Displaying drugs 526 - 550 of 8039 in total
Azilsartan medoxomil
Azilsartan medoxomil is a prodrug that is broken down to azilsartan, which belongs in the angiotensin-receptor blocking (ARB) drug class. It is a selective AT1 subtype angiotensin II receptor antagonist. Azilsartan medoxomil is a relatively recently-developed antihypertensive drug that was first approved by the FDA in February 2011. Many guidelines...
Approved
Investigational
Matched Description: … has several implications on patients' survival rate and quality of life in the future. ... [A7354] Many guidelines recommend the use of ARBs as first-line therapy when initiating antihypertensive ... therapy and indicate that the clinical efficacy of ARBs is comparable to angiotensin-converting enzyme …
Lusutrombopag
Lusutrombopag is an orally bioavailable thrombopoietin receptor (TPOR) agonist developed by Shionogi & Company (Osaka, Japan). TPOR is a regulatory target site for endogenous thrombopoietin, which acts as a primary cytokine to promote megakaryocyte proliferation and differentiation, and affect other hematopoietic lineages as well, including erythroid, granulocytic and lymphoid lineages...
Approved
Investigational
Matched Description: … Thrombocytopenia, which indicates abnormally low levels of platelets, is a common complication related ... This hematological abnormality, especially in cases of severe thrombocytopenia (platelet count <50,000 ... and differentiation of megakaryocytic progenitor cells from hematopoietic stem cells [FDA Label]. …
Olutasidenib
Olutasidenib (FT-2102) is a selective and potent isocitrate dehydrogenase-1 (IDH1) inhibitor approved by the FDA in December 2022.[L44256,L44261] It is indicated for the treatment of relapsed or refractory acute myeloid leukemia (AML) in patients with a susceptible IDH1 mutation as determined by an FDA-approved test. IDH1 mutations are common in...
Approved
Investigational
Matched Description: … [L44256,L44261] It is indicated for the treatment of relapsed or refractory acute myeloid leukemia (AML ... [A254736,A254741] Olutasidenib is orally bioavailable and capable of penetrating the blood-brain barrier ... , and is also being evaluated for the treatment of myelodysplastic syndrome (MDS), as well as solid tumors …
Famotidine
Famotidine is a competitive histamine-2 (H2) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H2 receptor antagonists, famotidine displays high selectivity towards...
Approved
Matched Description: … [L11166] While oral formulations of famotidine are more commonly used, the intravenous solution of the ... receptor antagonists, famotidine displays high selectivity towards this receptor; in a study consisting of …
Antihemophilic factor human
Antihemophilic factor human, also known as Coagulation Factor VIII or Anti-Hemophilic Factor (AHF), is a non-recombinant, lyophilized concentrate of coagulation factor VIII, an endogenous protein and essential component of the coagulation cascade. Antihemophilic factor is manufactured with reduced amounts of von Willebrand Factor antigen (VWF:Ag) and purified from extraneous plasma-derived...
Approved
Matched Description: … Activation of Factor IX leads to a cascade of signals that results in activation of Factor X, which then ... Unfortunately, purification of protein from human plasma carries an increased risk of transmission of ... Congenital loss or deficiency of Factor VIII results in the physiologic impairment of the coagulation …
Benzhydrocodone
Benzhydrocodone is a benzylic prodrug of hydrocodone. It was developed in an effort to reduce parenteral bioavailability of the active metabolite as a deterrent to abuse. Benzhydrocodone is indicated for use in the short-term management of pain. It was first approved by the FDA in February 2018 in combination with...
Approved
Matched Description: … Benzhydrocodone is a benzylic prodrug of hydrocodone. ... [A182177] Benzhydrocodone is indicated for use in the short-term management of pain. ... [L4894] It was developed in an effort to reduce parenteral bioavailability of the active metabolite as …
Desloratadine
Desloratadine is a second generation, tricyclic antihistamine that which has a selective and peripheral H1-antagonist action. It is the active descarboethoxy metabolite of loratidine (a second generation histamine). Desloratidine has a long-lasting effect and does not cause drowsiness because it does not readily enter the central nervous system.
Approved
Investigational
Matched Description: … It is the active descarboethoxy metabolite of loratidine (a second generation histamine). …
L-Glutamine
A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from glutamic acid and ammonia. It is the principal carrier of nitrogen in the body and is an important energy source for many cells. An oral formulation of L-glutamine was approved...
