Displaying drugs 1051 - 1075 of 2170 in total
Amedalin
Amedalin is a selective norepinephrine reuptake inhibitor developed in the 1970s. It has no significant effect on reuptake of serotonin and dopamine and no antihistamine or anticholinergic properties. This drug was never marketed.
Experimental
Matched Synonyms: … 3-methyl-3-(3-(methylamino)propyl)-1-phenyl-2-indolinone …
Matched Iupac: … (3S)-3-methyl-3-[3-(methylamino)propyl]-1-phenyl-2,3-dihydro-1H-indol-2-one …
Matched Description: … It has no significant effect on reuptake of serotonin and dopamine and no antihistamine or anticholinergic …
Matched Iupac: … (3S)-3-methyl-3-[3-(methylamino)propyl]-1-phenyl-2,3-dihydro-1H-indol-2-one …
Matched Description: … It has no significant effect on reuptake of serotonin and dopamine and no antihistamine or anticholinergic …
Tetradecyl hydrogen sulfate (ester)
Sodium tetradecyl sulfate is an anionic surface-active agent which is used for its wetting properties in the industry and is also used in medicine as a blood vessel irritant and sclerosing agent for hemorrhoids and varicose veins .
Sodium tetradecyl sulfate has been widely used since the 1950s, and in...
Approved
Matched Synonyms: … 7-Ethyl-2-methyl-4-undecanol sulfate …
Matched Description: … is also used in medicine as a blood vessel irritant and sclerosing agent for hemorrhoids and varicose ... sulfate is an anionic surface-active agent which is used for its wetting properties in the industry and ... Sodium tetradecyl sulfate has been widely used since the 1950s, and in 1978 the first successful report …
Matched Description: … is also used in medicine as a blood vessel irritant and sclerosing agent for hemorrhoids and varicose ... sulfate is an anionic surface-active agent which is used for its wetting properties in the industry and ... Sodium tetradecyl sulfate has been widely used since the 1950s, and in 1978 the first successful report …
Amisulpride
Amisulpride is a benzamide derivative and a dopamine receptor antagonist that selectively works on dopamine D2 and D3 receptors. As an antipsychotic agent, amisulpride alleviates both positive and negative symptoms of schizophrenia, and it exhibits antidepressant properties in patients with psychiatric disorders, dysthymia, and major depression. Amisulpride predominantly works in...
Approved
Investigational
Matched Synonyms: … 4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-O-anisamide ... 4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide …
Matched Iupac: … 4-amino-5-(ethanesulfonyl)-N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxybenzamide …
Matched Description: … D2 and D3 receptors. ... , and it exhibits antidepressant properties in patients with psychiatric disorders, dysthymia, and major ... Amisulpride is a benzamide derivative and a dopamine receptor antagonist that selectively works on dopamine …
Matched Categories: … Benzamides and benzamide derivatives …
Matched Iupac: … 4-amino-5-(ethanesulfonyl)-N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxybenzamide …
Matched Description: … D2 and D3 receptors. ... , and it exhibits antidepressant properties in patients with psychiatric disorders, dysthymia, and major ... Amisulpride is a benzamide derivative and a dopamine receptor antagonist that selectively works on dopamine …
Matched Categories: … Benzamides and benzamide derivatives …
Ivabradine
Ivabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and symptomatic chronic heart failure. Ivabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment of chronic heart failure in patients with an ejection fraction of ≤35%, in sinus...
