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Displaying drugs 701 - 725 of 2005 in total
Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher disease, the accumulation of glucosylceramide leads to...
Approved
Investigational
Matched Description: … This leads to complications such as anemia and thrombocytopenia. ... glucosylceramide leads to the formation of Gaucher cells that infiltrate the liver, spleen, bone marrow and ... characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and
Matched Categories: … Alimentary Tract and Metabolism ... Various Alimentary Tract and Metabolism Products …
Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the nephron in the kidneys by working on the lumenal side. Since it acts on...
Approved
Matched Description: … Triamterene is a weak antagonist of folic acid, and a photosensitizing drug. ... [L6163] Triamterene was approved by the Food and Drug Administration in the U.S. in 1964. ... is approved for use with other diuretics to enhance diuretic and potassium-sparing effects. …
Matched Mixtures name: … Triamterene and Hydrochlorothiazide ... Triamterene and Hydrochlorothiazide ... Triamterene and Hydrochlorothiazide …
Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug administration). Vilanterol was...
Approved
Matched Description: … 5 years and older respectively. ... [A259961] Vilanterol is 1000 and 400 fold more selective for β2 than β1 and β3 adrenoceptors, respectively ... BREO ELLIPTA are approved for maintenance treatments of asthma in patients aged 18 years and older and
Matched Mixtures name: … Fluticasone Furoate and Vilanterol ... Fluticasone Furoate and Vilanterol …
Matched Categories: … vilanterol and fluticasone furoate ... vilanterol and umeclidinium bromide ... vilanterol, umeclidinium bromide and fluticasone furoate …
Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of venlafaxine. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of adults with major depressive disorder (MDD).[L6016,A261271] MDD is a highly...
Approved
Investigational
Matched Description: … a highly prevalent psychiatric disorder, with a lifetime prevalence estimate of 16% in the US alone and ... [A261271] Desvenlafaxine has a very similar pharmacological, efficacy, and safety profile as [venlafaxine …
Matched Categories: … Serotonin and Noradrenaline Reuptake Inhibitors …
Tisotumab vedotin is a tissue factor-directed antibody-drug conjugate (ADC) comprised of an anti-tissue factor (TF) human IgG1-kappa antibody conjugated to monomethyl auristatin E (MMAE), a microtubule-disrupting agent, via a protease-cleavable valine-citrulline linker. Each monoclonal antibody molecule carries an average of four MMAE molecules. Tisotumab vedotin is the first TF-directed ADC...
Approved
Matched Description: … vedotin is a tissue factor-directed antibody-drug conjugate (ADC) comprised of an anti-tissue factor (TF) human ... head and neck cancers. ... tumor-associated angiogenesis, progression, and metastasis for tumor survival. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Ulipristal is a selective progesterone receptor modulator used for the purposes of emergency contraception (Ella) and for the treatment of uterine fibroids (Fibristal). It is a derivative of 19-norprogesterone and has both antagonistic and partial agonist activity at the progesterone receptor. It also binds to glucocorticoid receptor, however compared to...
Approved
Matched Description: … It is a derivative of 19-norprogesterone and has both antagonistic and partial agonist activity at the ... has lower glucocorticoid activity and better binding affinity. ... a selective progesterone receptor modulator used for the purposes of emergency contraception (Ella) and
Matched Categories: … Genito Urinary System and Sex Hormones ... Sex Hormones and Modulators of the Genital System …
Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including aripiprazole, paliperidone and clozapine available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumateperone is a newly approved 2nd generation antipsychotic currently indicated for the...
Approved
Investigational
Matched Description: … Schizophrenia is a complex mental illness and impacts approximately 1% of the population. ... [L10902] Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine ... ] available for clinical use, they are generally accompanied by significant metabolic and/or neurological …
Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quantities of the...
Approved
Matched Description: … a ratio of T4 to T3 of 4.2:1, which is significantly lower than the 14:1 ratio of secretion by the human ... produce sufficient quantities of the thyroid hormones T4 (tetraiodothyronine or thyroxine) and ... hypothyroidism begin to develop such as fatigue, increased heart rate, depression[A179620], dry skin and
Matched Mixtures name: … Levothyroxine and Liothyronine Thyroid ... Levothyroxine and Liothyronine Thyroid ... Levothyroxine and Liothyronine Thyroid …
Matched Categories: … Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins ... levothyroxine sodium and iodine compounds ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Synthetic conjugated estrogens A are composed of a blend of the following nine synthetic estrogenic substances: estrone sulfate, sodium equilin sulfate, sodium 17α-dihydroequilin sulfate, sodium 17α-estradiol sulfate, sodium 17β­ dihydroequilin sulfate, sodium 17α-dihydroequilenin sulfate, sodium 17β-dihydroequilenin sulfate, sodium equilenin sulfate, and sodium 17β-estradiol sulfate. This blend of nine estrogen derivatives...
