Displaying drugs 5026 - 5050 of 5775 in total
Zelavespib
Zelavespib (PU-H71) has been used in trials studying the treatment of LYMPHOMA, Solid Tumors, Metastatic Solid Tumor, and Myeloproliferative Neoplasms (MPN).
Investigational
Matched Synonyms: … 8-(6-iodo-benzo[1,3]dioxol-5-ylsulfanyl)-9-(3-isopropylamino-propyl)adenine ... 8-((6-Iodobenzo[d][1,3]dioxol-5-yl)thio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine …
Matched Iupac: … 8-[(6-iodo-2H-1,3-benzodioxol-5-yl)sulfanyl]-9-{3-[(propan-2-yl)amino]propyl}-9H-purin-6-amine …
Matched Description: … ) has been used in trials studying the treatment of LYMPHOMA, Solid Tumors, Metastatic Solid Tumor, and …
Matched Iupac: … 8-[(6-iodo-2H-1,3-benzodioxol-5-yl)sulfanyl]-9-{3-[(propan-2-yl)amino]propyl}-9H-purin-6-amine …
Matched Description: … ) has been used in trials studying the treatment of LYMPHOMA, Solid Tumors, Metastatic Solid Tumor, and …
Resmetirom
Resmetirom is a thyroid hormone receptor-beta (THR-beta) agonist. On March 14, 2024, it was approved by the FDA as the first treatment of liver fibrosis due to noncirrhotic non-alcoholic steatohepatitis (NASH), which is a form of non-alcoholic fatty liver disease (NAFLD). Thyroid hormones directly regulate lipid metabolism in the liver;...
Approved
Investigational
Matched Synonyms: … 1,2,4-Triazine-6-carbonitrile, 2-[3,5-dichloro-4-[[1,6-dihydro-5-(1-methylethyl)-6-oxo-3-pyridazinyl] ... 2-[3,5-Dichloro-4-[[1,6-dihydro-5-(1-methylethyl)-6-oxo-3-pyridazinyl]oxy]phenyl]-2,3,4,5-tetrahydro- ... oxy]phenyl]-2,3,4,5-tetrahydro-3,5-dioxo- …
Matched Iupac: … 2-(3,5-dichloro-4-{[6-oxo-5-(propan-2-yl)-1,6-dihydropyridazin-3-yl]oxy}phenyl)-3,5-dioxo-2,3,4,5-tetrahydro …
Matched Description: … [A263461] Resmetirom works to reduce liver fat by stimulating fatty acid degradation and oxidation. ... Resmetirom is a thyroid hormone receptor-beta (THR-beta) agonist. ... fibrosis due to noncirrhotic non-alcoholic steatohepatitis (NASH), which is a form of non-alcoholic fatty …
Matched Categories: … Thyroid hormone receptor-beta (THR-beta) agonist …
Matched Iupac: … 2-(3,5-dichloro-4-{[6-oxo-5-(propan-2-yl)-1,6-dihydropyridazin-3-yl]oxy}phenyl)-3,5-dioxo-2,3,4,5-tetrahydro …
Matched Description: … [A263461] Resmetirom works to reduce liver fat by stimulating fatty acid degradation and oxidation. ... Resmetirom is a thyroid hormone receptor-beta (THR-beta) agonist. ... fibrosis due to noncirrhotic non-alcoholic steatohepatitis (NASH), which is a form of non-alcoholic fatty …
Matched Categories: … Thyroid hormone receptor-beta (THR-beta) agonist …
Tozuleristide
Tozuleristide is under investigation in clinical trial NCT02464332 (Safety Study of BLZ-100 in Adult Subjects With Sarcoma Undergoing Surgery).
