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Displaying drugs 1576 - 1600 of 14950 in total

Opicapone

Opicapone is a potent, reversible, and peripherally-acting third-generation inhibitor of catechol-o-methyltransferase (COMT), an enzyme involved in the breakdown of various catecholamines including dopamine.[A36938, A203048] Many patients with Parkinson’s disease treated with levodopa plus a dopa decarboxylase (DDC) inhibitor (eg carbidopa) experience motor complications over time, which calls for the management...
Approved
Investigational
Matched Description: … disease and end-of-dose motor fluctuations. ... Opicapone is a potent, reversible, and peripherally-acting third-generation inhibitor of catechol-o-methyltransferase ... Opicapone was approved for use by the European Commission in June 2016 [L2339] and the FDA in April 2020 …

Phenylethyl resorcinol

A tyrosinase inhibitor with skin-lightening activity.
Approved
Experimental

Tranylcypromine

A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders (From AMA Drug Evaluations Annual, 1994, p311). Tranylcypromine is a racemate comprising...
Approved
Investigational
Matched Description: … monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and ... It also is useful in panic and phobic disorders (From AMA Drug Evaluations Annual, 1994, p311). ... Tranylcypromine is a racemate comprising equal amounts of (1R,2S)- and (1S,2R)-2-phenylcyclopropan-1- …

Gadopentetic acid

A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see pentetic acid), that is given to enhance the image in cranial and spinal MRIs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p706)
Approved
Matched Description: … diethylenetriamine penta-acetic acid (DTPA see pentetic acid), that is given to enhance the image in cranial and …

Prasterone

Prasterone, also known as dehydroepiandrosterone (DHEA) is a major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. In...
Approved
Investigational
Nutraceutical
Matched Description: … It is also produced in small quantities in the testis and the ovary. ... Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone ... DHEA and DHEAS are readily available in the United States, where they are marketed as over-the-counter …
Matched Categories: … Androgens and Estrogens ... prasterone and estrogen ... Alimentary Tract and Metabolism ... Genito Urinary System and Sex Hormones ... Sex Hormones and Modulators of the Genital System …

Ketotifen

Ketotifen is a benzocycloheptathiophene derivative with potent antihistaminic and mast cell stabilizing properties. It has a similar structure to some other first-generation antihistamines such as cyproheptadine and azatadine. Ketotifen was first developed in Switzerland in 1970 by Sandoz Pharmaceuticals and was initially marketed for the treatment of anaphylaxis. In the...
Approved
Matched Description: … allergic symptoms and disorders,[A231204] including urticaria, mastocytosis, and food allergy. ... Ketotifen is a benzocycloheptathiophene derivative[A231204] with potent antihistaminic and mast cell ... It has a similar structure to some other first-generation antihistamines such as [cyproheptadine] and …
Matched Categories: … Decongestants and Antiallergics …
Matched Products: … Up and Up Eye Itch Relief …

Plerixafor

Plerixafor is a small-molecule inhibitor of C-X-C chemokine receptor type 4 (CXCR4) that acts as a hematopoietic stem cell mobilizer.[A7117,L45678] It is used to stimulate the release of stem cells from the bone marrow into the blood in patients with non-Hodgkin's lymphoma (NHL) and multiple myeloma to stimulate their immune...
Approved
Investigational
Matched Iupac: … 1-({4-[(1,4,8,11-tetraazacyclotetradecan-1-yl)methyl]phenyl}methyl)-1,4,8,11-tetraazacyclotetradecane …
Matched Description: … [A7115] Plerixafor has orphan drug status in the United States and European Union and was approved ... Since CXCR4 and SDF-1α are involved in the trafficking and homing of CD34+ cells to the marrow compartment ... by the US Food and Drug Administration on December 15, 2008. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Benzyl benzoate

Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. It is characterised by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so...
Approved
Matched Description: … It is also used to treat lice infestation of the head and body. ... Benzyl benzoate is lethal to this mite and so is useful in the treatment of scabies. ... It is characterised by severe itching (particularly at night), red spots, and may lead to a secondary …
Matched Categories: … Scabicides, Insecticides and Repellents ... Antiparasitic Products, Insecticides and Repellents …

Pegvaliase

Pegvaliase is a recombinant phenylalanine ammonia lyase (PAL) enzyme derived from Anabaena variabilis that converts phenylalanine to ammonia and trans-cinnamic acid . Both the U.S. Food and Drug Administration and European Medicines Agency approved pegvaliase-pqpz in May 2018 for the treatment of adult patients with phenylketonuria (PKU). Phenylketonuria is a...
Approved
Investigational
Matched Description: … Food and Drug Administration and European Medicines Agency approved pegvaliase-pqpz in May 2018 for the ... , neurodevelopmental and psychiatric disabilities if untreated [A33284]. ... ammonia lyase (PAL) enzyme derived from _Anabaena variabilis_ that converts phenylalanine to ammonia and …
Matched Categories: … Enzymes and Coenzymes ... Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins …

