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Displaying drugs 1276 - 1300 of 2401 in total
Tadalafil is a selective phosphodiesterase-5 inhibitor that is used in the treatment of erectile dysfunction (ED), pulmonary arterial hypertension (PAH), and benign prostatic hypertrophy.[L39100, L39105] It was first approved in 2003 by the FDA for use in ED and later in 2009 for PAH. In contrast to other PDE5 inhibitors...
Approved
Investigational
Matched Synonyms: … (6R-trans)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino(1',2':1,6)pyrido(3,4-b ... (6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-(methylenedioxy)phenyl) pyrazino(1',2':1,6)pyrido( …
Matched Iupac: … (2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca …
Matched Description: … [L39100, L39105] It was first approved in 2003 by the FDA for use in ED and later in 2009 for PAH. ... In contrast to other PDE5 inhibitors like [sildenafil], tadalafil has greater selectivity for PDE5 and ... that is used in the treatment of erectile dysfunction (ED), pulmonary arterial hypertension (PAH), and
Matched Categories: … Antihypertensives for Pulmonary Arterial Hypertension ... tamsulosin and tadalafil ... macitentan and tadalafil ... ambrisentan and tadalafil ... finasteride and tadalafil …
Burosumab (KRN23) is an entirely human monoclonal IgG1 antibody that binds excess fibroblast growth factor 23 (FGF23) and has been successfully tested in clinical trials in children with X-linked hypophosphatemic rickets . The U.S. Food and Drug Administration approved Crysvita (burosumab) in April 2018. This is the first drug approved...
Approved
Investigational
Matched Description: … (XLH), which is a rare, inherited form of rickets. ... It causes impaired bone growth and development in children and adolescents and issues with bone mineralization ... This is the first drug approved to treat adults and children ages 1 year and older with X-linked hypophosphatemia …
Matched Categories: … Drugs for Treatment of Bone Diseases ... Amino Acids, Peptides, and Proteins ... Drugs Affecting Bone Structure and Mineralization …
Matched Products: … CRYSVITA® SOLUTION FOR INJECTION 10 MG/ML ... CRYSVITA® SOLUTION FOR INJECTION 30 MG/ML ... CRYSVITA® SOLUTION FOR INJECTION 20 MG/ML …
Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption via inhibiting RANK-mediated activation of osteoclasts. It is the first and currently the only RANKL inhibitor approved to prevent osteoclast-mediated bone loss. Chemically, it consists of 2 heavy...
Approved
Matched Description: … receiving androgen deprivation therapy for non-metastatic prostate cancer and women at high risk for ... fracture receiving adjuvant aromatase inhibitor therapy for breast cancer in September 2011 and in men ... [A263071] Chemically, it consists of 2 heavy and 2 light chains, with each light chain consisting of …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Drugs for Treatment of Bone Diseases ... Drugs Affecting Bone Structure and Mineralization …
Matched Products: … XGEVA 120mg Solution for Injection ... XGEVA Solution for Injection 120 mg/vial ... Prolia Solution for Injection 60mg Pre-filled Syringe …
Galcanezumab is a humanized monoclonal antibody developed by Eli Lilly and Company against human calcitonin gene-related peptide (CGRP). Although several small-molecule CGRP receptor antagonists have been developed, humanized monoclonal antibodies like galcanezumab are specifically designed to selectively bind to CGRP entities with high potency. Given this target specificity, lack of...
Approved
Investigational
Matched Description: … [A33112] Galcanezumab was approved by the FDA in September 2018, and is indicated for the preventive ... promising safety and tolerability. ... treatment of migraine and the treatment of episodic cluster headache. …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … EMGALITY SOLUTION FOR INJECTION IN PRE-FILLED PEN 120 MG/ML ... Pontevia 120 mg solution for injection in pre-filled pen ... Pontevia 120 mg solution for injection in pre-filled syringe …
Avibactam is a non-β-lactam β-lactamase inhibitor that is available in combination with ceftazidime (Avycaz). This combination was approved by the FDA on February 25, 2015 for the treatment of complicated intra-abdominal infections in combination with metronidazole, and the treatment of complicated urinary tract infections, including pyelonephritis caused by antibiotic resistant-pathogens,...
Approved
Matched Description: … As there is limited clinical safety and efficacy data, Avycaz should be reserved for patients over 18 ... infections in combination with metronidazole, and the treatment of complicated urinary tract infections ... This combination was approved by the FDA on February 25, 2015 for the treatment of complicated intra-abdominal …
Matched Products: … ZAVICEFTA POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 2G/0.5G …
Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic...
