Displaying drugs 626 - 650 of 1902 in total
Nedosiran
Nedosiran is an RNA interference targeting hepatic lactate dehydrogenase, the enzyme responsible for the conversion of glyoxylate to oxalate. Oxalate, particularly calcium oxalate, precipitation is the main cause of kidney stones formation; therefore, blocking the production of oxalate can help alleviate renal symptoms. Nedosiran was approved by the FDA on...
Approved
Investigational
Matched Description: … older and adults with primary hyperoxaluria type 1 (PH1) and relatively preserved kidney function. ... sup>, 2023, under the brand name RIVFLOZA to lower urinary oxalate levels in children 9 years of age and ... This approval is based on the favorable results from the pivotal phase 2 PHYOXTM2 and interim …
Matched Salts name: … Nedosiran sodium …
Matched Salts name: … Nedosiran sodium …
Icosapent
Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families.
Approved
Nutraceutical
Matched Description: … It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. ... inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families. ... lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and …
Matched Salts name: … Icosapent sodium …
Matched Salts name: … Icosapent sodium …
Tauroursodeoxycholic acid
Tauroursodeoxycholic acid, also known as ursodoxicoltaurine, is a highly hydrophilic tertiary bile acid that is produced in humans at a low concentration. It is a taurine conjugate of ursodeoxycholic acid with comparable therapeutic efficacy and safety, but a much higher hydrophilicity. Normally, hydrophilic bile acids regulates hydrophobic bile acids and...
Approved
Investigational
Matched Description: … It is a taurine conjugate of [ursodeoxycholic acid] [A249065] with comparable therapeutic efficacy and ... [A249060] Normally, hydrophilic bile acids regulates hydrophobic bile acids and their cytotoxic effects ... [A249080]
Tauroursodeoxycholic acid is currently used in Europe to treat and prevent gallstones as …
Matched Categories: … sodium phenylbutyrate and ursodoxicoltaurine ... Bile Acids and Salts ... Bile and Liver Therapy ... Bile acids and derivatives ... Alimentary Tract and Metabolism …
Matched Categories: … sodium phenylbutyrate and ursodoxicoltaurine ... Bile Acids and Salts ... Bile and Liver Therapy ... Bile acids and derivatives ... Alimentary Tract and Metabolism …
Fomivirsen
Fomivirsen is a antisense 21 mer phosphorothioate oligonucleotide. It is an antiviral agent that was used in the treatment of cytomegalovirus retinitis (CMV) in immunocompromised patients, including those with AIDS. As a complementary nucleotide to the messenger RNA of the major immediate-early region proteins of human cytomegalovirus, it disrupts the...
Approved
Investigational
Withdrawn
Matched Description: … drug to be approved by the Food and Drug Administration (FDA). ... _Isis Pharmaceuticals_ and subsequently licensed to _Novartis_ [A31990]. ... It was discovered by scientists at the National Institutes of Health (NIH) and was first developed by …
Matched Salts name: … Fomivirsen sodium …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Matched Salts name: … Fomivirsen sodium …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Nusinersen
An antisense oligonucleotide that induces survival motor neuron (SMN) protein expression, it was approved by the U.S. FDA in December, 2016 as Spinraza for the treatment of children and adults with spinal muscular atrophy (SMA). It is adminstrated as direct intrathecal injection.
Approved
Investigational
Matched Description: … FDA in December, 2016 as Spinraza for the treatment of children and adults with spinal muscular atrophy …
Matched Salts name: … Nusinersen sodium …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Matched Salts name: … Nusinersen sodium …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Inclisiran
Inclisiran is a long-acting, synthetic small interfering RNA (siRNA) directed against proprotein convertase subtilisin-kexin type 9 (PCSK9), which is a serine protease that regulates plasma low-density lipoprotein cholesterol (LDL-C) levels. By binding to PCSK9 messenger RNA, inclisiran prevents protein translation of PCSK9, leading to decreased concentrations of PCSK9 and plasma...
Approved
Investigational
Matched Description: … RNA, inclisiran prevents protein translation of PCSK9, leading to decreased concentrations of PCSK9 and ... 11, 2020, the European Commission (EC) granted authorization for marketing inclisiran as the first and ... plasma LDL-C levels offers an additional benefit of reducing the risk of cardiovascular disease (CVD) and …
Matched Salts name: … Inclisiran sodium …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Matched Salts name: … Inclisiran sodium …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Brilliant blue G
Brilliant Blue G is used in an ophthalmic solution for staining the internal limiting membrane (ILM) of the eye during ophthalmic procedures.[A188841,A188844] This membrane is thin and translucent, making it difficult to identify during eye surgeries that require high levels of visual accuracy. Brilliant blue G, like its name, imparts...
