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Displaying drugs 751 - 775 of 8324 in total
Rilonacept
Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold auto-inflammatory syndrome...
Approved
Investigational
Matched Description: … Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein ... linked to the Fc portion of immunoglobulin G1. ... Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as …
Turoctocog alfa pegol
Turoctocog alfa pegol is a pegylated version of turoctocog alfa. Novo Nordisk's brand name Esperoct (turoctocog alfa pegol, N8-GP) was approved by the US FDA on February 19, 2019.
Fundamentally, the N8-GP moiety is identical to turoctocog alfa, a recombinant human clotting factor VIII (rFVIII) with a truncated B-domain made...
Approved
Matched Description: … Turoctocog alfa pegol is a pegylated version of [turoctocog alfa]. ... During secretion, some rFVIII molecules are cleaved at the C-terminal of the heavy chain (HC) at amino ... from the sequence coding for 10 amino acids from the N-terminus and 11 amino acids from the C-terminus of …
Mexiletine
Antiarrhythmic agent pharmacologically similar to lidocaine. It may have some anticonvulsant properties.
Approved
Investigational
Chlordiazepoxide
An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal.
Approved
Illicit
Investigational
Matched Description: … It has also been used in the symptomatic treatment of alcohol withdrawal. …
Magnesium trisilicate
Magnesium trisilicate is an inorganic compound that is used as an antacid in the treatment of peptic ulcers.
Approved
Matched Description: … Magnesium trisilicate is an inorganic compound that is used as an antacid in the treatment of peptic …
Pomalidomide
Pomalidomide, an analogue of thalidomide, is an immunomodulatory antineoplastic agent. FDA approved on February 8, 2013.
Approved
Matched Description: … Pomalidomide, an analogue of thalidomide, is an immunomodulatory antineoplastic agent. …
Clozapine
Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical". . This low affinity to dopamine receptors results in fewer extrapyramidal side effects,...
Approved
Matched Description: … Despite its effectiveness in treating both positive and negative symptoms of schizophrenia, clozapine ... various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of ... [A256713,A256718] However, continued evidence of its effectiveness led to clozapine's eventual reintroduction …
Famciclovir
Famciclovir, marketed as Famvir by Novartis, is a guanine analogue used to treat herpes virus infections. It is most commonly used to treat herpes zoster (shingles). Famciclovir is a prodrug of penciclovir with higher oral bioavailability.
Approved
Investigational
Matched Description: … Famciclovir is a prodrug of penciclovir with higher oral bioavailability. …
Griseofulvin
An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections.
Approved
Investigational
Vet approved
Matched Description: … Griseofulvin may be given by mouth in the treatment of tinea infections. …
Cetuximab
Cetuximab is a recombinant chimeric human/mouse IgG1 monoclonal antibody that competitively binds to epidermal growth factor receptor (EGFR) and competitively inhibits the binding of epidermal growth factor (EGF). EGFR is a member of the ErbB family of receptor tyrosine kinases found in both normal and tumour cells; it is responsible...
Approved
Matched Description: … [A227963] EGFR is often mutated in certain types of cancer and serves as a driver of tumorigenesis. ... [A227973] EGFR is a member of the ErbB family of receptor tyrosine kinases found in both normal and tumour ... competitively binds to epidermal growth factor receptor (EGFR) and competitively inhibits the binding of …
Oprelvekin
Oprelvekin, the active ingredient in Neumega®, is recombinant Interleukin-11 (IL-11), which is produced in Escherichia coli (E. coli) by recombinant DNA technology. With a molecular mass of approximately 19,000 daltons, the non-glycosylated protein is 177 amino acids in length in comparison to the natural IL-11, which is 178 amino acid...
Approved
Investigational
Matched Description: … With a molecular mass of approximately 19,000 daltons, the non-glycosylated protein is 177 amino acids ... In mice and nonhuman primate studies of animals with moderate and severe myelosuppression, in addition ... animal studies, oprelvekin was also shown to regulate intestinal epithelium growth by enhancing healing of …
Histrelin
Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-controlled, hydrogel polymer reservoirs containing histrelin acetate that...
Approved
Withdrawn
Matched Description: … This drug is a synthetic analog of naturally occurring GnRH with a higher potency. ... (CPP) due to their capacity to reduce LH levels and the concentration of sex steroids. ... Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin …
Polidocanol
Polidocanol is a sclerosing agent indicated to treat uncomplicated spider veins (varicose veins ≤1 mm in diameter) and uncomplicated reticular veins (varicose veins 1 to 3 mm in diameter) in the lower extremity. It is marketed under the brand names Asclera and Varithena. The formula for Polidocanol has the structural...
Approved
Matched Description: … (n) of approximately 9 and a mean molecular weight of approximately 600. ... The formula for Polidocanol has the structural formula C12H25(OCH2CH2)nOH, a mean extent of polymerization …
Taliglucerase alfa
Taliglucerase alfa is the recombinant active form of the human lysosomal enzyme, β-glucocerebrosidase. It was approved in 2012 and is marketed under the name Elelyso for use in patients with type 1 Gaucher's disease.
