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Displaying drugs 101 - 125 of 1932 in total

Methyl nicotinate

Methyl nicotinate is the methyl ester of DB00627 that is used as an active ingredient as a rubefacient in over-the-counter topical preparations indicated for muscle and joint pain. The action of methyl nicotinate as a rubefacient is thought to involve peripheral vasodilation. For veterinary purposes, methyl nicotinate is used to...
Approved
Matched Description: … muscle and joint pains [F64]. ... an active ingredient as a rubefacient in over-the-counter topical preparations indicated for muscle and ... methyl nicotinate is used to treat respiratory diseases, vascular disorders, rheumatoid arthritis, and …

Vonoprazan

Vonoprazan is a potassium-competitive acid blocker (PCAB) that inhibits H+, K+-ATPase-mediated gastric acid secretion. PCABs represent an alternative to proton-pump inhibitors for the treatment of acid-related disorders. Unlike proton-pump inhibitors, PCABs are not affected by CYP2C19 genetic polymorphisms and do not require acid-resistant formulations. Furthermore, vonoprazan is 350-times more potent...
Approved
Investigational
Matched Description: … Unlike proton-pump inhibitors, PCABs are not affected by CYP2C19 genetic polymorphisms and do not require ... In February 2015, vonoprazan was first marketed in Japan for the treatment of acid-related disorders and ... In May 2022, the FDA approved the use of vonoprazan in a co-packaged product containing amoxicillin and …
Matched Categories: … Alimentary Tract and Metabolism ... vonoprazan and amoxicillin ... vonoprazan, amoxicillin and metronidazole ... vonoprazan, amoxicillin and clarithromycin ... Drugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord) …

Trastuzumab

Produced in CHO cell cultures, trastuzumab is a recombinant IgG1 kappa, humanized monoclonal antibody that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular domain of the human epidermal growth factor receptor protein (HER2). It is used as a treatment of human epidermal...
Approved
Investigational
Matched Description: … Produced in CHO cell cultures, trastuzumab is a recombinant IgG1 kappa, humanized monoclonal antibody ... Trastuzumab binds to HER2 and suppresses cancer cell growth, proliferation, and survival directly and ... [L14015] It is used as a treatment of human epidermal growth factor receptor (HER)-2+ metastatic breast …
Matched Categories: … HER2 (Human Epidermal Growth Factor Receptor 2) inhibitors ... Amino Acids, Peptides, and Proteins ... pertuzumab and trastuzumab ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …

Enfuvirtide

Enfuvirtide is a 36 amino acid biomimetic peptide that is structurally similar to the HIV proteins that are responsible for the fusion of the virus to cell membranes and subsequent intracellular uptake. The first agent in the novel class of antiretroviral drugs called HIV fusion inhibitors, enfuvirtide works by inhibiting...
Approved
Investigational
Matched Description: … structurally similar to the HIV proteins that are responsible for the fusion of the virus to cell membranes and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Human Immunodeficiency Virus Proteins ... env Gene Products, Human Immunodeficiency Virus ... Human Immunodeficiency Virus 1 Fusion Inhibitor …

Brimonidine

Brimonidine is an alpha-adrenergic agonist and 2-imidazoline derivative that was first introduced in 1996. It is considered to be a third generation alpha-2 aadrenergic receptor agonist, since it displays preferential binding at alpha-2 adrenoceptors over alpha-1 receptors. Brimonidine displays a higher selectivity toward the alpha-2 adrenergic receptors than clonidine or...
Approved
Matched Description: … Brimonidine is an alpha-adrenergic agonist and 2-imidazoline derivative that was first introduced in ... Early treatment and management of glaucoma, which predominantly involves the lowering of intraocular ... [A178945] Thus brimonidine is an effective and safe alternative to beta-blockers, in patients with, or …
Matched Mixtures name: … Brimonidine Tartrate and Timolol Maleate ... BRIMONIDINE TARTRATE and TIMOLOL MALEATE ... Brimonidine Tartrate and Timolol Maleate …
Matched Categories: … Decongestants and Antiallergics ... Skin and Mucous Membrane Agents ... Antiglaucoma Preparations and Miotics …
Matched Products: … MIRVASO GEL 3MG/G ... BRİMODER %0,33 JEL, 30 G …

