Displaying drugs 10451 - 10475 of 12433 in total
Nebicapone
Nebicapone is under investigation in clinical trial NCT03097211 (Effect of BIA 6-512 at Steady-state on the Levodopa Pharmacokinetics With a Single-dose of Levodopa/Benserazide 200/50 mg or With a Single-dose of Levodopa/Benserazide 200/50 mg Plus a Single-dose of Nebicapone 150 mg).
Investigational
Matched Description: … of Levodopa/Benserazide 200/50 mg Plus a Single-dose of Nebicapone 150 mg). ... Nebicapone is under investigation in clinical trial NCT03097211 (Effect of BIA 6-512 at Steady-state ... on the Levodopa Pharmacokinetics With a Single-dose of Levodopa/Benserazide 200/50 mg or With a Single-dose …
TST10088
TST10088 is a recombinant variant of a plant toxin belonging to the family of class II ribosome inactivating proteins. These molecules efficiently kill cells by activating preprogrammed death pathways known as apoptosis. TST10088 has been designed and engineered by Twinstrand to contain a peptide switch that is specifically cleaved by...
Investigational
Matched Description: … TST10088 is a recombinant variant of a plant toxin belonging to the family of class II ribosome inactivating ... Cleavage of the peptide switch activates the prodrug causing ribosomal inactivation and the death of …
BZL101
BZL101 is an oral drug designed for the treatment of advanced breast cancer with a novel mechanism of action. BZL101 targets diseased cells while leaving normal cells healthy and intact.
Investigational
Matched Description: … BZL101 is an oral drug designed for the treatment of advanced breast cancer with a novel mechanism of …
Bencyclane
A vasodilator agent found to be effective in a variety of peripheral circulation disorders. It has various other potentially useful pharmacological effects. Its mechanism may involve block of calcium channels.
Experimental
Matched Description: … Its mechanism may involve block of calcium channels. ... A vasodilator agent found to be effective in a variety of peripheral circulation disorders. …
Lorecivivint
Lorecivivint is under investigation in clinical trial NCT03246399 (A Study of the Safety, Tolerability, and Pharmacokinetics of SM04690 Injectable Suspension Following Single Intradiscal Injection in Subjects With Degenerative Disc Disease).
Investigational
Matched Description: … Lorecivivint is under investigation in clinical trial NCT03246399 (A Study of the Safety, Tolerability ... , and Pharmacokinetics of SM04690 Injectable Suspension Following Single Intradiscal Injection in Subjects …
JNJ-26489112
JNJ-26489112 is under investigation in clinical trial NCT00579384 (A Study of the Effects of JNJ-26489112 on the Photic Induced Paroxysmal Electroencephalogram (EEG) Response in Patients With Photosensitive Epilepsy).
Investigational
Matched Description: … JNJ-26489112 is under investigation in clinical trial NCT00579384 (A Study of the Effects of JNJ-26489112 …
Lulizumab pegol
Lulizumab pegol is under investigation in clinical trial NCT02843659 (Proof of Concept Study to Evaluate the Efficacy and Safety of BMS-931699 (Lulizumab) or BMS-986142 in Primary Sjögren's Syndrome).
Investigational
Matched Description: … the Efficacy and Safety of BMS-931699 (Lulizumab) or BMS-986142 in Primary Sjögren's Syndrome). ... Lulizumab pegol is under investigation in clinical trial NCT02843659 (Proof of Concept Study to Evaluate …
ST-36
ST-36 is a cell-penetrating dominant-negative form of activating transcription factor 5. In 2017, it received orphan drug designation by the FDA for the treatment of glioma.
Investigational
Matched Description: … ST-36 is a cell-penetrating dominant-negative form of activating transcription factor 5. ... In 2017, it received orphan drug designation by the FDA for the treatment of glioma.[L47341] …
16-Bromoepiandrosterone
16-Bromoepiandrosterone is an injectable formulation of a compound called alpha-epi-bromide. It is a chemical relative of DHEA which was selected for development after it showed antiretroviral activity in laboratory tests.
