Displaying drugs 526 - 550 of 3244 in total
Orotic acid
Investigational
Matched Synonyms: … Acido orotico ... Orotic acid ... Acidum oroticum …
Matched Name: … Orotic acid …
Matched Iupac: … 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid …
Matched Categories: … Acids, Heterocyclic …
Matched Name: … Orotic acid …
Matched Iupac: … 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid …
Matched Categories: … Acids, Heterocyclic …
Chloric acid
Approved
Experimental
Matched Name: … Chloric acid …
Matched Iupac: … chloric acid …
Matched Mixtures name: … Polyethylene Glycol 3350 and electrolytes - Unflavored …
Matched Salts name: … Sodium chlorate …
Matched Products: … Hemodialysis Acid Concentrate …
Matched Iupac: … chloric acid …
Matched Mixtures name: … Polyethylene Glycol 3350 and electrolytes - Unflavored …
Matched Salts name: … Sodium chlorate …
Matched Products: … Hemodialysis Acid Concentrate …
Mesoxalic acid
Experimental
Matched Synonyms: … alpha-Ketomalonic acid ... Ketomalonic acid ... Oxomalonic acid …
Matched Name: … Mesoxalic acid …
Matched Iupac: … 2-oxopropanedioic acid …
Matched Categories: … Acids, Acyclic ... Carboxylic Acids ... Dicarboxylic Acids …
Matched Name: … Mesoxalic acid …
Matched Iupac: … 2-oxopropanedioic acid …
Matched Categories: … Acids, Acyclic ... Carboxylic Acids ... Dicarboxylic Acids …
Sodium metabisulfite
Experimental
Matched Synonyms: … Disulfurous acid, disodium salt ... Sodium pyrosulfite ... Sodium metabisulfite …
Matched Name: … Sodium metabisulfite …
Matched Name: … Sodium metabisulfite …
Lactobacillus plantarum
Lactobacillus plantarum is a member of Lactobacillus, or lactic acid bacteria, that it is widely used in the food industry as a microbial starter and probiotic microorganism. It is considered to be one of versatile species that carry out fermentative and metabolic processes, while exhibiting an antagonistic activity against pathogenic...
Investigational
Matched Description: … in the food industry as a microbial starter and probiotic microorganism. ... , bacteriocins, and antimicrobial peptides [A27208]. ... It is considered to be one of versatile species that carry out fermentative and metabolic processes, …
Matched Products: … Kimchi Lactic Acid 1000 …
Matched Products: … Kimchi Lactic Acid 1000 …
Diatrizoate
A commonly used x-ray contrast medium. As diatrizoate meglumine and as Diatrizoate sodium, it is used for gastrointestinal studies, angiography, and urography.
Approved
Vet approved
Matched Synonyms: … Urografin acid ... Diatrizoic acid ... Methalamic acid …
Matched Iupac: … 3,5-diacetamido-2,4,6-triiodobenzoic acid …
Matched Description: … As diatrizoate meglumine and as Diatrizoate sodium, it is used for gastrointestinal studies, angiography ... , and urography. …
Matched Mixtures name: … Diatrizoate Meglumine and Diatrizoate Sodium ... Diatrizoate Meglumine and Diatrizoate Sodium ... Diatrizoate Meglumine and Diatrizoate Sodium …
Matched Salts name: … Diatrizoic acid dihydrate ... Diatrizoate sodium …
Matched Categories: … Acids, Carbocyclic ... Carboxylic Acids ... diatrizoic acid ... Triiodobenzoic Acids …
Matched Products: … Hypaque Sodium ... Hypaque Sodium 50% Liq ... Hypaque Sodium Liq 50% …
Matched Iupac: … 3,5-diacetamido-2,4,6-triiodobenzoic acid …
Matched Description: … As diatrizoate meglumine and as Diatrizoate sodium, it is used for gastrointestinal studies, angiography ... , and urography. …