Approved
Investigational
Nutraceutical
Matched Description: … It is the principal carrier of nitrogen in the body and is an important energy source for many cells. ... An oral formulation of L-glutamine was approved by the FDA in July 2017 for use in sickle cell disease …
Blinatumomab
Blinatumomab is a BiTE-class (bi-specific T-cell engager) constructed monoclonal antibody formed by the recombinant fusion of an anti-CD3 single-chain variable fragment (scFV) and an anti-CD19 scFV through a short peptide linker.[A254836,L44311] CD3 is an antigen expressed on the surface of T-cells, while CD19 is mostly expressed on the surface of...
Approved
Investigational
Matched Description: … on the surface of malignant B-cells. ... BiTE-class (bi-specific T-cell engager) constructed monoclonal antibody formed by the recombinant fusion of ... [A254836,L44311] CD3 is an antigen expressed on the surface of T-cells, while CD19 is mostly expressed …
Eftrenonacog alfa
Eftrenonacog alfa is a long-acting recombinant fusion protein used in the treatment of hemophilia B. It is comprised of a single molecule of human factor IX (FIX) covalently linked to the constant region (Fc) domain of human IgG1 via recombinant DNA technology in a human embryonic kidney cell line (HEK293H)...
Approved
Investigational
Matched Description: … It is comprised of a single molecule of human factor IX (FIX) covalently linked to the constant region ... The presence of the Fc domain extends the terminal half-life which confers clinical benefits of prolonged ... Eftrenonacog alfa is a long-acting recombinant fusion protein used in the treatment of hemophilia B. …
Nirogacestat
Nirogacestat is a small-molecule gamma-secretase inhibitor that was investigated as a potential treatment for desmoid tumors. Desmoid tumors are typically characterized by aberrant activation in Notch signaling. Interaction between the notch receptors and their ligands activates proteolytic cleavage by gamma-secretase; therefore, the inhibition of gamma-secretase can potentially inhibit Notch signaling...
Approved
Investigational
Matched Description: … gamma-secretase can potentially inhibit Notch signaling and thus impede the growth of desmoid tumors ... previously granted breakthrough therapy, fast track, and orphan drug designations for the treatment of ... receptors and their ligands activates proteolytic cleavage by gamma-secretase; therefore, the inhibition of …
Taurolidine
Taurolidine is an antimicrobial used for the prevention of catheter-related infections. It is a derivative of the amino acid taurine.
It was first synthesized in the 1970s and was originally used as a prophylactic against intraperitoneal bacterial infections in patients with peritonitis. In November 2023, a catheter lock solution of...
Approved
Investigational
Matched Description: … It is a derivative of the amino acid [taurine]. ... Taurolidine is an antimicrobial used for the prevention of catheter-related infections. ... Limited Population Pathway for Antibacterial and Antifungal Drugs (LPAD pathway) for the prevention of …
Pirtobrutinib
Pirtobrutinib is a small molecule and a highly selective non-covalent inhibitor of Bruton’s tyrosine kinase (BTK). Its high selectivity has been associated with lower discontinuation rates due to adverse events and a lower incidence of atrial fibrillation. Unlike BTK covalent inhibitors, such as ibrutinib, that bind to the cysteine 481...
Approved
Investigational
Matched Description: … BTK, the inhibitory activity of pirtobrutinib is maintained even in the presence of Cys481 mutations ... [A256788]
In January 2023, the use of pirtobrutinib for the treatment of relapsed or refractory mantle ... Pirtobrutinib is a small molecule and a highly selective non-covalent inhibitor of Bruton’s tyrosine …
Lansoprazole
Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor (PPI) and is structurally classified as a substituted benzimidazole. It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux disease (GERD) along with other pathologies...
Approved
Investigational
Pioglitazone
Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert in vivo with little consequence. The thiazolidinedione class...
Approved
Investigational
Matched Description: … [A19757] PPARs are ligand-activated transcription factors that are involved in the expression of more ... exerts its pharmacological effect primarily by promoting insulin sensitivity and the improved uptake of ... [A19759]
Thiazolidinediones, including pioglitazone, have fallen out of favor in recent years due …
Benzethonium
Benzethonium is a synthetic quaternary ammonium salt with surfactant, antiseptic, and broad spectrum antimicrobial properties. Its salt form, benzethonium chloride, is primarily used as a skin disinfectant at concentrations of 0.1-0.2 %, which are safe and effective concentrations for the compound specified by the U.S. Food and Drug Administration (FDA)....
Approved
Matched Description: … Its salt form, benzethonium chloride, is primarily used as a skin disinfectant at concentrations of 0.1 …
Levocetirizine
Levocetirizine is a selective histamine H1 antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of cetirizine. Levocetirizine has greater affinity for the histamine H1 receptor than cetirizine. Levocetirizine was granted FDA approval in 1995.
