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Intravenous immunoglobulin (IVIg) is a mixture of IgG1 and other antibodies derived from healthy human plasma via Cohn fractionation. The purification process includes cold alcohol fractionation, polyethylene glycol precipitation, and ion exchange chromatography. IVIg contains the same distribution of IgG antibody subclasses as is found in the general human population....
Approved
Investigational
Matched Description: … Intravenous immunoglobulin (IVIg) is a mixture of IgG1 and other antibodies derived from healthy human …
Matched Categories: … Antigen Neutralization …
Matched Products: … BERIGLOBINA P X 2 ML INYECTABLE ... Gamimune N 5% (iv) ... Gamimune N 10% (iv) …
Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled substance in the...
Approved
Illicit
Investigational
Withdrawn
Matched Iupac: … {1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}dimethylamine …
Matched Description: … It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule ... markets due to concerns that the drug increases the risk of heart attack and stroke in patients with a
Matched Products: … SINHABIT 15 MG ... SIBUTRAMINA 15 MG ... OBESTOP 15 MG CAPSULAS …
Ibrutinib is a small molecule that acts as an irreversible potent inhibitor of Burton's tyrosine kinase. It is designated as a targeted covalent drug and presented as a promising activity in B-cell malignancies in clinical trials. Ibrutinib was developed by Pharmacyclics Inc and was first approved by the FDA in...
Approved
Matched Synonyms: … 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one …
Matched Iupac: … 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one …
Matched Description: … It is designated as a targeted covalent drug and presented as a promising activity in B-cell malignancies ... [L12228] Notably, ibrutinib became the first FDA-approved cGVHD treatment for children in August 2017 ... leukemia (CLL), Waldenström's Macroglobulinemia, and chronic graft versus host disease (cGVHD) in August 2017
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Heterocyclic Compounds, 2-Ring …
Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated inflammation and immune responses. Baricitinib was...
Approved
Investigational
Matched Iupac: … 2-[1-(ethanesulfonyl)-3-(4-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1H-pyrazol-1-yl)azetidin-3-yl]acetonitrile …
Matched Description: … Baricitinib is a Janus kinase (JAK) inhibitor. ... of rheumatoid arthritis in adults [A248395] and was later approved by the FDA in 2018. ... [L41760] Baricitinib was first approved by the European Commission (EC) in February 2017 for the treatment …
Matched Categories: … MATE 2 Substrates with a Narrow Therapeutic Index ... Heterocyclic Compounds, 1-Ring ... MATE 2 Inhibitors ... MATE 2 Substrates ... Heterocyclic Compounds, 2-Ring …
Matched Products: … UNAMİTY 2 MG FİLM KAPLI TABLET, 14 ADET ... UNAMİTY 4 MG FİLM KAPLI TABLET, 14 ADET ... โอลูเมียนท์ (2 มก.) …
Butylscopolamine is a peripherally acting antimuscarinic, anticholinergic agent. It is used to treat pain and discomfort caused by abdominal cramps, menstrual cramps, or other spasmodic activity in the digestive system. It is also effective at preventing bladder spasms. It is not a pain medication in the normal sense, since it...
Approved
Investigational
Vet approved
Matched Synonyms: … N-butylscopolammonium ... N-butylscopolammonium ion ... N-butylscopolammonium cation …
Matched Iupac: … (1R,2R,4S,5S,7R)-9-butyl-7-{[(2S)-3-hydroxy-2-phenylpropanoyl]oxy}-9-methyl-3-oxa-9-azatricyclo[3.3.1.0 …
Matched Description: … Butylscopolamine is a peripherally acting antimuscarinic, anticholinergic agent. ... It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic ... It is not a pain medication in the normal sense, since it does not directly affect pain, but rather works …
Matched Mixtures name: … BIPASMIN COMPUESTO N ... DIPIRONA N- BULTILBROMURO DE HIOSCINA ... HIOSCINA N-BUTILBROMURO+ ACETAMINOFEN GOTAS …
Matched Products: … HIOSCINA N-BUTIL BROMURO 20 MG / 1 ML ... N-BUTIL BROMURO DE HIOSCINA 20 MG/1 ML ... N-BUTIL BROMURO HIOSCINA 20 MG/1 ML SOLUCION INYECTBLE …
Initially approved by the FDA in 2013, memantine is an N-methyl-D-aspartate (NMDA) receptor antagonist used in the management of Alzheimer's Disease (AD). It is different from many other Alzheimer's Disease medications, as it works by a different mechanism than the cholinesterase enzyme inhibitors normally employed in the management of Alzheimer's...
