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Displaying drugs 1026 - 1050 of 14678 in total

Technetium Tc-99m exametazime

Technetium Tc-99m exametazime is a radiopharmaceutical sold under the trade name Ceretec used in the detection of altered regional cerebral perfusion in stroke and other cerebrovascular diseases. It can also be used for the labelling of leukocytes to localise intra-abdominal infections and inflammatory bowel disease. Exametazime, also known as hexamethylpropyleneamine...
Approved
Matched Description: … under the trade name Ceretec used in the detection of altered regional cerebral perfusion in stroke and ... It can also be used for the labelling of leukocytes to localise intra-abdominal infections and inflammatory …
Matched Categories: … Indicators and Reagents …

Pyrantel

Pyrantel is a pyrimidine-derivative anthelmintic agent for the oral treatment of various parasitic worm infections including ascariasis, hookworm infections, enterobiasis (pinworm infection), trichostrongyliasis, and trichinellosis . Pyrantel was initially described in 1965 by researchers from Pfizer who sought cyclic amidines with suitable pharmacokinetic properties (specifically, duration of action) for use...
Approved
Vet approved
Matched Description: … Pyrantel is on the World Health Organization's List of Essential Medicines, which are the safest and ... Pyrantel is mainly available in formulations for dogs and cats as the embonate salt, containing a 34.7% ... infections including ascariasis, hookworm infections, enterobiasis (pinworm infection), trichostrongyliasis, and …
Matched Categories: … Antiparasitic Products, Insecticides and Repellents …

Upadacitinib

Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by synovial inflammation and hyperplasia, autoantibody production, cartilage damage...
Approved
Investigational
Matched Description: … and bone destruction, leading to co-morbidities. ... Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic ... It is characterized by synovial inflammation and hyperplasia, autoantibody production, cartilage damage …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Pentastarch

Pentastarch is an artificial colloid (hydroxyethyl starch derivative). Pentastarch is characterized by presenting five hydroxyethyl groups, which signifies an approximate 50% hydroxyethylation. It is sold under the name Pentaspan by Bristol-Myers Squibb and is used for fluid resuscitation. When administered, pentastarch remains mainly in the circulatory system and hence, it...
Approved
Investigational
Matched Description: … It is sold under the name Pentaspan by Bristol-Myers Squibb and is used for fluid resuscitation. ... When administered, pentastarch remains mainly in the circulatory system and hence, it is considered a …

Trimipramine

Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties.
Approved
Matched Description: … Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. …
Matched Categories: … Tricyclics and Other Norepinephrine-reuptake Inhibitors …

Remestemcel-L

Remestemcel-L is a third-party, off-the-shelf suspension of ex-vivo cultured adult human mesenchymal stem cells intended for intravenous infusion. The mesenchymal stem cells are derived from the bone marrow of unrelated and human leukocyte antigen (HLA)–unmatched healthy adult donors and have the ability to differentiate into different tissue cells. It was...
Approved
Investigational
Matched Description: … cytokines and growth factors to promote tissue repair [A31818]. ... The mesenchymal stem cells are derived from the bone marrow of unrelated and human leukocyte antigen ... (HLA)–unmatched healthy adult donors and have the ability to differentiate into different tissue cells …

Durlobactam

Durlobactam is a diazabicyclooctane non-beta-lactam, beta-lactamase inhibitor. It is typically given in combination with sulbactam to protect it from degradation by certain serine-beta-lactamases. The combination product of durlobactam and sulbactam was first approved by the FDA in May 2023. It is used to treat hospital-acquired bacterial pneumonia and ventilator-associated bacterial...
Approved
Investigational
Matched Description: … [L47336] The combination product of durlobactam and sulbactam was first approved by the FDA in May 2023 ... [A263306] It is used to treat hospital-acquired bacterial pneumonia and ventilator-associated bacterial …

Ipecac

Ipecac is obtained from the plant Cephaelis ipecacuanha and contains a number of emetic alkaloids including emetine and cephaeline. Ipecac was approved by Health Canada as an OTC but all those products are now discontinued. The FDA does not have currently any approved product containing ipecac, however, ipecac as an...
Approved
Withdrawn
Matched Description: … emetine and cephaeline. ... Ipecac is obtained from the plant _Cephaelis ipecacuanha_ and contains a number of emetic alkaloids including …
Matched Categories: … Cough and Cold Preparations …

Hydroxypropyl cellulose

Hydroxypropyl cellulose is an ether of cellulose where some of the hydroxyl groups of the cellulose have been hydroxypropylated forming -OCH2CH(OH)CH3 groups. Lacrisertis a formulation of hydroxypropyl cellulose that is used for artificial tears. It is used to treat syndromes characterized by insufficient tear production (keratoconjunctivitis sicca), recurrent corneal erosions,...
Approved
Matched Description: … neuroparalytic keratitis, and as a lubricant for artificial eyes. ... As a food additive, hydroxypropyl cellulose is used as a thickener and as an emulsion stabilizer. ... production (keratoconjunctivitis sicca), recurrent corneal erosions, decreased corneal sensitivity, exposure and …

Butaperazine

Butaperazine was approved in 1967 , and possibly discontinued in the 1980s .
Approved
Matched Description: … Butaperazine was approved in 1967 [L5143], and possibly discontinued in the 1980s [T397]. …

Ebola Zaire vaccine (live, attenuated)

Ebola virus vaccine is a vaccine used to prevent Ebola virus disease caused by Zaire ebolavirus in adults, prevent outbreaks, and reduce the extent of the virus spreading in case of outbreaks. Ebola virus disease, formerly known as Ebola hemorrhagic fever, is a rare but severe and often deadly disease....
Approved
Matched Description: … and external bleeding. ... These may be accompanied by hypotension and respiratory, kidney and liver failure, as well as internal ... total deaths during this time in Guinea, Liberia, and Sierra Leone. …

