Displaying drugs 10476 - 10500 of 12439 in total
BOS172722
BOS172722 is a novel and selective Monopolar spindle 1 (Mps1) kinase inhibitor identified as a potential anticancer agent. Normally, Mps1 supports the proper division of cancer cells, ensuring survival and replication. The key role of Mps1 in the growth of cancer cells renders it an appealing target for cancer treatment,...
Experimental
Matched Description: … The key role of Mps1 in the growth of cancer cells renders it an appealing target for cancer treatment ... [A187123] Normally, Mps1 supports the proper division of cancer cells, ensuring survival and replication ... [A187120] An in vivo study combined BOS172722 with [Paclitaxel] for the treatment of triple hormone …
PSN9301
PSN9301 is an oral small molecule inhibitor of Dipeptidyl Peptidase IV (DP-IV), being developed for the treatment of type 2 diabetes. PSN9301 has a very rapid onset and a relatively short duration of action, and available pre-clinical and clinical data indicate that it may be an ideal product candidate for...
Investigational
Matched Description: … treatment of type 2 diabetes. ... PSN9301 is an oral small molecule inhibitor of Dipeptidyl Peptidase IV (DP-IV), being developed for the ... PSN9301 has a very rapid onset and a relatively short duration of action, and available pre-clinical …
ETC-588
ETC-588, or LUV (large unilamellar vesicles), is made of naturally occurring lipids that circulate through arteries to facilitate the role of high-density lipoprotein (HDL) in removing accumulated cholesterol and other lipids from cells including those in the arterial wall. LUV are capable of transporting excess cholesterol from the vasculature to...
Investigational
Matched Description: … of atherosclerosis. ... as part of the reverse lipid transport (RLT) pathway. ... ETC-588, or LUV (large unilamellar vesicles), is made of naturally occurring lipids that circulate through …
Deoxyribonuclease I
Deoxyribonuclease I (DNase I) is a human enzyme responsible for the digestion of extracellular DNA7 . It is normally found in saliva, urine, pancreatic secretions, and blood . Because of the hypothesis that increased concentrations of high-molecular-weight DNA is a factor for airway obstruction, abnormal viscoelastic properties of the sputum,...
Investigational
Matched Description: … Because of the hypothesis that increased concentrations of high-molecular-weight DNA is a factor for ... airway obstruction, abnormal viscoelastic properties of the sputum, and recurrent exacerbations of respiratory ... Deoxyribonuclease I (DNase I) is a human enzyme responsible for the digestion of extracellular DNA7[A227723 …
16-Bromoepiandrosterone
16-Bromoepiandrosterone is an injectable formulation of a compound called alpha-epi-bromide. It is a chemical relative of DHEA which was selected for development after it showed antiretroviral activity in laboratory tests.
Investigational
Matched Description: … 16-Bromoepiandrosterone is an injectable formulation of a compound called alpha-epi-bromide. ... It is a chemical relative of DHEA which was selected for development after it showed antiretroviral activity …
Trebananib
Trebananib is under investigation for the treatment of Ovarian Cancer, Peritoneal Cancer, and Fallopian Tube Cancer. Trebananib has been investigated for the treatment of Cancer, Oncology, Carcinoma, Metastases, and Colon Cancer, among others.
Investigational
Matched Description: … Trebananib is under investigation for the treatment of Ovarian Cancer, Peritoneal Cancer, and Fallopian ... Trebananib has been investigated for the treatment of Cancer, Oncology, Carcinoma, Metastases, and Colon …
Nivatrotamab
Nivatrotamab is under investigation in clinical trial NCT03860207 (Study of the Safety and Efficacy of Humanized 3F8 Bispecific Antibody (Hu3f8-bsab) in Patients With Relapsed/refractory Neuroblastoma, Osteosarcoma and Other Solid Tumor Cancers).
Investigational
Matched Description: … Nivatrotamab is under investigation in clinical trial NCT03860207 (Study of the Safety and Efficacy of …
AVXS-301
AVXS-301 consists of an adeno-associated virus serotype 9 (AAV9) designed to express the superoxide dismutase 1 (SOD1) gene. It is being investigated for the treatment of Amyotrophic Lateral Sclerosis (ALS).
Investigational
Matched Description: … It is being investigated for the treatment of Amyotrophic Lateral Sclerosis (ALS).[L47077] ... AVXS-301 consists of an adeno-associated virus serotype 9 (AAV9) designed to express the superoxide dismutase …
Bavituximab
Bavituximab is a chimeric Anti-PS monoclonal antibody analog which is used to potentially treat cancers and viral infections. It binds to phosphatidylserine and other exposed host cell lipids when induced by cellular stress. Additional analogs in the class include 3G4, 2aG4, 9d2 and Hu3g4.
Investigational
MBO7133
MB07133 is a HepDirect prodrug of an activated form of cytarabine (araC), an anti-cancer drug that is used to treat leukemia but is ineffective against primary liver cancer. AraC's anti-cancer activity is associated with its ability to be converted to its biologically active form, araCTP. However, araC is only slowly...
Investigational
Matched Description: … MB07133 is a HepDirect prodrug of an activated form of cytarabine (araC), an anti-cancer drug that is ... activation pathway of the drug. ... , araC is only slowly converted to araCTP in the liver or in primary liver tumors due to low levels of …
BZL101
BZL101 is an oral drug designed for the treatment of advanced breast cancer with a novel mechanism of action. BZL101 targets diseased cells while leaving normal cells healthy and intact.
