Displaying drugs 176 - 200 of 6577 in total
Venetoclax
Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types...
Approved
Investigational
Matched Synonyms: … 4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-((tetrahydro ... 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro ... 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-(3-nitro …
Matched Iupac: … 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-(3-nitro-4-{[(oxan- ... 4-yl)methyl]amino}benzenesulfonyl)-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzamide …
Matched Description: … Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed ... A new indication was approved in 2018 for the treatment patients with chronic lymphocytic leukemia (CLL ... Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. …
Matched Categories: … BCL-2 Inhibitor ... Heterocyclic Compounds, 2-Ring ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Matched Iupac: … 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-(3-nitro-4-{[(oxan- ... 4-yl)methyl]amino}benzenesulfonyl)-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzamide …
Matched Description: … Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed ... A new indication was approved in 2018 for the treatment patients with chronic lymphocytic leukemia (CLL ... Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. …
Matched Categories: … BCL-2 Inhibitor ... Heterocyclic Compounds, 2-Ring ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Ramipril
Ramipril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to ramiprilat in the liver and, to a lesser extent, kidneys. Ramiprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII)....
Approved
Matched Synonyms: … (b)pyrrole-2-carboxylic acid ... (2S-(1(R*(R*)),2alpha,3abeta,6abeta))-1-(2-((1-(Ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydrocyclopenta …
Matched Iupac: … b]pyrrole-2-carboxylic acid ... (2S,3aS,6aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-octahydrocyclopenta[ …
Matched Description: … It is metabolized to ramiprilat in the liver and, to a lesser extent, kidneys. ... Ramipril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor class of medications ... ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS …
Matched Mixtures name: … RAMIPRIL COMP HEU 5/25MG N …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Iupac: … b]pyrrole-2-carboxylic acid ... (2S,3aS,6aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-octahydrocyclopenta[ …
Matched Description: … It is metabolized to ramiprilat in the liver and, to a lesser extent, kidneys. ... Ramipril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor class of medications ... ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS …
Matched Mixtures name: … RAMIPRIL COMP HEU 5/25MG N …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Thymol
A phenol obtained from thyme oil or other volatile oils. It is used as a stabilizer in pharmaceutic preparations. It has been used for its antiseptic, antibacterial, and antifungal actions, and was formerly used as a vermifuge. (Dorland, 28th ed)
Approved
Matched Synonyms: … 5-Methyl-2-(1-Methylethyl)Phenol ... 2-isopropyl-5-methylphenol …
Matched Iupac: … 5-methyl-2-(propan-2-yl)phenol …
Matched Description: … A phenol obtained from thyme oil or other volatile oils. ... It is used as a stabilizer in pharmaceutic preparations. ... It has been used for its antiseptic, antibacterial, and antifungal actions, and was formerly used as a …
Matched Mixtures name: … VICKS VAPORUB BUHARLASAN MERHEM, 1 ADET …
Matched Products: … Influenza Care Synergy …
Matched Iupac: … 5-methyl-2-(propan-2-yl)phenol …
Matched Description: … A phenol obtained from thyme oil or other volatile oils. ... It is used as a stabilizer in pharmaceutic preparations. ... It has been used for its antiseptic, antibacterial, and antifungal actions, and was formerly used as a …
Matched Mixtures name: … VICKS VAPORUB BUHARLASAN MERHEM, 1 ADET …
Matched Products: … Influenza Care Synergy …
Clascoterone
Clascoterone (cortexolone 17α-propionate, CB-03-01) is a novel antagonist of androgen receptors. It binds to androgen receptors with high affinity. By competing with androgens for binding to androgen receptors, clascoterone works by blocking the androgen receptor signalling cascades that promote acne pathogenesis, such as sebaceous gland proliferation, excess sebum production, and...