Approved
Matched Description: … sodium equilin sulfate), they vary by their original source (such as horse-, human-, or plant-derived ... dryness, and vulvovaginal atrophy. ... estradiol by the ovaries and a consequent fluctuation in LH and FSH due to a lack of feedback control …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Synthetic conjugated estrogens, B tablets contain a blend of ten synthetic estrogenic substances. The estrogenic substances are: sodium estrone sulfate, sodium equilin sulfate, sodium 17α-dihydroequilin sulfate, sodium 17α-estradiol sulfate, sodium 17β­ dihydroequilin sulfate, sodium 17α-dihydroequilenin sulfate, sodium 17β-dihydroequilenin sulfate, sodium equilenin sulfate, sodium 17β-estradiol sulfate, and sodium Δ8,9-dehydroestrone sulfate. This...
Approved
Matched Description: … sodium equilin sulfate), they vary by their original source (such as horse-, human-, or plant-derived ... dryness, and vulvovaginal atrophy. ... estradiol by the ovaries and a consequent fluctuation in LH and FSH due to a lack of feedback control …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Human growth hormone (HGH), also known as somatotropin, is a peptide hormone that is synthesized and secreted by the somatotropic cells of the anterior pituitary gland. Growth hormone plays an essential role in growth regulation during childhood as well as other basal metabolic functions, muscle and fat mass regulation, blood...
Approved
Investigational
Matched Synonyms: … Recombinant human growth hormone ... Somatropin recombinant ... Somatropin (recombinant DNA origin) …
Matched Description: … Human growth hormone (HGH), also known as somatotropin, is a peptide hormone that is synthesized and ... [A228188] Recombinant growth hormone is available as a subcutaneous injection for children and adults ... [Somatrem] was the first available recombinant HGH and was largely replaced by somatropin, another form …
Matched Categories: … Recombinant Human Growth Hormone ... Human Growth Hormone, antagonists & inhibitors ... Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins …
Matched Products: … ZOMACTON Powder and Solvent for Solution for Injection 10mg ... ZOMACTON Powder and Solvent for Solution for Injection 4 mg ... GENOTROPIN® 12MG POWDER AND SOLVENT FOR SOLUTION FOR INJECTION …
Approved
Investigational
Matched Name: … Human papillomavirus type 18 L1 capsid protein residues 2-472 antigen …
Talquetamab is a IgG4-PAA bispecific G protein-coupled receptor class C group 5 member D (GPRC5D)-directed CD3 T-cell engager. It consists of two arms - anti-GPRC5D and anti-CD3 arms - linked by two interchain disulfide bonds, each arm comprising a heavy and light chain. Talquetamab binds to GPRC5D, a cell surface...
Approved
Investigational
Matched Synonyms: … IMMUNOGLOBULIN G4-KAPPA/G4-LAMBDA, ANTI-(HOMO SAPIENS GPRC5D (G PROTEIN-COUPLED RECEPTOR CLASS C GROUP ... IMMUNOGLOBULIN G4-KAPPA/G4-LAMBDA, ANTI-(HOMO SAPIENS GPRC5D (G PROTEIN-COUPLED RECEPTOR CLASS C GROUP ... IMMUNOGLOBULIN G4 (233-PROLINE,239-ALANINE,240-ALANINE,410-LEUCINE,414-LYSINE), ANTI-(HUMAN CD3 ANTIGEN …
Matched Description: … Talquetamab is a IgG4-PAA bispecific G protein-coupled receptor class C group 5 member D (GPRC5D)-directed ... [A260890] The Committee for Medicinal Products for Human Use (CHMP) of the EMA recommended conditional ... arm comprising a heavy and light chain. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Vonicog alfa is a recombinant von Willebrand factor manufactured by Baxalta. It was FDA approved in December 2015. The gen of von Willebrand factor was first cloned in 1985 by Stuart Orkin and David Ginsburg. By the EMA, vonicog alfa is still under clinical analysis.
Approved
Investigational
Matched Synonyms: … Von willebrand factor, recombinant, human ... Von willebrand factor (recombinant) …
Matched Description: … Vonicog alfa is a recombinant von Willebrand factor manufactured by Baxalta. ... [A32230] The gen of von Willebrand factor was first cloned in 1985 by Stuart Orkin and David Ginsburg …
Human alpha-1 proteinase inhibitor or alpha-1-antitrypsin, prepared from human plasma via Cohn alcohol fractionation followed by PEG and zinc chloride fractionation.