Approved
Investigational
Matched Description: … It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. ... Its potential use in acute myeloid leukaemia (AML) and juvenile myelomonocytic leukaemia (JMML) has been …
Matched Categories: … Nucleic Acid Synthesis Inhibitors ... Antineoplastic and Immunomodulating Agents ... Nucleic Acids, Nucleotides, and Nucleosides …
Matched Products: … EVOLTRA 1 MG/ML CONCENTRATE FOR SOLUTION FOR INFUSION ... NUCLOFAR Clofarabine 1mg/mL Concentrate for Solution for Infusion ... Evoltra Concentrate Solution for Infusion 1mg/ml …
Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear. As of January 29 2018, CutisPharma's Firvanq is the only FDA approved vancomycin oral liquid treatment option available for the the treatment of...
Approved
Matched Iupac: … hydroxymethyl)oxan-2-yl]oxy}-22-(carbamoylmethyl)-5,47-dichloro-2,18,32,35,37-pentahydroxy-19-[(2R)-4-methyl
Matched Description: … kidneys and the inner ear. ... 2018, CutisPharma's Firvanq is the only FDA approved vancomycin oral liquid treatment option available for ... It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to …
Matched Categories: … Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins ... Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …
Matched Products: … VANCOMYCIN KABI POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 500 MG ... CELOVAN Powder for Solution for Injection/Infusion 500 mg ... VANCOMYCIN POWDER FOR SOLUTION FOR INJECTION/INFUSION 500mg …
Trastuzumab deruxtecan is a HER2-directed antibody attached to a topoisomerase inhibitor that is approved for use in certain types of treatment-resistant HER2-positive cancers. It is classified as an antibody-drug conjugate. The cleavable peptide linker used to bind the antibody and drug in this product distinguishes it from other members of...
Approved
Investigational
Matched Description: … The cleavable peptide linker used to bind the antibody and drug in this product distinguishes it from ... A188988] Trastuzumab deruxtecan was developed by Daiichi Sankyo in collaboration with AstraZeneca and ... Trastuzumab deruxtecan is a HER2-directed antibody attached to a topoisomerase inhibitor that is approved for
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Matched Products: … ENHERTU POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 100MG/VIAL …
Panitumumab (ABX-EGF) is a recombinant human IgG2 monoclonal antibody that binds specifically to the human epidermal growth factor receptor (EGFR). This drug is an antineoplastic agent. Panitumumab was granted FDA approval on 27 September 2006.
Approved
Investigational
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Matched Products: … Vectibix 100mg Concentrate for Solution for Infusion ... Vectibix Concentrate for Solution for Infusion 100 mg/vial …
Benralizumab is a humanized recombinant monoclonal antibody of the isotype IgG1k immunoglobulin that specifically binds to the alpha chain of the interleukin 5 receptor (IL-5R) expressed on eosinophils and basophils. It inhibits the binding of IL-5 as well as the hetero-oligomerization of the alpha and beta subunits of the IL-5R,...
Approved
Investigational
Matched Description: … It is an afucosylated IgG which gives it high affinity for the FcγRIIIα receptor in natural killer cells ... , macrophages and neutrophils. ... global biologic research and development arm. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Drugs for Obstructive Airway Diseases …
Matched Products: … Fasenra 30mg Solution for Injection in Pre-filled Pen ... Fasenra 30 mg solution for injection in pre-filled syringe ... FASENRA SOLUTION FOR INJECTION 30MG/ML (AUTOINJECTOR PEN) …
Dihydrocodeine is an opioid analgesic used as an alternative or adjunct to codeine to treat moderate to severe pain, severe dyspnea, and cough. It is semi-synthetic, and was developed in Germany in 1908 during an international search to find a more effective antitussive agent to help reduce the spread of...
Approved
Illicit
Matched International brands: … DF-118 Forte
Matched Iupac: … (1S,5R,13R,14S,17R)-10-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca …
Matched Description: … It is semi-synthetic, and was developed in Germany in 1908 during an international search to find a more ... analgesic used as an alternative or adjunct to codeine to treat moderate to severe pain, severe dyspnea, and
Matched Mixtures name: … dihydrocodeine bitartrate and aspirin and caffeine DC ... Acetaminophen, Caffeine and Dihydrocodeine Bitartrate ... Dihydrocodeine Bitartrate, Acetaminophen and Caffeine …
Matched Categories: … Semi-synthetic Opioids ... dihydrocodeine and paracetamol ... dihydrocodeine and acetylsalicylic acid …
Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as Dsuvia, the sublingual form is used for the management of acute pain in adults that...