Matched Mixtures name: … Diatrizoate Meglumine and Diatrizoate Sodium ... Diatrizoate Meglumine and Diatrizoate Sodium ... Diatrizoate Meglumine and Diatrizoate Sodium …
Matched Salts name: … Diatrizoic acid dihydrate ... Diatrizoate sodium …
Matched Categories: … Acids, Carbocyclic ... Carboxylic Acids ... diatrizoic acid ... Triiodobenzoic Acids …
Matched Products: … Hypaque Sodium ... Hypaque Sodium 50% Liq ... Hypaque Sodium Liq 50% …
Gadopentetic acid
A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see pentetic acid), that is given to enhance the image in cranial and spinal MRIs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p706)
Approved
Matched Synonyms: … Acide gadopentetique ... Acidum gadopenteticum ... Gadopentetic acid …
Matched Name: … Gadopentetic acid …
Matched Description: … acid), that is given to enhance the image in cranial and spinal MRIs. ... A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see pentetic …
Matched Categories: … Acids, Acyclic ... Carboxylic Acids ... gadopentetic acid …
Matched Products: … ACIDO GADOPENTETICO SANOCHEMIA PHARMAZEUTIKA …
Matched Name: … Gadopentetic acid …
Matched Description: … acid), that is given to enhance the image in cranial and spinal MRIs. ... A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see pentetic …
Matched Categories: … Acids, Acyclic ... Carboxylic Acids ... gadopentetic acid …
Matched Products: … ACIDO GADOPENTETICO SANOCHEMIA PHARMAZEUTIKA …
Ferric sodium citrate
Experimental
Matched Name: … Ferric sodium citrate …
Matched Iupac: … iron(3+) ion sodium 2-oxidopropane-1,2,3-tricarboxylate …
Matched Categories: … ferric sodium citrate ... Blood and Blood Forming Organs ... Iron Preparations ... Iron Trivalent, Oral Preparations …
Matched Iupac: … iron(3+) ion sodium 2-oxidopropane-1,2,3-tricarboxylate …
Matched Categories: … ferric sodium citrate ... Blood and Blood Forming Organs ... Iron Preparations ... Iron Trivalent, Oral Preparations …
Potassium iodate
Experimental
Matched Synonyms: … Iodic acid, potassium salt …
Matched Name: … Potassium iodate …
Matched Iupac: … potassium iodate …
Matched Categories: … Iodine Compounds …
Matched Name: … Potassium iodate …
Matched Iupac: … potassium iodate …
Matched Categories: … Iodine Compounds …
Edetic acid
A chelating agent (chelating agents) that sequesters a variety of polyvalent cations. It is used in pharmaceutical manufacturing and as a food additive.
Approved
Vet approved
Matched Synonyms: … Edetic acid ... Acide edetique ... Acido edetico …
Matched Name: … Edetic acid …
Matched Iupac: … 2-({2-[bis(carboxymethyl)amino]ethyl}(carboxymethyl)amino)acetic acid …
Matched Description: … It is used in pharmaceutical manufacturing and as a food additive. …
Matched Categories: … Diet, Food, and Nutrition ... Acids, Acyclic ... Carboxylic Acids ... Calcium Chelating Agents ... Calcium Chelating Activity …
Matched Products: … SODIO CALCIO EDETATO MONICO ... SODIO CALCIO EDETATO S.A.L.F. ... SODIO EDETATO MONICO …
Matched Name: … Edetic acid …
Matched Iupac: … 2-({2-[bis(carboxymethyl)amino]ethyl}(carboxymethyl)amino)acetic acid …
Matched Description: … It is used in pharmaceutical manufacturing and as a food additive. …
Matched Categories: … Diet, Food, and Nutrition ... Acids, Acyclic ... Carboxylic Acids ... Calcium Chelating Agents ... Calcium Chelating Activity …
Matched Products: … SODIO CALCIO EDETATO MONICO ... SODIO CALCIO EDETATO S.A.L.F. ... SODIO EDETATO MONICO …
Cocarboxylase
The coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex.
