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Displaying drugs 7526 - 7550 of 10582 in total

Darusentan

Darusentan is a selective endothelin ETA receptor antagonist. It is being evaluated as a treatment for congestive heart failure and hypertension.
Investigational
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Abafungin

Investigational
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Tezosentan

Tezosentan is an intravenous endothelin receptor A/B antagonist. Tezosentan was initially developed for vasodilation in patients with acute heart failure but studies have shown that it does not assist in the treatment of dyspnea or prevent cardiovascular events.
Investigational
Matched Categories: … Heterocyclic Compounds, 1-Ring …

PF-06282999

Pf 06282999 is under investigation in clinical trial NCT01626976 (A Study To Assess The Safety, Tolerability And Pharmacokinetics Of PF-06282999 Administered Orally In Healthy Adult Subjects).
Investigational
Matched Iupac: … 2-[6-(5-chloro-2-methoxyphenyl)-4-oxo-2-sulfanylidene-1,2,3,4-tetrahydropyrimidin-1-yl]acetamide …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Verdinexor

Kpt 335 is under investigation in clinical trial NCT02431364 (Trial of Safety and Tolerability of Oral Verdinexor (Verdinexor) in Healthy Adults).
Investigational
Matched Iupac: … (2Z)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-N'-(pyridin-2-yl)prop-2-enehydrazide …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

GDC-0152

GDC-0152 has been used in trials studying the treatment of Solid Cancers.
Investigational
Matched Iupac: … (2S)-1-[(2S)-2-cyclohexyl-2-[(2S)-2-(methylamino)propanamido]acetyl]-N-(4-phenyl-1,2,3-thiadiazol-5-yl …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Pimonidazole

Pimonidazole is under investigation for the diagnostic of Prostate Cancer and Head and Neck Cancer.
Investigational
Matched Iupac: … 1-(2-nitro-1H-imidazol-1-yl)-3-(piperidin-1-yl)propan-2-ol …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Rimacalib

Rimacalib has been used in trials studying the treatment of Rheumatoid Arthritis (RA).
Investigational
Matched Iupac: … N-{3-[(1S)-1-{2-fluoro-[1,1'-biphenyl]-4-yl}ethyl]-1,2-oxazol-5-yl}morpholine-4-carboximidamide …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Tipepidine

Experimental
Matched Iupac: … 3-[bis(thiophen-2-yl)methylidene]-1-methylpiperidine …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Inavolisib

Inavolisib (GDC-0077) is under investigation in clinical trial NCT03006172 (To Evaluate the Safety, Tolerability, and Pharmacokinetics of GDC-0077 Single Agent in Participants With Solid Tumors and in Combination With Endocrine and Targeted Therapies in Participants With Breast Cancer).
Investigational
Matched Iupac: … [(4S)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-9-oxa-3,6-diazatricyclo[8.4.0.0^{2,6}]tetradeca-1( …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Citarinostat

Citarinostat is under investigation in clinical trial NCT02886065 (A Study of PVX-410, a Cancer Vaccine, and Citarinostat +/- Lenalidomide for Smoldering MM).
Investigational
Matched Categories: … Heterocyclic Compounds, 1-Ring …

GSK2256098

GSK2256098 is under investigation in clinical trial NCT02523014 (Vismodegib and FAK Inhibitor GSK2256098 in Treating Patients With Progressive Meningiomas).
Investigational
Matched Iupac: … 2-[(5-chloro-2-{[3-methyl-1-(propan-2-yl)-1H-pyrazol-5-yl]amino}pyridin-4-yl)amino]-N-methoxybenzamide …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Treamid

Treamid, also known as bisamide derivative of dicarboxylic acid (BDDA), is a complexing agent that has been found to chelate metal ions, including calcium, copper, iron, magnesium, and zinc. This drug has shown regenerative properties and restoration of the function of various tissues and organs. It is has been investigated...
Investigational
Matched Categories: … Heterocyclic Compounds, 1-Ring …

