimental

Tropisetron

Tropisetron is an indole derivative with antiemetic activity. As a selective serotonin receptor antagonist, tropisetron competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting. Tropisetron appears to be well tolerated with the most frequently reported adverse effect being headache. Extrapyramidal...
Approved
Investigational
Matched Description: … radiotherapy-induced nausea and vomiting. ... Tropisetron is an indole derivative with antiemetic activity. ... Tropisetron appears to be well tolerated with the most frequently reported adverse effect being headache …
Matched Categories: … Alimentary Tract and Metabolism ... Antiemetics and Antinauseants …

Hexobendine

Hexobendine is a medication used to cause vasodilation, to treat several conditions including angina pectoris. It has not been approved in the United States or the United Kingdom, but has been used widely in Austria and Germany .
Approved
Matched Description: … has not been approved in the United States or the United Kingdom, but has been used widely in Austria and …

Ritiometan

Ritiometan is a nasal spray which is marketed by the name Nécyrane in France. It is indicated for use in viral rhinitis/ the common cold.
Approved

Gamolenic acid

Gamolenic acid, or gamma-linolenic acid (γ-Linolenic acid) or GLA, is an essential fatty acid (EFA) comprised of 18 carbon atoms with three double bonds that is most commonly found in human milk and other botanical sources . It is an omega-6 polyunsaturated fatty acid (PUFA) also referred to as 18:3n-6;...
Approved
Investigational
Matched Description: … gamma-linolenic acid (γ-Linolenic acid) or GLA, is an essential fatty acid (EFA) comprised of 18 carbon atoms with ... three double bonds [F27] that is most commonly found in human milk and other botanical sources [A32848 ... omega-6 polyunsaturated fatty acid (PUFA) also referred to as 18:3n-6; 6,9,12-octadecatrienoic acid; and …
Matched Mixtures name: … With Borage Oil Cap …

p-Phenylenediamine

Approved
Experimental
Matched Categories: … Indicators and Reagents ... Amino Acids, Peptides, and Proteins …

Nimodipine

Nimodipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nimodipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction. Compared to other calcium channel blocking...
Approved
Investigational
Matched Description: … of calcium in smooth muscle cells, nimodipine prevents calcium-dependent smooth muscle contraction and …
Matched Categories: … Calcium-Regulating Hormones and Agents ... Selective Calcium Channel Blockers With Mainly Vascular Effects …

Famciclovir

Famciclovir, marketed as Famvir by Novartis, is a guanine analogue used to treat herpes virus infections. It is most commonly used to treat herpes zoster (shingles). Famciclovir is a prodrug of penciclovir with higher oral bioavailability.
Approved
Investigational
Matched Description: … Famciclovir is a prodrug of penciclovir with higher oral bioavailability. …
Matched Categories: … Nucleosides and Nucleotides ... Nucleosides and Nucleotides Excl. Reverse Transcriptase Inhibitors …

Isoniazid

Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.
Approved
Investigational
Matched Categories: … ethambutol and isoniazid ... rifampicin and isoniazid ... streptomycin and isoniazid ... thioacetazone and isoniazid ... rifampicin, ethambutol and isoniazid …

Edetic acid

A chelating agent (chelating agents) that sequesters a variety of polyvalent cations. It is used in pharmaceutical manufacturing and as a food additive.
Approved
Vet approved
Matched Description: … It is used in pharmaceutical manufacturing and as a food additive. …
Matched Categories: … Diet, Food, and Nutrition …
Displaying drugs 401 - 425 of 14743 in total