Displaying drugs 4576 - 4600 of 8282 in total
Foretinib
Foretinib has been used in trials studying the treatment of Cancer, Breast Cancer, Carcinoma, Renal Cell, Recurrent Breast Cancer, and Neoplasms, Head and Neck, among others. Foretinib is an orally available small molecule compound designed to target multiple RTKs implicated in the development, progression and spread of cancer. It inhibits...
Investigational
Matched Description: … Foretinib has been used in trials studying the treatment of Cancer, Breast Cancer, Carcinoma, Renal Cell ... It inhibits the activation of MET, RON, ERK and AKT, decreased proliferation and increased apoptosis. ... molecule compound designed to target multiple RTKs implicated in the development, progression and spread of …
Denufosol
Denufosol was an inhaled drug used for the treatment of cystic fibrosis (CF), showing various improvements in lung function during a phase III clinical trial. A new drug application (NDA) was filed with the FDA in 2011, however, the second phase III clinical trial showed a lack of improvement in...
Investigational
Matched Description: … The drug was also evaluated in the treatment of retinal detachment and other diseases of the retina. ... Denufosol was an inhaled drug used for the treatment of cystic fibrosis (CF), showing various improvements ... application (NDA) was filed with the FDA in 2011, however, the second phase III clinical trial showed a lack of …
AN0128
AN0128 is a novel compound that contains a boron atom within a borinic acid complex. AN0128 has broad spectrum activity against a wide variety of Gram positive
bacteria, including many that are known skin colonizers. Of particular importance is P. acnes and its causal role in acne vulgaris. The rise...
Investigational
Matched Description: … The rise in antibiotic
resistance of P. acnes to standard antibiotics necessitates the development of ... Of particular importance is P. acnes and its causal role in acne vulgaris. ... AN0128 has broad spectrum activity against a wide variety of Gram positive
bacteria, including many …
OSI-7836
OSI-7836 is a member of the nucleoside class of cytotoxic drugs of which gemcitabine is the market leader. OSI Pharmaceuticals develops OSI-7836 as a next-generation gemcitabine. The anti-tumor activity of OSI-7836 appeares to be less schedule dependent than gemcitabine. It is also more active than ara-C (another clinically used nucleoside...
Investigational
Matched Description: … OSI-7836 is a member of the nucleoside class of cytotoxic drugs of which gemcitabine is the market leader ... The anti-tumor activity of OSI-7836 appeares to be less schedule dependent than gemcitabine. …
Horse chestnut
Horse chestnut is a flowering plant commonly referred to as Aesculus hippocastanum. Unprocessed horse chestnut seeds contain a toxin called esculin (also spelled aesculin) that increases the risk of bleeding due to anticoagulant actions. These seeds are processed to remove the toxic component, resulting in purified horse chestnut seed extract...
Experimental
Matched Description: … the veins and reduces swelling and inflammation of the legs. ... Its therapeutic potential in the treatment of chronic venous insufficiency is being studied. ... horse chestnut seeds contain a toxin called esculin (also spelled aesculin) that increases the risk of …
PSN9301
PSN9301 is an oral small molecule inhibitor of Dipeptidyl Peptidase IV (DP-IV), being developed for the treatment of type 2 diabetes. PSN9301 has a very rapid onset and a relatively short duration of action, and available pre-clinical and clinical data indicate that it may be an ideal product candidate for...
Investigational
Matched Description: … treatment of type 2 diabetes. ... PSN9301 is an oral small molecule inhibitor of Dipeptidyl Peptidase IV (DP-IV), being developed for the ... PSN9301 has a very rapid onset and a relatively short duration of action, and available pre-clinical …
Isoleucine
An essential branched-chain aliphatic amino acid found in many proteins. It is an isomer of leucine. It is important in hemoglobin synthesis and regulation of blood sugar and energy levels.