Investigational
Matched Synonyms: … )-1,1-DIMETHYL-1,2-DIHYDRO-3H-BENZO(E)INDOL-3-YL)HEXANOYL)(15-ARGININE(K>R),23-ARGININE(K>R))CHLOROTOXIN ... N6.27-(6-(2-(7-(1,1-DIMETHYL-3-(4-SULFONATOBUTYL)-1H-BENZO(E)INDOL-1-IUM-2-YL)HEPTA-2,4,6-TRIENYLIDENE …
LAS-191954
Investigational
Matched Synonyms: … -dihydro-4-oxo-3-phenyl- ... 2-((1s)-1-((6-amino-5-cyano-4-pyrimidinyl)amino)ethyl)-3,4-dihydro-4-oxo-3-phenylpyrrolo(2,1-f)(1,2,4 ... Pyrrolo(2,1-f)(1,2,4)triazine-5-carbonitrile, 2-((1s)-1-((6-amino-5-cyano-4-pyrimidinyl)amino)ethyl)-3,4 …
Matched Iupac: … 4-amino-6-{[(1S)-1-{5-cyano-4-oxo-3-phenyl-3H,4H-pyrrolo[2,1-f][1,2,4]triazin-2-yl}ethyl]amino}pyrimidine …
Matched Iupac: … 4-amino-6-{[(1S)-1-{5-cyano-4-oxo-3-phenyl-3H,4H-pyrrolo[2,1-f][1,2,4]triazin-2-yl}ethyl]amino}pyrimidine …
SN-38
7-ethyl-10-hydroxycamptothecin (SN 38) is a liposomal formulation of the active metabolite of Irinotecan DB00762, a chemotherapeutic pro-drug approved for the treatment of advanced colorectal cancer. SN 38 has been used in trials studying the treatment of Cancer, Advanced Solid Tumors, Small Cell Lung Cancer, Metastatic Colorectal Cancer, and Triple Negative...
Investigational
Matched Synonyms: … 1H-PYRANO(3',4':6,7)INDOLIZINO(1,2-B)QUINOLINE-3,14(4H,12H)-DIONE, 4,11-DIETHYL-4,9-DIHYDROXY-, (4S)- …
Matched Name: … SN-38 …
Matched Description: … Cancer, Metastatic Colorectal Cancer, and Triple Negative Breast Cancer, among others. ... 7-ethyl-10-hydroxycamptothecin (SN 38) is a liposomal formulation of the active metabolite of Irinotecan ... SN 38 has been used in trials studying the treatment of Cancer, Advanced Solid Tumors, Small Cell Lung …
Matched Name: … SN-38 …
Matched Description: … Cancer, Metastatic Colorectal Cancer, and Triple Negative Breast Cancer, among others. ... 7-ethyl-10-hydroxycamptothecin (SN 38) is a liposomal formulation of the active metabolite of Irinotecan ... SN 38 has been used in trials studying the treatment of Cancer, Advanced Solid Tumors, Small Cell Lung …
TAS-106
TAS-106 is a new nucleoside antimetabolite. TAS-106 has demonstrated strong antitumor activity without serious toxicity in nude rat models bearing human tumours .
Investigational
Matched Synonyms: … 3'-C-Ethynylcytidine ... 4-Amino-1-((2R,3R,4R,5R)-4-ethynyl-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)pyrimidin-2-one …
Matched Iupac: … 4-amino-1-[(2R,3R,4S,5R)-4-ethynyl-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2 …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Matched Iupac: … 4-amino-1-[(2R,3R,4S,5R)-4-ethynyl-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2 …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
LPT-99
Investigational
Matched Synonyms: … -3-yl)ethyl) acetamide ... -3-yl)ethyl)acetamide ... 2-piperazineacetamide, 4-(2-(2,4-dichlorophenyl)ethyl)-n-(2-(5-methoxy-1h-indol-3-yl)ethyl)-3,6-dioxo …
Matched Iupac: … -1H-indol-3-yl)ethyl]acetamide ... 2-{4-[2-(2,4-dichlorophenyl)ethyl]-3,6-dioxo-1-[2-(thiophen-2-yl)ethyl]piperazin-2-yl}-N-[2-(5-methoxy …
Matched Iupac: … -1H-indol-3-yl)ethyl]acetamide ... 2-{4-[2-(2,4-dichlorophenyl)ethyl]-3,6-dioxo-1-[2-(thiophen-2-yl)ethyl]piperazin-2-yl}-N-[2-(5-methoxy …
5-[(3R)-3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine
Experimental
Matched Name: … 5-[(3R)-3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine …
Matched Iupac: … 5-[(3R)-3-{5-methoxy-4'-methyl-[1,1'-biphenyl]-3-yl}but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine …
Matched Iupac: … 5-[(3R)-3-{5-methoxy-4'-methyl-[1,1'-biphenyl]-3-yl}but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine …
