Advanced Filter

Filter by Group

Filter by Market Availability

Clear
Displaying drugs 1751 - 1775 of 1990 in total

MDX-018

MDX-018, also known as HuMax-Inflam, is a fully human antibody that is directed to IL-8 (interleukin-8) and may have potential application in oncology and inflammation. Trials will initially focus on studies to treat glioblastoma, a cancer of the central nervous system. Other possible indications include chronic obstructive pulmonary disease (COPD)...
Investigational
Matched Description: … 8) and may have potential application in oncology and inflammation. ... MDX-018, also known as HuMax-Inflam, is a fully human antibody that is directed to IL-8 (interleukin- ... pre-clinical studies, HuMax-Inflam has been shown to inhibit tumor growth in tumor models using primary human …

Hu-rhEGF-rP64k/Mont

Hu-rhEGF-rP64k/Mont is a therapeutic vaccine composed by an antigen (recombinant human EGF (rhEGF) chemically conjugated to recombinant P64K (rP64K)) and an adjuvant (Montanide ISA51VG) being investigated for the treatment of advanced non-small cell lung cancer (NSCLC).
Investigational
Matched Description: … Hu-rhEGF-rP64k/Mont is a therapeutic vaccine composed by an antigen (recombinant human EGF (rhEGF) chemically ... conjugated to recombinant P64K (rP64K)) and an adjuvant (Montanide ISA51VG) being investigated for the …

NSI-566

NSI-566 is a stem cell therapy consisting of human spinal cord-derived neural stem cells. Developed by Seneca Biopharma, it is being investigated for the treatment of amyotrophic lateral sclerosis (ALS), stroke, and chronic spinal cord injury (cSCI).
Investigational
Matched Description: … NSI-566 is a stem cell therapy consisting of human spinal cord-derived neural stem cells. ... Biopharma, it is being investigated for the treatment of amyotrophic lateral sclerosis (ALS), stroke, and …

Tigapotide

Tigapotide is a synthetic 15-mer peptide that is derived from the natural sequence of amino acids of the prostate secretory protein (PSP94), one of three predominant proteins found in human seminal fluid.
Investigational
Matched Description: … of amino acids of the prostate secretory protein (PSP94), one of three predominant proteins found in human …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Eldelumab

MDX-1100, a fully human antibody that targets IP10 (also known as CXCL10), a chemokine expressed in association with multiple inflammatory disease indications, such as rheumatoid arthritis, inflammatory bowel disease and multiple sclerosis.
Investigational
Matched Description: … multiple inflammatory disease indications, such as rheumatoid arthritis, inflammatory bowel disease and ... MDX-1100, a fully human antibody that targets IP10 (also known as CXCL10), a chemokine expressed in association …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Cimlanod

Cimlanod is under investigation in clinical trial NCT02819271 (A First-in-Human Study of the Safety of Single Continuous Intravenous (IV) Infusions of CXL-1427 for up to 48 Hours in Healthy Volunteers).
Investigational
Matched Description: … Cimlanod is under investigation in clinical trial NCT02819271 (A First-in-Human Study of the Safety of …

XL281

XL281 is a novel anticancer compound designed to potently inhibit the RAS/RAF/MEK/ERK signaling pathway. Mutational activation of RAS occurs in about 30 percent of all human tumors, including non-small cell lung, pancreatic, and colon cancer. XL281 is a specific inhibitor of RAF kinases, including the mutant form of B-RAF, which...
Investigational
Matched Description: … lung, pancreatic, and colon cancer. ... Mutational activation of RAS occurs in about 30 percent of all human tumors, including non-small cell ... mutant form of B-RAF, which is activated in 60 percent of melanomas, 24-44 percent of thyroid cancers, and …