Investigational
Nutraceutical
Matched Description: … It is an isomer of leucine. ... It is important in hemoglobin synthesis and regulation of blood sugar and energy levels. …
Tofisopam
Tofisopam (marketed under brand names Emandaxin and Grandaxin) is a 2,3-benzodiazepine drug which is a benzodiazepine derivative. In contrast to classical 1,4-benzodiazepines, the compound does not bind to the benzodiazepine binding site of the gamma-aminobutyric acid receptor and its psychopharmacological profile differs from such compounds. Although Tofisopam is not approved...
Experimental
Matched Description: … contrast to classical 1,4-benzodiazepines, the compound does not bind to the benzodiazepine binding site of ... approved for sale in North America, it is approved for use in various countries worldwide, including parts of ... The D-enantiomer ([dextofisopam]) is currently in phase II trials in the U.S. for the treatment of irritable …
TST10088
TST10088 is a recombinant variant of a plant toxin belonging to the family of class II ribosome inactivating proteins. These molecules efficiently kill cells by activating preprogrammed death pathways known as apoptosis. TST10088 has been designed and engineered by Twinstrand to contain a peptide switch that is specifically cleaved by...
Investigational
Matched Description: … TST10088 is a recombinant variant of a plant toxin belonging to the family of class II ribosome inactivating ... Cleavage of the peptide switch activates the prodrug causing ribosomal inactivation and the death of …
16-Bromoepiandrosterone
16-Bromoepiandrosterone is an injectable formulation of a compound called alpha-epi-bromide. It is a chemical relative of DHEA which was selected for development after it showed antiretroviral activity in laboratory tests.
Investigational
Matched Description: … 16-Bromoepiandrosterone is an injectable formulation of a compound called alpha-epi-bromide. ... It is a chemical relative of DHEA which was selected for development after it showed antiretroviral activity …
Trebananib
Trebananib is under investigation for the treatment of Ovarian Cancer, Peritoneal Cancer, and Fallopian Tube Cancer. Trebananib has been investigated for the treatment of Cancer, Oncology, Carcinoma, Metastases, and Colon Cancer, among others.
Investigational
Matched Description: … Trebananib is under investigation for the treatment of Ovarian Cancer, Peritoneal Cancer, and Fallopian ... Trebananib has been investigated for the treatment of Cancer, Oncology, Carcinoma, Metastases, and Colon …
Nivatrotamab
Nivatrotamab is under investigation in clinical trial NCT03860207 (Study of the Safety and Efficacy of Humanized 3F8 Bispecific Antibody (Hu3f8-bsab) in Patients With Relapsed/refractory Neuroblastoma, Osteosarcoma and Other Solid Tumor Cancers).
Investigational
Matched Description: … Nivatrotamab is under investigation in clinical trial NCT03860207 (Study of the Safety and Efficacy of …
AVXS-301
AVXS-301 consists of an adeno-associated virus serotype 9 (AAV9) designed to express the superoxide dismutase 1 (SOD1) gene. It is being investigated for the treatment of Amyotrophic Lateral Sclerosis (ALS).
Investigational
Matched Description: … It is being investigated for the treatment of Amyotrophic Lateral Sclerosis (ALS).[L47077] ... AVXS-301 consists of an adeno-associated virus serotype 9 (AAV9) designed to express the superoxide dismutase …
Aetiocholanolone
The 5-beta-reduced isomer of androsterone. Etiocholanolone is a major metabolite of testosterone and androstenedione in many mammalian species including humans. It is excreted in the urine. [PubChem]
Experimental
Matched Description: … The 5-beta-reduced isomer of androsterone. ... Etiocholanolone is a major metabolite of testosterone and androstenedione in many mammalian species including …
Afelimomab
Afelimomab (also known as Fab 2 or MAK 195F) is an anti-TNF-α monoclonal antibody. Administration of 195F reduces the concentration of interleukin-6 in patients with sepsis.
Investigational
Matched Description: … Administration of 195F reduces the concentration of interleukin-6 in patients with sepsis. …
Omecamtiv Mecarbil
Omecamtiv Mecarbil has been used in trials studying the treatment and basic science of Heart Failure, Echocardiogram, Pharmacokinetics, Chronic Heart Failure, and History of Chronic Heart Failure, among others.