Approved
Investigational
Matched Synonyms: … 11-deoxycortisol 17α-propionate …
Matched Iupac: … ,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl propanoate ... (1R,3aS,3bR,9aR,9bS,11aS)-1-(2-hydroxyacetyl)-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH …
Matched Description: … Clascoterone (cortexolone 17α-propionate, CB-03-01) is a novel antagonist of androgen receptors. ... [L15621] Clascoterone is also being investigated as a novel treatment for androgenetic alopecia. …
Matched Iupac: … ,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl propanoate ... (1R,3aS,3bR,9aR,9bS,11aS)-1-(2-hydroxyacetyl)-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH …
Matched Description: … Clascoterone (cortexolone 17α-propionate, CB-03-01) is a novel antagonist of androgen receptors. ... [L15621] Clascoterone is also being investigated as a novel treatment for androgenetic alopecia. …
Belimumab
Belimumab is a fully human recombinant IgG1λ monoclonal antibody that inhibits soluble human B lymphocyte stimulator protein (BLyS, also referred to as BAFF and TNFSF13B), a B cell survival factor. BLyS levels are often elevated in immunodeficient and autoimmune disorders, such as systemic lupus erythematosus (SLE).[A251495, L42705] By binding to...
Approved
Matched Description: … stimulator protein (BLyS, also referred to as BAFF and TNFSF13B), a B cell survival factor. ... Belimumab is a fully human recombinant IgG1λ monoclonal antibody that inhibits soluble human B lymphocyte ... the survival of B cells. …
Matched Categories: … Decreased B Lymphocyte Activation ... B Lymphocyte Stimulator-specific Inhibitor ... B Lymphocyte Stimulator-directed Antibody Interactions …
Matched Products: … BENLYSTA 200 MG / 1 ML ... BENLYSTA SUBCUTÁNEO 200 MG / 1 ML ... BENLYSTA 400 MG IV INFUZYONLUK COZETI HAZIRLAMAK ICIN TOZ ICEREN FLAKON, 1 ADET …
Matched Categories: … Decreased B Lymphocyte Activation ... B Lymphocyte Stimulator-specific Inhibitor ... B Lymphocyte Stimulator-directed Antibody Interactions …
Matched Products: … BENLYSTA 200 MG / 1 ML ... BENLYSTA SUBCUTÁNEO 200 MG / 1 ML ... BENLYSTA 400 MG IV INFUZYONLUK COZETI HAZIRLAMAK ICIN TOZ ICEREN FLAKON, 1 ADET …
Quizartinib
Quizartinib is an oral and potent fms-like tyrosine kinase 3 (FLT3) inhibitor and it is the first drug developed specifically targeting FLT3, as other agents with FLT3 inhibition activities were investigated with other targets in mind. Additionally, quizartinib also demonstrates inhibitory activity toward FLT3 with internal tandem duplication (ITD), although...
Approved
Investigational
Matched Synonyms: … N-(5-(1,1-Dimethylethyl)isoxazol-3-yl)-N'-(4-(7-(2-(morpholin-4-yl)ethoxy)imidazo(2,1-b)benzothiazol- ... 2-yl)phenyl)urea …
Matched Iupac: … 3-(5-tert-butyl-1,2-oxazol-3-yl)-1-(4-{10-[2-(morpholin-4-yl)ethoxy]-7-thia-2,5-diazatricyclo[6.4.0.0²,⁶ ... ]dodeca-1(8),3,5,9,11-pentaen-4-yl}phenyl)urea …
Matched Description: … Quizartinib is an oral and potent fms-like tyrosine kinase 3 (FLT3) inhibitor and it is the first drug ... maintenance monotherapy resulted in a 22% reduction in the risk of death. ... demonstrates inhibitory activity toward FLT3 with internal tandem duplication (ITD), although with a …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Heterocyclic Compounds, 2-Ring …
Matched Iupac: … 3-(5-tert-butyl-1,2-oxazol-3-yl)-1-(4-{10-[2-(morpholin-4-yl)ethoxy]-7-thia-2,5-diazatricyclo[6.4.0.0²,⁶ ... ]dodeca-1(8),3,5,9,11-pentaen-4-yl}phenyl)urea …
Matched Description: … Quizartinib is an oral and potent fms-like tyrosine kinase 3 (FLT3) inhibitor and it is the first drug ... maintenance monotherapy resulted in a 22% reduction in the risk of death. ... demonstrates inhibitory activity toward FLT3 with internal tandem duplication (ITD), although with a …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Heterocyclic Compounds, 2-Ring …
Cyanocobalamin
Cyanocobalamin (commonly known as Vitamin B12) is a highly complex, essential vitamin, owing its name to the fact that it contains the mineral, cobalt. This vitamin is produced naturally by bacteria , and is necessary for DNA synthesis and cellular energy production. Vitamin B12 has many forms, including the cyano-,...