Approved
Matched Iupac: … sodium 3-({[4-({4-[(4-ethoxyphenyl)amino]phenyl}[(1E,4E)-4-{ethyl[(3-sulfonatophenyl)methyl]iminiumyl …
Matched Description: … It was approved by the FDA for ophthalmic use on December 20, 2019.[L10830] ... [A188841,A188844] This membrane is thin and translucent, making it difficult to identify during eye surgeries …
Matched Categories: … Indicators and Reagents …
Matched Description: … It was approved by the FDA for ophthalmic use on December 20, 2019.[L10830] ... [A188841,A188844] This membrane is thin and translucent, making it difficult to identify during eye surgeries …
Matched Categories: … Indicators and Reagents …
Triprolidine
First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness.
Approved
Matched Description: … It is a component of cough and cold medicines. It may cause drowsiness. ... First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. …
Matched Mixtures name: … A-FERIN DECO TABLET, 20 ADET ... A-FERIN SINUS 500/30/1.25 MG FİLM KAPLI TABLET, 20 ADET ... and Flu Clear and Cool …
Matched Salts name: … Triprolidine hydrochloride monohydrate …
Matched Mixtures name: … A-FERIN DECO TABLET, 20 ADET ... A-FERIN SINUS 500/30/1.25 MG FİLM KAPLI TABLET, 20 ADET ... and Flu Clear and Cool …
Matched Salts name: … Triprolidine hydrochloride monohydrate …
Penciclovir
Penciclovir is a synthetic acyclic guanine derivative with antiviral activity used for the treatment of various herpes simplex virus (HSV) infections. Displaying low toxicity and good selectivity, penciclovir is a nucleoside analogue.
Approved
Matched Description: … Displaying low toxicity and good selectivity, penciclovir is a nucleoside analogue. …
Matched Salts name: … Penciclovir sodium …
Matched Categories: … Nucleosides and Nucleotides Excl. Reverse Transcriptase Inhibitors …
Matched Salts name: … Penciclovir sodium …
Matched Categories: … Nucleosides and Nucleotides Excl. Reverse Transcriptase Inhibitors …
Lenacapavir
HIV/AIDS remains an area of concern despite the introduction of numerous successful therapies, mainly due to the emergence of multidrug resistance and patient difficulty in adhering to treatment regimens.[A244170, A244175] Lenacapavir is a first-in-class capsid inhibitor that demonstrates picomolar HIV-1 inhibition as a monotherapy in vitro, little to no cross-resistance...
Approved
Investigational
Matched Description: … introduction of numerous successful therapies, mainly due to the emergence of multidrug resistance and ... inhibition as a monotherapy _in vitro_, little to no cross-resistance with existing antiretroviral agents, and …
Matched Salts name: … Lenacapavir sodium …
Matched Salts name: … Lenacapavir sodium …
Cerivastatin
On August 8, 2001 the U.S. Food and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew Baycol from the U.S. market, due to reports of fatal rhabdomyolysis, a severe adverse reaction from this cholesterol-lowering (lipid-lowering) product. It has also been withdrawn from the Canadian market.[A669,L43942]
Approved
Withdrawn
Matched Description: … Food and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew …
Matched Salts name: … Cerivastatin sodium …
Matched Salts name: … Cerivastatin sodium …
Indomethacin
Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlorobenzoyl)25-methoxy-2-methylindole-3-acetic acid. The pharmacological effect of indometacin is not fully understood,...
Approved
Investigational
Matched Description: … ocular inflammation and pain and/or complications after cataract surgery. ... Indometacin was first discovered in 1963 and it was first approved for use in the U.S. by the Food and ... indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and …
Matched Salts name: … Indomethacin sodium …
Matched Categories: … indometacin and antiinfectives ... Acetic Acid Derivatives and Related Substances ... Antiinflammatory and Antirheumatic Products ... Topical Products for Joint and Muscular Pain ... Antiinflammatory and Antirheumatic Products, Non-Steroids …
Matched Salts name: … Indomethacin sodium …
Matched Categories: … indometacin and antiinfectives ... Acetic Acid Derivatives and Related Substances ... Antiinflammatory and Antirheumatic Products ... Topical Products for Joint and Muscular Pain ... Antiinflammatory and Antirheumatic Products, Non-Steroids …
Hydrogen fluoride
Hydrogen fluoride (Hydrofluoric acid) is a weak acid that is a precursor to almost all fluorine compounds, including pharmaceuticals such as DB00472 (Prozac). It is used as a chemical reagent in several industrial processes such as oil refinery. It is also used as etchant, cleaning agent, and a reagent to...