Atazanavir

Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses per day)...
Approved
Investigational
Matched Description: … Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). ... Food and Drug Administration (FDA) approved atazanavir on June 20, 2003. ... has lesser effects on the patient's lipid profile (the amounts of cholesterol and other fatty substances …
Matched Categories: … Amino Acids, Peptides, and Proteins ... atazanavir and ritonavir ... atazanavir and cobicistat …

Conjugated estrogens

The conjugated estrogens are noncrystalline mixtures of purified female sex hormones obtained either by its isolation from the urine of pregnant mares or by synthetic generation from vegetal material. Both of these products are later conjugated to natrium sulfate by ester bonds in order to make them more water soluble.[L5605,...
Approved
Matched Description: … also presents a large number of unidentified molecules with weak estrogenic activity as well as non-human ... 17-beta-dihydroequilenin sulfate, 2% of 17-alpha-estradiolsulfate and 3% of 17-beta-estradiolsulfate ... equilin sulfate, 15% of 17-alpha-dehydroequilenin sulfate, 3% of equilenin sulfate, 5% of 17-alpha and …
Matched Mixtures name: … Esterified Estrogens and Methyltestosterone ... Esterified Estrogens and Methyltestosterone …
Matched Categories: … Genito Urinary System and Sex Hormones ... conjugated estrogens and bazedoxifene ... Natural and Semisynthetic Estrogens, Plain ... Sex Hormones and Modulators of the Genital System ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Products: … Estrin Vaginal Cream 0.625mg/g ... PREMARIN VAGINAL CREAM 0.625MG/G …

Teplizumab

Teplizumab (teplizumab-mzwv) is a humanized IgG1 kappa CD3-directed monoclonal antibody used to delay the onset of type 1 diabetes (T1D).[A241480,A241045,A241475,L44091] T1D is an autoimmune condition in which T cell-mediated destruction of pancreatic β cells leads to loss of insulin production, impaired glycemic control, and reliance on exogenous insulin. Anti-CD3 therapy...
Approved
Investigational
Matched Description: … L44091] Fc-receptors can bind to the "tail-end" anti-CD3 antibodies in an antigen-non-specific manner and ... cell-mediated destruction of pancreatic β cells leads to loss of insulin production, impaired glycemic control, and ... mechanism of action of teplizumab has not been fully elucidated, it may involve partial agonistic signaling and …
Matched Categories: … Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins …

Diethyltoluamide

Diethyltoluamide (DEET) is the common active ingredient in many insect repellent products. It is widely used to repel biting pests such as mosquitoes and ticks. Every year, DEET formulations are used to protect populations from mosquito-borne illnesses like West Nile Virus, the Zika virus, malaria, and/or tick-borne illnesses like Lyme...
Approved
Matched Description: … products are largely designed to be applied directly to human skin, where the exact mechanisms of actions ... It is widely used to repel biting pests such as mosquitoes and ticks. ... /or tick-borne illnesses like Lyme disease and Rocky Mountain spotted fever. …
Matched Categories: … Insecticides and Repellents ... Benzamides and benzamide derivatives ... Scabicides, Insecticides and Repellents ... Antiparasitic Products, Insecticides and Repellents …

Grazoprevir

Grazoprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common...
Approved
Matched Description: … It can be used in patients with compensated cirrhosis, human immunodeficiency virus co-infection, or ... to achieve a SVR between 94% and 97% for genotype 1 and 97% and 100% for genotype 4 after 12 weeks of ... into mature proteins like NS3, NS4A, NS4B, NS5A and NS5B [FDA Label]. …
Matched Categories: … elbasvir and grazoprevir …

Cetirizine

Cetirizine, also commonly known as Zyrtec, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms , . One of the most common uses for this drug is for a condition called allergic...
Approved
Matched Description: … with sleep, and other difficulties with day to day activities for many individuals [A175057]. ... in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and ... prevalence of allergic rhinitis in the United States is about 15% according to physician diagnoses, and …
Matched Mixtures name: … ACERADOX® G ... ZYRTEC D Allergy and Congestion ... Wal Zyr D Allergy and Congestion …
Matched Categories: … Cetirizine and isomer ... Decongestants and Antiallergics …
Matched Products: … Up and Up Allergy Relief ... Up and Up Childrens Allergy ... Up and Up All Day Allergy Relief …

