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Displaying drugs 651 - 675 of 14709 in total
Bempedoic acid
High levels of LDL cholesterol (LDL-C) are a major risk factor for cardiovascular events. Caused by genetic mutations or lifestyle factors, hypercholesterolemia can significantly reduce quality of life and increase the risk of mortality from cardiovascular disease. About 1 in 4 patients, or 15 million Americans with elevated LDL-C, are...
Approved
Investigational
Matched Description: … genetic mutations or lifestyle factors, hypercholesterolemia can significantly reduce quality of life and ... [L12144,L12147] It was developed by Esperion Therapeutics Inc. and approved by the FDA on February 21 ... A combination product of bempedoic acid and [ezetimibe] was approved on February 26, 2020 for increased …
Matched Categories: … bempedoic acid and ezetimibe …
Matched Categories: … bempedoic acid and ezetimibe …
Lactitol
Lactitol, also known as 4-β-D-galactopyranosyl-D-glucitol, is a sugar alcohol synthesized from lactose. It is used in food manufacturing as a nutritive sweetener and is approximately 35% as sweet as table sugar (i.e. sucrose). Clinically, lactitol has been investigated for use as an osmotic laxative and, along with other non-absorbable disaccharides...
Approved
Investigational
Matched Description: … [A190918] It is used in food manufacturing as a nutritive sweetener and is approximately 35% as sweet ... [A190912] Clinically, lactitol has been investigated for use as an osmotic laxative and, along with other …
Matched Categories: … Diet, Food, and Nutrition ... Alimentary Tract and Metabolism …
Matched Categories: … Diet, Food, and Nutrition ... Alimentary Tract and Metabolism …
Lenograstim
Lenograstim is a recombinant granulocyte colony-stimulating factor used as an immunostimulating agent.
Approved
Investigational
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Intercellular Signaling Peptides and Proteins …
Estradiol benzoate
Estradiol Benzoate is a pro-drug ester of DB00783, a naturally occurring hormone that circulates endogenously within the human body. Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone. As a pro-drug of estradiol, estradiol benzoate therefore has the same downstream...
Approved
Investigational
Vet approved
Matched Description: … a chance to enter systemic circulation and exert its estrogenic effects [A12102]. ... Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex ... same downstream effects within the body through binding to the Estrogen Receptor (ER) including ERα and …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Collagenase clostridium histolyticum
Collagenase clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum. It is beneficial in the breakdown of collagen plaques for the treatment of Dupuytren's contracture and Peyronie's disease. The topical formulation is used for the debridement of necrotic tissue due to burns or chronic ulcers. On July 6,...
Approved
Investigational
Matched Description: … It is beneficial in the breakdown of collagen plaques for the treatment of Dupuytren's contracture and ... [L14872] Also known as Qwo, this injection is the first approved injectable treatment for cellulite and …
Matched Categories: … Enzymes and Coenzymes ... Skin and Mucous Membrane Agents ... Preparations for Treatment of Wounds and Ulcers …
Matched Categories: … Enzymes and Coenzymes ... Skin and Mucous Membrane Agents ... Preparations for Treatment of Wounds and Ulcers …
Valproic acid
Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investigations into...
Approved
Investigational
Matched Description: … Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in ... [A178051] It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for ... It is currently a compound of interest in the field of oncology for its anti-proliferative effects and …
Permethrin
A pyrethroid insecticide commonly used in the treatment of lice infestations and scabies. It is a yellow to light orange-brown, low melt-ing solid or viscous liquid.
Approved
Investigational
Matched Description: … A pyrethroid insecticide commonly used in the treatment of lice infestations and scabies. …
Matched Categories: … Scabicides and Pediculicides ... Scabicides, Insecticides and Repellents ... Antiparasitic Products, Insecticides and Repellents …
Matched Categories: … Scabicides and Pediculicides ... Scabicides, Insecticides and Repellents ... Antiparasitic Products, Insecticides and Repellents …
Ethanolamine oleate
Ethanolamine oleate is a mild sclerosing agent. It is composed of ethanolamine, a basic substance, which when combined with oleic acid forms a clear, straw to pale yellow colored, deliquescent oleate.
Approved
Sodium aurothiomalate
Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL. It is most effective in active progressive rheumatoid arthritis and of little or no value in...
