Displaying drugs 4376 - 4400 of 8179 in total
Quinolinic Acid
A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS. [PubChem]
Experimental
Matched Description: … Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits ... A metabolite of tryptophan with a possible role in neurodegenerative disorders. …
5alpha-androstane-3beta,17alpha-diol
5alpha-androstane-3beta,17alpha-diol is the unspecified form of the steroid, normally a major metabolite of testosterone with androgenic activity. It has been implicated as a regulator of gonadotropin secretion.
Experimental
Matched Description: … of [testosterone] with androgenic activity. ... It has been implicated as a regulator of gonadotropin secretion. ... 5alpha-androstane-3beta,17alpha-diol is the unspecified form of the steroid, normally a major metabolite …
Tanespimycin
Tanespimycin, manufactured by Conforma Therapeutics is under development as a small molecule inhibitor of heat shock protein 90 (HSP90). It is developed for the treatment of several types of cancer, solid tumors or chronic myelogenous leukemia.
Investigational
Matched Description: … It is developed for the treatment of several types of cancer, solid tumors or chronic myelogenous leukemia ... Tanespimycin, manufactured by Conforma Therapeutics is under development as a small molecule inhibitor of …
Arbekacin
An semisynthetic aminoglycoside antibiotic. Often used for treatment of multi-resistant bacterial infection such as methicillin-resistant Staphylococcus aureus (MRSA).
Experimental
Investigational
Matched Description: … Often used for treatment of multi-resistant bacterial infection such as methicillin-resistant _Staphylococcus …
Chlorproguanil
Chlorproguanil has been used in trials studying the treatment of MALARIA. It is a dichloro-derivative of chloroguanide.
Investigational
Matched Description: … It is a dichloro-derivative of chloroguanide. ... Chlorproguanil has been used in trials studying the treatment of MALARIA. …
Nordazepam
An intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam.
Experimental
Matched Description: … It may have actions similar to those of diazepam. ... An intermediate in the metabolism of DIAZEPAM to OXAZEPAM. …
TOL2
TOL2 is a modified form of the acetylcholine receptor being investigated for the treatment of myasthenia gravis.
Investigational
Matched Description: … TOL2 is a modified form of the acetylcholine receptor being investigated for the treatment of myasthenia …
Amediplase
Amediplase is a recombinant chimeric plasminogen activator, consisting of the kringle 2 domain from the A-chain of tissue plasminogen activator (t-PA) and the carboxy terminal region of pro-urokinase. [MeSH]
Investigational
Matched Description: … A-chain of tissue plasminogen activator (t-PA) and the carboxy terminal region of pro-urokinase. ... Amediplase is a recombinant chimeric plasminogen activator, consisting of the kringle 2 domain from the …
CAD106
CAD106 is an immunotherapeutic product in development for the treatment of Alzheimer's disease. It is designed to induce antibodies against the beta-amyloid-protein that inhibit the formation of plaques in the brain of Alzheimer's disease patients.
Investigational
Matched Description: … in the brain of Alzheimer's disease patients. ... CAD106 is an immunotherapeutic product in development for the treatment of Alzheimer's disease. ... It is designed to induce antibodies against the beta-amyloid-protein that inhibit the formation of plaques …
EW-A-401
EW-A-401 is a circle of genetic material (plasmid DNA) that instructs the body to produce a genetically-engineered transcription factor, a protein that regulates expression of genes. This specific transcription factor has been shown in animal studies to increase expression of the VEGF-A gene, and to promote the growth of new...
Investigational
Matched Description: … gene, and to promote the growth of new blood vessels. ... transcription factor, a protein that regulates expression of genes. ... This specific transcription factor has been shown in animal studies to increase expression of the VEGF-A …
PMI-001
PMI-001 is a stand-alone, disease-modifying, anti-rheumatic drug (DMARD) being developed by Phytomedics Inc. It is an extract of the roots of an undisclosed perennial shrub which interferes with the production of IL-2 and COX-2 proteins, for the potential treatment of autoimmune diseases, such as rheumatoid arthritis, lupus erythematosus and psoriasis.
Investigational
Matched Description: … It is an extract of the roots of an undisclosed perennial shrub which interferes with the production ... of IL-2 and COX-2 proteins, for the potential treatment of autoimmune diseases, such as rheumatoid arthritis …
Eperisone
Eperisone is an antispasmodic drug which relaxes both skeletal muscles and vascular smooth muscles, and demonstrates a variety of effects such as reduction of myotonia, improvement of circulation, and suppression of the pain reflex. It is not approved for use in the United States, but is available in other countries...
Investigational
Matched Description: … effects such as reduction of myotonia, improvement of circulation, and suppression of the pain reflex ... antispasmodic drug which relaxes both skeletal muscles and vascular smooth muscles, and demonstrates a variety of …
Penimepicycline
Penimepicycline is a tetracycline-class antibiotic. It is mentioned on List A produced by the Government of Canada, which is a list of antimicrobial active pharmaceutical ingredients . In the classification of the active ingredients included on this list, the classification document states that tetracycline class antibiotics are of medium importance,...
Experimental
Matched Description: … It is mentioned on List A produced by the Government of Canada, which is a list of antimicrobial active ... that tetracycline class antibiotics are of medium importance, and are used in humans [L5620]. ... In the classification of the active ingredients included on this list, the classification document states …
Adlinacogene civaparvovec
Adlinacogene civaparvovec is an investigational in vivo genome editing therapeutic product. It uses proprietary zinc finger nuclease (ZFN) genome editing to insert into the DNA of liver cells a copy of the F9 gene, which controls the production of Factor IX. Developed by Sangamo Therapeutics Inc., it is being investigated...