Approved
Investigational
Matched International brands: … Sufenta Forte
Matched Description: … It is administered by the intravenous, epidural and sublingual routes. ... Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and ... analgesic in certified medically supervised healthcare settings, including hospitals, surgical centers, and
Matched Categories: … Fentanyl and fentanyl analogues …
Bexagliflozin is a highly specific and potent sodium-glucose co-transporter 2 (SGLT2) inhibitor.[A256408,A256413,L44758] Similar to other SGLT2 inhibitors, bexagliflozin contains three basic moieties: glucose, two benzene rings and a methylene bridge. SGLT2 is responsible for 60% to 90% of renal glucose re-uptake, and unlike other isoforms such as SGLT1, SGLT2 is...
Approved
Investigational
Matched Synonyms: … D-glucitol, 1,5-anhydro-1-C-(4-chloro-3-((4-(2-(cyclopropyloxy)ethoxy)phenyl)methyl)phenyl)-, (1s)- ... (2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-(2-(cyclopropyloxy)ethoxy)phenyl)methyl)phenyl)-6-(hydroxymethyl)tetrahydro …
Matched Iupac: … (2S,3R,4R,5S,6R)-2-(4-chloro-3-{[4-(2-cyclopropoxyethoxy)phenyl]methyl}phenyl)-6-(hydroxymethyl)oxane …
Matched Description: … [A256413] SGLT2 is responsible for 60% to 90% of renal glucose re-uptake, and unlike other isoforms such ... Bexagliflozin is a highly specific and potent sodium-glucose co-transporter 2 (SGLT2) inhibitor. ... to other SGLT2 inhibitors, bexagliflozin contains three basic moieties: glucose, two benzene rings and
Matched Categories: … Alimentary Tract and Metabolism …
Eravacycline, known as Xerava by Tetraphase Pharmaceuticals, is a fully synthetic fluorocycline antibiotic of the tetracycline class with activity against clinically significant gram-negative, gram-positive aerobic, and facultative bacteria. This includes most of those bacteria resistant to cephalosporins, fluoroquinolones, β-lactam/β-lactamase inhibitors, multidrug-resistant strains, and carbapenem-resistant Enterobacteriaceae, and the majority of anaerobic...
Approved
Investigational
Matched Description: … Eravacycline, known as _Xerava_ by Tetraphase Pharmaceuticals, is a fully synthetic fluorocycline antibiotic ... Eravacycline has demonstrated superior potency to that of antibiotics that are currently being marketed for ... carbapenem-resistant Enterobacteriaceae, and the majority of anaerobic pathogens [A38683]. …
Matched Categories: … Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …
Matched Products: … XERAVA POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 50MG PER VIAL …
Corifollitropin alfa, also known as Elonva is used in women undergoing fertility treatment to stimulate the development of more than one mature egg (oocyte) at a time in the ovaries. This drug used together with a gonadotropin-releasing hormone (GnRH) antagonist, a type of medicine also used in fertility treatments. Elonva...
Approved
Investigational
Matched Description: … Multiple studies and a meta-analysis suggest that corifollitropin alfa is as efficacious as recombinant ... FDA for its New Drug Application for this drug. ... Corifollitropin alfa is produced by a method known as ‘recombinant DNA technology’. …
Matched Categories: … Genito Urinary System and Sex Hormones ... Sex Hormones and Modulators of the Genital System ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Products: … Elonva Solution for Injection 150mcg/0.5ml ... Elonva Solution for Injection 100mcg/0.5ml ... Elonva (solution for injection 100mcg/0.5ml) …
Evolocumab is a monoclonal antibody designed for the treatment of hyperlipidemia by Amgen. It is a subcutaneous injection approved by the FDA for individuals on maximum statin therapy who still require additional LDL-cholesterol lowering. It is approved for both homozygous and heterozygous familial cholesterolemia as an adjunct to other first-line...
Approved
Matched Description: … It is approved for both homozygous and heterozygous familial cholesterolemia as an adjunct to other first-line ... Evolocumab is designed to bind to PCSK9 and inhibit PCSK9 from binding to LDL receptors on the liver ... Evolocumab is a monoclonal antibody designed for the treatment of hyperlipidemia by Amgen. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Hypolipidemic Agents Indicated for Hyperlipidemia ... Non-statin Hypolipidemic Agents Indicated for Hyperlipidemia …
Matched Products: … REPATHA SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE 140MG/ML ... Repatha Solution for Injection in Pre-filled Syringe 140mg/mL (evolocumab) ... REPATHA SOLUTION FOR INJECTION IN PRE-FILLED AUTOINJECTOR 140MG/ML …
A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin.
Approved
Investigational
Matched Description: … It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. ... of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and ... Bleomycin A2 is used as the representative structure for Bleomycin. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Cytotoxic Antibiotics and Related Substances …
Matched Products: … Bleomycin for Injection ... Bleomycin for Injection USP ... BLOICIN-S FOR INJECTION 15 UNITS …
Methoxy polyethylene glycol-epoetin beta is a chemically synthesised Erythropoiesis Stimulating Agent (ESA) with a longer half-life than erythropoietin. ESA is used to increase synthesis of red blood cells to treat chronic kidney disease associated anemia.