ATG-Fresenius S

ATG-Fresenius S is a concentrated anti-human T-lymphocyte immunoglobulin preparation derived from rabbits after immunization with a T-lympoblast cell line. ATG-Fresenius S is an immunosuppressive product for the prevention and treatment of acute rejection following organ transplantation.
Investigational
Matched Description: … ATG-Fresenius S is a concentrated anti-human T-lymphocyte immunoglobulin preparation derived from rabbits ... ATG-Fresenius S is an immunosuppressive product for the prevention and treatment of acute rejection following …

Virus Specific T-Cell

Virus Specific T-Cells (VSTs) are a target therapy that are generated for specific viral antigens. These products are generated from virus-naive or virus-experienced autologous or allogenic sources. Antigens identified as an immune target are presented by antigen-presenting cells (APCs) to T-cells along with other molecules that stimulate their growth and...
Investigational
Matched Description: … These T-cells are then isolated from the donor and expanded in a culture to generate more VSTs. ... by antigen-presenting cells (APCs) to T-cells along with other molecules that stimulate their growth and …

ING-1

ING-1 is a high-affinity, human engineered trade mark monoclonal antibody that recognizes a 40 kilodalton epithelial cell adhesion molecule (EpCAM) glycoprotein that is expressed in high levels on most adenocarcinomas. It is an attractive target for immunotherapy.
Investigational
Matched Description: … ING-1 is a high-affinity, human engineered trade mark monoclonal antibody that recognizes a 40 kilodalton …

SRP-9005

SRP-9005 is a rAAVrh74 vector containing a codon-optimized human SGCG transgene. Developed by the Kurt+Peter Foundation and Sarepta Therapeutics, it is being investigated for the treatment of Limb-girdle muscular dystrophy (LGMD) type 2C/R5.
Investigational
Matched Description: … SRP-9005 is a rAAVrh74 vector containing a codon-optimized human SGCG transgene. ... Developed by the Kurt+Peter Foundation and Sarepta Therapeutics, it is being investigated for the treatment …

SNX-5422

SNX-5422 is a synthetic, novel, small molecule Hsp90 Inhibitor. As an oral formulation that demonstrates strong efficacy and tolerability, SNX-5422 is positioned as a breakthrough therapy with broad applicability across a wide range of cancers.
Investigational
Matched Description: … As an oral formulation that demonstrates strong efficacy and tolerability, SNX-5422 is positioned as …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Rupintrivir

Rupintrivir is a rhinovirus 3C protease inhibitor in development for use against human rhinoviral (HRV) infections. Rupintrivir was active against all 48 HRV serotypes tested in a cell protection assay in H1-HeLa cells. It is designed to combat colds caused by rhinovirus.
Investigational
Matched Description: … Rupintrivir is a rhinovirus 3C protease inhibitor in development for use against human rhinoviral (HRV …
Matched Categories: … Amino Acids, Peptides, and Proteins …

INGN 225

INGN 225 is a therapeutic consisting of a cancer patient's own immune cells treated with an adenovector carrying the human p53 gene, Ad-p53. INGN 225 is currently in Phase 1/2 trials in patients with small cell lung cancer and breast cancer.
Investigational
Matched Description: … therapeutic consisting of a cancer patient's own immune cells treated with an adenovector carrying the human ... INGN 225 is currently in Phase 1/2 trials in patients with small cell lung cancer and breast cancer. …

Etrolizumab

Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is typified by a chronic gastrointestinal inflammatory microenvironment, driven in part by the excessive infiltration and retention of intestinal-homing lymphocytes.[A244564, A244569, A244579, A244584] A recent class of drugs designed to impair lymphocyte homing, so-called "anti-trafficking agents" (ATAs), have shown some...
Investigational
Matched Description: … include approved drugs such as [natalizumab] and [vedolizumab], which target integrins and impair their ... Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is typified by a ... chronic gastrointestinal inflammatory microenvironment, driven in part by the excessive infiltration and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