Approved
Experimental
Matched Synonyms: … Thiamine diphosphate ... Thiamine pyrophosphate …
Matched Description: … It is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase …
Matched Categories: … Enzymes and Coenzymes …
Matched Description: … It is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase …
Matched Categories: … Enzymes and Coenzymes …
Tienilic acid
Tienilic acid, or ticrynafen, is a diuretic drug with uric acid-lowering action which was marketed for the treatment of hypertension. It was withdrawn in 1982 after case reports in the United States suggested a link between ticrynafen and hepatitis. (Manier et al., 1982)
Withdrawn
Matched Synonyms: … Tienilic acid ... Thienylic acid ... Acide tiénilique …
Matched Name: … Tienilic acid …
Matched Iupac: … 2-[2,3-dichloro-4-(thiophene-2-carbonyl)phenoxy]acetic acid …
Matched Description: … It was withdrawn in 1982 after case reports in the United States suggested a link between ticrynafen and ... Tienilic acid, or ticrynafen, is a diuretic drug with uric acid-lowering action which was marketed for …
Matched Categories: … Acids, Acyclic ... Carboxylic Acids ... Hydroxy Acids ... tienilic acid ... Aryloxyacetic Acid Derivatives …
Matched Name: … Tienilic acid …
Matched Iupac: … 2-[2,3-dichloro-4-(thiophene-2-carbonyl)phenoxy]acetic acid …
Matched Description: … It was withdrawn in 1982 after case reports in the United States suggested a link between ticrynafen and ... Tienilic acid, or ticrynafen, is a diuretic drug with uric acid-lowering action which was marketed for …
Matched Categories: … Acids, Acyclic ... Carboxylic Acids ... Hydroxy Acids ... tienilic acid ... Aryloxyacetic Acid Derivatives …
Acyclovir
Acyclovir is a deoxynucleoside analog antiviral used to treat herpes simplex, Varicella zoster, herpes zoster, herpes labialis, and acute herpetic keratitis.[L7303,L7315,L7318,L7321,L7324,L7327] Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young as 6 years old. Acyclovir was granted FDA...
Approved
Matched Description: … analog antiviral used to treat herpes simplex, _Varicella zoster_, herpes zoster, herpes labialis, and ... L7315,L7318,L7321,L7324,L7327] Acyclovir is generally used first line in the treatment of these viruses and …
Matched Salts name: … Acyclovir sodium …
Matched Categories: … Nucleic Acid Synthesis Inhibitors ... Acyclovir and prodrug ... Nucleosides and Nucleotides ... Nucleosides and Nucleotides Excl. Reverse Transcriptase Inhibitors …
Matched Products: … Acyclovir Sodium ... Acyclovir Sodium Injection ... ACIC 200 …
Matched Salts name: … Acyclovir sodium …
Matched Categories: … Nucleic Acid Synthesis Inhibitors ... Acyclovir and prodrug ... Nucleosides and Nucleotides ... Nucleosides and Nucleotides Excl. Reverse Transcriptase Inhibitors …
Matched Products: … Acyclovir Sodium ... Acyclovir Sodium Injection ... ACIC 200 …
Alpha-1-acid glycoprotein
Investigational
Matched Synonyms: … .ALPHA.-1-ACID GLYCOPROTEIN ... ALPHA-1-ACID GLYCOPROTEIN 1 ... ALPHA-1-ACID GLYCOPROTEIN-1 …
Matched Name: … Alpha-1-acid glycoprotein …
Matched Name: … Alpha-1-acid glycoprotein …
Isoglutamine
Experimental
Matched Synonyms: … Glutamic acid alpha-amide ... L-Glutamic acid alpha-amide ... L-alpha-Glutamine …
Matched Iupac: … (4S)-4-amino-4-carbamoylbutanoic acid …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Amino Acids ... Amino Acids, Basic ... Amino Acids, Diamino ... Amino Acids, Neutral …
Matched Iupac: … (4S)-4-amino-4-carbamoylbutanoic acid …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Amino Acids ... Amino Acids, Basic ... Amino Acids, Diamino ... Amino Acids, Neutral …
Alglucosidase alfa
Aglucosidase alfa consists of the human enzyme acid alpha-glucosidase (GAA) which is essential for the degradation of glygogen to glucose in lysosomes. It is encoded by the most predominant of nine observed haplotypes of this gene. Aglucosidase alfa is produced by recombinant DNA technology in a Chinese hamster ovary cell...
