Displaying drugs 4601 - 4625 of 8282 in total
Becocalcidiol
Becocalcidiol is a vitamin D(3) analogue which has not caused hypercalcaemia or significant irritation in preclinical trials.
Investigational
AM103
AM103 is a novel inhibitor of 5-lipoxygenase-activiting protein (FLAP) that has demonstrated potential to treat asthma and cardiovascular disease by preventing the synthesis of LT, which triggers inflammation. It is being developed by Amira.
Investigational
Matched Description: … AM103 is a novel inhibitor of 5-lipoxygenase-activiting protein (FLAP) that has demonstrated potential ... to treat asthma and cardiovascular disease by preventing the synthesis of LT, which triggers inflammation …
Telapristone acetate
Telapristone acetate, an orally-available, selective progesterone receptor modulator, is in development to alleviate symptoms associated with both uterine fibroids and endometriosis.
Investigational
8-chlorotheophylline
8-Chlorotheophylline is a stimulant drug of the xanthine chemical class, with physiological effects similar to caffeine. Its main use is in combination with Diphenhydramine as the antiemetic drug Dimenhydrinate. The stimulant properties of 8-chlorotheophylline are thought to ward off the drowsiness caused by diphenhydramine's anti-histamine activity in the central nervous...
Experimental
Matched Description: … 8-Chlorotheophylline is a stimulant drug of the xanthine chemical class, with physiological effects similar ... anti-histamine activity in the central nervous system.
8-chlorotheophylline produces a number of ... Because adenosine causes a decrease in neuronal firing, blockade of the adenosine receptor causes the …
Eritoran
Eritoran is a structural analogue of the lipid A portion of lipopolysaccharide (LPS). It is being developed by Eisai Research Institute of Boston for the treatment of severe sepsis.
Investigational
Matched Description: … Eritoran is a structural analogue of the lipid A portion of lipopolysaccharide (LPS). ... It is being developed by Eisai Research Institute of Boston for the treatment of severe sepsis. …
Mitiglinide
Mitiglinide is a drug for the treatment of type 2 diabetes. It may stimulate insulin secretion in beta-cells by closing off ATP dependant potassium ion channels.
Investigational
Matched Description: … Mitiglinide is a drug for the treatment of type 2 diabetes. …
Niflumic acid
Niflumic acid is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.
Experimental
Matched Description: … Niflumic acid is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis …
Sitimagene ceradenovec
Sitimagene ceradenovec is a novel gene-based product for the treatment of patients with operable high grade glioma, a type of malignant brain tumour, given in addition to standard surgery and radiotherapy/chemotherapy. It is being developed by Ark Therapeutics.
Investigational
Matched Description: … Sitimagene ceradenovec is a novel gene-based product for the treatment of patients with operable high ... grade glioma, a type of malignant brain tumour, given in addition to standard surgery and radiotherapy …
Aluminium monostearate
Aluminium monostearate is a salt of stearic acid and aluminium with the molecular formula Al(OH)2C18H35O2. Also known as dihydroxyaluminium or dihydroxy(stearato)aluminium, it is used to form gels in the packaging of pharmaceuticals and in the preparation of colors for cosmetics. While considered safe for use, extensive usage may result in...
Experimental
Matched Description: … pharmaceuticals and in the preparation of colors for cosmetics. ... Aluminium monostearate is a salt of stearic acid and aluminium with the molecular formula Al(OH)2C18H35O2 ... known as dihydroxyaluminium or dihydroxy(stearato)aluminium, it is used to form gels in the packaging of …
HZT-501
HZT-501 is under investigation by Horizon Therapeutics, Inc., a privately held biopharmaceutical company. It has entered Phase 3 clinical trials in March 2007 for reduction of the risk of development of ibuprofen-associated upper gastrointestinal (i.e., gastric and/or duodenal) ulcers. HZT-501 is a combination product including ibuprofen and the acid reducing...