Approved
Investigational
Matched Synonyms: … 1-Amino-3,5-dimethyladamantane ... 3,5-Dimethyl-1-adamantanamine ... 3,5-Dimethyl-1-aminoadamantane …
Matched Iupac: … 3,5-dimethyladamantan-1-amine …
Matched Description: … Initially approved by the FDA in 2013, memantine is an N-methyl-D-aspartate (NMDA) receptor antagonist ... with the objective of developing a cure or a disease-modifying therapy by the year 2025 [L5953, F4366 ... It is different from many other Alzheimer's Disease medications, as it works by a different mechanism …
Matched Salts cas: … 41100-52-1
Matched Mixtures name: … DEZİRA COMBİ 10 MG/14 MG UZATILMIŞ SALIMLI SERT KAPSÜL, 28 ADET ... MEXIA XR 7 MG + 14 MG + 21 MG + 28 MG TEDAVIYE BAŞLAMA PAKETI ,28 UZATILMIŞ SALINIMLI MIKROPELLET KAPSÜL ... MEXIA XR 7 MG + 14 MG + 21 MG + 28 MG TEDAVIYE BAŞLAMA PAKETI ,28 UZATILMIŞ SALINIMLI MIKROPELLET KAPSÜL …
Matched Categories: … N-methyl-D-aspartate Receptor Antagonist …
Matched Products: … FEMTA 5 MG FİLM KAPLI TABLET, 14 ADET ... MEXIA XR 14 MG UZATILMIŞ SALINIMLI MIKROPELLET KAPSÜL ,28 UZATILMIŞ SALINIMLI MIKROPELLET KAPSÜL ... MEMANTIN-HCL NEURAX 15 MG …
Iptacopan is a small-molecule factor B inhibitor previously investigated as a potential treatment for the rare blood disease paroxysmal nocturnal hemoglobinuria (PNH) by inhibiting the complement factor B. Factor B is a positive regulator of the alternative complement pathway, where it activates C3 convertase and subsequently C5 convertase. This is...
Approved
Investigational
Matched Synonyms: … 4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl) benzoic acid ... BENZOIC ACID, 4-((2S,4S)-4-ETHOXY-1-((5-METHOXY-7-METHYL-1H-INDOL-4-YL)METHYL)-2-PIPERIDINYL)- …
Matched Iupac: … 4-[(2S,4S)-4-ethoxy-1-[(5-methoxy-7-methyl-1H-indol-4-yl)methyl]piperidin-2-yl]benzoic acid …
Matched Description: … Iptacopan is a small-molecule factor B inhibitor previously investigated as a potential treatment for ... [A262566] Factor B is a positive regulator of the alternative complement pathway, where it activates ... progeny erythrocytes will lack the glycosyl phosphatidylinositol–anchored proteins that normally anchor 2
Matched Salts cas: … 2447007-60-3
Human interferon beta is a polypeptide used in the management of relapsing forms of Multiple Sclerosis (MS), and was initially approved by the FDA in 1992. Multiple Sclerosis is a devastating neurodegenerative disease that is usually progressive and significantly debilitating with a profound impact on the quality of life. Interferon...