Approved
Investigational
Matched Description: … It is most effective in active progressive rheumatoid arthritis and of little or no value in the presence …
Matched Categories: … Antiinflammatory and Antirheumatic Products …
Matched Categories: … Antiinflammatory and Antirheumatic Products …
Testosterone undecanoate
Testosterone undecanoate is the ester prodrug of testosterone and has a mid-chain fatty acid at the carbon 17β position. It was developed via fatty acid esterification of testosterone in order to achieve orally administer testosterone. There are oral and intramuscular formulations available for testosterone undecanoate: both formulations are indicated for...
Approved
Investigational
Matched Description: … of testosterone deficiency, such as decreased libido, erectile dysfunction, and loss of muscle and bone ... Testosterone undecanoate is the ester prodrug of [testosterone] and has a mid-chain fatty acid at the ... development of the male sex organs and for the maintenance of secondary sex characteristics. …
Matched Categories: … Testosterone and derivatives ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Categories: … Testosterone and derivatives ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Chlorquinaldol
Chlorquinaldol was used historically as a topical antiseptic under the trade name Sterosan. It was marketed in the 1950s as an iodine-free alternative which was also unrelated to sulfa drugs or hormones. Chlorquinaldol is currently approved by the European Medicines Agency as a combination tablet with promestriene for the treatment...
Approved
Matched Categories: … Antiseptics and Disinfectants ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics ... Antiparasitic Products, Insecticides and Repellents …
Nebivolol
Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than atenolol, propranolol, or pindolol. Nebivolol and other beta...
Approved
Investigational
Matched Description: … Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other ... [A182579] Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure ... [A182579] Nebivolol and other beta blockers are generally not first line therapies as many patients are …
Matched Categories: … valsartan and nebivolol ... nebivolol and thiazides ... nebivolol and amlodipine ... zofenopril and nebivolol ... Beta Blocking Agents and Thiazides …
Matched Categories: … valsartan and nebivolol ... nebivolol and thiazides ... nebivolol and amlodipine ... zofenopril and nebivolol ... Beta Blocking Agents and Thiazides …
Drotrecogin alfa
Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated...
Approved
Investigational
Withdrawn
Matched Description: … It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and …
Matched Categories: … Enzymes and Coenzymes ... Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …
Matched Categories: … Enzymes and Coenzymes ... Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …
Magaldrate
Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market.
Approved
Withdrawn
Matched Description: … Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and …
Matched Categories: … Alimentary Tract and Metabolism ... magaldrate and antiflatulents ... Aluminum and magnesium containing antacids …
Matched Categories: … Alimentary Tract and Metabolism ... magaldrate and antiflatulents ... Aluminum and magnesium containing antacids …
Phthalylsulfathiazole
Phthalylsulfathiazole is a broad spectrum antibiotic which is part of the drug class, sulfonamides. It was used as an antibiotic for bowel surgery, and for infections of the colon .
Approved
Matched Description: … It was used as an antibiotic for bowel surgery, and for infections of the colon [A175006]. …
Matched Categories: … Alimentary Tract and Metabolism ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …
Matched Categories: … Alimentary Tract and Metabolism ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …
Cilgavimab
SARS-CoV-2, the causative agent of COVID-19, enters cells via the interaction between the trimeric spike (S) glycoprotein and host cell angiotensin-converting enzyme 2 (ACE2). Blocking the interaction between the receptor-binding domain (RBD) of the S1 subunit and ACE2 inhibits viral host cell entry; animal studies indicate that antibodies capable of...
Approved
Investigational
Matched Description: … The FDA and Health Canada advise healthcare providers to inform patients of this risk. ... The combination is co-packaged and available under the name EVUSHELD (formerly AZD7442). ... causative agent of COVID-19, enters cells via the interaction between the trimeric spike (S) glycoprotein and …
Matched Categories: … tixagevimab and cilgavimab ... Amino Acids, Peptides, and Proteins ... Immune Sera and Immunoglobulins …
Matched Categories: … tixagevimab and cilgavimab ... Amino Acids, Peptides, and Proteins ... Immune Sera and Immunoglobulins …
Tixagevimab
SARS-CoV-2, the causative agent of COVID-19, enters cells via the interaction between the trimeric spike (S) glycoprotein and host cell angiotensin-converting enzyme 2 (ACE2). Blocking the interaction between the receptor-binding domain (RBD) of the S1 subunit and ACE2 inhibits viral host cell entry; animal studies indicate that antibodies capable of...