Approved
Investigational
Matched Description: … Taliglucerase alfa is the recombinant active form of the human lysosomal enzyme, β-glucocerebrosidase …
Macimorelin
Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dependently increase GH levels...
Approved
Investigational
Matched Description: … Risk factors of AGHD include a history of childhood-onset GH deficiency or with hypothalamic/pituitary ... Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of ... specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of …
Nicergoline
An ergot derivative that has been used as a cerebral vasodilator and in peripheral vascular disease. It has been suggested to ameliorate cognitive deficits in cerebrovascular disease.
Approved
Investigational
Enalaprilat
Enalaprilat is the active metabolite of the orally available pro-drug, enalapril. Used in the treatment of hypertension, enalapril is an ACE inhibitor that prevents Angiotensin Converting Enzyme (ACE) from transforming angiotensin I into angiotensin II. As angiotensin II is responsible for vasoconstriction and sodium reabsorption in the proximal tubule of...
Approved
Matched Description: … Enalaprilat is the active metabolite of the orally available pro-drug, [enalapril]. ... Used in the treatment of hypertension, enalapril is an ACE inhibitor that prevents Angiotensin Converting ... the kidney, down-regulation of this protein results in reduced blood pressure and blood fluid volume …
Isosulfan blue
Approved
Guselkumab
Guselkumab is a human immunoglobulin G1 lambda (IgG1λ) monoclonal antibody that selectively blocks interleukin-23. IL-23 is an inflammatory cytokine that activates the CD4+ T-helper (Th17) cell pathway to mediate the inflammatory cascade that induces psoriatic plaque formation . In clinical trials, guselkumab demonstrated improved skin clearance and symptomatic improvements in...
Approved
Investigational
Matched Description: … market name Tremfya for the treatment of adult patients with moderate-to-severe plaque psoriasis. ... demonstrated improved skin clearance and symptomatic improvements in dermatological manifestations of ... Developed by Janssen, the subcutenous injection form of guselkumab was approved in July 2017 under the …
Mogamulizumab
Mogamulizumab is a humanized monoclonal antibody (mAb) directed against CC chemokine receptor 4 (CCR4) for the treatment of Mycosis Fungoides (MF) and Sézary Syndrome (SS), the most common subtypes of cutaneous T-cell lymphoma. Cutaneous T-cell lymphomas occur when certain white blood cells, called T cells, become cancerous; these cancers typically...
Approved
Investigational
Matched Description: … humanized monoclonal antibody (mAb) directed against CC chemokine receptor 4 (CCR4) for the treatment of ... Mycosis Fungoides (MF) and Sézary Syndrome (SS), the most common subtypes of cutaneous T-cell lymphoma ... approved mogamulizumab injection (also known as _Poteligeo_) for intravenous use for the treatment of …
Balsalazide
Balsalazide is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease. It is sold under the name "Colazal" in the US and "Colazide" in the UK.
The chemical name is (E)-5-[[-4-(2-carboxyethyl) aminocarbonyl] phenyl]azo] -2-hydroxybenzoic acid. It is usually administered as the disodium salt.
Balsalazide works by deliverying mesalazine...
Approved
Investigational
Matched Description: … Balsalazide is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease. …
Ambenonium
Ambenonium is a cholinesterase inhibitor. It is used in the management of myasthenia gravis.
Approved
Matched Description: … It is used in the management of myasthenia gravis. …
Thiethylperazine
A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457)
Approved
Withdrawn
Bacillus calmette-guerin substrain connaught live antigen
Bacillus calmette-guerin substrain connaught live antigen is intravesically administered for the treatment and prophylaxis of carcinoma in situ (CIS) of the urinary bladder and for the prophylaxis of primary or recurrent stage Ta and/or T1 papillary tumors following transurethral resection (TUR). The solution contains live, attenuated strain of Mycobacterium bovis....
Approved
Investigational
Matched Description: … carcinoma in situ (CIS) of the urinary bladder and for the prophylaxis of primary or recurrent stage ... The solution contains live, attenuated strain of Mycobacterium bovis. ... It is prepared from the Connaught strain of Bacillus Calmette and Guérin. …
Luspatercept
Luspatercept is a recombinant fusion protein comprised of a modified extracellular domain of activin receptor type IIB fused to the FC domain of human IgG1.[A187829,L42455] It was first approved for use in the United States in November 2019 under the brand name Reblozyl® for the treatment of anemia in patients...
Approved
Investigational
Matched Description: … Luspatercept is a recombinant fusion protein comprised of a modified extracellular domain of activin ... [A187835] Luspatercept's novel mechanism of action, then, is uniquely suited for the treatment of conditions ... receptor type IIB fused to the FC domain of human IgG1. …
Displaying drugs 751 - 775 of 8324 in total