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Displaying drugs 51 - 75 of 9336 in total

Megestrol acetate

17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione. A progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative treatment of breast cancer.
Approved
Investigational
Vet approved
Matched Description: … As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor …

Gadodiamide

Gadodiamide is a linear, non-ionic gadolinium-based contrast agent (GBCA) that is used in magnetic resonance imaging (MRI) procedures to assist in the visualization of blood vessels.[A263086,A263091] GBCAs constitute the largest group of MR agents, and they are thought to be safer than nonionic iodinated contrast agents. Approved by the FDA...
Approved
Investigational
Matched Description: … [A263096] Approved by the FDA in 1993, gadodiamide is the first non-ionic GBCA to be used. ... Gadodiamide is a linear, non-ionic gadolinium-based contrast agent (GBCA) that is used in magnetic resonance ... [A263086,A263091] GBCAs constitute the largest group of MR agents, and they are thought to be safer than …
Matched Categories: … Paramagnetic Contrast Agent …

Quaternium-15

Quaternium-15 is a quaternary ammonium salt used as a surfactant and preservative in many products including cosmetics. It is an anti-microbial agent by virtue of being a formaldehyde releaser, however this can also cause contact dermatitis, a symptom of an allergic reaction, especially in those with sensitive skin. In 2005,...
Approved
Experimental
Matched Description: … It is an anti-microbial agent by virtue of being a formaldehyde releaser, however this can also cause ... most frequently positive allergens identified in patch tests by the North American Contact Dermatitis Group ... contact dermatitis, a symptom of an allergic reaction, especially in those with sensitive skin. …

Brinzolamide

Brinzolamide is a highly specific, non-competitive, reversible carbonic anhydrase II (CA-II) inhibitor indicated to reduce ocular pressure in patients with ocular hypertension or open-angle glaucoma. Although the exact pathophysiology of glaucoma is still unknown, one of the main hallmarks of this disease is vascular dysregulation and abnormalities.[A2049,A2051] The resulting vascular...
Approved
Matched Description: … has been used for almost 50 years with varying degrees of success, systemic administration results in an ... [L35310,L35315] In Europe, it was also approved as a combination product with timolol in 2008. ... [A2051] Brinzolamide was approved by the FDA in 1998 as a standalone product and in 2013 as a combination …

Castor oil

Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (Ricinus communis L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of DB02955, which represents up to 90% of the total castor oil content. It also consists...
Approved
Investigational
Nutraceutical
Vet approved
Matched Description: … It is an FDA-approved food additive directly added to food products for human consumption. ... [DB02955] has a hydroxyl group that provides a functional group location for various chemical reactions ... It can also be found in hard candies as a release agent and anti-sticking agent, or supplementary vitamins …

Propanoic acid

Sodium propionate is the sodium salt of propionic acid that exists as colorless, transparent crystals or a granular crystalline powder. It is considered generally recognized as safe (GRAS) food ingredient by FDA, where it acts as an antimicrobial agent for food preservation and flavoring agent. Its use as a food...
Approved
Vet approved
Matched Description: … Sodium propionate was previously approved in Canada as an active ingredient in Amino-Cerv (used to treat ... agent for food preservation and flavoring agent. ... Its use as a food additive is also approved in Europe. …

Foreskin keratinocyte (neonatal)

Skin, the largest organ of the human body, plays the main role in protecting the body from mechanical damage. It is composed of epidermal, dermal and hypodermal layers. The barrier function of the skin owed to its avascular epidermal layer, which is made mainly of keratinocytes. The keratinocytes form a...
Approved
Matched Description: … In 1981, O’Conner and his group utilized cultured autologous epithelium to coat burn defects for the ... When an epidermal layer was added, this approach became known as "skin equivalent", "composite culture ... Foreskin keratinocytes are an important ingredient in several skin substitutes [L2460], used for various …

N-alkyl ethylbenzyl dimethyl ammonium (C12-C14)

N-alkyl ethylbenzyl dimethyl ammonium (c12-c14) is a quaternary ammonium compound with surfactant properties. It is found in sanitizing solutions or soaps as an active ingredient due to its antimicrobial properties. Employed in a great variety of cleaning agents and sanitizing agents, it possesses relatively broad gram-positive and gram-negative antibacterial activities...
Approved
Matched Description: … It is found in sanitizing solutions or soaps as an active ingredient due to its antimicrobial properties …

Pafolacianine

Pafolacianine, or OTL38, is a folate analogue conjugated with a fluorescent dye that absorbs light in the near-infrared (NIR) spectrum within a range of 760 nm to 785 nm, with a peak absorption of 776 nm. It emits fluorescence within a range of 790 nm to 815 nm with a...
Approved
Investigational
Matched Description: … [A242572] On November 29, 2021, the FDA approved pafolacianine as an adjunct imaging agent for intraoperative …
Matched Categories: … Optical Imaging Agent …

Ambrisentan

Ambrisentan is an orally active selective type A endothelin receptor antagonist indicated for the treatment of pulmonary arterial hypertension. It is approved in Europe, Canada and the United States for use as a single agent to improve exercise ability and delay clinical worsening. In addition, it is approved in the...
Approved
Investigational
Matched Description: … It is approved in Europe, Canada and the United States for use as a single agent to improve exercise ... Ambrisentan is an orally active selective type A endothelin receptor antagonist indicated for the treatment ... In addition, it is approved in the United States for use in combination with tadalafil to reduce the …

Andusomeran

Andusomeran is a COVID-19 mRNA vaccine developed for use during the 2023-2024 season.[L40074,L48832,L48837] It is similar to previous mRNA vaccines developed by Moderna (e.g. elasomeran, imelasomeran), but is designed to be effective against the Omicron XBB.1.5 subvariant.
Approved

