This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
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Identification
- Summary
Horse chestnut is a plant extract indicated in the treatment of venous insufficiency and other disorders caused by poor circulation.
- Generic Name
- Horse chestnut
- DrugBank Accession Number
- DB13195
- Background
Horse chestnut is a flowering plant commonly referred to as Aesculus hippocastanum. Unprocessed horse chestnut seeds contain a toxin called esculin (also spelled aesculin) that increases the risk of bleeding due to anticoagulant actions. These seeds are processed to remove the toxic component, resulting in purified horse chestnut seed extract (HCSE) 1. The active component of this pure extract is escin, or aescin, that promotes blood circulation through the veins and reduces swelling and inflammation of the legs. Its therapeutic potential in the treatment of chronic venous insufficiency is being studied.
- Type
- Biotech
- Groups
- Experimental
- Biologic Classification
- Protein Based Therapies
Other protein based therapies - Protein Chemical Formula
- Not Available
- Protein Average Weight
- Not Available
- Sequences
- Not Available
- Synonyms
- Hippocastani semen
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Used in combination to treat Back pain lower back Combination Product in combination with: Salicylic acid (DB00936) •••••••••••• ••• Used in combination to treat Back pain, unspecified Combination Product in combination with: Salicylic acid (DB00936) •••••••••••• ••• Used in combination to treat Bruises Combination Product in combination with: Salicylic acid (DB00936) •••••••••••• ••• Used in combination to treat Cervical syndrome Combination Product in combination with: Salicylic acid (DB00936) •••••••••••• ••• Treatment of Hemorrhoids •••••••••••• - Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
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Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Liquid Horse chestnut (0.4 mg/4mg) + Aloe vera leaf (0.4 mg/4mg) + Ascorbic acid (0.6 mg/4mg) + Camellia japonica seed oil (0.6 mg/4mg) Liquid Cutaneous Shantou Youjia E-Commerce Co., Ltd. 2024-02-01 2024-12-31 US 
Nail Care Pen Horse chestnut (0.8 mg/4mg) + Aloe vera leaf (0.3 mg/4mg) + Ascorbic acid (0.3 mg/4mg) + Camellia japonica seed oil (0.8 mg/4mg) Solution / drops Infiltration Shantou Youjia E-Commerce Co., Ltd. 2024-02-02 2024-12-31 US REPARİL-GEL N %1 + %5 JEL, 50 G Horse chestnut (1 g/100g) + Diethylamine salicylate (5 g/100g) Gel Topical MEDA PHARMA İLAÇ SAN. VE TİC. LTD. ŞTİ. 2016-12-02 Not applicable Turkey 
Varicose Veins Cream Horse chestnut (4 mg/20g) + Centella asiatica (4 mg/20g) + Oat (4 mg/20g) + Rosemary (4 mg/20g) Cream Cutaneous Shantou Youjia E-Commerce Co., Ltd. 2024-02-01 2024-12-31 US
Categories
- ATC Codes
- C05CX03 — Hippocastani semen
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- Not Available
- Kingdom
- Organic Compounds
- Super Class
- Organic Acids
- Class
- Carboxylic Acids and Derivatives
- Sub Class
- Amino Acids, Peptides, and Analogues
- Direct Parent
- Peptides
- Alternative Parents
- Not Available
- Substituents
- Not Available
- Molecular Framework
- Not Available
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 3C18L6RJAZ
- CAS number
- Not Available
References
- General References
- Pittler MH, Ernst E: Horse chestnut seed extract for chronic venous insufficiency. Cochrane Database Syst Rev. 2006 Jan 25;(1):CD003230. [Article]
- Siebert U, Brach M, Sroczynski G, Berla K: Efficacy, routine effectiveness, and safety of horsechestnut seed extract in the treatment of chronic venous insufficiency. A meta-analysis of randomized controlled trials and large observational studies. Int Angiol. 2002 Dec;21(4):305-15. [Article]
- External Links
Clinical Trials
- Clinical Trials
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Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Gel Topical Capsule Liquid Cutaneous Solution / drops Infiltration Cream Cutaneous Tablet, coated Oral 50 mg - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
Drug created at June 23, 2017 20:37 / Updated at June 05, 2021 09:12