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Displaying drugs 126 - 150 of 10402 in total

Levetiracetam

Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures stemming from epileptic disorders. It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated to other anti-epileptic drugs (AEDs).[L8606,L8600,L8615] Levetiracetam possesses a wide therapeutic index[L8615,A185918]...
Approved
Matched Description: … It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated …
Matched Categories: … Central Nervous System Agents …
Matched Products: … LEVETIRACETAM ACTAVIS GROUP ... Levetiracetam Actavis Group …

Dichloroacetic acid

Dichloroacetic acid, often abbreviated DCA, is an acid analogue of acetic acid in which two of the three hydrogen atoms of the methyl group have been replaced by chlorine atoms. Salts of DCA are used as drugs since they inhibit the enzyme pyruvate dehydrogenase kinase. Early reports of its activity...
Approved
Investigational
Matched Description: … hydrogen atoms of the methyl group have been replaced by chlorine atoms. ... Dichloroacetic acid, often abbreviated DCA, is an acid analogue of acetic acid in which two of the three ... DCA was approved for use in Canada in 1989 (as a topical formulation for treatment of warts and for cauterization …

Omaveloxolone

Omaveloxolone (RTA-408) is a semisynthetic oleanane triterpenoid with antioxidant and anti-inflammatory properties.[A257534,A257539] Omaveloxolone acts as an activator of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), a transcription factor that mitigates oxidative stress. In patients with Friedreich's ataxia, a genetic disease involving mitochondrial dysfunction, the Nrf2 pathway is impaired, and Nrf2 activity...
Approved
Investigational
Matched Description: … [A257534,A257539] Omaveloxolone acts as an activator of nuclear factor (erythroid-derived 2)-like 2 ( ... [A257529] In February 2023, omaveloxolone was approved by the FDA for the treatment of Friedreich's ataxia ... Therefore, the use of Nrf2 activators such as omaveloxolone represents a therapeutic advantage in this group …
Matched Categories: … Anti-Inflammatory Agents …

Difenoxin

Difenoxin is a 4-phenylpiperidine which is closely related to the opioid analgesic meperidine. Difenoxin alone is a USA Schedule I controlled drug, as it may be habit forming. However, it is listed as a Schedule IV controlled drug if combined with atropine, which is added to decrease deliberate misuse. Motofen(R)...
Approved
Illicit
Matched Description: … It is approved by the FDA to treat acute and chronic diarrhea. ... However, the antidiarrheal potency of difenoxin is much greater than its CNS effects, which makes it an ... Difenoxin is an active metabolite of the anti-diarrheal drug, diphenoxylate, which is also used in combination …
Matched Categories: … Antidiarrheals, Intestinal Antiinflammatory/antiinfective Agents …

Viltolarsen

Duchenne muscular dystrophy (DMD) is an X-linked recessive allelic disorder characterized by a lack of functional dystrophin protein, which leads to progressive ambulatory, pulmonary, and cardiac function and is invariably fatal. A related, albeit a less severe, form of muscular dystrophy known as Becker muscular dystrophy (BMD) is characterized by...
Approved
Investigational
Matched Description: … Duchenne muscular dystrophy (DMD) is an X-linked recessive allelic disorder characterized by a lack of ... A218176] Viltolarsen was granted accelerated FDA approval on August 12, 2020, based on data showing an …

Migalastat

Fabry disease is a rare, progressive genetic disorder characterized by a defective GLA gene that causes a deficiency in the enzyme alpha-Galactosidase A (alpha-Gal A). This enzyme is responsible for breaking down glycosphingolipid substrate that, when deficient in patients with Fabry disease, builds up in the blood vessels, the kidneys,...
Approved
Investigational
Matched Description: … ., it is estimated that more than 3,000 people are living with Fabry disease, and an estimated more than ... an oral pharmacological chaperone of alpha-Gal A for the treatment of Fabry disease in adults who have ... [L4274] Migalastat (approved and sold under Amicus Therapeutics' brand name Galafold) is subsequently …

