Displaying drugs 826 - 850 of 8179 in total
Povidone
Povidone, also known as polyvinylpyrrolidone (PVP) or polyvidone, is a synthetic water-soluble polymer made from the monomer N-vinylpyrrolidone used as a binder in many pharmaceutical tablets and lubricant in eye drops. It is also used in many technical applications with various roles as an adhesive, additive, and emulsifier. When in...
Approved
Withdrawn
Matched Description: … [L43942] Other formulations of povidone continue to be available. ... The FDA withdrew its approval for the use of all intravenous drug products containing povidone. ... in a few clinical studies that the application of the compound in wounds was associated with impaired …
Efmoroctocog alfa
Efmoroctocog alfa is a fully recombinant factor VIII-Fc fusion protein (rFVIIIFc) with an extended half-life compared with conventional factor VIII (FVIII) preparations, including recombinant FVIII (rFVIII) products such as DB13999 . It is an antihemorrhagic agent used in replacement therapy for patients with haemophilia A (congenital factor VIII deficiency). It...
Approved
Investigational
Matched Description: … The B domain of factor VIII is deleted. ... reduced frequency of injections required and improved adherence to prophylaxis [A31551]. ... Prophylactic treatment may dramatically improve the management of severe haemophilia A in the future …
Omaveloxolone
Omaveloxolone (RTA-408) is a semisynthetic oleanane triterpenoid with antioxidant and anti-inflammatory properties.[A257534,A257539] Omaveloxolone acts as an activator of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), a transcription factor that mitigates oxidative stress. In patients with Friedreich's ataxia, a genetic disease involving mitochondrial dysfunction, the Nrf2 pathway is impaired, and Nrf2 activity...
Approved
Investigational
Matched Description: … group of patients. ... [L45424] The use of omaveloxolone for the treatment of conditions involving mitochondrial dysfunction ... [A257534,A257539] Omaveloxolone acts as an activator of nuclear factor (erythroid-derived 2)-like 2 ( …
Varicella zoster vaccine (recombinant)
Recombinant zoster vaccine, manufactured as the product Shingrix by GlaxoSmithKline, is an adjuvanted non-live recombinant vaccine indicated for prevention of shingles. First approved in October 2017 by the Food and Drug Administration, Shingrix is the preferred vaccine for preventing varicella zoster infection in people aged 50 years and older, replacing...
Approved
Investigational
Matched Description: … Following initial infection of VZV and resolution of Chickenpox as a child, VZV then lies dormant within ... of varicella zoster virus (VZV). ... One of the most common complications associated with shingles is the development of Post-Herpetic Neuralgia …
Mirikizumab
Mirikizumab is a monoclonal antibody developed by Eli Lilly intended to treat ulcerative colitis. It inhibits the actions of interleukin-23 (IL-23), a pro-inflammatory cytokine that activates pathways contributing to the development of inflammatory diseases.[L46237,L46257]
Mirikizumab is approved in Japan and received a positive opinion from the EMA's Committee for Medicinal...
Approved
Investigational
Matched Description: … on the basis of manufacturing concerns. ... contributing to the development of inflammatory diseases. ... It inhibits the actions of interleukin-23 (IL-23), a pro-inflammatory cytokine that activates pathways …
Thyroid, porcine
Thyroid extract is dried and powdered thyroid glands from pigs containing tiiodothyronine (T3) and thyroxine (T4) used to supplement low or absent thyroid activity.[A190831,L11755] Thyroid extract has been described in literature to treat hypothyroidism since 1891 but its use dates back as far as the 6th century. Thyroid extract is...
Approved
Matched Description: … considered a first line therapy as it delivers a dose that is inconsistent with the stated strength of …
Dalfampridine
Dalfampridine is a potassium channel blocker used to help multiple sclerosis patients walk. This is the first drug that was specifically approved to help with mobility in these patients. FDA approved on January 22, 2010.
Approved
Padimate O
Padimate O is an active sunscreen agent in cosmetics and over-the-counter sunscreen drug products in concentrations up to 8%, as regulated by the FDA . It is a structurally-related compound to DB02362 that absorbs UV-B rays to prevent photodamage. It penetrates human skin, and is shown to induce non-ligatable strand...
Approved
Miglitol
Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the body.
Miglitol should be taken at the start...
Approved
Matched Description: … amount of poly and oligosaccharides in the diet. ... used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of ... Miglitol should be taken at the start of a meal for maximal effect and the effect will depend on the …
Imatinib
Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated with...
Approved
Matched Description: … with a daily dosage of 300 mg or more and typically occurred in the first four weeks of therapy". ... The discovery of imatinib also established a new group of therapy called "targeted therapy", since treatment ... can be tailored specifically to the unique cancer genetics of each patient. …
Isoprenaline
Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160]
Isoprenaline research in the 1940s found that this isopropyl analog of epinephrine dilated the bronchi, as well as raising...
Approved
Investigational
Matched Description: … [A15638,L33160]
Isoprenaline research in the 1940s found that this isopropyl analog of epinephrine …
Idelalisib
Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination with rituximab in patients for whom rituximab...
Approved
Matched Description: … Treatment of lymphoma cells with idelalisib has been shown to result in inhibition of chemotaxis and ... Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic ... For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination with …
Boric acid
Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing, but is also used as an additive in pharmaceutical products, cosmetics, lotions, soaps, mouthwash, toothpaste, astringents, and eyewashes . It...
Approved
Matched Description: … Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical …
Cenegermin
Cenegermin is a human beta-nerve growth factor (beta-ngf)-(1-118)- peptide (non-covalent dimer) produced in escherichia coli. It received European Union Approval in July 2017 for the treatment of moderate to severe neurotrophic keratitis. Cenegermin received approval from the US FDA a year later in August of 2018. Neurotrophic keratitis is a...