Norethisterone

Norethisterone, also known as norethindrone, is a synthetic progestational hormone belonging to the 19-nortestosterone-derived class of progestins. It is further classified as a second-generation progestin, along with levonorgestrel and its derivatives, and is the active form of several other progestins including norethynodrel and lynestrenol. Norethisterone mimics the actions of endogenous...
Approved
Matched Description: … derivatives, and is the active form of several other progestins including [norethynodrel] and [lynestrenol ... endometriosis, and was not marketed for use as an oral contraceptive until 1962. ... [A10367] It is further classified as a second-generation progestin, along with [levonorgestrel] and its …
Matched Mixtures name: … Norethindrone and Ethinyl Estradiol and Ferrous Fumarate ... Norethindrone and Ethinyl Estradiol and Ferrous Fumarate ... Norethindrone and Ethinyl Estradiol, and Ferrous Fumarate …
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... norethisterone and estrogen ... norethisterone and estrogen ... norethisterone and ethinylestradiol …

Warfarin

Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be noted when used medicinally,...
Approved
Matched Description: … , and drug interactions have also been documented with warfarin use. ... during pregnancy which can result in fetal bleeding, spontaneous abortion, preterm birth, stillbirth, and ... Additional adverse effects such as necrosis, purple toe syndrome, osteoporosis, valve and artery calcification …
Matched Categories: … Warfarin and isomers ... Blood and Blood Forming Organs …

Oxyphenisatin acetate

Oxyphenisatin acetate is the pro-drug of oxyphenisatin (3,3-bis(4-hydroxyphenyl)-1H-indol-2-one). The FDA withdrew its approval for the use of oxyphenisatin acetate due to safety reasons.
Approved
Investigational
Withdrawn
Matched Iupac: … 4-{3-[4-(acetyloxy)phenyl]-2-oxo-2,3-dihydro-1H-indol-3-yl}phenyl acetate …

Dehydrocholic acid

Dehydrocholic acid is a synthetic bile acid that was prepared from the oxidation of cholic acid with chromic acid . It has been used for stimulation of biliary lipid secretion. The use of dehydrocholic acid in over-the-counter products has been discontinued by Health Canada.
Approved
Investigational
Matched Categories: … Bile Acids and Salts ... Cholagogues and Choleretics …

Aripiprazole

Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects through agonism of dopaminergic and 5-HT1A receptors and...
Approved
Investigational
Matched Description: … [L45859] Aripiprazole exerts its effects through agonism of dopaminergic and 5-HT1A receptors and antagonism ... of alpha-adrenergic and 5-HT2A receptors. ... treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and …
Matched Categories: … Aripiprazole and prodrugs …
Matched Products: … Abilify Maintena 400 mg powder and solvent for prolonged-release suspension for injection ... ABILIFY MAINTENA POWDER AND SOLVENT FOR PROLONGED RELEASE SUSPENSION FOR INJECTION 400 MG …

Norethynodrel

A synthetic progestational hormone with actions and uses similar to those of PROGESTERONE. It has been used in the treatment of functional uterine bleeding and endometriosis. As a contraceptive, it has usually been administered in combination with MESTRANOL.
Approved
Matched Description: … It has been used in the treatment of functional uterine bleeding and endometriosis. ... A synthetic progestational hormone with actions and uses similar to those of PROGESTERONE. …
Matched Categories: … noretynodrel and estrogen ... Genito Urinary System and Sex Hormones ... Sex Hormones and Modulators of the Genital System ... Combination Contraceptives (with Estrogen and derivatives) …

Erythromycin

Erythromycin is a bacteriostatic antibiotic drug produced by a strain of Saccharopolyspora erythraea (formerly Streptomyces erythraeus) and belongs to the macrolide group of antibiotics which consists of Azithromycin, Clarithromycin, Spiramycin and others. It was originally discovered in 1952. Erythromycin is widely used for treating a variety of infections, including those...
Approved
Investigational
Vet approved
Matched Description: … antibiotic drug produced by a strain of Saccharopolyspora erythraea (formerly Streptomyces erythraeus) and ... the macrolide group of antibiotics which consists of [Azithromycin], [Clarithromycin], [Spiramycin] and ... [L5245,L7261] It is available for administration in various forms, including intravenous, topical, and …
Matched Mixtures name: … Erythromycin and Benzoyl Peroxide ... Erythromycin and Benzoyl Peroxide ... Erythromycin and Benzoyl Peroxide …
Matched Categories: … Erythromycin and similars ... Macrolides, Lincosamides and Streptogramins …

Megestrol acetate

17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione. A progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative treatment of breast cancer.
Approved
Investigational
Vet approved
Matched Description: … As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor …
Matched Categories: … megestrol and estrogen ... megestrol and estrogen ... Hormones and Related Agents ... megestrol and ethinylestradiol ... megestrol and ethinylestradiol …