Approved
Matched Synonyms: … 3-[3-({[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino)propyl]-7,8-dimethoxy …
Matched Iupac: … 3-[3-({[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino)propyl]-7,8-dimethoxy …
Matched Description: … is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and ... Although non-dihydropyridine calcium channel blockers and beta blockers also effectively lower heart ... pacemaker current (If) in the sinoatrial node in a dose-dependent fashion, resulting in a lower heart rate and …
Matched Categories: … metoprolol and ivabradine ... carvedilol and ivabradine …
Matched Iupac: … 3-[3-({[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino)propyl]-7,8-dimethoxy …
Matched Description: … is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and ... Although non-dihydropyridine calcium channel blockers and beta blockers also effectively lower heart ... pacemaker current (If) in the sinoatrial node in a dose-dependent fashion, resulting in a lower heart rate and …
Matched Categories: … metoprolol and ivabradine ... carvedilol and ivabradine …
Navtemadlin
Navtemadlin (AMG-232) is under investigation in clinical trial NCT03041688 (MDM2 Inhibitor AMG-232 and Decitabine in Treating Patients With Relapsed, Refractory, or Newly-Diagnosed Acute Myeloid Leukemia).
Investigational
Matched Synonyms: … {(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-[ (2S)-3 -methyl-1-(propan-2- ylsulfonyl …
Matched Iupac: … 2-[(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-[(2S)-3-methyl-1-(propane-2-sulfonyl)butan …
Matched Description: … Navtemadlin (AMG-232) is under investigation in clinical trial NCT03041688 (MDM2 Inhibitor AMG-232 and …
Matched Iupac: … 2-[(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-[(2S)-3-methyl-1-(propane-2-sulfonyl)butan …
Matched Description: … Navtemadlin (AMG-232) is under investigation in clinical trial NCT03041688 (MDM2 Inhibitor AMG-232 and …
ARM-210
Investigational
Matched Synonyms: … 4-((7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5h)-yl)methyl)benzoic acid ... Benzoic acid, 4-((2,3-dihydro-7-methoxy-1,4-benzothiazepin-4(5h)-yl)methyl)- …
Matched Iupac: … 4-[(7-methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepin-4-yl)methyl]benzoic acid …
Matched Iupac: … 4-[(7-methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepin-4-yl)methyl]benzoic acid …
Amotosalen
Investigational
Matched Synonyms: … 3-((2-aminoethoxy)methyl)-2,5,9-trimethyl-7h-furo(3,2-g)chromen-7-one ... 7h-furo(3,2-g)(1)benzopyran-7-one, 3-((2-aminoethoxy)methyl)-2,5,9-trimethyl- …
Matched Iupac: … 3-[(2-aminoethoxy)methyl]-2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one …
Matched Iupac: … 3-[(2-aminoethoxy)methyl]-2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one …
Levotofisopam
Levotofisopam is under investigation in clinical trial NCT01519687 (Study of Levotofisopam 50 Mg Three Times a Day (TID) Administered for 7 Days on Hyperuricemia and Gout).
Investigational
Matched Synonyms: … (-)-(5s)-1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5h-2,3-benzodiazepine ... 5h-2,3-benzodiazepine, 1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl, (5s)- …
Matched Description: … NCT01519687 (Study of Levotofisopam 50 Mg Three Times a Day (TID) Administered for 7 Days on Hyperuricemia and …
Matched Description: … NCT01519687 (Study of Levotofisopam 50 Mg Three Times a Day (TID) Administered for 7 Days on Hyperuricemia and …
Ofloxacin
A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Approved
Matched Synonyms: … 8-Fluoro-3-methyl-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic …
Matched Iupac: … 7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.0^{5,13}]trideca-5(13), …
Matched Description: … A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity …
Matched Categories: … ofloxacin and ornidazole ... Metabolic Side Effects of Drugs and Substances …
Matched Iupac: … 7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.0^{5,13}]trideca-5(13), …
Matched Description: … A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity …
Matched Categories: … ofloxacin and ornidazole ... Metabolic Side Effects of Drugs and Substances …
Ralmitaront
Ralmitaront is under investigation in clinical trial NCT04512066 (A Trial of the Efficacy and the Safety of RO6889450 (Ralmitaront) vs Placebo in Patients With an Acute Exacerbation of Schizophrenia or Schizoaffective Disorder).