Lapatinib

Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a...
Approved
Investigational
Matched Description: … Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours ... It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer …

Albumin iodinated I-125 serum

I-125 iodinated albumin is a radiolabeled albumin-based diagnostic agent used in the determination of total blood and plasma volume.
Approved
Matched Description: … I-125 iodinated albumin is a radiolabeled albumin-based diagnostic agent used in the determination of …
Matched Categories: … Radioactive Diagnostic Agent …

Technetium Tc-99m albumin colloid

Approved
Experimental
Matched Categories: … Radioactive Diagnostic Agent …

Carteolol

A beta-adrenergic antagonist used as an anti-arrhythmia agent, an anti-angina agent, an antihypertensive agent, and an antiglaucoma agent.
Approved
Matched Description: … agent, and an antiglaucoma agent. ... A beta-adrenergic antagonist used as an anti-arrhythmia agent, an anti-angina agent, an antihypertensive …

Dicyclomine

Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may have been based on a small...
Approved
Matched Categories: … Synthetic Anticholinergics, Esters With Tertiary Amino Group …

Phenylacetic acid

Phenylacetic acid is an organic compound containing a phenyl functional group and a carboxylic acid functional group. It is a white solid with a disagreeable odor. Because it is used in the illicit production of phenylacetone (used in the manufacture of substituted amphetamines), it is subject to controls in countries...
Approved
Matched Description: … Phenylacetic acid is an organic compound containing a phenyl functional group and a carboxylic acid functional ... group. …
Matched Categories: … Nitrogen Binding Agent …

Tafenoquine

Tafenoquine is an 8-aminoquinoline analogue of primaquine which varies only on the presence of a 5-phenoxy group.[A35671, A35690] It was discovered by the scientists at the Walter Reed Army Institute of Research in 1978 as a substitute for primaquine that would be more effective against relapsing vivax malaria. Tafenoquine was...
Approved
Investigational
Matched Description: … group. ... [A35677] It was FDA approved on July 20, 2018.[L3770] ... Tafenoquine is an 8-aminoquinoline analogue of primaquine which varies only on the presence of a 5-phenoxy …

Lutetium Lu-177 vipivotide tetraxetan

Lutetium Lu-177 vipivotide tetraxetan is a radioligand therapeutic agent. It consists of a radionuclide, lutetium Lu-177, linked to a moiety that binds to PSMA, a transmembrane protein that is expressed in prostate cancer. Lutetium Lu-177 vipivotide tetraxetan was first approved by the FDA on March 23, 2022 as a treatment...
Approved
Matched Description: … Lutetium Lu-177 vipivotide tetraxetan is a radioligand therapeutic agent. ... [L43787] In December 2022, lutetium Lu-177 vipivotide tetraxetan was approved by the EMA. ... [L41280] Lutetium Lu-177 vipivotide tetraxetan was first approved by the FDA on March 23, 2022 as …
Matched Categories: … Radioactive Therapeutic Agent ... Radioligand Therapeutic Agent …

Thallous chloride

Thallous chloride (also known as Thallium(I) chloride) is a colourless solid intermediate in the isolation of thallium from its ores. It is created from the treatment of thallium(I) sulfate with hydrochloric acid. This solid crystallizes in the caesium chloride motif. It is used as a diagnostic radiopharmaceutical. It is used...
Approved
Matched Categories: … Radioactive Diagnostic Agent …

Antrafenine

Antrafenine is a piperazine derivative drug that acts as an analgesic and anti-inflammatory drug with similar efficacy to naproxen. It is not widely used as it has largely been replaced by newer drugs.
Approved
Matched Description: … Antrafenine is a piperazine derivative drug that acts as an analgesic and anti-inflammatory drug with …

Clotrimazole

This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s . Clotrimazole falls under the imidazole category of azole antifungals, possessing broad-spectrum antimycotic activity . It is available in various preparations, including creams, pessaries, and troche formulations (slowly dissolving tablets). As...
Approved
Vet approved
Matched Description: … This drug is a broad spectrum antimycotic or antifungal agent. ... Clotrimazole falls under the _imidazole_ category of _azole_ antifungals, possessing broad-spectrum antimycotic …

Thiotepa

N,N'N'-triethylenethiophosphoramide (ThioTEPA) is a cancer chemotherapeutic member of the alkylating agent group, now in use for over 50 years. It is a stable derivative of N,N',N''- triethylenephosphoramide (TEPA). It is mostly used to treat breast cancer, ovarian cancer and bladder cancer. It is also used as conditioning for Bone marrow...
Approved
Investigational
Matched Description: … group, now in use for over 50 years. ... ,N'N'-triethylenethiophosphoramide (ThioTEPA) is a cancer chemotherapeutic member of the alkylating agent …

Repotrectinib

Repotrectinib is a next-generation tyrosine kinase inhibitor (TKI) specifically designed to address resistance in the treatment of non-small cell lung cancer (NSCLC), specifically due to mutations in the ROS1 gene. ROS1 mutations are one of the defined oncogenic drives of NSCLC, and the solvent-front mutation ROS1 G2032R is responsible for...
Approved
Investigational
Matched Description: … [A262066] On November 15th, 2023, the FDA approved repotrectinib under the brand name Augtyro for …

Gallium citrate Ga-67

Gallium citrate Ga 67 is the citrate salt of the radioisotope gallium Ga 67. Although the mechanism is unknown, gallium Ga 67 concentrates in lysosomes and is bound to a soluble intracellular protein in certain viable primary and metastatic tumors and focal sites of inflammation, allowing scintigraphic localization. Ga-67 scintigraphy...
Approved
Matched Categories: … Radioactive Diagnostic Agent …
Displaying drugs 51 - 75 of 9336 in total