Approved
Matched Description: … ESA is used to increase synthesis of red blood cells to treat chronic kidney disease associated anemia …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Blood and Blood Forming Organs ... Intercellular Signaling Peptides and Proteins …
Matched Products: … MIRCERA SOLUTION FOR INJECTION IN PRE FILLED SYRINGE, 200MCG/0.3ML ... MIRCERA SOLUTION FOR INJECTION IN PRE FILLED SYRINGE, 150MCG/0.3ML ... MIRCERA SOLUTION FOR INJECTION IN PRE FILLED SYRINGE, 100MCG/0.3ML …
Cimicoxib is a selective COX-2 inhibitor being developed by Affectis as a treatment for depression and schizophrenia. If approved, Cimicoxib would be the first drug in decades to treat depression by a new mechanism of action.
Investigational
Matched Description: … Cimicoxib is a selective COX-2 inhibitor being developed by Affectis as a treatment for depression and
Matched Products: … Cimalgex 30mg chewable tablets for dogs ... Cimalgex 80mg chewable tablets for dogs ... Cimalgex 8mg chewable tablets for dogs …
Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. It is structurally similar to polymeric glycosaminoglycan heparin and heparan sulfate (HS) when they are cleaved into monomeric units. The monomeric sequence in heparin and HS...
Approved
Investigational
Matched Iupac: … ]oxan-2-yl]oxy}-3,4-dihydroxyoxan-2-yl]oxy}-3-(sulfoamino)-4-(sulfooxy)-6-[(sulfooxy)methyl]oxan-2-yl ... 5R,6R)-5-{[(2R,3R,4R,5S,6S)-6-carboxy-5-{[(2R,3R,4R,5S,6R)-4,5-dihydroxy-3-(sulfoamino)-6-[(sulfooxy)methyl ... ]oxy}-4-hydroxy-6-{[(2R,3S,4R,5R,6S)-4-hydroxy-6-methoxy-5-(sulfoamino)-2-[(sulfooxy)methyl]oxan-3-yl …
Matched Description: … The monomeric sequence in heparin and HS is thought to form the high affinity binding site for the natural ... Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and ... a O-methyl group at the reducing end of the molecule. …
Matched Categories: … Blood and Blood Forming Organs …
Matched Products: … ARIXTRA 12.5MG/ML SOLUTION FOR INJECTION ... ARIXTRA 2.5MG/0.5ML SOLUTION FOR INJECTION ... Arixtra Solution for Injection 7.5 mg/0.6 ml …
Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant regions, and complementarity-determining regions from a...
Approved
Investigational
Matched Description: … [L43397] It is marketed as LEMTRADA for multiple sclerosis (MS) treatment and CAMPTAH for B-cell chronic ... The dose of alemtuzumab used for B-CLL is much higher than that for MS, and also at more frequent dosing ... The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant regions, and
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Products: … LEMTRADA Concentrate for Solution for Infusion 12 mg ... LEMTRADA CONCENTRATE FOR SOLUTION FOR INFUSION 12 MG/ 1.2 ML …
Dezapelisib is under investigation in clinical trial NCT02456675 (INCB040093 and INCB040093 Combined With Itacitinib (INCB039110) in Relapsed/refractory Hodgkin Lymphoma).
Investigational
Matched Synonyms: … 6-(3-fluorophenyl)-3-methyl-7-[(1S)-1-(7H-purin-6-ylamino)ethyl]-[1,3]thiazolo[3,2-a]pyrimidin-5-one …
Matched Iupac: … 6-(3-fluorophenyl)-3-methyl-7-[(1S)-1-[(9H-purin-6-yl)amino]ethyl]-5H-[1,3]thiazolo[3,2-a]pyrimidin-5 …
Matched Description: … Dezapelisib is under investigation in clinical trial NCT02456675 (INCB040093 and INCB040093 Combined …
Experimental
Matched Synonyms: … Quercetin 3'-methyl ether …
Investigational
Matched Synonyms: … 2-(2-chlorophenyl)-4-[3-(dimethylamino)phenyl]-5-methyl-1H-pyrazolo[4,3-C]pyridine-3,6(2H,5H)-dione …
Matched Iupac: … 2-(2-chlorophenyl)-4-[3-(dimethylamino)phenyl]-5-methyl-1H,2H,3H,5H,6H-pyrazolo[4,3-c]pyridine-3,6-dione …
Investigational
Matched Synonyms: … 4h-1-benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)- …
Displaying drugs 1276 - 1300 of 2401 in total