Approved
Investigational
Matched Description: … results from infection with the novel 2019 SARS-CoV-2 virus. ... It is therefore a potential drug candidate for SARS-CoV-2 based on viral genetic similarity. ... the past in clinical studies with other coronaviruses due to its demonstrated activity against the virus
Erenumab (AMG-334) (INN; trade name Aimovig) is a human monoclonal antibody designed specifically to bind and antagonize the calcitonin gene-related peptide receptor (CGRPR) as a means to prevent migraines. Aimovig, as released and marketed by Novartis and Amgen, is in fact a novel therapeutic approach as the first and only...
Approved
Investigational
Matched Description: … It is composed of 2 heavy chains, each containing 456 amino acids, and 2 light chains of the lambda subclass ... Erenumab (AMG-334) (INN; trade name Aimovig) is a human monoclonal antibody designed specifically to ... bind and antagonize the calcitonin gene-related peptide receptor (CGRPR) as a means to prevent migraines …
Matched Products: … Pasurta 70mg/ml Solution for Injection in a Prefilled Syringe ... KUZELVA 70 MG ENJEKSİYONLUK ÇÖZELTİ İÇEREN KULLANIMA HAZIR ENJEKTÖR, 1 ADET …
A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid. As the sodium salt form, sodium benzoate is used as a treatment for urea cycle disorders due to its ability to bind amino acids. This leads...
Approved
Investigational
Matched Description: … Recent research shows that sodium benzoate may be beneficial as an add-on therapy (1 gram/day) in schizophrenia ... A fungistatic compound that is widely used as a food preservative. ... This leads to excretion of these amino acids and a decrease in ammonia levels. …
Matched Salts cas: … 532-32-1 ... 2090-05-3
Matched Mixtures name: … POLY-N OINTMENT …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Patent blue is aniline dye and it is one of the most common dyes used. It is a sodium or calcium salt of diethylammonium hydroxide inner salt. It has the chemical designation of (4-(alpha-(p-(diethylamino)phenyl)-2,4-disulfobenzylidene)-2,5-cyclohexadiene-1-ylidene)diethylammonium hydroxide. Patent blue was developed by Guerbet and approved by Health Canada on December 31, 1979....
Approved
Matched Iupac: … 4-{[4-(diethylamino)phenyl](5-hydroxy-2,4-disulfophenyl)methylidene}-N,N-diethylcyclohexa-2,5-dien-1- …
Matched Description: … [A32573] It is a sodium or calcium salt of diethylammonium hydroxide inner salt. ... chemical designation of (4-(alpha-(p-(diethylamino)phenyl)-2,4-disulfobenzylidene)-2,5-cyclohexadiene-1- …
Matched Categories: … Compounds used in a research, industrial, or household setting …
A synthetic morphinan analgesic with narcotic antagonist action. It is used in the management of severe pain.
Approved
Illicit
Vet approved
Matched Synonyms: … (−)-N-cyclobutylmethyl-3,14-dihydroxymorphinan …
Matched Iupac: … (1S,9R,10S)-17-(cyclobutylmethyl)-17-azatetracyclo[7.5.3.0^{1,10}.0^{2,7}]heptadeca-2(7),3,5-triene-4,10 …
Matched Description: … A synthetic morphinan analgesic with narcotic antagonist action. …
Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the...
Approved
Matched Description: … Type 1 and Type 2 Diabetes. ... Marketed as the brand name product Apidra, insulin glulisine begins to exert its effects within 15 minutes ... Insulin is also used in the treatment of Type 2 Diabetes (T2D), another form of diabetes mellitus that …
Matched Products: … Apidra SoloStar 100 Units/ml Solution for injection in a pre-filled pen ... APIDRA SOLOSTAR 100 UNITS/ML, SOLUTION FOR INJECTION IN A PRE-FILLED PEN …
Inositol is a collection of nine different stereoisomers but the name is usually used to describe only the most common type of inositol, myo-inositol. Myo-inositol is the cis-1,2,3,5-trans-4,6-cyclohexanehexol and it is prepared from an aqueous extract of corn kernels by precipitation and hydrolysis of crude phytate. These molecules have structural...