Investigational
Matched Description: … It has entered Phase 3 clinical trials in March 2007 for reduction of the risk of development of ibuprofen-associated …
ATX-201
ATX-201 is one of a family of novel compounds that inhibits microtubule polymerization. It is developed by Kythera Biopharmaceuticals, Inc. for the treatment of actinic
keratosis. The company announced the decision to discontinue its ATX-201 clinical program for actinic keratosis. The Company determined that the program was not meeting their...
Investigational
Matched Description: … ATX-201 is one of a family of novel compounds that inhibits microtubule polymerization. ... It is developed by Kythera Biopharmaceuticals, Inc. for the treatment of actinic
keratosis. …
Peginterferon alfacon-1
PEGylation is a technology for the chemical attachment of polyethylene glycol (PEG) polymer chains to a broad range of drug substances such as peptides and proteins including antibody fragments; small molecules, and other drugs. [Infergen] is a bio-engineered type I interferon alpha that is FDA-approved for the treatment of patients...
Investigational
Matched Description: … PEGylation is a technology for the chemical attachment of polyethylene glycol (PEG) polymer chains to ... [Infergen] is a bio-engineered type I interferon alpha that is FDA-approved for the treatment of patients ... a broad range of drug substances such as peptides and proteins including antibody fragments; small molecules …
Bardoxolone
Bardoxolone has been used in trials studying the treatment of LYMPHOMA and Solid Tumors. It is a synthetic triterpenoid and a highly potent activator of redox-sensitive signaling pathways that induce programmed cell death (apoptosis) in cancer cells that are under high levels of intrinsic oxidative stress. In contrast, Bardoxolone in...
Investigational
Matched Description: … Bardoxolone has been used in trials studying the treatment of LYMPHOMA and Solid Tumors. ... It is a synthetic triterpenoid and a highly potent activator of redox-sensitive signaling pathways that ... induce programmed cell death (apoptosis) in cancer cells that are under high levels of intrinsic oxidative …
Amuvatinib
Amuvatinib has been used in trials studying the treatment of Solid Tumors and Small Cell Lung Carcinoma. Amuvatinib is an oral, selective multi-targeted tyrosine kinase inhibitor that suppresses c-MET, c-RET and the mutant forms of c-KIT, PDGFR and FLT3. Amuvatinib also suppresses Rad51 protein, a critical component of double-stranded DNA...
Investigational
Matched Description: … Amuvatinib has been used in trials studying the treatment of Solid Tumors and Small Cell Lung Carcinoma ... selective multi-targeted tyrosine kinase inhibitor that suppresses c-MET, c-RET and the mutant forms of ... Amuvatinib also suppresses Rad51 protein, a critical component of double-stranded DNA repair in cancer …
OAV201
OAV201 is a non-replicating, recombinant adeno-associated virus serotype 9 (AAV9) containing the human Methyl CpG Binding Protein 2B (MECP2B) cDNA under the control of a segment of the murine MECP2 promoter. It was first developed by Novartis and investigated for the treatment of Rett syndrome, but further investigation in clinical...
Investigational
Matched Description: … a segment of the murine MECP2 promoter. ... serotype 9 (AAV9) containing the human Methyl CpG Binding Protein 2B (MECP2B) cDNA under the control of ... It was first developed by Novartis and investigated for the treatment of Rett syndrome, but further investigation …
Benzquinamide
Benzquinamide is a discontinued antiemetic compound with antihistaminic, mild anticholinergic, and sedative properties. The mechanism of action is not known, but presumably benzquinamide works via antagonism of muscarinic acetycholine receptors and histamine H1 receptors.
Withdrawn
Matched Description: … The mechanism of action is not known, but presumably benzquinamide works via antagonism of muscarinic …
CX157
CX157,3-fluoro-7-(2,2,2,-trifluoroethoxy)phenoxathiin-10,10-dioxide, is a reversible, selective inhibitor of MAO-A designed to have improved oral bioavailability and reduced clearance compared to previous MAO-A inhibitors of this class.