Investigational
Matched Description: … BZL101 is an oral drug designed for the treatment of advanced breast cancer with a novel mechanism of …
Bencyclane
A vasodilator agent found to be effective in a variety of peripheral circulation disorders. It has various other potentially useful pharmacological effects. Its mechanism may involve block of calcium channels.
Experimental
Matched Description: … Its mechanism may involve block of calcium channels. ... A vasodilator agent found to be effective in a variety of peripheral circulation disorders. …
Lorecivivint
Lorecivivint is under investigation in clinical trial NCT03246399 (A Study of the Safety, Tolerability, and Pharmacokinetics of SM04690 Injectable Suspension Following Single Intradiscal Injection in Subjects With Degenerative Disc Disease).
Investigational
Matched Description: … Lorecivivint is under investigation in clinical trial NCT03246399 (A Study of the Safety, Tolerability ... , and Pharmacokinetics of SM04690 Injectable Suspension Following Single Intradiscal Injection in Subjects …
JNJ-26489112
JNJ-26489112 is under investigation in clinical trial NCT00579384 (A Study of the Effects of JNJ-26489112 on the Photic Induced Paroxysmal Electroencephalogram (EEG) Response in Patients With Photosensitive Epilepsy).
Investigational
Matched Description: … JNJ-26489112 is under investigation in clinical trial NCT00579384 (A Study of the Effects of JNJ-26489112 …
Lulizumab pegol
Lulizumab pegol is under investigation in clinical trial NCT02843659 (Proof of Concept Study to Evaluate the Efficacy and Safety of BMS-931699 (Lulizumab) or BMS-986142 in Primary Sjögren's Syndrome).
Investigational
Matched Description: … the Efficacy and Safety of BMS-931699 (Lulizumab) or BMS-986142 in Primary Sjögren's Syndrome). ... Lulizumab pegol is under investigation in clinical trial NCT02843659 (Proof of Concept Study to Evaluate …
ST-36
ST-36 is a cell-penetrating dominant-negative form of activating transcription factor 5. In 2017, it received orphan drug designation by the FDA for the treatment of glioma.
Investigational
Matched Description: … ST-36 is a cell-penetrating dominant-negative form of activating transcription factor 5. ... In 2017, it received orphan drug designation by the FDA for the treatment of glioma.[L47341] …
NS-398
NS-398 is a COX-2 inhibitor. It was developed as part of the mechanistic study of the cyclooxygenases.
Experimental
Matched Description: … It was developed as part of the mechanistic study of the cyclooxygenases. …
GBR-12783
A selective inhibitor of dopamine uptake.
Investigational
Matched Description: … A selective inhibitor of dopamine uptake.[A252997] …
Albinterferon Alfa-2B
Albumin-interferon alpha (Albuferon) is a novel, long-acting form of interferon alpha. Recombinant interferon alpha is approved for the treatment of hepatitis C, hepatitis B, and a broad range of cancers. Human Genome Sciences modified interferon alpha to improve its pharmacological properties by using the company's proprietary albumin fusion technology. Human...
Investigational
Matched Description: … of cancers. ... Albumin-interferon alpha (Albuferon) is a novel, long-acting form of interferon alpha. ... Recombinant interferon alpha is approved for the treatment of hepatitis C, hepatitis B, and a broad range …
IDM-4
IDM-4 is an immuno-designed molecule that completed phase I/II of investigation for the treatment of Leukemia. It is a monoclonal antibody-specific antigen that can selectively target cancer-affected cells by coupling with tumor cell-killing MAK cells, which are derived from the patient's own monocytes. Trials of this drug have most likely...
Investigational
Matched Description: … IDM-4 is an immuno-designed molecule that completed phase I/II of investigation for the treatment of ... Trials of this drug have most likely been discontinued by the manufacturer. …
TST10088
TST10088 is a recombinant variant of a plant toxin belonging to the family of class II ribosome inactivating proteins. These molecules efficiently kill cells by activating preprogrammed death pathways known as apoptosis. TST10088 has been designed and engineered by Twinstrand to contain a peptide switch that is specifically cleaved by...
Investigational
Matched Description: … TST10088 is a recombinant variant of a plant toxin belonging to the family of class II ribosome inactivating ... Cleavage of the peptide switch activates the prodrug causing ribosomal inactivation and the death of …
Becatecarin
Becatecarin is a derivative of rebeccamycin.
Investigational
Matched Description: … Becatecarin is a derivative of [rebeccamycin]. …
Desmethylsertraline
Desmethylsertraline is a metabolite of sertraline.
Experimental
Matched Description: … Desmethylsertraline is a metabolite of sertraline. …
Arachidonyltrifluoromethane
Specific inhibitor of phospholipase A2.
Investigational
Matched Description: … Specific inhibitor of phospholipase A2.[A252972] …
CX157
CX157,3-fluoro-7-(2,2,2,-trifluoroethoxy)phenoxathiin-10,10-dioxide, is a reversible, selective inhibitor of MAO-A designed to have improved oral bioavailability and reduced clearance compared to previous MAO-A inhibitors of this class.
Investigational
Matched Description: … CX157,3-fluoro-7-(2,2,2,-trifluoroethoxy)phenoxathiin-10,10-dioxide, is a reversible, selective inhibitor of ... designed to have improved oral bioavailability and reduced clearance compared to previous MAO-A inhibitors of …
Displaying drugs 10476 - 10500 of 12439 in total