Approved
Nutraceutical
Matched Iupac: … )-4-(2-{[(2R)-2-{[(2R,3S,4R,5S)-5-(5,6-dimethyl-1H-1,3-benzodiazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan ... -3-yl phosphonato]oxy}propyl]carbamoyl}ethyl)-1,4,6,9,9,14,16,19-octamethyl-20,21,22,23-tetraazapentacyclo ... [15.2.1.1^{2,5}.1^{7,10}.1^{12,15}]tricosa-5(23),6,10(22),11,15(21),16-hexaen-20-yl]cobaltylium ... cyano[(1R,2R,3R,4R,6Z,8S,11Z,13S,14S,16Z,18S,19S)-8,13,18-tris(2-carbamoylethyl)-3,14,19-tris(carbamoylmethyl …
Matched Description: … Cyanocobalamin (commonly known as Vitamin B12) is a highly complex, essential vitamin, owing its name …
Matched Mixtures name: … Multi-11 ... H. Formula - Tab ... ENJEKSİYONLUK ÇÖZELTİ İÇEREN AMPUL (1 ML VE 2 ML) X 25 AMPUL …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Vitamin B Complex ... Vitamin B 12, biosynthesis …
Matched Products: … CIANOCOBALAMINA - VITAMINA B-12 X 1 ML ... VITAMIN B12 RATIOPHARM N ... VITAMINA B12 1 MG/ML INYECTABLE …
Matched Description: … Cyanocobalamin (commonly known as Vitamin B12) is a highly complex, essential vitamin, owing its name …
Matched Mixtures name: … Multi-11 ... H. Formula - Tab ... ENJEKSİYONLUK ÇÖZELTİ İÇEREN AMPUL (1 ML VE 2 ML) X 25 AMPUL …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Vitamin B Complex ... Vitamin B 12, biosynthesis …
Matched Products: … CIANOCOBALAMINA - VITAMINA B-12 X 1 ML ... VITAMIN B12 RATIOPHARM N ... VITAMINA B12 1 MG/ML INYECTABLE …
Pegademase
Bovine adenosine deaminase derived from bovine intestine that has been extensively pegylated for extended serum half life.
Approved
Matched Synonyms: … (monomethoxypolyethylene glycol succinimidyl) 11-17-adenosine deaminase …
Ofatumumab
Ofatumumab is a novel anti-CD20 monoclonal antibody that targets B-cells. It is an IgG1κ human monoclonal antibody produced from a recombinant murine cell line (NS0) via transgenic mouse and hybridoma technology. Ofatumumab works by recognizing antigens that are expressed on the tumour cells in certain cancers; however, the antigen is...
Approved
Matched Description: … Ofatumumab is a novel anti-CD20 monoclonal antibody that targets B-cells. ... works by recognizing antigens that are expressed on the tumour cells in certain cancers; however, the antigen ... has a higher affinity towards CD20. …
Matched Products: … İNFÜZYONLUK ÇÖZELTİ KONSATRESİ İÇEREN FLAKON (3 ADET) ... İNFÜZYONLUK ÇÖZELTİ KONSATRESİ İÇEREN FLAKON (1 ADET) ... Jemvy 20 mg/0,4 mL Enjeksiyonluk Çözelti İçeren Kullanıma Hazır Kalem, 1 ADET …
Matched Products: … İNFÜZYONLUK ÇÖZELTİ KONSATRESİ İÇEREN FLAKON (3 ADET) ... İNFÜZYONLUK ÇÖZELTİ KONSATRESİ İÇEREN FLAKON (1 ADET) ... Jemvy 20 mg/0,4 mL Enjeksiyonluk Çözelti İçeren Kullanıma Hazır Kalem, 1 ADET …
Tafasitamab
Tafasitamab is a humanized, CD19-directed cytolytic monoclonal antibody intended for the treatment of B-cell malignancies. It is produced using recombinant DNA technology in Chinese hamster ovary cells, and contains an IgG1/2 hybrid Fc-domain which has been modified with 2 amino acid substitutions to enhance its cytotoxicity relative to non-engineered anti-CD19...