Investigational
Matched Synonyms: … 1h-pyrazole-3-carboxamide, 5-ethyl-4-methyl-n-(4-(2s)-2-morpholinylphenyl)- ... 5-ethyl-4-methyl-n-(4-((2s)-morpholin-2-yl)phenyl)-1h-pyrazole-3-carboxamide …
Matched Description: … Ralmitaront is under investigation in clinical trial NCT04512066 (A Trial of the Efficacy and the Safety …
Matched Description: … Ralmitaront is under investigation in clinical trial NCT04512066 (A Trial of the Efficacy and the Safety …
Carbazochrome
Carbazochrome is a hemostatic agent that promotes clotting, preventing blood loss from open wounds. It is an oxidation product of adrenaline which enhances the microcirculatory tone . In the future this may prevent excessive blood flow during surgical operations and the treatment of hemorrhoids, but research on effectiveness and severity...
Experimental
Withdrawn
Matched Synonyms: … 3-Hydroxy-1-methyl-5,6-inodlindionsemicarbazon …
Matched Iupac: … {[(5Z)-3-hydroxy-1-methyl-6-oxo-2,3,5,6-tetrahydro-1H-indol-5-ylidene]amino}urea …
Matched Description: … , but research on effectiveness and severity of side effects remains inconclusive. ... In the future this may prevent excessive blood flow during surgical operations and the treatment of hemorrhoids ... for use in the treatment of non-surgical acute uncomplicated hemorrhoids in a mixture with [DB13124], and …
Matched Categories: … Blood and Blood Forming Organs …
Matched Iupac: … {[(5Z)-3-hydroxy-1-methyl-6-oxo-2,3,5,6-tetrahydro-1H-indol-5-ylidene]amino}urea …
Matched Description: … , but research on effectiveness and severity of side effects remains inconclusive. ... In the future this may prevent excessive blood flow during surgical operations and the treatment of hemorrhoids ... for use in the treatment of non-surgical acute uncomplicated hemorrhoids in a mixture with [DB13124], and …
Matched Categories: … Blood and Blood Forming Organs …
Pirlindole
This drug is classified as a reversible inhibitor of monoamine oxidase A enzyme (also known as a RIMA drug). It was developed and is currently used as an antidepressant in Russia. Its chemical structure is similar to metralindole, and it also shares pharmacological properties with this drug.
Pirlindole is a...
Experimental
Matched Synonyms: … 2,3,3a,4,5,6-Hexahydro-8-methyl-1H-pyrazino(3,2,1-jk)carbazole …
Matched Iupac: … 12-methyl-1,4-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-9(16),10,12,14-tetraene …
Matched Description: … The antidepressant efficacy and safety of pirlindole have been demonstrated in numerous studies and, ... It was developed and is currently used as an antidepressant in Russia. ... This drug is classified as a reversible inhibitor of monoamine oxidase A enzyme (also known as a RIMA …
Matched Categories: … Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates ... Monoamine Oxidase Inhibitors …
Matched Iupac: … 12-methyl-1,4-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-9(16),10,12,14-tetraene …
Matched Description: … The antidepressant efficacy and safety of pirlindole have been demonstrated in numerous studies and, ... It was developed and is currently used as an antidepressant in Russia. ... This drug is classified as a reversible inhibitor of monoamine oxidase A enzyme (also known as a RIMA …
Matched Categories: … Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates ... Monoamine Oxidase Inhibitors …
Aticaprant
Aticaprant has been used in trials studying the health services research and basic science of Anxiety Disorders and Alcohol Dependence.