Approved
Matched Synonyms: … Acid-alpha glucosidase ... Human acid precursor alpha-glucosidase, recombinant ... Acid maltase …
Matched Description: … Aglucosidase alfa consists of the human enzyme acid alpha-glucosidase (GAA) which is essential for the ... Alglucosidase alfa degrades glycogen by catalyzing the hydrolysis of a-1,4- and a-1,6- glycosidic linkages ... glycoprotein with a calculated mass of 98,008 daltons for the 883 residue mature polypeptide chain, and …
Matched Categories: … Alimentary Tract and Metabolism ... Enzymes and Coenzymes …
Matched Description: … Aglucosidase alfa consists of the human enzyme acid alpha-glucosidase (GAA) which is essential for the ... Alglucosidase alfa degrades glycogen by catalyzing the hydrolysis of a-1,4- and a-1,6- glycosidic linkages ... glycoprotein with a calculated mass of 98,008 daltons for the 883 residue mature polypeptide chain, and …
Matched Categories: … Alimentary Tract and Metabolism ... Enzymes and Coenzymes …
Stearic acid
Stearic acid (IUPAC systematic name: octadecanoic acid) is one of the useful types of saturated fatty acids that comes from many animal and vegetable fats and oils. It is a waxy solid.
Approved
Experimental
Matched Synonyms: … Acide stéarique ... Stearic acid ... Acide octadécanoïque …
Matched Name: … Stearic acid …
Matched Iupac: … octadecanoic acid …
Matched Description: … acids that comes from many animal and vegetable fats and oils. ... Stearic acid (IUPAC systematic name: octadecanoic acid) is one of the useful types of saturated fatty …
Matched Categories: … Fatty Acids ... Stearic Acids …
Matched Name: … Stearic acid …
Matched Iupac: … octadecanoic acid …
Matched Description: … acids that comes from many animal and vegetable fats and oils. ... Stearic acid (IUPAC systematic name: octadecanoic acid) is one of the useful types of saturated fatty …
Matched Categories: … Fatty Acids ... Stearic Acids …
Sodium phosphate, monobasic
Sodium phosphate is a saline laxative that is thought to work by increasing fluid in the small intestine. It usually results in a bowel movement after 30 minutes to 6 hours.
Approved
Matched Synonyms: … Sodium acid phosphate ... Phosphoric acid, monosodium salt, anhydrous ... Sodium orthophosphate …
Matched Name: … Sodium phosphate, monobasic …
Matched Iupac: … sodium dihydrogen phosphate …
Matched Description: … Sodium phosphate is a saline laxative that is thought to work by increasing fluid in the small intestine …
Matched Mixtures name: … Monobasic Sodium Phosphate and Dibasic Sodium Phosphate ... Dibasic Sodium Phosphate, Monobasic Potassium Phosphate and Monobasic Sodium Phosphate ... Monobasic Sodium Phosphate and Dibasic Sodium Phosphate …
Matched Salts name: … Sodium phosphate, monobasic, dihydrate ... Sodium phosphate, monobasic, monohydrate …
Matched Categories: … Alimentary Tract and Metabolism ... Blood and Blood Forming Organs ... Blood Substitutes and Perfusion Solutions ... Acids ... Acids, Noncarboxylic …
Matched Products: … SODIO FOSFATO SELLA ... SODIO FOSFATO AFOM ... SODIO FOSFATO LJ PHARMA …
Matched Name: … Sodium phosphate, monobasic …
Matched Iupac: … sodium dihydrogen phosphate …
Matched Description: … Sodium phosphate is a saline laxative that is thought to work by increasing fluid in the small intestine …
Matched Mixtures name: … Monobasic Sodium Phosphate and Dibasic Sodium Phosphate ... Dibasic Sodium Phosphate, Monobasic Potassium Phosphate and Monobasic Sodium Phosphate ... Monobasic Sodium Phosphate and Dibasic Sodium Phosphate …
Matched Salts name: … Sodium phosphate, monobasic, dihydrate ... Sodium phosphate, monobasic, monohydrate …
Matched Categories: … Alimentary Tract and Metabolism ... Blood and Blood Forming Organs ... Blood Substitutes and Perfusion Solutions ... Acids ... Acids, Noncarboxylic …
Matched Products: … SODIO FOSFATO SELLA ... SODIO FOSFATO AFOM ... SODIO FOSFATO LJ PHARMA …
Cholecalciferol
Vitamin D, in general, is a secosteroid generated in the skin when 7-dehydrocholesterol located there interacts with ultraviolet irradiation - like that commonly found in sunlight . Both the endogenous form of vitamin D (that results from 7-dehydrocholesterol transformation), vitamin D3 (cholecalciferol), and the plant-derived form, vitamin D2 (ergocalciferol), are...