Approved
Investigational
Matched Description: … The FDA and Health Canada advise healthcare providers to inform patients of this risk. ... The combination is co-packaged and available under the name EVUSHELD (formerly AZD7442). ... causative agent of COVID-19, enters cells via the interaction between the trimeric spike (S) glycoprotein and …
Matched Categories: … tixagevimab and cilgavimab ... Amino Acids, Peptides, and Proteins ... Immune Sera and Immunoglobulins …
Matched Categories: … tixagevimab and cilgavimab ... Amino Acids, Peptides, and Proteins ... Immune Sera and Immunoglobulins …
Corticotropin
Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis.
Approved
Investigational
Vet approved
Matched Description: … Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by …
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins ... Anterior Pituitary Lobe Hormones and Analogues ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins ... Anterior Pituitary Lobe Hormones and Analogues ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Meticrane
Meticrane is a diuretic medication. It has been marketed in Japan under the trade name Arresten and is used to lower blood pressure .
Approved
Matched Description: … It has been marketed in Japan under the trade name Arresten and is used to lower blood pressure [L5647 …
Matched Categories: … Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …
Matched Categories: … Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …
Imiglucerase
Human Beta-glucocerebrosidase or Beta-D-glucosyl-N-acylsphingosine glucohydrolase E.C. 3.2.1.45. 497 residue protein with N-linked carbohydrates, MW=59.3 kD. Alglucerase is prepared by modification of the oligosaccharide chains of human Beta-glucocerebrosidase. The modification alters the sugar residues at the non-reducing ends of the oligosaccharide chains of the glycoprotein so that they are predominantly terminated...
Approved
Matched Categories: … Enzymes and Coenzymes ... Alimentary Tract and Metabolism …
Octreotide
Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. In most cases, it results from an anterior pituitary growth hormone-releasing tumor. Typically, the feet, hands, and face grow abnormally large; organomegaly and insulin resistance may also occur. Acromegaly is...
Approved
Investigational
Matched Description: … Typically, the feet, hands, and face grow abnormally large; organomegaly and insulin resistance may also ... , including carcinoid tumors and vasoactive intestinal tumors (VIPomas). ... Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and …
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins ... Somatostatin and Analogues …
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins ... Somatostatin and Analogues …
Urokinase
Urokinase is an endogenous peptide that is cleaved in the presence of plasmin between lysine 158 and isoleucine 159 to yield active urokinase. Urokinase remains connected between these 2 chains by a sulfhydryl bond. Urokinase was granted FDA approval on 16 January 1978.
Approved
Investigational
Withdrawn
Matched Description: … Urokinase is an endogenous peptide that is cleaved in the presence of plasmin between lysine 158 and …
Matched Categories: … Enzymes and Coenzymes ... Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …
Matched Categories: … Enzymes and Coenzymes ... Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …
Taliglucerase alfa
Taliglucerase alfa is the recombinant active form of the human lysosomal enzyme, β-glucocerebrosidase. It was approved in 2012 and is marketed under the name Elelyso for use in patients with type 1 Gaucher's disease.
Approved
Investigational
Matched Description: … It was approved in 2012 and is marketed under the name Elelyso for use in patients with type 1 Gaucher's …
Matched Categories: … Enzymes and Coenzymes ... Alimentary Tract and Metabolism …
Matched Categories: … Enzymes and Coenzymes ... Alimentary Tract and Metabolism …
Tenecteplase
Tenecteplase is a tissue plasminogen activator (tPA) developed from modifications of natural human tPA complementary DNA (cDNA). It is a 527 amino acid with a substitution of threonine 103 with asparagine and substitution of asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at amino acids...
Approved
Matched Description: … 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296- ... It is a 527 amino acid with a substitution of threonine 103 with asparagine and substitution of asparagine …
Matched Categories: … Enzymes and Coenzymes ... Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …
Matched Categories: … Enzymes and Coenzymes ... Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …
Elotuzumab
Elotuzumab is a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies. Elotuzumab targets SLAMF7, also known as Signaling Lymphocytic Activation Molecule Family member 7, a cell surface glycoprotein. Elotuzumab...
Approved
Matched Description: … Food and Drug Administration. ... a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and ... complementary determining regions (CDR) of the mouse antibody, MuLuc63, grafted onto human IgG1 heavy and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Displaying drugs 651 - 675 of 14709 in total