1-(2-cyclopropylethyl)-3-(1,1-dioxo-2H-1,2,4-benzothiadiazin-3-yl)-6-fluoro-4-hydroxy-2(1H)-quinolinone
Experimental
Matched Name: … 1-(2-cyclopropylethyl)-3-(1,1-dioxo-2H-1,2,4-benzothiadiazin-3-yl)-6-fluoro-4-hydroxy-2(1H)-quinolinone …
Matched Iupac: … 3-[1-(2-cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl]-4H-1lambda6,2,4-benzothiadiazine …
Matched Categories: … Thiazines …
Matched Iupac: … 3-[1-(2-cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl]-4H-1lambda6,2,4-benzothiadiazine …
Matched Categories: … Thiazines …
VB-312
Investigational
Matched Synonyms: … (2S,3R,4S,5S,6R)-2-(((2S,3R,4S,5R,6R)-2-(((2R,3S,4R,5R,6S)-4,5-dihydroxy-2-(hydroxymethyl)-6-(((6aR,10aR ... )-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-yl)oxy)tetrahydro-2H-pyran-3-yl ... )oxy)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2 …
Matched Name: … VB-312 …
Matched Iupac: … (2S,3R,4S,5S,6R)-2-{[(2S,3R,4S,5R,6R)-2-{[(2R,3S,4R,5R,6S)-6-{[(6aR,10aR)-6,6,9-trimethyl-3-pentyl-6H ... ,6aH,7H,8H,10aH-benzo[c]isochromen-1-yl]oxy}-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy}-3,5-dihydroxy …
Matched Categories: … Cannabinoids and similars …
Matched Name: … VB-312 …
Matched Iupac: … (2S,3R,4S,5S,6R)-2-{[(2S,3R,4S,5R,6R)-2-{[(2R,3S,4R,5R,6S)-6-{[(6aR,10aR)-6,6,9-trimethyl-3-pentyl-6H ... ,6aH,7H,8H,10aH-benzo[c]isochromen-1-yl]oxy}-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy}-3,5-dihydroxy …
Matched Categories: … Cannabinoids and similars …
Triflupromazine
A phenothiazine used as an antipsychotic agent and as an antiemetic.
Approved
Vet approved
Matched Synonyms: … 10-(3-(Dimethylamino)propyl)-2-(trifluoromethyl)phenothiazine …
Matched Iupac: … dimethyl({3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl})amine …
Matched Description: … A phenothiazine used as an antipsychotic agent and as an antiemetic. …
Matched Salts name: … Triflupromazine hydrochloride …
Matched Categories: … Heterocyclic Compounds, 3-Ring …
Matched Iupac: … dimethyl({3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl})amine …
Matched Description: … A phenothiazine used as an antipsychotic agent and as an antiemetic. …
Matched Salts name: … Triflupromazine hydrochloride …
Matched Categories: … Heterocyclic Compounds, 3-Ring …
Zalcitabine
A dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of 5' to 3' phosphodiester linkages, which are needed for the elongation of DNA chains, thus resulting in the termination of viral DNA growth. The compound is...
Approved
Investigational
Matched Synonyms: … 2',3'-Dideoxycytidine …
Matched Description: … A dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by ... This modification prevents the formation of 5' to 3' phosphodiester linkages, which are needed for the …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides ... Nucleic Acid Synthesis Inhibitors ... Nucleoside and Nucleotide Reverse Transcriptase Inhibitors …
Matched Description: … A dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by ... This modification prevents the formation of 5' to 3' phosphodiester linkages, which are needed for the …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides ... Nucleic Acid Synthesis Inhibitors ... Nucleoside and Nucleotide Reverse Transcriptase Inhibitors …
Drospirenone
Drospirenone is a synthetic progestin commonly found in the popular oral contraceptive, Yaz in combination with Ethinyl estradiol. Most recently, it was approved by both Health Canada and the FDA in combination with Estetrol as an oral contraceptive therapy.[L33199,L33174] Aside from its contraceptive effects, drospirenone is used with estrogens to...