Investigational
Matched Description: … 16-Bromoepiandrosterone is an injectable formulation of a compound called alpha-epi-bromide. ... It is a chemical relative of DHEA which was selected for development after it showed antiretroviral activity …
Trebananib
Trebananib is under investigation for the treatment of Ovarian Cancer, Peritoneal Cancer, and Fallopian Tube Cancer. Trebananib has been investigated for the treatment of Cancer, Oncology, Carcinoma, Metastases, and Colon Cancer, among others.
Investigational
Matched Description: … Trebananib is under investigation for the treatment of Ovarian Cancer, Peritoneal Cancer, and Fallopian ... Trebananib has been investigated for the treatment of Cancer, Oncology, Carcinoma, Metastases, and Colon …
Nivatrotamab
Nivatrotamab is under investigation in clinical trial NCT03860207 (Study of the Safety and Efficacy of Humanized 3F8 Bispecific Antibody (Hu3f8-bsab) in Patients With Relapsed/refractory Neuroblastoma, Osteosarcoma and Other Solid Tumor Cancers).
Investigational
Matched Description: … Nivatrotamab is under investigation in clinical trial NCT03860207 (Study of the Safety and Efficacy of …
AVXS-301
AVXS-301 consists of an adeno-associated virus serotype 9 (AAV9) designed to express the superoxide dismutase 1 (SOD1) gene. It is being investigated for the treatment of Amyotrophic Lateral Sclerosis (ALS).
Investigational
Matched Description: … It is being investigated for the treatment of Amyotrophic Lateral Sclerosis (ALS).[L47077] ... AVXS-301 consists of an adeno-associated virus serotype 9 (AAV9) designed to express the superoxide dismutase …
IDM-4
IDM-4 is an immuno-designed molecule that completed phase I/II of investigation for the treatment of Leukemia. It is a monoclonal antibody-specific antigen that can selectively target cancer-affected cells by coupling with tumor cell-killing MAK cells, which are derived from the patient's own monocytes. Trials of this drug have most likely...
Investigational
Matched Description: … IDM-4 is an immuno-designed molecule that completed phase I/II of investigation for the treatment of ... Trials of this drug have most likely been discontinued by the manufacturer. …
Zinc glycinate
Glycoprotein marker of gastrointestinal cancer.
Experimental
Matched Description: … Glycoprotein marker of gastrointestinal cancer. …
5-Methoxy-N,N-diisopropyltryptamine
5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) is a tryptamine derivative and shares many similarities with schedule I tryptamine hallucinogens such as alpha-ethyltryptamine, N,N-dimethyltryptamine, N,N-diethyltryptamine, bufotenine, psilocybin and psilocin. Since 1999, there has been a growing popularity of 5-MeO-DIPT among drug abusers. This substance is abused for its hallucinogenic effects.
Experimental
Illicit
Matched Description: … Since 1999, there has been a growing popularity of 5-MeO-DIPT among drug abusers. …
ATX-201
ATX-201 is one of a family of novel compounds that inhibits microtubule polymerization. It is developed by Kythera Biopharmaceuticals, Inc. for the treatment of actinic
keratosis. The company announced the decision to discontinue its ATX-201 clinical program for actinic keratosis. The Company determined that the program was not meeting their...
Investigational
Matched Description: … ATX-201 is one of a family of novel compounds that inhibits microtubule polymerization. ... It is developed by Kythera Biopharmaceuticals, Inc. for the treatment of actinic
keratosis. …
Peginterferon alfacon-1
PEGylation is a technology for the chemical attachment of polyethylene glycol (PEG) polymer chains to a broad range of drug substances such as peptides and proteins including antibody fragments; small molecules, and other drugs. [Infergen] is a bio-engineered type I interferon alpha that is FDA-approved for the treatment of patients...