Brexanolone

As of March 2019, brexanolone - developed and made available commercially by Sage Therapeutics Inc. as the brand name product Zulresso - is the first drug to have ever been approved by the US FDA specifically for the treatment of postpartum depression (PPD) in adult females . Since PPD, like...
Approved
Investigational
Matched Description: … provides a new and promising therapy where few existed before [F4066]. ... As of March 2019, brexanolone - developed and made available commercially by Sage Therapeutics Inc. as ... depression, is characterized by feelings of sadness, worthlessness or guilt, cognitive impairment, and …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …

Golimumab

Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate treatment in patients with...
Approved
Matched Description: … Golimumab binds and inhibits soluble and transmembrane human TNFα. ... human TNFα. ... Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …

Catumaxomab

Catumaxumab is a trifunctional monoclonal antibody developed for use in cancer treatment. It has affinity for T-cells, accessory immune cells, and cancer cells. Catumaxumab was initially authorized for market by the European Medicines Agency in April 2009 for the treatment of malignant ascites . Its market authorization was withdrawn in...
Approved
Investigational
Withdrawn
Matched Description: … It has affinity for T-cells, accessory immune cells, and cancer cells. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …

Etranacogene dezaparvovec

Hemophilia B - also called factor IX deficiency or Christmas disease - is an X-linked genetic disorder resulting in an absence or deficiency of clotting factor IX. Clotting factors, including factor IX, are necessary components of the signaling cascade responsible for blood clotting and subsequent wound healing. Symptoms of hemophilia...
Approved
Investigational
Matched Description: … [L44161] Treatment of hemophilia B primarily involves the routine replacement of factor IX using recombinant ... [L44186] In December 2022, the EMA's Committee for Medicinal Products for Human Use (CHMP) recommended ... of a viral vector carrying a codon-optimized DNA sequence of the gain-of-function Padua variant of human …
Matched Categories: … Cellular and Gene Therapy ... Blood and Blood Forming Organs …

Pasireotide

Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease.
Approved
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins ... Somatostatin and Analogues ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Products: … SIGNIFOR LAR(60 MG POWDER AND SOLVENT FOR SUSPENSION FOR INJECTION) ... Signifor LAR 20mg powder and solvent for suspension for injection ... Signifor LAR 40mg powder and solvent for suspension for injection …

Lenacapavir

HIV/AIDS remains an area of concern despite the introduction of numerous successful therapies, mainly due to the emergence of multidrug resistance and patient difficulty in adhering to treatment regimens.[A244170, A244175] Lenacapavir is a first-in-class capsid inhibitor that demonstrates picomolar HIV-1 inhibition as a monotherapy in vitro, little to no cross-resistance...
Approved
Investigational
Matched Description: … introduction of numerous successful therapies, mainly due to the emergence of multidrug resistance and ... inhibition as a monotherapy _in vitro_, little to no cross-resistance with existing antiretroviral agents, and …
Matched Categories: … Human Immunodeficiency Virus 1 Capsid Inhibitor …

Zinc sulfate

Zinc sulfate is the inorganic compound with the formula ZnSO4 and historically known as "white vitriol". It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.
Approved
Investigational
Matched Description: … Zinc sulfate is the inorganic compound with the formula ZnSO4 and historically known as "white vitriol …
Matched Mixtures name: … /g + 5 mg/g Gel ... Multiple Vitamins and Minerals ... Calcium and Magnesium W Zinc Tab …
Matched Categories: … Alimentary Tract and Metabolism ... Blood and Blood Forming Organs ... Skin and Mucous Membrane Agents ... Blood Substitutes and Perfusion Solutions ... Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …

Plerixafor

Plerixafor is a small-molecule inhibitor of C-X-C chemokine receptor type 4 (CXCR4) that acts as a hematopoietic stem cell mobilizer.[A7117,L45678] It is used to stimulate the release of stem cells from the bone marrow into the blood in patients with non-Hodgkin's lymphoma (NHL) and multiple myeloma to stimulate their immune...
Approved
Investigational
Matched Description: … [A7117] Compared to placebo with G-CSF, the plerixafor and G-CSF mobilization regimen has a higher probability ... [A7115] Plerixafor has orphan drug status in the United States and European Union and was approved ... Since CXCR4 and SDF-1α are involved in the trafficking and homing of CD34+ cells to the marrow compartment …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Hydrogen peroxide

Hydrogen peroxide is the simplest peroxide with a chemical formula H2O2. Hydrogen peroxide is an unstable compound in the presence of a base or catalyst, and is typically stored with a stabilizer in a weakly acidic solution. If heated to its boiling point, it may undergo potentially explosive thermal decomposition....
Approved
Vet approved
Matched Description: … whites, and dried egg yolks. ... cheese products, and as an oxidizing and reducing agent in products containing dried eggs, dried egg ... and gas form for preservative, disinfection and sterilization applications as an oxidative biocide [A32369 …
Matched Mixtures name: … Prevention Wound and Burn ... QCare Oral Cleansing and Suctioning System, Q4 ... Oral Cleansing and Suctioning System, q2 …
Matched Categories: … Alimentary Tract and Metabolism ... Antiseptics and Disinfectants ... Antiinfectives and Antiseptics for Local Oral Treatment …
Matched Products: … Up and Up 3 Hydrogen Peroxide Wipes ... Multi Purpose Sanitizer and Cleaner Wipes ... QCare Oral Cleansing and Suctioning System …

Eltrombopag

Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of...
Approved
Matched Description: … thrombocytopenia (low blood platelet counts) in patients with chronic hepatitis C to allow them to initiate and …
Matched Categories: … Blood and Blood Forming Organs …

Cysteine

A thiol-containing non-essential amino acid that is oxidized to form cystine.
Approved
Nutraceutical
Matched Mixtures name: … Numeta G 13 % E Emulsion zur Infusion ... Numeta G 16 % E Emulsion zur Infusion ... Numeta G 19 % E Emulsion zur Infusion …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Sulfisoxazole

A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms.
Approved
Vet approved
Matched Description: … A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive …
Matched Categories: … Sulfonamides and trimethoprim ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Omeprazole

Originally approved by the FDA in 1989, omeprazole is a proton-pump inhibitor, used to treat gastric acid-related disorders. These disorders may include gastroesophageal reflux disease (GERD), peptic ulcer disease, and other diseases characterized by the oversecretion of gastric acid. This drug was the first clinical useful drug in its class,...
Approved
Investigational
Vet approved
Matched Description: … Omeprazole is generally effective and well-tolerated, promoting its popular use in children and adults ... These disorders may include gastroesophageal reflux disease (GERD), peptic ulcer disease, and other diseases ... This drug was the first clinical useful drug in its class, and its approval was followed by the formulation …
Matched Mixtures name: … Omeprazole and Sodium Bicarbonate ... Omeprazole and Sodium Bicarbonate ... Omeprazole and Sodium Bicarbonate …
Matched Categories: … Alimentary Tract and Metabolism ... Omeprazole and enantiomer ... omeprazole, amoxicillin and rifabutin ... omeprazole, amoxicillin and metronidazole ... omeprazole, amoxicillin and clarithromycin …
Matched Products: … OMEPRAZOLO D&G ... Up and Up Omeprazole ... Berkley and Jensen Omeprazole …

Lutetium Lu-177 vipivotide tetraxetan

Lutetium Lu-177 vipivotide tetraxetan is a radioligand therapeutic agent. It consists of a radionuclide, lutetium Lu-177, linked to a moiety that binds to PSMA, a transmembrane protein that is expressed in prostate cancer. Lutetium Lu-177 vipivotide tetraxetan was first approved by the FDA on March 23, 2022 as a treatment...
Approved
Matched Description: … [L41290] In October 2022, the EMA's Committee for Medicinal Products for Human Use (CHMP) recommended …
Displaying drugs 101 - 125 of 1932 in total