Investigational
Matched Synonyms: … BENZAMIDE, 4-(4-(((2S)-2-(3,5-DIMETHYLPHENYL)-1-PYRROLIDINYL)METHYL)PHENOXY)-3-FLUORO- …
Matched Iupac: … 4-(4-{[(2S)-2-(3,5-dimethylphenyl)pyrrolidin-1-yl]methyl}phenoxy)-3-fluorobenzamide …
Matched Description: … Disorders and Alcohol Dependence. ... Aticaprant has been used in trials studying the health services research and basic science of Anxiety …
Matched Iupac: … 4-(4-{[(2S)-2-(3,5-dimethylphenyl)pyrrolidin-1-yl]methyl}phenoxy)-3-fluorobenzamide …
Matched Description: … Disorders and Alcohol Dependence. ... Aticaprant has been used in trials studying the health services research and basic science of Anxiety …
Bicyclol
Bicyclol is under investigation in clinical trial NCT02944552 (The Multi Center, Randomized, Double-blind, Positive Controlled Study of Bicyclol in the Treatment of Acute DILI).
Investigational
Matched Synonyms: … 4,4'-bi-1,3-benzodioxole)-5-carboxylic acid, 5'-(hydroxymethyl)-7,7'-dimethoxy-, methyl ester …
Matched Iupac: … methyl 4-[5-(hydroxymethyl)-7-methoxy-2H-1,3-benzodioxol-4-yl]-7-methoxy-2H-1,3-benzodioxole-5-carboxylate …
Matched Iupac: … methyl 4-[5-(hydroxymethyl)-7-methoxy-2H-1,3-benzodioxol-4-yl]-7-methoxy-2H-1,3-benzodioxole-5-carboxylate …
Diazoxide
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.[A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release....
Approved
Matched Synonyms: … 7-chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide …
Matched Iupac: … 7-chloro-3-methyl-4H-1lambda6,2,4-benzothiadiazine-1,1-dione …
Matched Description: … and electrolyte disturbances. ... [A255647] Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular ... A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and …
Matched Iupac: … 7-chloro-3-methyl-4H-1lambda6,2,4-benzothiadiazine-1,1-dione …
Matched Description: … and electrolyte disturbances. ... [A255647] Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular ... A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and …
4-methylthio-2-oxobutanoic acid
Experimental
Matched Synonyms: … gamma-Methiol-keto-butyric acid ... S-Methyl-alpha-ketobutyric acid …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
(5-Hydroxy-6-methyl-4-{[(E)-(3-oxo-1,2-oxazolidin-4-ylidene)amino]methyl}-3-pyridinyl)methyl dihydrogen phosphate
Experimental
Matched Name: … (5-Hydroxy-6-methyl-4-{[(E)-(3-oxo-1,2-oxazolidin-4-ylidene)amino]methyl}-3-pyridinyl)methyl dihydrogen …
Matched Iupac: … {[5-hydroxy-6-methyl-4-({[(4E)-3-oxo-1,2-oxazolidin-4-ylidene]amino}methyl)pyridin-3-yl]methoxy}phosphonic …
Matched Iupac: … {[5-hydroxy-6-methyl-4-({[(4E)-3-oxo-1,2-oxazolidin-4-ylidene]amino}methyl)pyridin-3-yl]methoxy}phosphonic …
(4'-{[Allyl(Methyl)Amino]Methyl}-1,1'-Biphenyl-4-Yl)(4-Bromophenyl)Methanone
Experimental
Matched Name: … (4'-{[Allyl(Methyl)Amino]Methyl}-1,1'-Biphenyl-4-Yl)(4-Bromophenyl)Methanone …
Matched Iupac: … {[4'-(4-bromobenzoyl)-[1,1'-biphenyl]-4-yl]methyl}(methyl)(prop-2-en-1-yl)amine …
Matched Iupac: … {[4'-(4-bromobenzoyl)-[1,1'-biphenyl]-4-yl]methyl}(methyl)(prop-2-en-1-yl)amine …
2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE
Experimental
Matched Name: … 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE …
Matched Iupac: … {[hydroxy(2-{methyl[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl]amino}ethoxy)phosphoryl]oxy}phosphonic …
Matched Iupac: … {[hydroxy(2-{methyl[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl]amino}ethoxy)phosphoryl]oxy}phosphonic …
Nomifensine
Nomifensine, formerly marketed as Merital capsules, was associated with an increased incidence of hemolytic anemia. The approved application holder removed Merital capsules from the market on January 23, 1986. FDA published a notice of its determination that Merital capsules were removed from the market for safety reasons (see the Federal...
