Displaying drugs 651 - 675 of 8178 in total
Kappadione
Kappadione is a Vitamin K derivative (chemically, it is menadiol sodium diphosphate), previously approved by FDA prior to 1982 and marketed by Lilly Marketing for this drug has been discontinued and is not available in North America . It has been found to have carcinogenic potential in mammalian cells as...
Approved
Matched Description: … of mice [L1544]. ... Studies involving the active metabolite of this formulation, menadione, showed oocyte toxicity in a study …
Desonide
A nonfluorinated corticosteroid anti-inflammatory agent used topically for dermatoses.
Approved
Investigational
Dalfampridine
Dalfampridine is a potassium channel blocker used to help multiple sclerosis patients walk. This is the first drug that was specifically approved to help with mobility in these patients. FDA approved on January 22, 2010.
Approved
Antilymphocyte immunoglobulin (horse)
Equine anti-thymocyte globulin is composed of purified gamma globulin containing primarily IgG against human thymus lymphocytes. It is formed by inoculating a horse with an antigen (human thymoyctes) which then induces the horse immune system's B-lymphocytes to produce IgG immunoglobulins specific for that antigen. The result is polyclonal IgG that...
Approved
Investigational
Matched Description: … Although the exact mechanism of action is unknown, equine anti-thymocyte globulin targets a variety of ... rejection and in the treatment of aplastic anemia. ... Equine anti-thymocyte globulin is composed of purified gamma globulin containing primarily IgG against …
Guanidine
A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is...
Approved
Matched Description: … It is found in the urine as a normal product of protein metabolism. ... Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of …
Abaloparatide
Abaloparatide is an N-terminal analog of parathyroid hormone-related protein (PTHrP) and an agonist at the parathyroid hormone type 1 (PTH1) receptor. It is a synthetic 34 amino acid peptide with 41% homology to human parathyroid hormone 1-34 and human PTHrP 1-34. Abaloparatide and PTHrP share the first 21 amino acids...
Approved
Investigational
Matched Description: … Abaloparatide is an N-terminal analog of parathyroid hormone-related protein (PTHrP) [A256778] and an ... [L740] It was first approved by the FDA on April 28, 2017,[A256748] for the treatment of osteoporosis …
Bulevirtide
Hepatitis D is considered the most severe type of viral hepatitis and leads to the rapid development of cirrhosis, severe decompensation of liver function, and an increased risk of mortality.[A226340,L30235] Until recently, there have been extremely limited treatments available for Hepatitis D infection. Bulevirtide, also known as Hepcludex, is a...
Approved
Investigational
Matched Description: … of cirrhosis, severe decompensation of liver function, and an increased risk of mortality. ... Completion of this clinical trial is anticipated in early 2023.[L30240] ... chronic Hepatitis D infection developed by MYR Pharmaceuticals, now part of Gilead. …
Clemastine
An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness.
Approved
Investigational
Cresol
Cresol is a hydroxytoluene that can be extracted naturally from coal tar or made synthetically. Pure cresol is a mixture of ortho-, meta-, and para- isomers. Cresols are precursors or synthetic intermediates to various other compounds and materials, including plastics, pesticides, pharmaceuticals, disinfectants, and dyes. Ingestion of cresol induces toxicity...
Approved
Matched Description: … Ingestion of cresol induces toxicity in humans and can lead to burning of the mouth and throat, abdominal ... Pure cresol is a mixture of ortho-, meta-, and para- isomers. …
Lesinurad
Lesinurad is an oral uric acid transporter 1 (URAT1) inhibitor indicated for the treatment of hyperuricemia associated with gout. It reduces serum uric acid concentration through the inhibition of URAT1, an enzyme responsible for reuptake of uric acid from the renal tubule, and OAT4, another uric acid transporter associated with...
Approved
Investigational
Matched Description: … Lesinurad is an oral uric acid transporter 1 (URAT1) inhibitor indicated for the treatment of hyperuricemia ... Zurampic, it is indicated for use in combination with a xanthine oxidase inhibitor for the treatment of ... It reduces serum uric acid concentration through the inhibition of URAT1, an enzyme responsible for reuptake …
Durlobactam
Durlobactam is a diazabicyclooctane non-beta-lactam, beta-lactamase inhibitor. It is typically given in combination with sulbactam to protect it from degradation by certain serine-beta-lactamases. The combination product of durlobactam and sulbactam was first approved by the FDA in May 2023. It is used to treat hospital-acquired bacterial pneumonia and ventilator-associated bacterial...
Approved
Investigational
Matched Description: … [L47336] The combination product of durlobactam and sulbactam was first approved by the FDA in May 2023 ... pneumonia and ventilator-associated bacterial pneumonia (HABP/VABP), caused by susceptible isolates of …
Ceftazidime
Bacteria possess a cell wall comprising a glycopeptide polymer commonly known as peptidoglycan, which is synthesized and remodelled through the action of a family of enzymes known as "penicillin-binding proteins" (PBPs). β-lactam antibiotics, including cephalosporins, are PBP inhibitors that, through inhibition of essential PBPs, result in impaired cell wall homeostasis,...
Approved
Matched Description: … a family of enzymes known as "penicillin-binding proteins" (PBPs). ... A232920] β-lactam antibiotics, including cephalosporins, are PBP inhibitors that, through inhibition of ... glycopeptide polymer commonly known as peptidoglycan, which is synthesized and remodelled through the action of …
Aluminum hydroxide
Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects.