Approved
Investigational
Withdrawn
Matched Description: … It is considered a pseudovitamin as it is a molecule that does not qualify to be an essential vitamin ... Inositol is a collection of nine different stereoisomers but the name is usually used to describe only ... because even though its presence is vital in the body, a deficiency in this molecule does not translate …
Matched Mixtures name: … Hoa 1 ... Vege 1 Daily Tab ... For-2
Matched Categories: … Vitamin B Complex …
Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination with rituximab in patients for whom rituximab...
Approved
Matched Synonyms: … 5-Fluoro-3-phenyl-2-((S)-1-(9H-purin-6-ylamino)-propyl)-3H-quinazolin-4-one ... 5-fluoro-3-phenyl-2-[(1S)-1-(3H-purin-6-ylamino)propyl]quinazolin-4(3H)-one …
Matched Iupac: … 5-fluoro-3-phenyl-2-[(1S)-1-[(9H-purin-6-yl)amino]propyl]-3,4-dihydroquinazolin-4-one …
Matched Description: … Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic ... receptor (BCR) signaling and C-X-C chemokine receptors type 5 and type 4 signalling, which are involved ... specifically, idelalisib targets P110δ, the delta isoform of the enzyme phosphatidylinositol-4,5-bisphosphate 3- …
Matched Categories: … Heterocyclic Compounds, 2-Ring ... Phosphatidylinositol-3-kinase (Pi3K) inhibitors ... Class Ia Phosphatidylinositol 3-Kinase, antagonists & inhibitors ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Ménière's disease is a progressive disease of the inner ear characterized by vertigo, tinnitus, and hearing loss. It has a significant impact on both the physical and social functioning of affected individuals.[A220318,L16408] Betahistine is a histamine-like antivertigo drug used for treating symptoms associated with Ménière's disease. It is thought to...
Approved
Investigational
Matched Synonyms: … N-methyl-2-(2-pyridinyl)ethanamine ... N-methyl-2-pyridineethanamine ... [2-(2-pyridyl)ethyl]methylamine …
Matched Iupac: … methyl[2-(pyridin-2-yl)ethyl]amine …
Matched Description: … It has a significant impact on both the physical and social functioning of affected individuals. ... Ménière's disease is a progressive disease of the inner ear characterized by vertigo, tinnitus, and hearing ... [A220318,L16408] Betahistine is a histamine-like antivertigo drug used for treating symptoms associated …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Products: … BETAVERT N 8MG ... BETAVERT N 16MG ... BETAVERT N 24MG …
Obiltoxaximab, an affinity-enhanced monoclonal antibody (Mab), is used for prevention and treatment of infection and death caused by anthrax toxin. Obiltoxaximab is a chimeric IgG1 kappa monoclonal antibody (mAb) that binds the PA component of B. anthracis toxin. It has an approximate molecular weight of 148 kDa.
Approved
Matched Description: … Obiltoxaximab is a chimeric IgG1 kappa monoclonal antibody (mAb) that binds the PA component of B. anthracis …
Matched Categories: … Anthrax Protective Antigen-directed Antibody ... Anthrax Protective Antigen-directed Antibody Interactions …
A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United States, as it has been implicated in causing...
Approved
Withdrawn
Matched Iupac: … N-benzyl-N-[3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl]aniline …
Matched Description: … A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. ... It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. …
Matched Salts cas: … 74764-40-2
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Approved
Matched Iupac: … 4-{[4-(diethylamino)phenyl](2,5-disulfophenyl)methylidene}-N,N-diethylcyclohexa-2,5-dien-1-iminium …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … Lymphazurin 1% …
Becaplermin is produced by recombinant DNA technology by insertion of the gene for the B chain of platelet derived growth factor (PDGF) into the yeast, Saccharomyces cerevisiae. Becaplermin has a molecular weight of approximately 25 KD and is a homodimer composed of two identical polypeptide chains that are bound together...
Approved
Investigational
Matched Synonyms: … PDGF-2
Matched Description: … Becaplermin has a molecular weight of approximately 25 KD and is a homodimer composed of two identical ... Becaplermin is produced by recombinant DNA technology by insertion of the gene for the B chain of platelet …
Insulin beef has been discontinued in the US and Canada since 2017.
