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Displaying drugs 476 - 500 of 2469 in total
Olvimulogene nanivacirepvec is under investigation in clinical trial NCT01443260 (A Study of GL-ONC1, an Oncolytic Vaccinia Virus, in Patients With Advanced Peritoneal Carcinomatosis).
Investigational
Matched Synonyms: … DNA (synthetic vaccinia virus oncolytic-strain GLV-1h68 (complete genome)) …
Valoctocogene roxaparvovec is an adeno-associated virus serotype 5 (AAV5) based gene therapy vector that expresses the B-domain deleted SQ form of human coagulation factor VIII (hFVIII-SQ). The expression of hFVIII-SQ is driven by a liver-specific promoter, which enables hepatocytes to produce factor VIII protein and increase the levels of active...
Approved
Investigational
Matched Synonyms: … DNA (synthetic adeno-associated virus 5 vector BMN 270 human blood-coagulation factor VIII SQ variant-specifying …
Matched Description: … [L43282,A252807] Valoctocogene roxaparvovec was approved by EMA in September 2022 and is indicated for ... hFVIII-SQ is driven by a liver-specific promoter, which enables hepatocytes to produce factor VIII protein and ... A252797] As opposed to these therapies, valoctocogene roxaparvovec offers the advantage of continuous and
Matched Categories: … Cellular and Gene Therapy ... Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …
A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy.
Approved
Investigational
Matched Synonyms: … 1-Cyano-2-methyl-3-(2-(((5-methyl-4-imidazolyl)methyl)thio)ethyl)guanidine ... N''-cyano-N-methyl-N'-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]thio}ethyl)guanidine ... N-cyano-N'-methyl-N''-(2-([(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl)ethyl)guanidine …
Matched Iupac: … (Z)-N''-cyano-N-methyl-N'-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl)guanidine …
Matched Description: … It inhibits gastric acid secretion, as well as pepsin and gastrins output. ... It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant …
Matched Categories: … Drugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord) ... Alimentary Tract and Metabolism ... Metabolic Side Effects of Drugs and Substances ... Drugs for Acid Related Disorders …
Matched Products: … Up and Up Acid Reducer …
Salsalate is a nonsteroidal anti-inflammatory agent for oral administration. Salsalate's mode of action as an anti-inflammatory and antirheumatic agent may be due to inhibition of synthesis and release of prostaglandins. The usefulness of salicylic acid, the active in vivo product of salsalate, in the treatment of arthritic disorders has been...
Approved
Matched Synonyms: … 2-Carboxyphenyl salicylate
Matched Description: … synthesis and release of prostaglandins. ... Salsalate is a nonsteroidal anti-inflammatory agent for oral administration. ... Salsalate's mode of action as an anti-inflammatory and antirheumatic agent may be due to inhibition of …
Matched Categories: … Salicylic Acid and Derivatives …
Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic ofloxacin. It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin, along with other quinolones...
Approved
Investigational
Matched Synonyms: … Ofloxacin S-(-)-form ... (3S)-(-)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine ... (S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine …
Matched Iupac: … (2S)-7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.0^{5,13}]trideca-5 …
Matched Description: … [A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and ... Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. ... [A190663] It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive …
Matched Categories: … Alimentary Tract and Metabolism ... Antibacterials for Systemic Use ... Antiinfectives for Systemic Use ... levofloxacin and ornidazole ... lansoprazole, amoxicillin and levofloxacin …
Matched Products: … For Infusion 5mg/ml ... Levores 5mg/ml Solution for Infusion ... JW Levofloxacin Solution for Infusion 5mg/mL …
Experimental
Matched Name: … Mentha arvensis leaf oil …
L-3972-T is one of the components of the human papilloma virus (HPV) type 16 E6/E7 synthetic long peptide (SLP) vaccine ISA101b.
Investigational
Matched Synonyms: … Human Papilloma Virus (HPV) Type 16 E6/E7 Synthetic Long Peptide (SLP) Vaccine Component L-3972-T …
Matched Description: … L-3972-T is one of the components of the human papilloma virus (HPV) type 16 E6/E7 synthetic long peptide …
5-Hydroxytryptophan (5-HTP), also known as oxitriptan (INN), is a naturally occurring amino acid and metabolic intermediate in the synthesis of serotonin and melatonin. 5-HTP is sold over-the-counter in the United Kingdom, United States and Canada as a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, and...