Investigational
Matched Description: … PEGylation is a technology for the chemical attachment of polyethylene glycol (PEG) polymer chains to ... [Infergen] is a bio-engineered type I interferon alpha that is FDA-approved for the treatment of patients ... a broad range of drug substances such as peptides and proteins including antibody fragments; small molecules …
OAV201
OAV201 is a non-replicating, recombinant adeno-associated virus serotype 9 (AAV9) containing the human Methyl CpG Binding Protein 2B (MECP2B) cDNA under the control of a segment of the murine MECP2 promoter. It was first developed by Novartis and investigated for the treatment of Rett syndrome, but further investigation in clinical...
Investigational
Matched Description: … a segment of the murine MECP2 promoter. ... serotype 9 (AAV9) containing the human Methyl CpG Binding Protein 2B (MECP2B) cDNA under the control of ... It was first developed by Novartis and investigated for the treatment of Rett syndrome, but further investigation …
OSI-7836
OSI-7836 is a member of the nucleoside class of cytotoxic drugs of which gemcitabine is the market leader. OSI Pharmaceuticals develops OSI-7836 as a next-generation gemcitabine. The anti-tumor activity of OSI-7836 appeares to be less schedule dependent than gemcitabine. It is also more active than ara-C (another clinically used nucleoside...
Investigational
Matched Description: … OSI-7836 is a member of the nucleoside class of cytotoxic drugs of which gemcitabine is the market leader ... The anti-tumor activity of OSI-7836 appeares to be less schedule dependent than gemcitabine. …
Horse chestnut
Horse chestnut is a flowering plant commonly referred to as Aesculus hippocastanum. Unprocessed horse chestnut seeds contain a toxin called esculin (also spelled aesculin) that increases the risk of bleeding due to anticoagulant actions. These seeds are processed to remove the toxic component, resulting in purified horse chestnut seed extract...
Experimental
Matched Description: … the veins and reduces swelling and inflammation of the legs. ... Its therapeutic potential in the treatment of chronic venous insufficiency is being studied. ... horse chestnut seeds contain a toxin called esculin (also spelled aesculin) that increases the risk of …
EA-2353
EA-2353 is a small molecule inhibitor of kinase mediators of the Wnt pathway.
Investigational
Matched Description: … EA-2353 is a small molecule inhibitor of kinase mediators of the Wnt pathway. …
ABH001
ABH001 is under investigation in clinical trial NCT01749306 (A Study of the Efficacy and Safety of ABH001 in the Treatment of Patients With Epidermolysis Bullosa Who Have Wounds That Are Not Healing).
Investigational
Matched Description: … ABH001 is under investigation in clinical trial NCT01749306 (A Study of the Efficacy and Safety of ABH001 ... in the Treatment of Patients With Epidermolysis Bullosa Who Have Wounds That Are Not Healing). …
Bavituximab
Bavituximab is a chimeric Anti-PS monoclonal antibody analog which is used to potentially treat cancers and viral infections. It binds to phosphatidylserine and other exposed host cell lipids when induced by cellular stress. Additional analogs in the class include 3G4, 2aG4, 9d2 and Hu3g4.
Investigational
GEM-231
GEM231 is a second-generation antisense oligonucleotide targeting the mRNA of the R1alpha regulatory subunit of cAMP dependent protein kinase. A monoclonal antibody combined with a toxic substance that is used treat certain types of acute myeloid leukemia in older patients and is being studied in the treatment of other types...
Investigational
Matched Description: … leukemia in older patients and is being studied in the treatment of other types of cancer. ... subunit of cAMP dependent protein kinase. ... GEM231 is a second-generation antisense oligonucleotide targeting the mRNA of the R1alpha regulatory …
CX157
CX157,3-fluoro-7-(2,2,2,-trifluoroethoxy)phenoxathiin-10,10-dioxide, is a reversible, selective inhibitor of MAO-A designed to have improved oral bioavailability and reduced clearance compared to previous MAO-A inhibitors of this class.
Investigational
Matched Description: … CX157,3-fluoro-7-(2,2,2,-trifluoroethoxy)phenoxathiin-10,10-dioxide, is a reversible, selective inhibitor of ... designed to have improved oral bioavailability and reduced clearance compared to previous MAO-A inhibitors of …
Displaying drugs 10451 - 10475 of 12433 in total