Approved
Matched Synonyms: … Recombinant secretory leucocyte protease inhibitor ... Recombinant secretory leukocyte protease inhibitor ... .Alpha.1-proteinase inhibitor human
Matched Description: … fractionation followed by PEG and zinc chloride fractionation. ... Human alpha-1 proteinase inhibitor or alpha-1-antitrypsin, prepared from human plasma via Cohn alcohol …
Matched Categories: … Human alpha-1 Proteinase Inhibitor ... Enzymes and Coenzymes ... Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …
Matched Products: … Alpha1-proteinase Inhibitor (human) …
Teprotumumab is a fully human IgG1 monoclonal antibody directed against the human insulin-like growth factor-1 receptor. Following a clinical trial in which its efficacy in the treatment of thyroid eye disease (TED) was assessed, it received "breakthrough therapy" designation from the FDA in 2016 and was approved by the FDA...
Approved
Investigational
Matched Synonyms: … Immunoglobulin G1, anti-(human insulin-like growth factor I receptor) (human monoclonal heavy chain), ... disulfide with human monoclonal light chain, dimer …
Matched Description: … Teprotumumab is a fully human IgG1 monoclonal antibody directed against the human insulin-like growth ... tissue remodeling behind the eye, and previous treatment options typically involved multiple invasive ... disease (TED) was assessed, it received "breakthrough therapy" designation from the FDA in 2016[A190129] and
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Lecanemab is a recombinant humanized immunoglobulin gamma 1 (IgG1) monoclonal antibody directed against aggregated soluble and insoluble forms of amyloid beta (Aβ), which are implicated in the pathophysiology of Alzheimer’s disease. Lecanemab works to reduce Aβ plaques and prevent Aβ deposition in the brain [A253947,A253952] with high selectivity to Aβ...
Approved
Investigational
Matched Synonyms: … Immunoglobulin G1, anti-(human beta-amyloid protofibril) (human-mus musculus monoclonal BAN2401 heavy ... chain), disulfide with human-mus musculus monoclonal BAN2401 light chain, dimer …
Matched Description: … Lecanemab is a recombinant humanized immunoglobulin gamma 1 (IgG1) monoclonal antibody directed against ... [L44537] Lecanemab works to reduce Aβ plaques and prevent Aβ deposition in the brain [A253947,A253952 ... aggregated soluble and insoluble forms of amyloid beta (Aβ), which are implicated in the pathophysiology …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This recombinant form differs from...
Approved
Matched Synonyms: … Recombinant human interleukin-2 ... Recombinant interleukin-2 human ... 125-L-serine-2-133-interleukin 2 (human reduced) …
Matched Description: … Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression ... clone encodes a modified human interleukin-2. ... Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Intercellular Signaling Peptides and Proteins …
Teriparatide is a recombinant parathyroid hormone (PTH) analog and a potent osteoanabolic agent. It is made up of the first amino(N)-terminal 34 amino acids of the human PTH. First approved in the United States in November 2002 and in Europe in April 2003, teriparatide makes the first approved drug in...
Approved
Investigational
Matched Synonyms: … Teriparatide recombinant human
Matched Description: … Teriparatide is a recombinant parathyroid hormone (PTH) analog and a potent osteoanabolic agent. ... [A251395] It is made up of the first amino(N)-terminal 34 amino acids of the human PTH. ... [A251395] Teriparatide is used in the treatment of osteoporosis in men and women.[L42590, L42595] …
Matched Categories: … Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins ... Parathyroid Hormones and Analogues ... Calcium-Regulating Hormones and Agents ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Products: … MEGAPTH-G Teriparatide 20 micrograms / 80 microliters solution for injection …
Velmanase alfa is a recombinant human lysosomal alpha-mannosidase developed for enzyme replacement therapy to treat alpha-mannosidosis. Alpha-mannosidosis is a rare autosomal recessive lysosomal storage disorder. Patients with alpha-mannosidosis have a genetic mutation that causes a deficiency in the lysosomal enzyme alpha-mannosidase, which is an enzyme responsible for breaking down complex...