Approved
Nutraceutical
Matched Synonyms: … Calciol ... Cholecalciferol ... Cholecalciferolum …
Matched Name: … Cholecalciferol …
Matched Description: … Appropriate levels of vitamin D must be upheld in the body in order to maintain calcium and phosphorus ... C22 and C23 and has an additional methyl group at C24 [L5689]. ... d and are found in various types of food for daily intake [L5689]. …
Matched Mixtures name: … Prenatal Vitamin No 53 Iron Fum Folic Acid Docusate CA DHA ... PNV Ferrous Fumarate Docusate Folic Acid ... Iron Polysaccharides Folic Acid DHA …
Matched Categories: … zoledronic acid, calcium and colecalciferol, sequential ... alendronic acid, calcium and colecalciferol, sequential ... risedronic acid, calcium and colecalciferol, sequential ... Calcium-Regulating Hormones and Agents ... ibandronic acid and colecalciferol …
Matched Products: … CHOLECALCIFEROL …
Matched Name: … Cholecalciferol …
Matched Description: … Appropriate levels of vitamin D must be upheld in the body in order to maintain calcium and phosphorus ... C22 and C23 and has an additional methyl group at C24 [L5689]. ... d and are found in various types of food for daily intake [L5689]. …
Matched Mixtures name: … Prenatal Vitamin No 53 Iron Fum Folic Acid Docusate CA DHA ... PNV Ferrous Fumarate Docusate Folic Acid ... Iron Polysaccharides Folic Acid DHA …
Matched Categories: … zoledronic acid, calcium and colecalciferol, sequential ... alendronic acid, calcium and colecalciferol, sequential ... risedronic acid, calcium and colecalciferol, sequential ... Calcium-Regulating Hormones and Agents ... ibandronic acid and colecalciferol …
Matched Products: … CHOLECALCIFEROL …
N-Methylmesoporphyrin containing copper
Experimental
Matched Synonyms: … 3-[18-(2-Carboxyethyl)-7,12-diethyl-3,8,13,17,23-pentamethylporphyrin-21-id-2-yl]propanoic acid;copper …
Matched Name: … N-Methylmesoporphyrin containing copper …
Matched Iupac: … lambda1-copper(1+) 4,20-bis(2-carboxyethyl)-10,15-diethyl-5,9,14,19,23-pentamethyl-21,22,23,24-tetraazapentacyclo …
Matched Name: … N-Methylmesoporphyrin containing copper …
Matched Iupac: … lambda1-copper(1+) 4,20-bis(2-carboxyethyl)-10,15-diethyl-5,9,14,19,23-pentamethyl-21,22,23,24-tetraazapentacyclo …
gamma-Tocopherol
gamma-Tocopherol is under investigation in clinical trial NCT00836368 (In Vitro Basophil Responsiveness to Allergen Challenge After Gamma-tocopherol Supplementation in Allergic Asthmatics).