Approved
Investigational
Matched Synonyms: … Hydrogen fluoride, anhydrous …
Matched Description: … It is also used as etchant, cleaning agent, and a reagent to dissolve oxides and silicates. …
Matched Mixtures name: … Denti-Care Topical Sodium Fluoride Strawberry ... Perfect Choice 0.717% Root and Dentin Desens ... Acidulated Phosphate Fluoride Oral Solution …
Matched Description: … It is also used as etchant, cleaning agent, and a reagent to dissolve oxides and silicates. …
Matched Mixtures name: … Denti-Care Topical Sodium Fluoride Strawberry ... Perfect Choice 0.717% Root and Dentin Desens ... Acidulated Phosphate Fluoride Oral Solution …
Zinc acetate
Approved
Investigational
Matched Synonyms: … Zinc acetate anhydrous …
Matched Mixtures name: … Up and Up itch relief ... Rugid Itch and Pain Relief ... Anti Itch and Skin Protectant …
Matched Categories: … Alimentary Tract and Metabolism ... Various Alimentary Tract and Metabolism Products ... Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …
Matched Mixtures name: … Up and Up itch relief ... Rugid Itch and Pain Relief ... Anti Itch and Skin Protectant …
Matched Categories: … Alimentary Tract and Metabolism ... Various Alimentary Tract and Metabolism Products ... Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …
Pyrophosphoric acid
Approved
Experimental
Matched Salts name: … Sodium pyrophosphate ... Sodium pyrophosphate decahydrate …
Matched Categories: … Phosphate salts …
Matched Categories: … Phosphate salts …
Brincidofovir
Brincidofovir is an oral antiviral drug used in the treatment of human smallpox infections. It is a lipid conjugate pro-drug of the acyclic nucleotide analogue cidofovir[L34404,A235725] - this lipid conjugate improves drug delivery to the target cells and significantly reduces the nephrotoxicity typically associated with cidofovir therapy.[A235725,A235735] Due to its...
Approved
Investigational
Matched Description: … analogue [cidofovir][L34404,A235725] - this lipid conjugate improves drug delivery to the target cells and ... treatment of cytomegalovirus (CMV), BK Virus (BKV), adenoviruses (AdV), and Epstein-Barr virus (EBV) ... against several DNA viruses,[A235725] resulting in brincidofovir being investigated for the prevention and …
Matched Salts name: … Brincidofovir sodium …
Matched Categories: … Nucleosides and Nucleotides Excl. Reverse Transcriptase Inhibitors …
Matched Salts name: … Brincidofovir sodium …
Matched Categories: … Nucleosides and Nucleotides Excl. Reverse Transcriptase Inhibitors …
Acetazolamide
One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is...
Approved
Vet approved
Matched Description: … (From Smith and Reynard, Textbook of Pharmacology, 1991, p337) ... It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures ... anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and …
Matched Salts name: … Acetazolamide sodium …
Matched Categories: … Antiglaucoma Preparations and Miotics ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …
Matched Salts name: … Acetazolamide sodium …
Matched Categories: … Antiglaucoma Preparations and Miotics ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …
Levobupivacaine
Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted
pipecoloxylidide. It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by AstraZeneca under the trade name Chirocaine. In particular, the specific levobupivacaine enantiomer is a worthwhile pursuit because it demonstrates less vasodilation and possesses a...
Approved
Investigational
Matched Description: … intrathecal anaesthesia in adults; and infiltration analgesia in children. ... specific levobupivacaine enantiomer is a worthwhile pursuit because it demonstrates less vasodilation and ... predominantly associated with inappropriate administration methods that may cause systemic exposure and …
Sulfabenzamide
Sulfabenzamide is an antimicrobial agent often used in conjunction with sulfathiazole and sulfacetamide as a topical intravaginal antibacterial preparation.
Approved
Matched Description: … Sulfabenzamide is an antimicrobial agent often used in conjunction with sulfathiazole and sulfacetamide …
Matched Salts name: … Sulfabenzamide sodium …
Matched Salts name: … Sulfabenzamide sodium …
Desmopressin
Desmopressin (dDAVP), a synthetic analogue of 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1-cysteine and substitution of 8-L-arginine by 8-D-arginine. ADH is an endogenous pituitary hormone that has a crucial role in the control of the water content in the body. Upon release from the...