Approved
Investigational
Nutraceutical
Matched Synonyms: … 5-hydroxytryptophan L-form
Matched Description: … metabolic intermediate in the synthesis of serotonin and melatonin. 5-HTP is sold over-the-counter in ... suppressant, and sleep aid, and is also marketed in many European countries for the indication of major ... the United Kingdom, United States and Canada as a dietary supplement for use as an antidepressant, appetite …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Experimental
Matched Synonyms: … 1α,2α-epoxy-4βH-p-menth-8-ene ... (1S,4R,6R)-4-isopropenyl-1-methyl-7-oxabicyclo[4.1.0]heptane …
Matched Iupac: … (1R,4R,6S)-1-methyl-4-(prop-1-en-2-yl)-7-oxabicyclo[4.1.0]heptane …
Synthetic peptide, 32 residues long formulated as a nasal spray.
Approved
Investigational
Matched Synonyms: … Calcitonin (Salmon Synthetic) …
Matched Description: … Synthetic peptide, 32 residues long formulated as a nasal spray. …
Matched Categories: … calcitonin (salmon synthetic) ... Amino Acids, Peptides, and Proteins ... Sex Hormones and Insulins ... Calcium-Regulating Hormones and Agents ... Parathyroid Hormones and Analogues …
Investigational
Matched Synonyms: … Lt-253(former code) ... Lor-253(former code) ... 1h-imidazo(4,5-f)(1,10)phenanthroline, 2-(5-fluoro-2-methyl-1h-indol-3-yl)- …
Matched Iupac: … 5-fluoro-3-{1H-imidazo[4,5-f]1,10-phenanthrolin-2-yl}-2-methyl-1H-indole …
NADH is the reduced form of NAD+, and NAD+ is the oxidized form of NADH, a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by...
Approved
Nutraceutical
Matched Synonyms: … NAD reduced form
Matched Description: … NADH is the reduced form of NAD+, and NAD+ is the oxidized form of NADH, a coenzyme composed of ribosylnicotinamide ... electron carrier by being alternately oxidized (NAD+) and reduced (NADH). ... It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an …
Matched Categories: … Enzymes and Coenzymes ... Nucleic Acids, Nucleotides, and Nucleosides …
Experimental
Matched Synonyms: … L-Glutamic acid, N-[4-[[[(6R)-2-amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl]methyl]amino] ... N-{[4-({[(6R)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl} ... [6R]-5-formyl-5,6,7,8-tetrahydrofolate …
Matched Iupac: … (2S)-2-{[4-({[(6R)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]formamido …
Matched Categories: … Folic Acid and Derivatives …
Experimental
Matched Name: … 3-O-Methylfructose in Linear Form
The 4-carboxyaldehyde form of vitamin B 6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. [PubChem]
Experimental
Nutraceutical
Matched Synonyms: … 2-methyl-3-hydroxy-4-formyl-5-hydroxymethylpyridine ... 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde …
Matched Description: … for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic ... The 4-carboxyaldehyde form of vitamin B 6 which is converted to pyridoxal phosphate which is a coenzyme …
Terpin hydrate is an expectorant, commonly used to loosen mucus and ease congestion in patients presenting with acute or chronic bronchitis, and related pulmonary conditions. It is derived from sources such as turpentine, oregano, thyme and eucalyptus. It was popular in the United States since the late nineteenth century, but...
Approved
Experimental
Matched Synonyms: … Terpin cis-form hydrate …
Matched Description: … with acute or chronic bronchitis, and related pulmonary conditions. ... It is derived from sources such as turpentine, oregano, thyme and eucalyptus. ... Terpin hydrate is an expectorant, commonly used to loosen mucus and ease congestion in patients presenting …
AT132 is under investigation in clinical trial NCT03199469 (Gene Transfer Clinical Study in X-linked Myotubular Myopathy).
Investigational
Matched Synonyms: … DNA (synthetic adeno-associated virus 8 vector AT132 human myotubularin cDNA-specifying) …
Trimebutine is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu opioid agonist effects. It is marketed for the treatment of irritable bowel syndrome (IBS) and lower gastrointestinal tract motility disorders, with IBS being one of the most common multifactorial GI...
Approved
Matched International brands: … Dolpic Forte ... Puridat Fort
Matched Description: … It is marketed for the treatment of irritable bowel syndrome (IBS) and lower gastrointestinal tract motility ... maleate salt form. ... Trimebutine is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal …
Matched Categories: … Alimentary Tract and Metabolism ... Drugs for Functional Gastrointestinal Disorders ... Synthetic Anticholinergics, Esters With Tertiary Amino Group …
Matched Products: … DEBRIDAT FOR ORAL SUSPENSION ... TRIMOT FORTE 200 MG TABLET ,20 ADET ... DEBRIDAT FORT TABLET, 20 ADET …
Methyldopa, or α-methyldopa, is a centrally acting sympatholytic agent and an antihypertensive agent. It is an analog of DOPA (3,4‐hydroxyphenylanine), and it is a prodrug, meaning that the drug requires biotransformation to an active metabolite for therapeutic effects. Methyldopa works by binding to alpha(α)-2 adrenergic receptors as an agonist, leading...