Investigational
Matched Description: … CX157,3-fluoro-7-(2,2,2,-trifluoroethoxy)phenoxathiin-10,10-dioxide, is a reversible, selective inhibitor of ... designed to have improved oral bioavailability and reduced clearance compared to previous MAO-A inhibitors of …
Bertilimumab
Bertilimumab is a fully human anti-eotaxin monoclonal antibody with potential in the treatment of allergic disorders, has moved into pre-clinical development. It is developed by MedImmune for the treatment of Allergic Rhinitis.
Investigational
Matched Description: … It is developed by MedImmune for the treatment of Allergic Rhinitis. ... Bertilimumab is a fully human anti-eotaxin monoclonal antibody with potential in the treatment of allergic …
Ulixertinib
Ulixertinib is a a novel, reversible, ATP-competitive ERK1/2 inhibitor with high potency and ERK1/2 selectivity . It is currently in clinical trials for the treatment of a wide range of tumors.
Investigational
Matched Description: … It is currently in clinical trials for the treatment of a wide range of tumors. …
Trestolone acetate
Trestolone acetate is a synthetic and injected anabolic–androgenic steroid (AAS) and a derivative of nandrolone (19-nortestosterone) which was never marketed. It is an androgen ester – specifically, the C17 acetate ester of DB05830.
Experimental
Matched Description: … It is an androgen ester – specifically, the C17 acetate ester of [DB05830]. ... Trestolone acetate is a synthetic and injected anabolic–androgenic steroid (AAS) and a derivative of …
Serabelisib
Serabelisib is under investigation in clinical trial NCT02625259 (A Study to Evaluate the Relative Bioavailability, Effect of Food, and Gastric Potential Hydrogen (pH) Modification on the Pharmacokinetics of TAK-117 (MLN1117) in Healthy Participants).
Investigational
Matched Description: … investigation in clinical trial NCT02625259 (A Study to Evaluate the Relative Bioavailability, Effect of ... Food, and Gastric Potential Hydrogen (pH) Modification on the Pharmacokinetics of TAK-117 (MLN1117) …
ABT-072
ABT-072 is under investigation in clinical trial NCT00890318 (A Study in Healthy Adult Subjects to Evaluate the Safety, Tolerability, and Pharmacokinetic Profiles of Multiple Doses of ABT-072 Used to Treat Hepatitis C).
Investigational
Matched Description: … Multiple Doses of ABT-072 Used to Treat Hepatitis C). ... Study in Healthy Adult Subjects to Evaluate the Safety, Tolerability, and Pharmacokinetic Profiles of …
2X-121
2X-121 is under investigation in clinical trial NCT03562832 (Investigation of Anti-tumour Effect and Tolerability of the PARP Inhibitor 2X-121 in Patients With Metastatic Breast Cancer Selected by the 2X-121 DRP).
Investigational
Matched Description: … 2X-121 is under investigation in clinical trial NCT03562832 (Investigation of Anti-tumour Effect and ... Tolerability of the PARP Inhibitor 2X-121 in Patients With Metastatic Breast Cancer Selected by the 2X …
Fosclevudine alafenamide
Fosclevudine alafenamide is under investigation in clinical trial NCT05238844 (A Study of Safety and Efficacy of ATI-2173 and Vebicorvir in Combination With Tenofovir Disoproxil Fumarate in Subjects With Chronic Hepatitis B Virus Infection).
Investigational
Matched Description: … Fosclevudine alafenamide is under investigation in clinical trial NCT05238844 (A Study of Safety and ... Efficacy of ATI-2173 and Vebicorvir in Combination With Tenofovir Disoproxil Fumarate in Subjects With …
Radotermin
Radotermin is under investigation in clinical trial NCT01182337 (A Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of Single Administration Intradiscal Rhgdf-5 for the Treatment of Early Stage Lumbar Disc Degeneration).
Investigational
Matched Description: … trial NCT01182337 (A Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of ... Single Administration Intradiscal Rhgdf-5 for the Treatment of Early Stage Lumbar Disc Degeneration) …
Displaying drugs 4601 - 4625 of 8282 in total