Approved
Matched Description: … solution, intravenous solution, oral tablet and oral lyophilisate [A31662]. ... a prolonged half-life and duration of action compared to endogenous ADH [A31661]. ... 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1-cysteine and …
Matched Salts name: … Desmopressin acetate anhydrous …
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Vasopressin and Analogues ... Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Products: … EMOSINT 20 MCG / 1 ML SOLUCION INYECTABLE …
Matched Salts name: … Desmopressin acetate anhydrous …
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Vasopressin and Analogues ... Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Products: … EMOSINT 20 MCG / 1 ML SOLUCION INYECTABLE …
Timolol
Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers...
Approved
Matched Synonyms: … Timolol anhydrous …
Matched Description: … of conditions such as open-angle glaucoma and hypertension. ... [L6724] This drug is marketed by several manufacturers [L6736] and is an effective agent for the management …
Matched Mixtures name: … COSOPT S 20/5MG/ML ... DORZOCOMP VISI 20+5MG/ML ... DORZOCOMP VISI 20+5MG/ML …
Matched Categories: … timolol and thiazides ... Beta Blocking Agents and Thiazides ... Antiglaucoma Preparations and Miotics ... timolol, thiazides and other diuretics ... Beta Blocking Agents, Non-Selective, and Thiazides …
Matched Products: … Timolol-20 Tab 20mg …
Matched Description: … of conditions such as open-angle glaucoma and hypertension. ... [L6724] This drug is marketed by several manufacturers [L6736] and is an effective agent for the management …
Matched Mixtures name: … COSOPT S 20/5MG/ML ... DORZOCOMP VISI 20+5MG/ML ... DORZOCOMP VISI 20+5MG/ML …
Matched Categories: … timolol and thiazides ... Beta Blocking Agents and Thiazides ... Antiglaucoma Preparations and Miotics ... timolol, thiazides and other diuretics ... Beta Blocking Agents, Non-Selective, and Thiazides …
Matched Products: … Timolol-20 Tab 20mg …
Lincomycin
Lincomycin is a lincosamide antibiotic first isolated from the soil bacterium Streptomyces lincolnensis in Lincoln, Nebraska. Clinical use of lincomycin has largely been superseded by its semisynthetic derivative clindamycin due to its higher efficacy and a wider range of susceptible organisms, though lincomycin remains in use.[A190657, A190621]
Lincomycin was approved...
Approved
Vet approved
Matched Description: … has largely been superseded by its semisynthetic derivative [clindamycin] due to its higher efficacy and …
Matched Salts name: … Lincomycin hydrochloride monohydrate …
Matched Categories: … Macrolides, Lincosamides and Streptogramins …
Matched Salts name: … Lincomycin hydrochloride monohydrate …
Matched Categories: … Macrolides, Lincosamides and Streptogramins …
Urea
A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.
Approved
Investigational
Matched Description: … It is the principal end product of protein catabolism and constitutes about one half of the total urinary …
Matched Mixtures name: … Hyaluronic Acid Sodium Salt 1% / Tacrolimus 0.1% / Urea 20% ... Ciclopirox 3% / Itraconazole 5% / Urea 20% …
Matched Categories: … Blood and Blood Forming Organs ... Emollients and Protectives ... Blood Substitutes and Perfusion Solutions …
Matched Products: … Bare 20 ... Urea 20 ... CARMED 20 …
Matched Mixtures name: … Hyaluronic Acid Sodium Salt 1% / Tacrolimus 0.1% / Urea 20% ... Ciclopirox 3% / Itraconazole 5% / Urea 20% …
Matched Categories: … Blood and Blood Forming Organs ... Emollients and Protectives ... Blood Substitutes and Perfusion Solutions …
Matched Products: … Bare 20 ... Urea 20 ... CARMED 20 …
Desvenlafaxine
Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of venlafaxine. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of adults with major depressive disorder (MDD).[L6016,A261271]
MDD is a highly...
Approved
Investigational
Matched Description: … a highly prevalent psychiatric disorder, with a lifetime prevalence estimate of 16% in the US alone and ... [A261271] Desvenlafaxine has a very similar pharmacological, efficacy, and safety profile as [venlafaxine …
Matched Salts name: … Desvenlafaxine fumarate monohydrate …
Matched Categories: … Serotonin and Noradrenaline Reuptake Inhibitors …
Matched Salts name: … Desvenlafaxine fumarate monohydrate …
Matched Categories: … Serotonin and Noradrenaline Reuptake Inhibitors …
Displaying drugs 626 - 650 of 1902 in total