Investigational
Matched Synonyms: … D-gamma-Tocopherol …
Matched Name: … gamma-Tocopherol …
Matched Description: … to Allergen Challenge After Gamma-tocopherol Supplementation in Allergic Asthmatics). ... gamma-Tocopherol is under investigation in clinical trial NCT00836368 (In Vitro Basophil Responsiveness …
Matched Categories: … Diet, Food, and Nutrition ... Tocopherols …
Matched Name: … gamma-Tocopherol …
Matched Description: … to Allergen Challenge After Gamma-tocopherol Supplementation in Allergic Asthmatics). ... gamma-Tocopherol is under investigation in clinical trial NCT00836368 (In Vitro Basophil Responsiveness …
Matched Categories: … Diet, Food, and Nutrition ... Tocopherols …
Cupric sulfate
Cupric sulfate is a salt created by treating cupric oxide with sulfuric acid. This forms as large, bright blue crystals containing five molecules of water (CuSO4∙5H2O) and is also known as blue vitriol. The anhydrous salt is created by heating the hydrate to 150 °C (300 °F). Cupric sulfate is...
Approved
Matched International brands: … Intense Copper ... Hi Trace Copper …
Matched Synonyms: … Copper sulfate ... Copper monosulfate ... Copper sulphate …
Matched Iupac: … copper(2+) sulfate …
Matched Description: … After zinc and iron, copper is the third most abundant trace element found in the human body. ... Copper is an essential trace element and an important catalyst for heme synthesis and iron absorption ... Cupric sulfate is a salt created by treating cupric oxide with sulfuric acid. …
Matched Mixtures name: … Stress B Complex With C,e, Zinc and Copper ... Stress Tab With Zinc, Copper and Vitamin E ... Iron Plus Tab …
Matched Categories: … copper sulfate ... Sulfur Acids ... Sulfuric Acids …
Matched Synonyms: … Copper sulfate ... Copper monosulfate ... Copper sulphate …
Matched Iupac: … copper(2+) sulfate …
Matched Description: … After zinc and iron, copper is the third most abundant trace element found in the human body. ... Copper is an essential trace element and an important catalyst for heme synthesis and iron absorption ... Cupric sulfate is a salt created by treating cupric oxide with sulfuric acid. …
Matched Mixtures name: … Stress B Complex With C,e, Zinc and Copper ... Stress Tab With Zinc, Copper and Vitamin E ... Iron Plus Tab …
Matched Categories: … copper sulfate ... Sulfur Acids ... Sulfuric Acids …
Cupric glycinate
Vet approved
Matched Synonyms: … Copper glycinate ... Copper(II) glycinate ... Copper(II) biglycinate …
Matched Iupac: … copper(2+) bis(2-aminoacetate) …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Amino Acids …
Matched Iupac: … copper(2+) bis(2-aminoacetate) …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Amino Acids …
Flavin adenine dinucleotide
A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)
Flavin adenine dinucleotide is approved for use in Japan under the trade name Adeflavin as an ophthalmic treatment for vitamin B2 deficiency.
Approved
Matched Synonyms: … Riboflavin 5'-adenosine diphosphate ... adenosine 5'-[3-(riboflavin-5'-yl) dihydrogen diphosphate] ... Adenosine 5'-(trihydrogen pyrophosphate), 5'-5'-ester with riboflavine …
Matched Iupac: … -2H,3H,4H,10H-benzo[g]pteridin-10-yl}-2,3,4-trihydroxypentyl]oxy}(hydroxy)phosphoryl)oxy]phosphinic acid …
Matched Description: … ., D-amino acid oxidase and L-amino acid oxidase. ... A condensation product of riboflavin and adenosine diphosphate. …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides ... Enzymes and Coenzymes …
Matched Iupac: … -2H,3H,4H,10H-benzo[g]pteridin-10-yl}-2,3,4-trihydroxypentyl]oxy}(hydroxy)phosphoryl)oxy]phosphinic acid …
Matched Description: … ., D-amino acid oxidase and L-amino acid oxidase. ... A condensation product of riboflavin and adenosine diphosphate. …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides ... Enzymes and Coenzymes …
Displaying drugs 526 - 550 of 3244 in total