Osimertinib

Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the T790M mutation as detected by FDA-approved testing...
Approved
Matched Description: … Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor ... (NSCLC) in cases where tumour EGFR expression is positive for the T790M mutation as detected by FDA-approved …
Matched Categories: … Antineoplastic Agents ... Antineoplastic and Immunomodulating Agents …

Boric acid

Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing, but is also used as an additive in pharmaceutical products, cosmetics, lotions, soaps, mouthwash, toothpaste, astringents, and eyewashes . It...
Approved
Matched Description: … Boric acid is typically utilized in industrial processing and manufacturing, but is also used as an additive …
Matched Categories: … Anti-Infective Agents …

Selenious acid

Selenious acid is the acid form of sodium selenite, a form of selenium . Selenium is an essential trace element and antioxidant. It is a cofactor metabolic enzyme regulation. It also plays an important role in maintaining the general health of tissue and muscle and has antioxidant properties. Selenium is...
Approved
Investigational
Matched Description: … Selenium is an essential trace element and antioxidant. ... It also plays an important role in maintaining the general health of tissue and muscle and has antioxidant …

Doxorubicin

Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed...
Approved
Investigational
Matched Description: … compared to the methyl group of daunorubicin. ... [A257614] Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat ... both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group …
Matched Categories: … Antineoplastic Agents ... Myelosuppressive Agents ... Photosensitizing Agents ... Immunosuppressive Agents ... Cardiotoxic antineoplastic agents …

Busulfan

Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought...
Approved
Investigational
Matched Categories: … Antineoplastic Agents ... Myelosuppressive Agents ... Immunosuppressive Agents ... Antineoplastic Agents, Alkylating ... Cardiotoxic antineoplastic agents …

Disulfiram

A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms...
Approved
Matched Description: … A carbamate derivative used as an alcohol deterrent. …
Matched Categories: … QTc Prolonging Agents ... Central Nervous System Agents ... Agents that reduce seizure threshold ... Potential QTc-Prolonging Agents …

Mianserin

A tetracyclic compound with antidepressant effects. Mianserin was previously available internationally, however in most markets it has been phased out in favour of mirtazapine.
Approved
Investigational
Matched Categories: … Antidepressive Agents ... Antidepressive Agents, Tetracyclic ... Antidepressive Agents, Second-Generation ... Adrenergic Agents ... Histamine Agents …

Dasatinib

Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the breakpoint cluster region (BCR) gene transcribe the chimeric protein...
Approved
Investigational
Matched Description: … [A2226] The use of dasatinib was first approved by the FDA in 2006.[L45171,L45186] ... Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome …
Matched Categories: … Antineoplastic Agents ... QTc Prolonging Agents ... Myelosuppressive Agents ... Photosensitizing Agents ... Immunosuppressive Agents …

Infigratinib

Infigratinib is a pan-fibroblast growth factor receptor (FGFR) kinase inhibitor. By inhibiting the FGFR pathway, which is often aberrated in cancers such as cholangiocarcinoma, infigratinib suppresses tumour growth. Cholangiocarcinoma is the most common primary malignancy affecting the biliary tract and the second most common primary hepatic malignancy. Infitratinib is a...
Approved
Investigational
Matched Description: … FDA-approved test. ... [A198963] Infitratinib is a pan-FGFR inhibitor, as it is an ATP-competitive inhibitor of all four FGFR ... [L34304] This approval follows [pemigatinib], another FGFR inhibitor approved by the FDA for the same …
Matched Categories: … Antineoplastic Agents ... Antineoplastic and Immunomodulating Agents …

Meclofenamic acid

A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.
Approved
Vet approved
Matched Categories: … Nephrotoxic agents ... Antirheumatic Agents ... Agents causing hyperkalemia ... Anti-Inflammatory Agents ... Sensory System Agents …

Luspatercept

Luspatercept is a recombinant fusion protein comprised of a modified extracellular domain of activin receptor type IIB fused to the FC domain of human IgG1.[A187829,L42455] It was first approved for use in the United States in November 2019 under the brand name Reblozyl® for the treatment of anemia in patients...
Approved
Investigational
Matched Description: … [A187829,L42455] It was first approved for use in the United States in November 2019 under the brand ... ameliorates anemia via action on late-stage erythropoiesis, in contrast to typical erythropoiesis-stimulating agents …
Matched Categories: … Phosphotransferases (Alcohol Group Acceptor) ... Hematologic Agents ... Erythroid Maturation Agents …

