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Displaying drugs 1851 - 1875 of 15227 in total

Ethiodized oil

Ethiodized oil is used by injection as a radio-opaque contrast agent. The composition of the oil is comprised of iodine combined with ethyl esters of fatty acids of poppyseed oil. And although these esters are primarily as ethyl monoiodostearate and ethyl diiodostearate, the actual, specific structure is unknown.
Approved
Investigational
Matched Description: … And although these esters are primarily as ethyl monoiodostearate and ethyl diiodostearate, the actual …

Ecallantide

Ecallantide is a potent and selective human plasma kallikrein inhibitor that is indicated for the symptomatic treatment of hereditary angioedema. Ecallantide is a recombinant 60-amino-acid protein produced in Pichia pastoris yeast cells that contains three intramolecular disulfide bonds [FDA Label]. It was discovered by phage display technology . It shares...
Approved
Investigational
Matched Description: … The amino acid sequence of two compounds differ by seven amino acids [L1458]. ... Ecallantide is a recombinant 60-amino-acid protein produced in _Pichia pastoris_ yeast cells that contains ... activity of kallikrein and excessive bradykinin production [FDA Label]. …
Matched Categories: … Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …

Clobetasone

Clobetasone is a corticosteroid that is often employed topically as a treatment for a variety of conditions such as eczema, psoriasis, various forms of dermatitis, and also for certain ophthalmologic conditions. Topical clobetasone butyrate has shown minimal suppression of the Hypothalamic-pituitary-adrenal axis.
Approved
Matched Description: … as a treatment for a variety of conditions such as eczema, psoriasis, various forms of dermatitis, and …
Matched Categories: … clobetasone and antiinfectives ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Avobenzone

Avobenzone is dibenzoyl methane derivative. It is oil soluble ingredient. Avobenzone has the ability to absorb ultraviolet light over wider range of wavelengths. It is included in many commercially available sunscreens which are used as wide spectrum sunscreens. Avobenzone is very sensitive to light, to increase its stability and duration...
Approved
Investigational
Matched Description: … Avobenzone is very sensitive to light, to increase its stability and duration of action, photostablizers ... sun, using sunscreen agents may help reduce long-term sun damage such as premature aging of the skin and …
Matched Mixtures name: … HEB SPF 50 Hydrate 50 Sunscreen with Hyaluronic Acid and Collagen Continuous Sunscreen ... Polyglutamic Acid Dewy Sunscreen SPF 30 ... Hyalu-melon With Conditioning (hyaluronic Acid + Watermelon) …

Metoclopramide

Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition to...
Approved
Investigational
Matched Description: … [L8417] One unique property of this drug is that it does not increase gastric acid secretion. ... impact on quality of life and poses a significant burden on the healthcare system. ... Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative …
Matched Categories: … Alimentary Tract and Metabolism ... Benzamides and benzamide derivatives …

Diethylcarbamazine

An anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa.
Approved
Investigational
Vet approved
Matched Categories: … Piperazine and Derivatives ... Antiparasitic Products, Insecticides and Repellents …

Telavancin

Telavancin is a semi-synthetic derivative of vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive bacteria. MRSA is an important pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and skin and subcutaneous tissue infections among others.
Approved
Matched Iupac: … }.0^{34,39}]pentaconta-3,5,8,10,12(48),14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid …
Matched Description: … skin and subcutaneous tissue infections among others. ... vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and ... pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Idursulfase

Idursulfase is a purified form of human iduronate-2-sulfatase, a lysosomal enzyme. Idursulfase is produced by recombinant DNA technology in a human cell line. Idursulfase is an enzyme that hydrolyzes the 2-sulfate esters of terminal iduronate sulfate residues from the glycosaminoglycans dermatan sulfate and heparan sulfate in the lysosomes of various...
Approved
Matched Description: … -sulfate esters of terminal iduronate sulfate residues from the glycosaminoglycans dermatan sulfate and ... Idursulfase is a 525-amino acid glycoprotein with a molecular weight of approximately 76 kilodaltons. …
Matched Categories: … Enzymes and Coenzymes ... Alimentary Tract and Metabolism …

Dosulepin

Dosulepin (INN, BAN) formerly known as dothiepin (USAN), is a tricyclic antidepressant with anxiolytic properties that is used in several European and South Asian countries, as well as Australia, South Africa, and New Zealand. It is not FDA-approved due to low therpeutic index and significant toxicity in overdose. Dosulepin inhibits...
Approved
Matched Description: … South Asian countries, as well as Australia, South Africa, and New Zealand. ... anticholinergic, antihistamine and central sedative properties [L882]. ... It is not FDA-approved due to low therpeutic index and significant toxicity in overdose. …

Cannabidiol

Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact...
Approved
Investigational
Matched Description: … CBD are obtained through conversion from their precursors, tetrahydrocannabinolic acid-A (THCA-A) and ... acid (GABA), and cellular uptake of anandamide, acts on mitochondria Ca2+ stores, blocks low-voltage-activated ... cannabidiolic acid (CBDA), through decarboxylation reactions. …
Matched Categories: … Cannabinoids and similars …

Etidocaine

Etidocaine is marketed under the name Duranest. It is an injectable local anesthetic during surgery, labor, and delivery. Etidocaine has a long duration of activity, but has the main disadvantage of increased bleeding during oral surgery.
Approved
Matched Description: … It is an injectable local anesthetic during surgery, labor, and delivery. …

Valbenazine

Valbenazine is a modified metabolite of tetrabenazine, and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine receptor therapy, and until 2008 with the advent of tetrabenazine,...
Approved
Investigational
Matched Description: … safety and tolerability concerns. ... Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment ... of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Nirogacestat