Approved
Matched Description: … Insulin beef has been discontinued in the US and Canada since 2017.[L10827] …
Polyethylene glycol (PEG) is a synthetic polymer produced via polymerization of ethylene oxide molecules to make joining units of ethylene glycol by an ether linkage.[A190975,A190978] PEGs are water-soluble polymers that can form hydrogen bonds in a ratio of 100 water molecules per one PEG molecule. Molecular weights of PEGs vary...
Approved
Vet approved
Matched Description: … PEGs have a long history of gastroenterology: PEG 3350 is a common over-the-counter osmotic laxative ... Polyethylene glycol (PEG) is a synthetic polymer produced via polymerization of ethylene oxide molecules ... [A190975,A190978] PEGs are water-soluble polymers that can form hydrogen bonds in a ratio of 100 water …
Matched Mixtures name: … Gavilyte-N ... GaviLyte-H and Bisacodyl ... SYSTANE LUBRIKANT % 0,4 + %0,3 GÖZ DAMLASI, ÇÖZELTI, 15 ML …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … PEGDİN 227,1 G ORAL ÇÖZELTİ İÇİN TOZ, 1 POŞET ... Lax-A-day ... NEXTOLAC 17 G ORAL ÇÖZELTİ HAZIRLAMAK İÇİN TOZ, 14 SAŞE …
Trolamine salicylate is an organic compound or a salt formed between triethanolamine and salicylic acid. Triethanolamine neutralizes the acidity of the salicylic acid. It is a topical analgesic used for temporary relief of minor pain associated with arthritis, simple backache, muscle strains, sprains, and bruises. Unlike other topical analgesics, trolamine...
Approved
Matched Iupac: … 2-[bis(2-hydroxyethyl)amino]ethan-1-ol; 2-hydroxybenzoic acid …
Matched Description: … Trolamine salicylate is an organic compound or a salt formed between triethanolamine and salicylic acid ... It is a topical analgesic used for temporary relief of minor pain associated with arthritis, simple backache ... trolamine salicylate is an inhibitor of cyclo-oxygenase (COX) enzymes with no reported selectivity towards a
Matched Mixtures name: … ELF Flawless Finish Foundation SPF 15 Oil Free …
Matched Categories: … Non COX-2 selective NSAIDS …
Matched Products: … Antiphlogistine Rub A-535 No Odour Fmla Ont ... Myoflex Extra Cream 15% ... Myoflex Arthritic Cream 15% …
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor...
Approved
Investigational
Matched Description: … heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 ... It is a naturally occurring anticoagulant released from mast cells. ... Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers …
Matched Mixtures name: … BARICUS 50 IU/%1/%10 JEL , 50 G …
Matched Products: … THROMBOCUTAN 30000IE GEL N ... THROMBOCUTAN 30000IE SAL N ... B. BRAUN HEPARINISED SALINE 10IU/ML SOLUTION FOR INJECTION …
Oxybuprocaine (also known as Benoxinate) is a local anesthetic, which is used especially in ophthalmology and otolaryngology. Oxybuprocaine binds to sodium channels and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions.
Approved
Investigational
Matched Synonyms: … 4-Amino-3-n-butoxy-benzoesäure-diäthylaminoäthylester ... 4-Amino-3-butoxy-2-(diethylamino)ethyl ester benzoic acid ... 4-Amino-3-butoxy-benzoic acid 2-diethylamino-ethyl ester …
Matched Iupac: … 2-(diethylamino)ethyl 4-amino-3-butoxybenzoate …
Matched Description: … Oxybuprocaine (also known as Benoxinate) is a local anesthetic, which is used especially in ophthalmology …
Matched Mixtures name: … AMIGDAL-B® …
Matched Products: … Benoxinat 1% - Lösung zur Anästhesie in der Oto-Rhino-Laryngologie …
Displaying drugs 426 - 450 of 6329 in total