Experimental
Matched Description: … copy of the F9 gene, which controls the production of Factor IX. ... It uses proprietary zinc finger nuclease (ZFN) genome editing to insert into the DNA of liver cells a ... [L46711] Developed by Sangamo Therapeutics Inc., it is being investigated for the treatment of hemophilia …
GFT14
GFT14 is a new class of medicaction for treatment of cardiometabolic disease. GFT14 aims to target mixed dyslipidemia of type IIb (high levels of triglycerides and LDL-C) as one of the major indications of cardiometabolic disease.
GFT14 is destined to improve the condition of patients at risk from cardiovascular disease...
Investigational
Matched Description: … GFT14 aims to target mixed dyslipidemia of type IIb (high levels of triglycerides and LDL-C) as one of ... GFT14 is a new class of medicaction for treatment of cardiometabolic disease. ... and favorable action on the plasmatic lipids (rise of HDL- cholesterol et lowering of triglycerides) …
Theobromine
Theobromine (3,7-dimethylxanthine) is the principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than theophylline and is also a less powerful stimulant of smooth muscle. It has practically no...
Investigational
Matched Description: … It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. ... It has a weaker diuretic activity than theophylline and is also a less powerful stimulant of smooth muscle …
CTA018
CTA018 is a member of a new class of vitamin D analogues with a dual mechanism of action, called Vitamin D Signal Amplifiers. This proprietary new drug is both a potent inhibitor of CYP24 (the enzyme responsible for the breakdown of vitamin D) and a potent activator of vitamin D...
Investigational
Matched Description: … CTA018 is a member of a new class of vitamin D analogues with a dual mechanism of action, called Vitamin ... of vitamin D) and a potent activator of vitamin D signaling pathways. ... This proprietary new drug is both a potent inhibitor of CYP24 (the enzyme responsible for the breakdown …
Cimlanod
Cimlanod is under investigation in clinical trial NCT02819271 (A First-in-Human Study of the Safety of Single Continuous Intravenous (IV) Infusions of CXL-1427 for up to 48 Hours in Healthy Volunteers).
Investigational
Matched Description: … Cimlanod is under investigation in clinical trial NCT02819271 (A First-in-Human Study of the Safety of ... Single Continuous Intravenous (IV) Infusions of CXL-1427 for up to 48 Hours in Healthy Volunteers). …
Modimelanotide
Modimelanotide is under investigation in clinical trial NCT01897519 (A Safety and Efficacy Trial of Multiple Dosing Regimens of ABT-719 for the Prevention of Acute Kidney Injury in Subjects Undergoing High Risk Surgery).
Investigational
Matched Description: … Dosing Regimens of ABT-719 for the Prevention of Acute Kidney Injury in Subjects Undergoing High Risk ... Modimelanotide is under investigation in clinical trial NCT01897519 (A Safety and Efficacy Trial of Multiple …
Centanafadine
Centanafadine is under investigation in clinical trial NCT02827513 (A Phase 1 Study to Investigate the Safety, Tolerance, Food Effect, Pharmacokinetics and Pharmacodynamics of Single and Multiple Doses of Extended Release Formulations of Centanafadine (CTN) in Young Healthy Subjects).
Investigational
Matched Description: … Single and Multiple Doses of Extended Release Formulations of Centanafadine (CTN) in Young Healthy Subjects ... Phase 1 Study to Investigate the Safety, Tolerance, Food Effect, Pharmacokinetics and Pharmacodynamics of …
Vilamakitug
Vilamakitug is under investigation in clinical trial NCT05201352 (Evaluation of Efficacy of Trifluridine/tipiracil Plus an Anti-il-1α True Human Antibody Versus Trifluridine/tipiracil Plus Placebo in Metastatic Colorectal Cancer Patients After Failure of Oxaliplatin, Irinotecan, Fluoropyrimidine).
Investigational
Matched Description: … Vilamakitug is under investigation in clinical trial NCT05201352 (Evaluation of Efficacy of Trifluridine ... Antibody Versus Trifluridine/tipiracil Plus Placebo in Metastatic Colorectal Cancer Patients After Failure of …
PF-06305591
Pf 06305591 is under investigation in clinical trial NCT01776619 (Safety and Tolerability Study of Multiple Doses of PF-06305591).
Investigational
Matched Description: … Doses of PF-06305591). ... Pf 06305591 is under investigation in clinical trial NCT01776619 (Safety and Tolerability Study of Multiple …
Nifekalant
Nifekalant is under investigation in clinical trial NCT03855826 (Evaluation of the Efficacy and Safety of Nifekalant Hydrochloride (NIF) Injection).
Investigational
Matched Description: … of Nifekalant Hydrochloride (NIF) Injection). ... Nifekalant is under investigation in clinical trial NCT03855826 (Evaluation of the Efficacy and Safety …
Cenderitide
Cenderitide is under investigation for the treatment of ST Elevation (STEMI) Myocardial Infarction of Anterior Wall.
Investigational
Matched Description: … Cenderitide is under investigation for the treatment of ST Elevation (STEMI) Myocardial Infarction of …
Miridesap
Miridesap has been used in trials studying the prevention of HIV and treatment of AL amyloidosis.
Investigational
Matched Description: … Miridesap has been used in trials studying the prevention of HIV and treatment of AL amyloidosis. …
Displaying drugs 4376 - 4400 of 8179 in total