Approved
Matched Synonyms: … 6β,7β;15β,16β-Dimethylene-3-oxo-17α-pregn-4-ene-21,17-carbolactone …
Matched Description: … [L7973] Most recently, it was approved by both Health Canada and the FDA in combination with [Estetrol ... ,L33174] Aside from its contraceptive effects, drospirenone is used with estrogens to control acne and ... Some studies have demonstrated a significantly increased risk and some demonstrating no risk of thromboembolic …
Matched Mixtures name: … Drospirenone/Ethinyl Estradiol/Levomefolate Calcium and Levomefolate Calcium ... Drospirenone/ethinyl estradiol/levomefolate calcium and levomefolate calcium ... Drospirenone, Ethinyl Estradiol and Levomefolate Calcium and Levomefolate Calcium …
Matched Categories: … Combination Contraceptives (with Estrogen and derivatives) ... Genito Urinary System and Sex Hormones ... drospirenone and estetrol ... drospirenone and estrogen ... drospirenone and ethinylestradiol …
Matched Description: … [L7973] Most recently, it was approved by both Health Canada and the FDA in combination with [Estetrol ... ,L33174] Aside from its contraceptive effects, drospirenone is used with estrogens to control acne and ... Some studies have demonstrated a significantly increased risk and some demonstrating no risk of thromboembolic …
Matched Mixtures name: … Drospirenone/Ethinyl Estradiol/Levomefolate Calcium and Levomefolate Calcium ... Drospirenone/ethinyl estradiol/levomefolate calcium and levomefolate calcium ... Drospirenone, Ethinyl Estradiol and Levomefolate Calcium and Levomefolate Calcium …
Matched Categories: … Combination Contraceptives (with Estrogen and derivatives) ... Genito Urinary System and Sex Hormones ... drospirenone and estetrol ... drospirenone and estrogen ... drospirenone and ethinylestradiol …
5'-Guanosine-Diphosphate-Monothiophosphate
Guanosine 5'-(trihydrogen diphosphate), monoanhydride with phosphorothioic acid. A stable GTP analog which enjoys a variety of physiological actions such as stimulation of guanine nucleotide-binding proteins, phosphoinositide hydrolysis, cyclic AMP accumulation, and activation of specific proto-oncogenes.
Experimental
Matched Synonyms: … Guanosine 5'-O-(3-thiotriphosphate) …
Matched Iupac: … )phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonothioic acid ... ({[({[(2R,3S,4R,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy …
Matched Description: … Guanosine 5'-(trihydrogen diphosphate), monoanhydride with phosphorothioic acid. ... , phosphoinositide hydrolysis, cyclic AMP accumulation, and activation of specific proto-oncogenes. ... analog which enjoys a variety of physiological actions such as stimulation of guanine nucleotide-binding proteins …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Matched Iupac: … )phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonothioic acid ... ({[({[(2R,3S,4R,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy …
Matched Description: … Guanosine 5'-(trihydrogen diphosphate), monoanhydride with phosphorothioic acid. ... , phosphoinositide hydrolysis, cyclic AMP accumulation, and activation of specific proto-oncogenes. ... analog which enjoys a variety of physiological actions such as stimulation of guanine nucleotide-binding proteins …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
ENMD-981693
Investigational
Matched Synonyms: … (E)-N-(5-Methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-styrylpyrimidin-4-amine …
Matched Iupac: … N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-[(1E)-2-phenylethenyl]pyrimidin-4-amine …
Matched Salts cas: … 1453868-32-0 …
Matched Categories: … Protein Kinase Inhibitors …
Matched Iupac: … N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-[(1E)-2-phenylethenyl]pyrimidin-4-amine …
Matched Salts cas: … 1453868-32-0 …
Matched Categories: … Protein Kinase Inhibitors …
Sepantronium
Sepantronium is a compound that suppresses survivin expression in a dose and time-dependent manner, and causes broad-range apoptosis.