Nirogacestat is a small-molecule gamma-secretase inhibitor that was investigated as a potential treatment for desmoid tumors. Desmoid tumors are typically characterized by aberrant activation in Notch signaling. Interaction between the notch receptors and their ligands activates proteolytic cleavage by gamma-secretase; therefore, the inhibition of gamma-secretase can potentially inhibit Notch signaling...
Approved
Investigational
Matched Description: … [A262556] Interaction between the notch receptors and their ligands activates proteolytic cleavage by ... of desmoid tumors, and the final approval was based on positive results obtained in the Phase 3 DeFi ... gamma-secretase; therefore, the inhibition of gamma-secretase can potentially inhibit Notch signaling and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Gamma Secretase Inhibitors and Modulators …

Capivasertib

Hormone receptor (HR) positive, especially estrogen receptor-positive, HER2-negative breast cancer is the most common subtype of metastatic breast cancer, resulting in more than 400,000 deaths annually. Although endocrine-based therapy is the first line of treatment, resistance eventually emerges, leaving chemotherapy the only but often ineffective treatment left. Therefore, significant research...
Approved
Investigational
Matched Description: … based on favorable results obtained from the CAPItello-291 trial, where the combination of capivasertib and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Indinavir

A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem]
Approved
Matched Description: … A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. …

Gadodiamide

Gadodiamide is a linear, non-ionic gadolinium-based contrast agent (GBCA) that is used in magnetic resonance imaging (MRI) procedures to assist in the visualization of blood vessels.[A263086,A263091] GBCAs constitute the largest group of MR agents, and they are thought to be safer than nonionic iodinated contrast agents. Approved by the FDA...
Approved
Investigational
Matched Description: … [A263086,A263091] GBCAs constitute the largest group of MR agents, and they are thought to be safer than ... macrocyclic or ionic GBCA, gadodiamide can potentially lead to more gadolinium retention in the brain and …

Bupivacaine

Bupivacaine is a widely used local anesthetic agent.
Approved
Investigational
Matched Mixtures name: … Bupivacaine Hci and Epinephrine ... Bupivacaine Hydrochloride and Epinephrine ... Bupivacaine Hydrochloride and Epinephrine …
Matched Categories: … bupivacaine and meloxicam …

Prilocaine

A local anesthetic that is similar pharmacologically to lidocaine. Currently, it is used most often for infiltration anesthesia in dentistry. (From AMA Drug Evaluations Annual, 1992, p165)
Approved
Matched Mixtures name: … Lidocaine and Prilocaine ... Lidocaine and Prilocaine ... Lidocaine and Prilocaine …

Valrubicin

Valrubicin (N-trifluoroacetyladriamycin-14-valerate) is a chemotherapy drug commonly marketed under the trade name VALSTAR. It is a semisynthetic analog of the doxorubicin, which is an anthracycline drug. Used in the treatment of the bladder cancer, valrubicin is administered by direct infusion into the bladder.
Approved
Matched Categories: … Anthracyclines and Related Substances ... Antineoplastic and Immunomodulating Agents ... Cytotoxic Antibiotics and Related Substances …

Framycetin

A component of neomycin that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed)
Approved
Matched Description: … On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed) …

Bendroflumethiazide

A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810)
Approved
Matched Description: … A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. ... It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders …
Matched Mixtures name: … Nadolol and Bendroflumethiazide ... Nadolol and Bendroflumethiazide ... Nadolol and Bendroflumethiazide …
Matched Categories: … bendroflumethiazide and potassium ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics ... bendroflumethiazide and potassium-sparing agents ... Low-Ceiling Diuretics and Potassium-Sparing Agents …

Ifosfamide

Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent.
Approved
Matched Description: … It is active as an alkylating agent and an immunosuppressive agent. ... Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog …
Matched Mixtures name: … IFEX and MESNEX ... IFEX and MESNEX ... IFEX and MESNEX …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Tasimelteon

Tasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD). Occurring commonly in blind individuals without light perception, this condition is often characterized by periods of night-time insomnia and day-time sleepiness. In blind individuals, a lack of light stimulation causes an extension of...
Approved
Investigational
Matched Description: … By activating melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, tasimelteon ... In blind individuals, a lack of light stimulation causes an extension of the 24-hour circadian cycle and ... Tasimelteon is currently the only drug available for the treatment of N24HSWD and was granted orphan …
Matched Categories: … Hypnotics and Sedatives …

Aliskiren

Aliskiren is the first drug in the renin inhibitor drug class and is used for the treatment of hypertension. It was developed by Speedel and Novartis and initially approved by the FDA in early 2007. Aliskiren has been proven to efficacious in reducing blood pressure when used alone or in...
Approved
Investigational
Matched Description: … [A203624] It was developed by Speedel and Novartis and initially approved by the FDA in early 2007. ... Aliskiren is the first drug in the renin inhibitor drug class and is used for the treatment of hypertension …
Matched Categories: … valsartan and aliskiren ... aliskiren and amlodipine ... aliskiren and hydrochlorothiazide ... aliskiren, amlodipine and hydrochlorothiazide …

Prochlorperazine

Prochlorperazine, also known as compazine, is a piperazine phenothiazine and first-generation antipsychotic drug that is used for the treatment of severe nausea and vomiting, as well as short-term management of psychotic disorders such as generalized non-psychotic anxiety and schizophrenia.[label] It mainly works by depressing the chemoreceptor trigger zone and blocking...
Approved
Vet approved
Matched Description: … of psychotic disorders such as generalized non-psychotic anxiety and schizophrenia. ... It was shown to also block histaminergic, cholinergic and noradrenergic receptors. ... Prochlorperazine, also known as compazine, is a piperazine phenothiazine and first-generation antipsychotic …
Displaying drugs 1851 - 1875 of 15227 in total