Anethole

Approved
Experimental
Matched Categories: … Flavoring Agents …

Pirenzepine

An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also...
Approved
Matched Description: … It also potentiates the effect of other antiulcer agents such as cimetidine and ranitidine. ... An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal …
Matched Categories: … Anti-Ulcer Agents ... Cholinergic Agents ... Anticholinergic Agents ... Agents producing tachycardia ... Gastrointestinal Agents …

Cinnamyl alcohol

Cinnamyl alcohol is a naturally occurring compound that is found within cinnamon. Due to the low levels found in cinnamon, cinnamyl alcohol is usually supplied as DB14184 within commercial products. Cinnamyl alcohol has been shown to be a skin sensitizer, with a NOEL (No Effect Level) of ~4% . Sensitivity...
Approved
Experimental

Tolcapone

Tolcapone is a drug that inhibits the enzyme catechol-O-methyl transferase (COMT). It is used in the treatment of Parkinson's disease as an adjunct to levodopa/carbidopa medication. It is a yellow, odorless, non-hygroscopic, crystalline compound. Tolcapone is associated with a risk of hepatotoxicity.
Approved
Withdrawn
Matched Description: … It is used in the treatment of Parkinson's disease as an adjunct to levodopa/carbidopa medication. …
Matched Categories: … Dopamine Agents ... Anti-Dyskinesia Agents ... Hypotensive Agents ... Central Nervous System Agents …

Enmetazobactam

Enmetazobactam is a penicillanic acid sulfone extended-spectrum beta (β)-lactamase (ESBL) inhibitor. Because ESBL enzymes can hydrolyze important antibiotics such as penicillins, broad-spectrum cephalosporins and monobactams, ESBL-producing bacteria poses challenges in the treatment of serious infections. The combination product of enmetazobactam and cefepime was first approved by the FDA on February...
Approved
Matched Description: … [A263276] The combination product of enmetazobactam and [cefepime] was first approved by the FDA …
Matched Categories: … Anti-Bacterial Agents ... Anti-Infective Agents …

Indacaterol

Indacaterol is a novel, ultra-long-acting, rapid onset β(2)-adrenoceptor agonist developed for Novartis for the once-daily management of asthma and chronic obstructive pulmonary disease. It was approved by the European Medicines Agency (EMA) on 30 November 2009 and by the FDA on 1 July 2011. It is marketed in Europe as...
Approved
Matched Description: … It was approved by the European Medicines Agency (EMA) on 30 November 2009 and by the FDA on 1 July 2011 …
Matched Categories: … QTc Prolonging Agents ... Agents producing tachycardia ... Agents to Treat Airway Disease ... Agents that produce hypertension ... Potential QTc-Prolonging Agents …

Amoxapine

Amoxapine, the N-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, amoxapine does not affect mood or arousal, but may cause sedation....
Approved
Matched Description: … They contain a tricyclic ring system with an alkyl amine substituent on the central ring. ... The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission …
Matched Categories: … Antidepressive Agents ... Antidepressive Agents, Tricyclic ... Antidepressive Agents, Tetracyclic ... Antidepressive Agents Indicated for Depression ... Adrenergic Agents …

Tiaprofenic acid

Tiaprofenic acid is a non-steroidal anti-inflammatory drug employed in the treatment of pain, particularly arthritis pain. It belongs to the arylpropionic acid (profen) group of nonsteroidal anti-inflammatory drugs (NSAIDs).
Approved
Matched Description: … It belongs to the _arylpropionic acid_ (profen) group of nonsteroidal anti-inflammatory drugs (NSAIDs …
Matched Categories: … Nephrotoxic agents ... Antirheumatic Agents ... Agents causing hyperkalemia ... Anti-Inflammatory Agents ... Sensory System Agents …
Displaying drugs 126 - 150 of 10402 in total