Approved
Investigational
Matched Description: … The loss of corneal sensation impairs corneal health, causing progressive damage to the top layer of ... [L4563]
While the prevalence of neurotrophic keratitis is low, the impact of this serious condition ... the treatment, diagnosis or prevention of a serious condition. …
Sodium borate
Approved
Experimental
Isradipine
Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affinity and specificity...
Approved
Investigational
Matched Description: … used class of CCBs. ... the alpha-1 subunit of the channel and increased prevalence of inactive channels in smooth muscle cells ... Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely …
Trilostane
Trilostane is an inhibitor of 3 beta-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome. It was withdrawn from the United States market in April 1994.
Approved
Investigational
Vet approved
Withdrawn
Matched Description: … Trilostane is an inhibitor of 3 beta-hydroxysteroid dehydrogenase used in the treatment of Cushing's …
Corticorelin ovine triflutate
Corticorelin, available commercially as corticorelin ovine triflutate (tradename Acthrel), is a synthetic form of the peptide human corticotropin-releasing hormone (hCRH), a potent stimulator of adrenocorticotropic hormone (ACTH) release from the anterior pituitary. Endogenous forms hCRH are involved in the stress response and its main function is stimulation of the pituitary...
Approved
Matched Description: … of a pituitary source from an ectopic source of excessive ACTH secretion. ... It provides a differential diagnosis for Cushing's disease (a pituitary source of ACTH excess) or of ... ectopic ACTH syndrome (an ectopic source of ACTH excess). …
Potassium citrate
Potassium citrate (also known as tripotassium citrate) is a potassium salt of citric acid. It is a white, hygroscopic crystalline powder. It is odorless with a saline taste. It contains 38.3% potassium by mass. In the monohydrate form it is highly hygroscopic and deliquescent.
Potassium citrate is used to treat...
Approved
Investigational
Vet approved
Matched Description: … Potassium citrate (also known as tripotassium citrate) is a potassium salt of citric acid. ... Potassium Citrate is indicated also for the management of Hypocitraturic calcium oxalate nephrolithiasis …
Thonzonium
Thonzonium is a monocationic surface-active agent with surfactant and detergent properties. It is widely used as an additive to in ear and nasal drops to enhance dispersion and penetration of cellular debris and exudate, thereby promoting tissue contact of the administered medication. A common pharmaceutical formulation of thonzonium bromide is...
Approved
Matched Description: … debris and exudate, thereby promoting tissue contact of the administered medication. ... A common pharmaceutical formulation of thonzonium bromide is cortisporin-TC ear drops. ... It is widely used as an additive to in ear and nasal drops to enhance dispersion and penetration of cellular …
Guselkumab
Guselkumab is a human immunoglobulin G1 lambda (IgG1λ) monoclonal antibody that selectively blocks interleukin-23. IL-23 is an inflammatory cytokine that activates the CD4+ T-helper (Th17) cell pathway to mediate the inflammatory cascade that induces psoriatic plaque formation . In clinical trials, guselkumab demonstrated improved skin clearance and symptomatic improvements in...
Approved
Investigational
Matched Description: … market name Tremfya for the treatment of adult patients with moderate-to-severe plaque psoriasis. ... demonstrated improved skin clearance and symptomatic improvements in dermatological manifestations of ... Developed by Janssen, the subcutenous injection form of guselkumab was approved in July 2017 under the …
Plazomicin
Developed by Achaogen biopharmaceuticals, plazomicin is a next-generation aminoglycoside synthetically derived from DB12604. The structure of plazomicin was established via appending hydroxylaminobutyric acid to DB12604 at position 1 and 2-hydroxyethyl group at position 6' . It was designed to evade all clinically relevant aminoglycoside-modifying enzymes, which contribute to the main...
Approved
Investigational
Matched Description: … However, acquired resistance of aminoglycosides may arise through over expression of efflux pumps and ... The structure of plazomicin was established via appending hydroxylaminobutyric acid to [DB12604] at position ... 28th, 2018, plazomicin sulfate was approved by the FDA for use in adult patients for the treatment of …
Faricimab
Retinal vascular diseases (RVDs) such as diabetic macular edema (DME), age-related macular degeneration (AMD), and retinal vein occlusion (RVO) are typically caused by retinal ischemia and subsequent neovascularization (NV).[A225985, A225990, A225995] Vascular endothelial growth factor A (VEGF-A) is a well-known mediator of retinal NV, and many currently approved RVD therapies...
Approved
Investigational
Matched Description: … [A225985, A225990, A225995] Vascular endothelial growth factor A (VEGF-A) is a well-known mediator of ... However, another set of factors, the Tie/Ang axis, comprising the transmembrane Tie-2 receptor and its ... Products for Human Use (CHMP) recommended faricimab be granted marketing authorization for the treatment of …
Tick-borne encephalitis vaccine (whole virus, inactivated)
Tick-borne encephalitis (TBE) is a disease caused by the TBE virus (TBEV), transmitted by ticks from the genus Ixodes. The disease course is variable. Some patients will be asymptomatic or experience a mild febrile illness, while others will experience the full course including neurological symptoms. TBE often manifests in a...
Approved
Matched Description: … then a second phase characterized by various neurological symptoms falling under the categorizations of ... [A237520] Due to a paucity of effective safe and effective acute therapeutic agents, vaccination remains ... recover fully following neurological TBE, neurological sequelae can last for years and rare chronic forms of …
Busulfan
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought...
Approved
Investigational
Matched Description: … It is not a structural analog of the nitrogen mustards. ... It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), …
Displaying drugs 826 - 850 of 8179 in total