Investigational
Matched Description: … Omecamtiv Mecarbil has been used in trials studying the treatment and basic science of Heart Failure, ... Echocardiogram, Pharmacokinetics, Chronic Heart Failure, and History of Chronic Heart Failure, among …
Creatinolfosfate
COP is under investigation for the treatment of Rheumatoid Arthritis, Mature B-Cell Lymphoma, and Noninflammatory Degenerative Joint Disease. COP has been investigated for the treatment of Diabetic Retinopathy.
Investigational
Matched Description: … COP has been investigated for the treatment of Diabetic Retinopathy. ... COP is under investigation for the treatment of Rheumatoid Arthritis, Mature B-Cell Lymphoma, and Noninflammatory …
PF-06751979
PF-06751979 is under investigation in clinical trial NCT03126721 (The Study is to Evaluate the Effect of Multiple Doses PF-06751979 on the Pharmacokinetics of Midazolam in Healthy Adults).
Investigational
Matched Description: … Multiple Doses PF-06751979 on the Pharmacokinetics of Midazolam in Healthy Adults). ... -06751979 is under investigation in clinical trial NCT03126721 (The Study is to Evaluate the Effect of …
Hemoximer
Hemoximer is a modified version of hemoglobin that undergoes pyridoxylation, for the purpose of lowering the oxygen affinity, and coupling with polyoxyethylene (POE), to increase its molecular weight.
Investigational
Matched Description: … Hemoximer is a modified version of hemoglobin that undergoes pyridoxylation, for the purpose of lowering …
LB-001
LB-001 is a gene editing therapy designed to incorporate a functioning version of the faulty methylmalonyl-COA mutase (MUT) gene into the genome of patients with methylmalonic acidemia.
Investigational
Matched Description: … mutase (MUT) gene into the genome of patients with methylmalonic acidemia. ... LB-001 is a gene editing therapy designed to incorporate a functioning version of the faulty methylmalonyl-COA …
Desoxycorticosterone pivalate
Desoxycorticosterone pivalate is a mineralocorticoid hormone and an analog of desoxycorticosterone. It is white, odorless, and stable in air. It is practically insoluble in water, sparingly soluble in acetone, slightly soluble in methanol, ether and vegetable oils. Federal (U.S.A.) law restricts this drug to use by or on the order...
Experimental
Vet approved
Matched Description: … Desoxycorticosterone pivalate is a mineralocorticoid hormone and an analog of desoxycorticosterone. ... Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian. …
Metharbital
Metharbital is a barbiturate anticonvulsant, similar to phenobarbital, marketed as Gemonil by Abbott Laboratories. It was patented in 1905 by Emil Fischer of Merck.
Withdrawn
Matched Description: … It was patented in 1905 by Emil Fischer of Merck. …
Apramycin
Apramycin is an aminoglycoside antibiotic and has a bactericidal action against many gram-negative bacteria. Apramycin is a structurally unique antibiotic that contains a bicyclic sugar moiety and a monosubstituted deoxystreptamine. It is not approved for use in humans.
Experimental
Vet approved
Halofuginone
Halofuginone is a low molecular weight quinazolinone alkaloid, and a potent inhibitor of collagen alpha1(I) and matrix metalloproteinase 2 (MMP-2) gene expression. Halofuginone also effectively suppresses tumor progression and metastasis in mice. Collgard Biopharmaceuticals is developing halofuginone for the treatment of scleroderma and received orphan drug designation from the U.S....
Investigational
Vet approved
Matched Description: … Halofuginone is a low molecular weight quinazolinone alkaloid, and a potent inhibitor of collagen alpha1 ... Collgard Biopharmaceuticals is developing halofuginone for the treatment of scleroderma and received …
Picoplatin
Picoplatin is a cytotoxic platinum compound in clinical development for the treatment of patients with solid tumors. It causes apoptosis (cell death) by binding to DNA and interfering with DNA replication and transcription.
Investigational
Matched Description: … Picoplatin is a cytotoxic platinum compound in clinical development for the treatment of patients with …
Displaying drugs 4576 - 4600 of 8282 in total