Approved
Withdrawn
Matched Synonyms: … 2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine ... 8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline …
Matched Iupac: … 2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine …
Matched Description: … Also withdrawn from the Canadian and UK markets. …
Matched Iupac: … 2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine …
Matched Description: … Also withdrawn from the Canadian and UK markets. …
Ochromycinone
Ochromycinone is under investigation in clinical trial NCT01047943 (STA-21 Topical Efficacy on Psoriasis).
Investigational
Matched Synonyms: … -methyl-8-hydroxy-1,2,3,4,7,12-hexahydrobenzo(a)anthracene-1,7,12-trione ... Benz(a)anthracene-1,7,12(2h)-trione, 3,4-dihydro-8-hydroxy-3-methyl-, (s)- …
Matched Iupac: … (3S)-8-hydroxy-3-methyl-1,2,3,4,7,12-hexahydrotetraphene-1,7,12-trione …
Matched Iupac: … (3S)-8-hydroxy-3-methyl-1,2,3,4,7,12-hexahydrotetraphene-1,7,12-trione …
Chelerythrine
A benzophenanthridine alkaloid evaluated as a kinase-inhibitor.
Investigational
Matched Synonyms: … (1,3)benzodioxolo(5,6-c)phenanthridinium, 1,2-dimethoxy-12-methyl- ... 1,2-dimethoxy-12-methyl(1,3)dioxolo)4',5':4,5)benzo(1,2-c)phenanthridinium …
Matched Iupac: … 17,18-dimethoxy-21-methyl-5,7-dioxa-21-azapentacyclo[11.8.0.0^{2,10}.0^{4,8}.0^{14,19}]henicosa-1(13) …
Matched Iupac: … 17,18-dimethoxy-21-methyl-5,7-dioxa-21-azapentacyclo[11.8.0.0^{2,10}.0^{4,8}.0^{14,19}]henicosa-1(13) …
Allisartan isoproxil
Allisartan isoproxil is under investigation in clinical trial NCT03264352 (Intervention for High-normal Blood Pressure in Adults With Type 2 Diabetes).
Investigational
Matched Synonyms: … )-, (((1-METHYLETHOXY)CARBONYL)OXY)METHYL ESTER ... 1H-IMIDAZOLE-5-CARBOXYLIC ACID, 2-BUTYL-4-CHLORO-1-((2'-(2H-TETRAZOL-5-YL)(1,1'-BIPHENYL)-4-YL)METHYL …
Paroxetine
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline...
Approved
Investigational
Matched Synonyms: … (3S-trans)-3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine ... (−)-(3S,4R)-4-(p-fluorophenyl)-3-((3,4-(methylenedioxy)phenoxy)methyl)piperidine …
Matched Iupac: … (3S,4R)-3-[(2H-1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine …
Matched Description: … of serotonin reuptake and has little effect on other neurotransmitters. ... [T653] It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham. ... uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and …
Matched Iupac: … (3S,4R)-3-[(2H-1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine …
Matched Description: … of serotonin reuptake and has little effect on other neurotransmitters. ... [T653] It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham. ... uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and …
Pyridoxal
The 4-carboxyaldehyde form of vitamin B 6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. [PubChem]
Experimental
Nutraceutical
Matched Synonyms: … 2-methyl-3-hydroxy-4-formyl-5-hydroxymethylpyridine ... 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde …
Matched Description: … carboxyaldehyde form of vitamin B 6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis …
Matched Description: … carboxyaldehyde form of vitamin B 6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis …
Displaying drugs 1051 - 1075 of 2170 in total