105AD7

105AD7 is a human monoclonal antibody that mimics the complement regulatory protein, CD55, overexpressed by many solid tumours including osteosarcoma. 105AD7 induced antitumour inflammatory responses in metastatic colorectal cancer patients. 105AD7 may be a suitable vaccine for treatment of this disease.
Investigational
Matched Description: … 105AD7 is a human monoclonal antibody that mimics the complement regulatory protein, CD55, overexpressed …

AME-527

AME-527 is a humanized monoclonal antibody that recognizes human TNF-alpha (hTNF-alpha) with high affinity and specificity. AME-527 was generated by protein engineering and identified from a library of antibody variants based on its improved binding properties.
Investigational
Matched Description: … and specificity. ... AME-527 is a humanized monoclonal antibody that recognizes human TNF-alpha (hTNF-alpha) with high affinity ... AME-527 was generated by protein engineering and identified from a library of antibody variants based …

SIG-007

SIG-007 is a gene therapy that consists of cells that are genetically modified with a non-viral vector to express human alpha-galactosidase A. Developed by Sigilon Therapeutics, t is being investigated for the treatment of Fabry Disease.
Investigational
Matched Description: … gene therapy that consists of cells that are genetically modified with a non-viral vector to express human …

HGTV-43

HGTV43 is an anti-sense treatment designed to produce T cells that are genetically resistant to HIV infection. HGTV43 is one of a number of so-called 'gene transfer vectors' developed by the biotechnology company Enzo Biochem, Inc.
Investigational

Denibulin

Denibulin is a novel small molecule Vascular Disrupting Agent under development by MediciNova for treatment of solid tumor cancers.
Investigational

Cinalukast

Used in the treatment of asthma, cinalukast selectively antagonizes leukotriene D4 (LTD4) at the cysteinyl leukotriene receptor, CysLT1, in the human airway. Cinalukast inhibits the actions of LTD4 at the CysLT1 receptor, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus.
Experimental
Matched Description: … selectively antagonizes leukotriene D4 (LTD4) at the cysteinyl leukotriene receptor, CysLT1, in the human ... inhibits the actions of LTD4 at the CysLT1 receptor, preventing airway edema, smooth muscle contraction, and …

CDX-1135

CDX-1135, formerly TP-10, is a soluble, recombinant human Complement Receptor Type 1 (sCR1) developed by Avant Immunotherapeutics (now Celldex). It was investigated in clinical trials for post-cardiopulmonary bypass syndrome and kidney damage.
Investigational
Matched Description: … CDX-1135, formerly TP-10, is a soluble, recombinant human Complement Receptor Type 1 (sCR1) developed ... It was investigated in clinical trials for post-cardiopulmonary bypass syndrome and kidney damage. …
Matched Categories: … Amino Acids, Peptides, and Proteins …

XL765

XL765 is an orally available small molecule that has been shown in preclinical studies to selectively inhibit the activity of phosphoinositide-3 kinase (PI3K) and mammalian target of rapamycin (mTOR). It is being developed by Exelixis, Inc.
Investigational
Matched Description: … shown in preclinical studies to selectively inhibit the activity of phosphoinositide-3 kinase (PI3K) and …

CHF 4227

CHF 4227 is a new selective estrogen receptor modulator (SERM). The compound has a high receptor affinity and has shown promising efficacy in the prevention of bone loss in animal models of osteoporosis. Additionally, the compound has shown no uterotrophic activity suggesting a potential therapeutic advantage over drugs normally used...
Investigational
Matched Description: … The compound has a high receptor affinity and has shown promising efficacy in the prevention of bone …

TB-402

TB-402 is a human antibody binding to Factor VIII, which plays a crucial role in the coagulation of the blood. It is expected to be developed as a potential treatment to prevent blood clot formation in connection with certain types of heart arrhythmia, such as atrial fibrillation.
Investigational
Matched Description: … TB-402 is a human antibody binding to Factor VIII, which plays a crucial role in the coagulation of the …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Displaying drugs 1751 - 1775 of 1990 in total