Thiopental

A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. It is also used for hypnosis and for the control of convulsive states. It has been used in neurosurgical patients to reduce increased intracranial pressure. It does not...
Approved
Vet approved
Matched Description: … It is also used for hypnosis and for the control of convulsive states. ... Small doses have been shown to be anti-analgesic and lower the pain threshold. ... It does not produce any excitation but has poor analgesic and muscle relaxant properties. …
Matched Categories: … Hypnotics and Sedatives …

Pitolisant

Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnagogic hallucinations. About...
Approved
Investigational
Matched Description: … [L8063] Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized ... [A32023] Adolescent patients with cataplexy also experienced a slight improvement in the frequency and ... treating refractory sleepiness in adolescent patients with narcolepsy, where it decreased ESS score and …

Yttrium Y-90

Yttrium 90 has been investigated for the treatment of Colon Cancer and Colorectal Cancer.
Approved
Investigational
Matched Description: … Yttrium 90 has been investigated for the treatment of Colon Cancer and Colorectal Cancer. …

Viper antivenom

Viper antivenom consists of antibodies derived from horses immunized and subsequently developed antibodies against snake venoms. ANAVIP, an equine-derived antivenom made with venom from Bothrops asper and Crotalus durissus, was first approved by the FDA on October 1, 2015, for the management of North American rattlesnake envenomation.
Approved
Matched Description: … Viper antivenom consists of antibodies derived from horses immunized and subsequently developed antibodies ... ANAVIP, an equine-derived antivenom made with venom from _Bothrops asper_ and _Crotalus durissus_, was …

Vemurafenib

Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann...
Approved
Matched Description: … [A31270] Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Recombinant stabilized RSV B prefusion F antigen

Recombinant stabilized RSV B prefusion F antigen is one component of a bivalent respiratory syncytial virus (RSV) vaccine called Abrysvo. The vaccine comprises two antigens - the other being recombinant stabilized RSV A prefusion F antigen - which have been expressed in Chinese hamster ovary cell lines and then purified...
Approved
Matched Description: … then purified and lyophilized. ... stabilized RSV A prefusion F antigen] - which have been expressed in Chinese hamster ovary cell lines and ... virus vaccine, adjuvanted] (Arexvy), Abrysvo is reconstituted with sterile water prior to injection and …

Lovastatin

Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of Aspergillus terreus. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid...
Approved
Investigational
Matched Description: … Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite ... studies to significantly reduce the risk of development of CVD and all-cause mortality. ... belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and …
Matched Categories: … lovastatin and nicotinic acid …

Olsalazine

Olsalazine is an aminosalicylate and a prodrug of mesalamine (5-aminosalicylic acid, 5-ASA). It was first developed for delivering mesalamine to the colon without the use of sulfapyridine. Olsalazine comprises two mesalamine molecules joined by an azo bridge, which is cleaved in the colon. Olsalazine is an anti-inflammatory agent that works...
Approved
Matched Description: … Olsalazine is an aminosalicylate and a prodrug of [mesalamine] (5-aminosalicylic acid, 5-ASA). ... , subsequently reducing the production of pro-inflammatory factors like prostaglandin and leukotriene ... [A257078] Olsalazine is an anti-inflammatory agent that works by inhibiting cyclooxygenase and lipoxygenase …
Matched Categories: … Alimentary Tract and Metabolism …

Rilmenidine

Rilmenidine has been used in trials studying the treatment of Hypertension and Chronic Kidney Disease.
Approved
Investigational
Matched Description: … Rilmenidine has been used in trials studying the treatment of Hypertension and Chronic Kidney Disease …

Cianidanol

An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.
Approved
Withdrawn
Matched Description: … An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin …

Protokylol

Protokylol is a β-adrenergic receptor agonist used as a bronchodilator in Europe and the United States.
Approved
Vet approved
Matched Description: … Protokylol is a β-adrenergic receptor agonist used as a bronchodilator in Europe and the United States …
Matched Categories: … Epinephrine and similars …

Phentolamine

Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[A261781, A261786] It has several therapeutic uses, including...
Approved
Matched Description: … to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and ... [L48420, L48415, L48390] Phentolamine is administered intravenously, intramuscularly, submucosally, and ... norepinephrine-induced extravasation, diagnosis of pheochromocytoma, reversal of soft-tissue anesthesia, and …

Remoxipride

Remoxipride is an atypical antipsychotic agent that is specific for dopamine D2 receptors. It gained approval in the UK in 1989 but was withdrawn in 1993 after it was found to be associated with an increased incidence of aplastic anemia.[A215422,A215512]
Approved
Withdrawn
Matched Categories: … Benzamides and benzamide derivatives …

Efmoroctocog alfa

Efmoroctocog alfa is a fully recombinant factor VIII-Fc fusion protein (rFVIIIFc) with an extended half-life compared with conventional factor VIII (FVIII) preparations, including recombinant FVIII (rFVIII) products such as DB13999 . It is an antihemorrhagic agent used in replacement therapy for patients with haemophilia A (congenital factor VIII deficiency). It...
Approved
Investigational
Matched Description: … is purified endogenous Factor VIII from human pooled blood and contains both A- and B-subunits. ... other hemorrhages that cause chronic pain and disability to patients [A31551, A31552]. ... Patients with this disorder are more susceptible to recurrent bleeding episodes and excessive bleeding …
Displaying drugs 1026 - 1050 of 14678 in total