Approved
Matched Description: … [A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. ... Levocetirizine is a selective histamine H1 antagonist used to treat a variety of allergic …
Levomefolic acid
Levomefolic acid (INN) is the metabolite of folic acid (Vitamin B9) and it is a predominant active form of folate found in foods and in the blood circulation, accounting for 98% of folates in human plasma . It is transported across the membranes including the blood-brain barrier into various tissues...
Approved
Investigational
Matched Description: … of folate found in foods and in the blood circulation, accounting for 98% of folates in human plasma ... Levomefolic acid (INN) is the metabolite of folic acid (Vitamin B9) and it is a predominant active form ... various tissues where it plays an essential role in the DNA synthesis, cysteine cycle and regulation of …
Thrombin alfa
Thrombin Alfa is a human coagulation protein produced via recombinant DNA technology from a genetically modified CHO cell line. Thrombin Alfa is identical in amino acid sequence and structurally similar to naturally occurring human thrombin. Thrombin Alfa precursor is secreted to culture medium as single chain form that is proteolytically...
Approved
Matched Description: … The cell culture process used in the manufacture of Thrombin Alfa employs no additives of human or animal ... The cell line used to manufacture Thrombin Alfa has been tested and shown to be free of known infectious ... the use of thrombin alfa and the placebo treatment in patient subjects, thrombin alfa is not currently …
Opicapone
Opicapone is a potent, reversible, and peripherally-acting third-generation inhibitor of catechol-o-methyltransferase (COMT), an enzyme involved in the breakdown of various catecholamines including dopamine.[A36938, A203048] Many patients with Parkinson’s disease treated with levodopa plus a dopa decarboxylase (DDC) inhibitor (eg carbidopa) experience motor complications over time, which calls for the management...
Approved
Investigational
Matched Description: … (COMT), an enzyme involved in the breakdown of various catecholamines including dopamine. ... ) inhibitor (eg carbidopa) experience motor complications over time, which calls for the management of ... Opicapone is a potent, reversible, and peripherally-acting third-generation inhibitor of catechol-o-methyltransferase …
Idecabtagene vicleucel
Multiple myeloma is a cancer where plasma cells rapidly divide out of control. These cancerous cells generally express the B-cell maturation antigen, while it is rarely expressed on non-cancerous cells. Multiple myeloma is typically treated with an immunomodulatory agent like lenalidomide, a proteasome inhibitor like bortezomib, or an anti-CD38 monoclonal...
Approved
Matched Description: … Multiple myeloma is a cancer where plasma cells rapidly divide out of control. ... [A232558] The chimeric antigen receptor of idecabtagene vicleucel includes an anti-B-cell maturation ... [L32858] Idecabtagene vicleucel is indicated as a fifth line treatment of adult patients with relapsed …
Tioguanine
An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
Approved
Matched Description: … The drug is used in the therapy of acute leukemia. …
Crofelemer
Crofelemer, previously known as the investigational drug SP-303, is a novel proanthocyanidin purified from the bark latex of the Amazonian Croton tree Croton lechleri. It is marketed under the brand name Fulyzaq and indicated for the symptomatic treatment of non-infectious diarrhea in adult patients with HIV/AIDS who are taking antiretroviral...
Approved
Matched Description: … known as the investigational drug SP-303, is a novel proanthocyanidin purified from the bark latex of ... It is marketed under the brand name Fulyzaq and indicated for the symptomatic treatment of non-infectious …
Nateglinide
Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that induces an early insulin...
Approved
Investigational
Matched Description: … be lower than that of sulfonylureas since their action is dependent on the presence of glucose. ... the last 8-10 weeks of glucose control. ... cells of the pancreas to stimulate insulin release. …
Bismuth subsalicylate
Bismuth subsalicylate is an antacid and anti-diarrheal agent. Exhibiting antibacterial and gastroprotective properties, bismuth subsalicylate is an insoluble salt of salicylic acid linked to trivalent bismuth cation. Each molecule of bismuth subsalicylate contains 58% bismuth and 42% salicylate by weight. Bismuth subsalicylate has been around for over 100 years: it...
Approved
Vet approved
Matched Description: … treatment of patients with _H. pylori_ infection and duodenal ulcer disease. ... Each molecule of bismuth subsalicylate contains 58% bismuth and 42% salicylate by weight. ... Exhibiting antibacterial and gastroprotective properties, bismuth subsalicylate is an insoluble salt of …
Displaying drugs 526 - 550 of 8039 in total