Investigational
Matched Synonyms: … 1h-naphth(2,3-d)imidazolium, 4,9-dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)- …
Matched Iupac: … 3-(2-methoxyethyl)-2-methyl-4,9-dioxo-1-[(pyrazin-2-yl)methyl]-1H,4H,9H-naphtho[2,3-d]imidazol-3-ium …
Matched Description: … Sepantronium is a compound that suppresses survivin expression in a dose and time-dependent manner, and …
Matched Iupac: … 3-(2-methoxyethyl)-2-methyl-4,9-dioxo-1-[(pyrazin-2-yl)methyl]-1H,4H,9H-naphtho[2,3-d]imidazol-3-ium …
Matched Description: … Sepantronium is a compound that suppresses survivin expression in a dose and time-dependent manner, and …
FN-1501
Investigational
Matched Synonyms: … -((7h-pyrrolo (2,3-d)pyrimidin-4-yl)amino)-n-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1h-pyrazole-3- …
Matched Iupac: … N-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-4-({7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)-1H-pyrazole-3- …
Matched Iupac: … N-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-4-({7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)-1H-pyrazole-3- …
N-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)METHYL]-3-{[(E)-(2-OXODIHYDROFURAN-3(2H)-YLIDENE)METHYL]AMINO}BENZENESULFONAMIDE
Experimental
Matched Name: … N-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)METHYL]-3-{[(E)-(2-OXODIHYDROFURAN-3(2H)-YLIDENE)METHYL]AMINO}BENZENESULFONAMIDE …
Matched Iupac: … N-[(2-amino-6-methylpyrimidin-4-yl)methyl]-3-({[(3E)-2-oxooxolan-3-ylidene]methyl}amino)benzene-1-sulfonamide …
Matched Iupac: … N-[(2-amino-6-methylpyrimidin-4-yl)methyl]-3-({[(3E)-2-oxooxolan-3-ylidene]methyl}amino)benzene-1-sulfonamide …
2-{3-[(2S)-4,4-difluoro-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-3-oxopropyl}-isoindole-1,3(2H)-dione
Experimental
Matched Name: … 2-{3-[(2S)-4,4-difluoro-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-3-oxopropyl}-isoindole-1,3(2H)-dione …
Matched Iupac: … 2-{3-[(2S)-4,4-difluoro-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]-3-oxopropyl}-2,3-dihydro-1H-isoindole …
Matched Iupac: … 2-{3-[(2S)-4,4-difluoro-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]-3-oxopropyl}-2,3-dihydro-1H-isoindole …
Bedaquiline
Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affect DNA gyrase; instead, bedaquiline inhibits the c subunit of ATP...
Approved
Matched Synonyms: … 1-(6-Bromo-2-methoxy-quinolin-3-yl)-4-dimethylamino-2-naphthalen-1-yl-1-phenyl-butan-2-ol …
Matched Iupac: … (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol …
Matched Description: … The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated ... the current standard of TB treatment of anti-TB drugs for 2 months, including 2 key drugs [isoniazid] and ... [rifampin], is highly effective, the emergence of multidrug-resistant TB (MDR-TB) to [isoniazid] and …
Matched Iupac: … (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol …
Matched Description: … The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated ... the current standard of TB treatment of anti-TB drugs for 2 months, including 2 key drugs [isoniazid] and ... [rifampin], is highly effective, the emergence of multidrug-resistant TB (MDR-TB) to [isoniazid] and …
Vinflunine
Vinflunine is a third-generation member of the vinca alkaloid family with anti-tumour actions. It was first described in 1998 at the Pierre Fabre research center in France. Like other vinca agents, vinflunine is an anti-mitotic agent that induces a cell cycle arrest at the G2/M phase and promotes cell death...
