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Displaying drugs 126 - 150 of 10489 in total

Fluticasone

Fluticasone is a synthetic glucocorticoid available as 2 esters, DB08906 and DB00588[F4355,F4358,F4361,F4364][FDA Label]. These drugs are available as inhalers, nasal, sprays, and topical treatments for various inflammatory indications[F4355,F4358,F4361,F4364][FDA Label]. DB00588 was first approved in 1990 and DB08906 was approved in 2007 .
Approved
Experimental
Matched Description: … [DB00588] was first approved in 1990[L5962] and [DB08906] was approved in 2007[L5965]. …

Dexchlorpheniramine maleate

Dexchlorpheniramine is the S-enantiomer of chlorpheniramine which is a 1st generation anti-histamine. Dexchlorpheniramine has more pharmacological activity than the R and so is more potent than the racemic mixture.
Approved
Matched Description: … Dexchlorpheniramine is the S-enantiomer of chlorpheniramine which is a 1st generation anti-histamine. …

Clonazepam

A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop.[FDA Label][L5572,F3763,F3787,F3796] The agent has also been indicated for treating panic disorder.[FDA Label][A175438,L5572,F3763,F3787,F3796] The mechanism of action appears to involve the enhancement of gamma-aminobutyric acid receptor responses.[FDA Label][A175438,A175441,L5572,F3763,F3787,F3796] Since being...
Approved
Illicit
Matched Description: … of gamma-aminobutyric acid receptor responses. ... [FDA Label][A175438,L5572,F3763,F3787,F3796] The mechanism of action appears to involve the enhancement ... Now available as a generic medication, the agent continues to see exceptionally high use as millions of …
Matched Products: … GABACLOTEC-S …

N-acetyltyrosine

N-acetyltyrosine, also referred to as N-acetyl-L-tyrosine, is used in place of as a tyrosine precursor. DB00135 is a non-essential amino acid with a polar side group. N-acetyltyrosine is administered as parenteral nutrition or intravenous infusion due to its enhanced solubility compared to tyrosine . It is typically administered as a...
Approved
Matched Description: … N-acetyltyrosine, also referred to as N-acetyl-L-tyrosine, is used in place of as a tyrosine precursor ... It is typically administered as a source of nutritional support where oral nutrition is inadequate or …

Lutropin alfa

Lutropin alfa is a recombinant human luteinizing hormone produced in yeast with 2 subunits, alpha = 92 residues, beta = 121 residues. It is a heterodimeric glycoprotein made up of monomeric units. Lutropin alfa was the first and only recombinant human form of luteinizing hormone (LH) developed for use in...
Approved
Matched Description: … Its pharmacological action mimics the biological activity of endogenous LH; an acute rise of LH, or LH ... use in the stimulation of follicular development. ... It is a heterodimeric glycoprotein made up of monomeric units. …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Choriogonadotropin alfa

Recombinant human chorionic gonadotropin with 2 subunits, alpha = 92 residues, beta = 145 residues, each with N-and O-linked carbohydrate moieties linked to ASN-52 and ASN-78 (on alpha subunit) and ASN-13, ASN-30, SER-121, SER-127, SER-132 and SER-138 (on beta subunit). The primary structure of the alpha-chain of r-hCG is identical...
Approved
Matched Description: … The primary structure of the alpha-chain of r-hCG is identical to that of the alpha-chain of hCG, FSH …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Verapamil

Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes drugs...
Approved
Matched Description: … , each of which is pharmacologically distinct - the S-enantiomer carries approximately 20-fold greater ... [L8791] Verapamil is administered as a racemic mixture containing equal amounts of the S- and R-enantiomer ... [A188514] It is a member of the non-dihydropyridine class of calcium channel blockers, which includes …

Drotrecogin alfa

Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated...
Approved
Investigational
Withdrawn
Matched Description: … It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and …

Triamcinolone

Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermatoses. Triamcinolone is more...
Approved
Vet approved
Matched Description: … or first line as a topical treatment of corticosteroid responsive dermatoses. ... to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of ... [L8255] Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain,[L8264] …
Matched Mixtures name: … Point Of Care Kit KM …

Tetracycline

Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some extent to the...
Approved
Vet approved
Withdrawn
Matched Description: … [L43942] Other formulations of tetracycline continue to be used. ... Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria ... The FDA withdrew its approval for the use of all liquid oral drug products formulated for pediatric use …
Matched Categories: … combinations of tetracyclines …
Matched Products: … S-MEPROTETRA …

Nebivolol

Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than atenolol, propranolol, or pindolol. Nebivolol and other beta...
Approved
Investigational
Matched Description: … [A182594] Nebivolol was granted FDA approval on 17 December 2007.[L7985] ... Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other …