12-Bromododecanoic Acid

Experimental

18-methoxycoronaridine

18-methoxycoronaridine is under investigation in clinical trial NCT03084952 (Phase 2 Trial to Evaluate 18-Methoxycoronaridine Efficacy, Safety and Tolerability in Cutaneous Leishmaniasis Patients).
Investigational
Matched Iupac: … methoxyethyl)-3,13-diazapentacyclo[13.3.1.0^{2,10}.0^{4,9}.0^{13,18}]nonadeca-2(10),4(9),5,7-tetraene-1- …

Acetyleneurea

Experimental
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Asimadoline

Asimadoline is a proprietary small molecule therapeutic, originally discovered by Merck KGaA of Darmstadt, Germany. Asimadoline was originally developed to treat peripheral pain such as arthritis. Asimadoline is an orally administered agent that acts as a kappa opioid receptor agonist. It has shown encouraging clinical efficacy for the treatment of...
Investigational
Matched Iupac: … N-[(1S)-2-[(3S)-3-hydroxypyrrolidin-1-yl]-1-phenylethyl]-N-methyl-2,2-diphenylacetamide …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

TAK-475

TAK-475 is a "squalene synthase inhibitor", a type of cholesterol-lowering drug that has not yet been brought to market.
Investigational
Matched Categories: … Heterocyclic Compounds, 1-Ring …

PF-03758309

PF-03758309 has been used in trials studying the treatment of Advanced Solid Tumors.
Investigational
Matched Iupac: … N-[(1S)-2-(dimethylamino)-1-phenylethyl]-6,6-dimethyl-3-({2-methylthieno[3,2-d]pyrimidin-4-yl}amino)- …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

PF-04418948

Pf 04418948 is under investigation in clinical trial NCT01002963 (A Study To Investigate The Safety And Toleration Of A Single Dose Of PF-04418948 In Healthy Volunteers).
Investigational
Matched Iupac: … 1-(4-fluorobenzoyl)-3-{[(6-methoxynaphthalen-2-yl)oxy]methyl}azetidine-3-carboxylic acid …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Radiprodil

Radiprodil has been used in trials studying the treatment of Infantile Spasms (IS) and Diabetic Peripheral Neuropathic Pain.
Investigational
Matched Iupac: … 2-{4-[(4-fluorophenyl)methyl]piperidin-1-yl}-2-oxo-N-(2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)acetamide …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

ACT-451840

ACT-451840 has been used in trials studying Malaria.
Investigational
Matched Iupac: … )methyl]piperazin-1-yl}-1-oxo-3-phenylpropan-2-yl]prop-2-enamide ... (2E)-N-{[4-(4-acetylpiperazin-1-yl)phenyl]methyl}-3-(4-tert-butylphenyl)-N-[(2S)-1-{4-[(4-cyanophenyl …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

PM-060184

PM060184 has been used in trials studying Solid Tumors.
Investigational
Matched Iupac: … (1Z,4S,6Z)-1-[(2S)-2-[(2Z,4Z,6E,8S)-8-[(2S)-5-methoxy-6-oxo-3,6-dihydro-2H-pyran-2-yl]-6-methylnona-2,4,6 …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

PF-5190457

PF-5190457 is under investigation in clinical trial NCT01522807 (A Study Of Three PF-05190457 Formulations In Healthy Volunteers).
Investigational
Matched Iupac: … -1-yl]-2,7-diazaspiro[3.5]nonan-7-yl}ethan-1-one ... 2-{2-methylimidazo[2,1-b][1,3]thiazol-6-yl}-1-{2-[(1R)-5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

PF-06700841

PF-06700841 is under investigation in clinical trial NCT03236493 (Safety and Pharmacokinetic Study of PF-06700841 in Japanese Healthy Volunteers).
Investigational
Matched Iupac: … 4-[(1R,5S)-8-[(1S)-2,2-difluorocyclopropanecarbonyl]-3,8-diazabicyclo[3.2.1]octan-3-yl]-N-(1-methyl-1H-pyrazol …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Displaying drugs 7526 - 7550 of 10582 in total