Approved
Investigational
Matched Description: … Subsequent increases in pH may inhibit the action of pepsin. …
Potassium
Potassium is an essential nutrient, like Calcium and Magnesium. It was identified as a shortfall nutrient by the 2015-2020 Advisory Committee of Dietary Guidelines for Americans. Many conditions and diseases interfere with normal body potassium balance, and underconsumption of potassium is one example. Hypokalemia (low potassium) or hyperkalemia (high potassium)...
Approved
Experimental
Matched Description: … It was identified as a shortfall nutrient by the 2015-2020 Advisory Committee of Dietary Guidelines for ... A186928] Many conditions and diseases interfere with normal body potassium balance, and underconsumption of ... Examples of potassium formulations include potassium citrate, potassium chloride, and potassium with …
Corticorelin ovine triflutate
Corticorelin, available commercially as corticorelin ovine triflutate (tradename Acthrel), is a synthetic form of the peptide human corticotropin-releasing hormone (hCRH), a potent stimulator of adrenocorticotropic hormone (ACTH) release from the anterior pituitary. Endogenous forms hCRH are involved in the stress response and its main function is stimulation of the pituitary...
Approved
Matched Description: … of a pituitary source from an ectopic source of excessive ACTH secretion. ... It provides a differential diagnosis for Cushing's disease (a pituitary source of ACTH excess) or of ... ectopic ACTH syndrome (an ectopic source of ACTH excess). …
Lenograstim
Lenograstim is a recombinant granulocyte colony-stimulating factor used as an immunostimulating agent.
Approved
Investigational
Rifaximin
Rifaximin is a semisynthetic, rifamycin-based non-systemic antibiotic, meaning that the drug will not pass the gastrointestinal wall into the circulation as is common for other types of orally administered antibiotics. It has multiple indications and is used in treatment of traveller's diarrhea caused by E. coli; reduction in risk of...
Approved
Investigational
Matched Description: … the drug will not pass the gastrointestinal wall into the circulation as is common for other types of ... in risk of overt hepatic encephalopathy recurrence; as well as diarrhea-predominant irritable bowel ... It has multiple indications and is used in treatment of traveller's diarrhea caused by E. coli; reduction …
Crotamiton
Crotamiton is a scabicidal and antipruritic agent available as a cream or lotion for topical use only. It is a colorless to slightly yellowish oil, having a faint amine-like odor. It is miscible with alcohol and with methanol.
Approved
Profenamine
Profenamine (also known as ethopropazine) is a medication derived from phenothiazine. It is primarily used as an antidyskinetic to treat Parkinsonism. It is sold under the trade name Parsitan in Canada. In the US, the marketing of profenamine has been discontinued.
Approved
Matched Description: … [L46812] In the US, the marketing of profenamine has been discontinued.[L46817] …
Terconazole
Terconazole is an anti-fungal drug that is mainly used to treat vaginal yeast infections (or vaginal candidiasis). It is classified as a triazole ketal derivative. Terconazole was initially approved by the FDA in 1987.[FDA label] This drug is available in cream and suppository forms and both have demonstrated high levels...
Approved
Matched Description: … label] This drug is available in cream and suppository forms and both have demonstrated high levels of ... [A178093]Due to the existence of 2 stereocentres, there are 4 possible stereoisomers for terconazole. …
Tenoxicam
Tenoxicam, an antiinflammatory agent with analgesic and antipyretic properties, is used to treat osteoarthritis and control acute pain.
Approved
Setmelanotide
Setmelanotide is the first available treatment for patients with pro-opiomelanocortin, proprotein subilisin/kexin type 1, or leptin deficiencies. It is an agonist of the melanocortin 4 receptor. Earlier attempts at agonizing MC4R (such as LY2112688) lead to successful weight loss, but also an increase in blood pressure and heart rate. Other...
Approved
Investigational
Matched Description: … [L24474] It is an agonist of the melanocortin 4 receptor. ... [A224449] Patients taking setmelanotide experienced an average weight loss of 0.6 kg/week. …
Eculizumab
Eculizumab is a monoclonal antibody that targets complement protein C5.[L6919,A2245] Binding to this protein prevents the activation of a complement terminal complex, which is used to treat a number of autoimmune conditions.[L6919,A2245,A2246]
Eculizumab was granted FDA approval on 16 March 2007. In Q1 2023, the EMA's Committee for Medicinal Products...
Approved
Investigational
Matched Description: … two formulations of eculizumab indicated for the treatment of paroxysmal nocturnal hemoglobinuria. ... is used to treat a number of autoimmune conditions. ... [L6919,A2245] Binding to this protein prevents the activation of a complement terminal complex, which …
Ubrogepant
Ubrogepant is indicated for the acute treatment of migraine headaches with or without aura in adults. It was approved by the FDA on December 23, 2019, and is the first oral calcitonin gene-related peptide (CGRP) receptor antagonist approved for the acute treatment of migraine. Several oral small molecule CGRP receptor...
Approved
Investigational
Matched Description: … advance in migraine headache treatment and may become the new standard of therapy in the treatment of ... Ubrogepant is indicated for the acute treatment of migraine headaches with or without aura in adults. ... first oral calcitonin gene-related peptide (CGRP) receptor antagonist approved for the acute treatment of …
Ropivacaine
Ropivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin. It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the purified S-enantiomer.
Approved
Matched Description: … It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the …
Displaying drugs 651 - 675 of 8178 in total