Rolapitant

Rolapitant is a potent, highly selective, long-acting Neurokinin-1 (NK-1) receptor antagonist approved for the prevention of delayed chemotherapy-induced nausea and vomiting (CINV) in adults. Delayed-phase CINV typically occurs >24 hours after chemotherapy treatment and is principally mediated by Neurokinin-1 and its ligand Substance P, which is released in the gut...
Approved
Investigational
Matched Iupac: … (5S,8S)-8-{[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl}-8-phenyl-1,7-diazaspiro[4.5]decan-2 …
Matched Description: … Delayed-phase CINV typically occurs >24 hours after chemotherapy treatment and is principally mediated ... Neurokinin-1 (NK-1) receptor antagonist approved for the prevention of delayed chemotherapy-induced nausea and ... By blocking Substance P from interacting with NK-1 receptors in the gut and the central nervous system …
Matched Categories: … Antiemetics and Antinauseants ... Alimentary Tract and Metabolism …

Paricalcitol

Paricalcitol is a synthetic vitamin D analog. Paricalcitol has been used to reduce parathyroid hormone levels. Paricalcitol is indicated for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure.
Approved
Investigational
Matched Description: … Paricalcitol is indicated for the prevention and treatment of secondary hyperparathyroidism associated …
Matched Categories: … Vitamin D and Analogues ... Sex Hormones and Insulins …

Deoxycholic acid

Deoxycholic acid is a a bile acid which emulsifies and solubilizes dietary fats in the intestine, and when injected subcutaneously, it disrupts cell membranes in adipocytes and destroys fat cells in that tissue. In April 2015, deoxycholic acid was approved by the FDA for the treatment submental fat to improve...
Approved
Matched Description: … Deoxycholic acid is a a bile acid which emulsifies and solubilizes dietary fats in the intestine, and ... when injected subcutaneously, it disrupts cell membranes in adipocytes and destroys fat cells in that ... It is marketed under the brand name Kybella by Kythera Biopharma and is the first pharmacological agent …
Matched Categories: … Bile Acids and Salts ... Cholagogues and Choleretics …

Chlorcyclizine

Chlorcyclizine is a first generation phenylpiperazine class antihistamine used to treat urticaria, rhinitis, pruritus, and other allergy symptoms. Chlorcyclizine also has some local anesthetic, anticholinergic, and antiserotonergic properties, and can be used as an antiemetic.
Approved
Matched Iupac: … 1-[(4-chlorophenyl)(phenyl)methyl]-4-methylpiperazine …
Matched Description: … Chlorcyclizine also has some local anesthetic, anticholinergic, and antiserotonergic properties, and ... first generation phenylpiperazine class antihistamine used to treat urticaria, rhinitis, pruritus, and …

Levodopa

Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prevent...
Approved
Matched Description: … Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally ... Once past the blood-brain barrier, levodopa is metabolized to dopamine and supplements the low endogenous ... The first developed drug product that was approved by the FDA was a levodopa and carbidopa combined product …
Matched Mixtures name: … Carbidopa and Levodopa ... Carbidopa and Levodopa ... Carbidopa and Levodopa …
Matched Categories: … Dopa and Dopa Derivatives ... Amino Acids, Peptides, and Proteins ... levodopa and decarboxylase inhibitor ... levodopa, decarboxylase inhibitor and COMT inhibitor …

Etafedrine

Etafedrine (INN) or ethylephedrine is a long-acting bronchodilator and has been an ingredient combined with other drugs in the brand names Nethaprin and Dalmacol . It was previously available as both the free base and as the hydrochloride salt manufactured by Sanofi-Aventis (now Sanofi) has been discontinued . Ethylephedrine is...
Approved
Matched Description: … with other drugs in the brand names Nethaprin [A32757] and Dalmacol [L2568]. ... Etafedrine (INN) or ethylephedrine is a long-acting bronchodilator and has been an ingredient combined ... It was previously available as both the free base and as the hydrochloride salt manufactured by Sanofi-Aventis …

Triamterene

Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the nephron in the kidneys by working on the lumenal side. Since it acts on...
Approved
Matched Description: … Triamterene is a weak antagonist of folic acid, and a photosensitizing drug. ... [L6163] Triamterene was approved by the Food and Drug Administration in the U.S. in 1964. ... is approved for use with other diuretics to enhance diuretic and potassium-sparing effects. …
Matched Mixtures name: … Triamterene and Hydrochlorothiazide ... Triamterene and Hydrochlorothiazide ... Triamterene and Hydrochlorothiazide …

Pirfenidone

Pirfenidone is a synthetic pyridone drug. It is an antifibrotic agent with anti-inflammatory and antioxidant properties that is used to treat idiopathic pulmonary fibrosis (IPF), which is a chronic, progressive form of interstitial pneumonia. While its mechanism of action is not yet fully understood, pirfenidone is proposed to primarily regulate...
Approved
Investigational
Matched Iupac: … 5-methyl-1-phenyl-1,2-dihydropyridin-2-one …
Matched Description: … [A251370] It is an antifibrotic agent with anti-inflammatory and antioxidant properties [A251370] that ... fully understood, pirfenidone is proposed to primarily regulate tumor necrosis factor (TNF) pathways and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Displaying drugs 1576 - 1600 of 14950 in total