Armodafinil

Armodafinil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea (OSA), narcolepsy, or shift work disorder (SWD). Research has shown that armodafinil significantly improves driving simulator performance in patients with SWD. Armodafinil consists...
Approved
Investigational
Matched Description: … Food and Drug Administration (FDA) in June 2007. ... Armodafinil consists of the (−)-R-enantiomer of the racemic modafinil. ... Armodafinil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated …
Matched Categories: … Metabolic Side Effects of Drugs and Substances …

Imatinib

Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated with...
Approved
Matched Description: … with a daily dosage of 300 mg or more and typically occurred in the first four weeks of therapy". ... The discovery of imatinib also established a new group of therapy called "targeted therapy", since treatment ... can be tailored specifically to the unique cancer genetics of each patient. …

Hydroxyamphetamine

Hydroxyamphetamine is a derivative of amphetamines. Hydroxyamphetamine is intended mainly as local eye drops for diagnostic purposes. It is indirect sympathomimetic agent which cause dilation of the eye pupil before diagnostic test. Among the minor side effects from its use are: change in color vision, difficulty seeing at night, dry...
Approved
Matched Description: … The main use of hydroxyamphetamines as eye drops is the diagnosis of Horner's syndrome which is characterized ... Hydroxyamphetamine is a derivative of amphetamines. ... It is indirect sympathomimetic agent which cause dilation of the eye pupil before diagnostic test. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Meticrane

Meticrane is a diuretic medication. It has been marketed in Japan under the trade name Arresten and is used to lower blood pressure .
Approved
Matched Categories: … combinations of sulfonamides …

Zinc sulfate, unspecified form

Zinc sulfate is a common zinc supplement in parenteral nutrition.[A216916,L12888]
Approved
Experimental
Matched Categories: … Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …

Nutmeg

Nutmeg allergenic extract is used in allergenic testing.
Approved
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Lomifylline

Approved
Matched Categories: … combinations of xanthines …

Clodronic acid

Clodronic acid is a first generation bisphosphonate similar to etidronic acid and tiludronic acid. These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. clodronate’s use has decreased over the years in favor of the third generation, nitrogen containing bisphosphonate zoledronic acid, ibandronic acid,...
Approved
Investigational
Vet approved
Matched Description: … [A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification ... [A1923] clodronate’s use has decreased over the years in favor of the third generation, nitrogen containing …
Matched Categories: … Drugs for Treatment of Bone Diseases …

Flunisolide

Flunisolide (marketed as AeroBid, Nasalide, Nasarel) is a corticosteroid with anti-inflammatory actions. It is often prescribed as treatment for allergic rhinitis and its principle mechanism of action involves activation of glucocorticoid receptors.
Approved
Investigational
Matched Description: … activation of glucocorticoid receptors. ... It is often prescribed as treatment for allergic rhinitis and its principle mechanism of action involves …

Phenyltoloxamine

Phenyltoloxamine is an antihistamine drug with sedative and analgesic effects. It is a H1 receptor blocker and a member of the ethanolamine class of antihistaminergic drugs. It is available in combination products that also contain other analgesics and antitussives such as acetaminophen. Phenyltoloxamine citrate is the more common salt form...
Approved
Matched Description: … It is a H1 receptor blocker and a member of the ethanolamine class of antihistaminergic drugs. ... It also potentiates the effects of other drugs, such as codeine and codeine derivatives. ... Phenyltoloxamine acts as an adjuvant analgesic, which augments the analgesic effect of acetaminophen. …

Gadolinium

Gadolinium is under investigation in Hypertension, ACUTE KIDNEY INJURY, and Chronic Kidney Disease. Gadolinium has been investigated for the basic science of CAD, Multiple Sclerosis, and Coronary Artery Disease.
Approved
Investigational
Matched Description: … Gadolinium has been investigated for the basic science of CAD, Multiple Sclerosis, and Coronary Artery …
Matched Categories: … Diagnostic Uses of Chemicals …

Doripenem

Doripenem is a broad-spectrum, carbapenem antibiotic marketed under the brand name Doribax by Janssen. Doripenem injection was approved by the FDA in 2007 to treat complicated urinary tract and intra-abdominal infections. In a clinical trial of doripenem treatment in ventilator associated pneumonia (vs. imipenem and cilastatin), it was found that...
Approved
Investigational
Matched Description: … Doripenem injection was approved by the FDA in 2007 to treat complicated urinary tract and intra-abdominal ... in a premature termination of the trial. ... In a clinical trial of doripenem treatment in ventilator associated pneumonia (vs. imipenem and cilastatin …

Alogliptin

Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25, 2013.
Approved
Matched Description: … It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. ... Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase …

Lanthanum carbonate

Lanthanum carbonate is a phosphate binder marketed under the trade name Fosrenol by Shire Pharmaceuticals. It is a large pill that requires thorough chewing to avoid choking and other gastrointestinal adverse effects. It is used to treat elevated phosphate levels, primarily in patients with chronic kidney disease, by binding to...
Approved
Matched Categories: … Drugs for Treatment of Hyperkalemia and Hyperphosphatemia …
Displaying drugs 126 - 150 of 10489 in total