Approved
Investigational
Matched Synonyms: … 20',20'-difluoro-3',4'-dihydrovinorelbine …
Matched Iupac: … )-16-(1,1-difluoroethyl)-12-(methoxycarbonyl)-1,10-diazatetracyclo[12.3.1.0^{3,11}.0^{4,9}]octadeca-3( …
Matched Description: … , [DB00570], and [DB00541] [A31975]. ... vinca agents, vinflunine is an anti-mitotic agent that induces a cell cycle arrest at the G2/M phase and ... In murine tumors and human tumor xenografts, vinflunine exhibits an antitumor efficacy than [DB00361] …
Matched Salts cas: … 194468-36-5 …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Iupac: … )-16-(1,1-difluoroethyl)-12-(methoxycarbonyl)-1,10-diazatetracyclo[12.3.1.0^{3,11}.0^{4,9}]octadeca-3( …
Matched Description: … , [DB00570], and [DB00541] [A31975]. ... vinca agents, vinflunine is an anti-mitotic agent that induces a cell cycle arrest at the G2/M phase and ... In murine tumors and human tumor xenografts, vinflunine exhibits an antitumor efficacy than [DB00361] …
Matched Salts cas: … 194468-36-5 …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
GDC-0134
Investigational
Matched Synonyms: … 2-pyridinamine, 3-(difluoromethoxy)-5-(2-(3,3-difluoro-1-pyrrolidinyl)-6-(1s,4s)-2-oxa-5-azabicyclo(2.2.1 …
Matched Iupac: … 3-(difluoromethoxy)-5-[2-(3,3-difluoropyrrolidin-1-yl)-6-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl …
Matched Iupac: … 3-(difluoromethoxy)-5-[2-(3,3-difluoropyrrolidin-1-yl)-6-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl …
Emavusertib
Investigational
Matched Synonyms: … 4-oxazolecarboxamide, n-(5-((3r)-3-hydroxy-1-pyrrolidinyl)-2-(4-morpholinyl)oxazolo(4,5-b)pyridin-6-yl …
Matched Iupac: … N-{5-[(3R)-3-hydroxypyrrolidin-1-yl]-2-(morpholin-4-yl)-[1,3]oxazolo[4,5-b]pyridin-6-yl}-2-(2-methylpyridin …
Matched Iupac: … N-{5-[(3R)-3-hydroxypyrrolidin-1-yl]-2-(morpholin-4-yl)-[1,3]oxazolo[4,5-b]pyridin-6-yl}-2-(2-methylpyridin …
Riociguat
Riociguat is a soluble guanylate cyclase (sGC) agonist approved in the USA, Europe and several other regions for patients with group I PAH (pulmonary arterial hypertension) in WHO FC II or III; and for the treatment of patients with inoperable CTEPH (chronic thromboembolic pulmonary hypertension), or persistent/recurrent PH (pulmonary hypertension)...
Approved
Matched Synonyms: … Methyl N-[4,6-Diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-methyl-carbaminate …
Matched Iupac: … methyl N-(4,6-diamino-2-{1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl}pyrimidin-5-yl)-N-methylcarbamate …
Matched Description: … Riociguat is a soluble guanylate cyclase (sGC) agonist approved in the USA, Europe and several other ... regions for patients with group I PAH (pulmonary arterial hypertension) in WHO FC II or III; and for ... Treatment with riociguat costs USD $7,500 for 30 days of treatment. …
Matched Iupac: … methyl N-(4,6-diamino-2-{1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl}pyrimidin-5-yl)-N-methylcarbamate …
Matched Description: … Riociguat is a soluble guanylate cyclase (sGC) agonist approved in the USA, Europe and several other ... regions for patients with group I PAH (pulmonary arterial hypertension) in WHO FC II or III; and for ... Treatment with riociguat costs USD $7,500 for 30 days of treatment. …
Dazostinag
Dazostinag is under investigation in clinical trial NCT04420884 (A Study of Dazostinag as Single Agent and Dazostinag in Combination With Pembrolizumab in Adults With Advanced or Metastatic Solid Tumors).
Investigational
Matched Synonyms: … 7-Deazainosine, [P(R)]-2′-deoxy-2′-fluoro-5′-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(3′→5′) …
Matched Description: … Dazostinag is under investigation in clinical trial NCT04420884 (A Study of Dazostinag as Single Agent and …
Matched Description: … Dazostinag is under investigation in clinical trial NCT04420884 (A Study of Dazostinag as Single Agent and …
Displaying drugs 5026 - 5050 of 5775 in total