Approved
Investigational
Matched Synonyms: … Recombinant Human Alpha Mannosidase …
Matched Description: … Velmanase alfa is a recombinant human lysosomal alpha-mannosidase developed for enzyme replacement therapy ... recombinant form of alpha-mannosidase for the treatment of alpha-mannosidosis. ... deterioration, such as skeletal abnormalities, motor function impairment, intellectual disability, and
Matched Categories: … Recombinant Human Lysosomal alpha-Mannosidase ... Enzymes and Coenzymes ... Alimentary Tract and Metabolism …
Coagulation Factor XIII A-Subunit (Recombinant), also known as catridecacog, is a recombinant form of the Factor XIII-A2 homodimer composed of two factor XIII (FXIII) A-subunits [FDA Label]. For people with congenital deficiency or mutation of Factor XIII, a rare bleeding disorder, exogenous replacement of this key coagulation factor is essential...
Approved
Matched Synonyms: … Human Factor XIII (A2) homodimer (allele F13A*1B), recombinant DNA origin ... Blood Coagulation Factor XIII (Synthetic Human A-Chain Precursor) ... Factor XIII A-Subunit (Recombinant) …
Matched Description: … technology where the target protein is grown in yeast and then isolated, the human form is isolated ... human FXIII B-subunit resulting in a heterotetramer (rA2B2) with a similar activity profile and half-life ... from pooled human plasma. …
Matched Categories: … Blood and Blood Forming Organs …
Interferon a (human leukocyte protein moiety reduced). A type I interferon consisting of 165 amino acid residues with lysine in position 23. This protein is produced by recombinant DNA technology and resembles interferon secreted by leukocytes. It is used extensively as an antiviral or antineoplastic agent. An oral form is...
Approved
Investigational
Matched Synonyms: … Recombinant human interferon alfa-2a ... Recombinant human interferon-alfa-2a ... Interferon alfa-2a,recombinant
Matched Description: … This protein is produced by recombinant DNA technology and resembles interferon secreted by leukocytes ... Interferon a (human leukocyte protein moiety reduced). …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Intercellular Signaling Peptides and Proteins …
Somatrogon is a long-acting recombinant human growth hormone. Growth hormone is a peptide hormone secreted by the pituitary gland that plays a crucial role in promoting longitudinal growth during childhood and adolescence and regulating metabolic function in adulthood. Recombinant growth hormone therapy for growth hormone deficiency and other conditions has...
Approved
Matched Synonyms: … Recombinant human growth hormone long acting (fused w beta chains of HCG) ... .)-(118-145)-PEPTIDE (1-28) WITH HUMAN SOMATOTROPIN (GROWTH HORMONE, GH) (29-219) AND TWO TANDEM COPIES ... (HUMAN .BETA. …
Matched Description: … Somatrogon is a long-acting recombinant human growth hormone. ... chorionic gonadotropin (hCG) to the N-terminus and C-terminus of human growth hormone. ... [A241515] Recombinant growth hormone therapy for growth hormone deficiency and other conditions has been …
Matched Categories: … Recombinant Human Growth Hormone ... Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins ... Somatropin and Somatropin Agonists …
Human recombinant alpha-L-iduronidase, 628 residues (mature form), produced by recombinant DNAtechnology in a Chinese hamster ovary cell line. Laronidase is a glycoprotein with a molecular weight of approximately 83 kD. The predicted amino acid sequence of the recombinant form, as well as the nucleotide sequence that encodes it, are identical...
Approved
Matched Synonyms: … Human Recombinant alpha-L-iduronidase …
Matched Description: … Human recombinant alpha-L-iduronidase, 628 residues (mature form), produced by recombinant DNAtechnology ... it, are identical to a polymorphic form of human a-L-iduronidase. ... The predicted amino acid sequence of the recombinant form, as well as the nucleotide sequence that encodes …
Matched Categories: … Enzymes and Coenzymes ... Alimentary Tract and Metabolism …
Dornase alfa is a biosynthetic form of human deoxyribunuclease I (DNase I) enzyme. It is produced in genetically modified Chinese hamster ovary (CHO) cells using recombinant DNA technology. The 260-amino acid sequence of dornase alfa is identical to the endogenous human enzyme. Dornase alfa cleaves extracellular DNA to 5´-phosphodinucleotide and...
Approved
Matched Synonyms: … Deoxyribonuclease (human clone 18-1 protein moiety) ... Dornase alfa, recombinant ... Recombinant deoxyribonuclease (DNAse) …
Matched Description: … It is produced in genetically modified Chinese hamster ovary (CHO) cells using recombinant DNA technology ... Dornase alfa is a biosynthetic form of human deoxyribunuclease I (DNase I) enzyme. ... The 260-amino acid sequence of dornase alfa is identical to the endogenous human enzyme. …
Matched Categories: … Recombinant Human Deoxyribonuclease 1 ... Enzymes and Coenzymes ... Cough and Cold Preparations ... Amino Acids, Peptides, and Proteins …
Displaying drugs 701 - 725 of 2005 in total