Approved
Matched Synonyms: … Methyl dopa ... L-Methyl Dopa ... α-Methyl dopa …
Matched Description: … [A1499] Methyldopa exists in two isomers D-α-methyldopa and L-α-methyldopa, which is the active form. ... requires biotransformation to an active metabolite for therapeutic effects. ... Methyldopa, or α-methyldopa, is a centrally acting sympatholytic agent and an antihypertensive agent. …
Matched Mixtures name: … Methyldopa and Hydrochlorothiazide ... Methyldopa and Hydrochlorothiazide ... Methyldopa and Hydrochlorothiazide …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antihypertensive Agents Indicated for Hypertension …
Matched Products: … METIL-DOPA TABLETAS 500 …
Experimental
Matched Synonyms: … 4-Imino-5-Methidyl-2-Methylpyrimidine ... 2-Methyl-5-methylene-4(5H)-pyrimidinimine …
Matched Name: … 2-methyl-5-methylidenepyrimidin-4-imine …
Matched Iupac: … 2-methyl-5-methylidene-4,5-dihydropyrimidin-4-imine …
Glucose is a simple sugar (monosaccharide) generated during phosynthesis involving water, carbon and sunlight in plants. It is produced in humans via hepatic gluconeogenesis and breakdown of polymeric glucose forms (glycogenolysis). It circulates in human circulation as blood glucose and acts as an essential energy source for many organisms through...
Approved
Investigational
Vet approved
Matched Synonyms: … D-Glucose in linear form
Matched Description: … [T28] The unspecified form of glucose is commonly supplied as an injection for nutritional supplementation ... It is produced in humans via hepatic gluconeogenesis and breakdown of polymeric glucose forms (glycogenolysis ... It circulates in human circulation as blood glucose and acts as an essential energy source for many organisms …
Matched Mixtures name: … Accusol 35 Potassium 4 mmol/l Solution for Haemofiltration, Haemodialysis and Haemodiafiltration ... ELECTRAL FORTE GRANULES ... Plasma-Lyte 148 and dextrose …
Matched Categories: … Diet, Food, and Nutrition …
Matched Products: … Glucose 5% Solution for Infusion ... DEXTROSE SOLUTION FOR I.V. INJECTION 50% ... DEXTROSE 5% IN WATER FOR INTRAVENOUS INFUSION …
Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically prior to ocular surgery to prevent or reduce intraoperative miosis....
Approved
Investigational
Matched Synonyms: … (±)-2-fluoro-α-methyl-4-biphenylacetic acid ... 2-fluoro-α-methyl-(1,1'-biphenyl)-4-acetic acid …
Matched Description: … Flurbiprofen is structurally and pharmacologically related to fenoprofen, ibuprofen, and ketoprofen. ... osteoarthritis and anklylosing spondylitis. ... Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, …
Matched Categories: … Topical Products for Joint and Muscular Pain ... Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids ... Antiinflammatory Preparations, Non-Steroids for Topical Use …
Matched Products: … Strepsils MaxPro Honey and Lemon lozenges 8.75mg …
Investigational
Matched Synonyms: … A cd33/cd3 bispecific t-cell engager antibody for acute myeloid leukemia therapy …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Ceftriaxone is a broad-spectrum third-generation cephalosporin antibiotic. It has a very long half-life compared to other cephalosporins and is high penetrable into the meninges , eyes , and inner ear . Ceftriaxone has broader and stronger gram-negative coverage then first or second-generation cephalosporins, but worse activity against methicillin-susceptible S.aureus. Ceftriaxone...
Approved
Matched Iupac: … (6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3-{[(2-methyl-5,6-dioxo-1,2,5,6 ... -tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic …
Matched Description: … its long half-life which allows for the convenience of daily or twice-daily dosing. ... meninges[A215582], eyes[A215647], and inner ear[A215627]. ... [A215582] It has a very long half-life compared to other cephalosporins and is high penetrable into the …
Matched Categories: … Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …
Matched Products: … Ceftriaxone and Dextrose ... CYROSEF POWDER FOR SOLUTION FOR INJECTION 2GM ... CYROSEF POWDER FOR SOLUTION FOR INJECTION 1GM …
Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, gonorrhea, and haemophilus.
Approved
Matched Synonyms: … (6R,7R)-3-[(carbamoyloxy)methyl]-7-{[(2Z)-2-furan-2-yl-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo …
Matched Iupac: … (6R,7R)-3-[(carbamoyloxy)methyl]-7-[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo …
Matched Description: … It has been proposed for infections with gram-negative and gram-positive organisms, gonorrhea, and haemophilus …
Matched Categories: … cefuroxime and metronidazole ... Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …
Matched Products: … Cefuroxime and Dextrose ... Cefuroxime Axetil For Oral Suspension ... Cefuroxime for Injection USP …
Displaying drugs 476 - 500 of 2469 in total