Approved
Investigational
Matched Description: … appears to play a role in enhancing B-cell receptor signaling. ... made it a desirable target in the treatment these B-cell malignancies. ... Tafasatimab is designed to bind to and block the activity of the CD19 surface antigen, which ultimately …
Matched Categories: … Lymphoma, B-Cell …
Matched Categories: … Lymphoma, B-Cell …
Plasma protein fraction (human)
The plasma protein fraction human (PPFh) is defined as a sterile solution of proteins composed mainly of albumin and globulin derived from human plasma. It is already reviewed under the category of biologics by the FDA where the processing, required tests, requirements and labeling are incorporated. This biologic should come...
Approved
Matched Description: … It is also stated that no more than 1% of the total protein should be gamma globulin. ... The plasma protein fraction human (PPFh) is defined as a sterile solution of proteins composed mainly ... [L2260]
PPFh is a sterile, frozen solution of solvent/detergent treated human plasma. …
Matched Products: … OCTAPLAS Blood Group A ... OCTAPLAS Blood Group B ... Octaplas SD Blutgruppe A zur Infusion …
Matched Products: … OCTAPLAS Blood Group A ... OCTAPLAS Blood Group B ... Octaplas SD Blutgruppe A zur Infusion …
Desoxycorticosterone acetate
Approved
Matched Synonyms: … 11-deoxycorticosterone acetate …
Matched Iupac: … [a]phenanthren-1-yl]-2-oxoethyl acetate ... 2-[(1S,3aS,3bS,9aR,9bS,11aS)-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta …
Matched Iupac: … [a]phenanthren-1-yl]-2-oxoethyl acetate ... 2-[(1S,3aS,3bS,9aR,9bS,11aS)-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta …
Alemtuzumab
Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant regions, and complementarity-determining regions from a...
Approved
Investigational
Matched Description: … lymphocytic leukemia (B-CLL). ... Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. ... [L43397] It is marketed as LEMTRADA for multiple sclerosis (MS) treatment and CAMPTAH for B-cell chronic …
Matched Products: … MABCAMPATH INF SOL ICIN 30 MG/ML KONS 1 ML 3 FLK (10 MG/ML KONSANTRE 3 AMP) ... LEMTRADA 12 MG /1.2 ML İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 1 ADET …
Matched Products: … MABCAMPATH INF SOL ICIN 30 MG/ML KONS 1 ML 3 FLK (10 MG/ML KONSANTRE 3 AMP) ... LEMTRADA 12 MG /1.2 ML İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 1 ADET …
Benzocaine
Benzocaine is an ester local anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. It is commonly used for local anesthesia in many over the counter products.[L32454,L32459,L32464] Benzocaine was first used for local anesthesia in dentistry.
Approved
Investigational
Matched Mixtures name: … Adventure Medical Kits 1-2 Person First Aid ... Adventure Medical Kits 1-2 Person National Ski Patrol First Aid ... CARMEX Multi-Symptom 3 in 1 COLD Sore treatment External Analgesic Skin Protectant …
Matched Products: … Mark 3 ... Blt 1 ... KANK-A …
Matched Products: … Mark 3 ... Blt 1 ... KANK-A …
Ibritumomab tiuxetan
Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and...
Approved
Investigational
Matched Description: … which is found on the surface of normal and malignant B lymphocytes. ... Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, ... Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains …
Matched Categories: … Lymphoma, B-Cell …
Matched Categories: … Lymphoma, B-Cell …
Rituximab
Rituximab is a genetically engineered chimeric murine/human monoclonal antibody directed against the CD20 antigen found on the surface of normal and malignant B lymphocytes. The antibody is an IgG1 kappa immunoglobulin containing murine light and heavy-chain variable region sequences and human constant region sequences , [FDA label]. It was originally...
Approved
Matched Description: … CD20 antigen found on the surface of normal and malignant B lymphocytes. ... FDA in 1997 as a single agent to treat patients with B-cell Non-Hodgkin's Lymphoma (NHL) [L4811], however ... On November 28, 2018, the US FDA approved _Truxima_, the first biosimilar to Rituxan (Rituximab) [L4808 …
Matched Products: … RİXATHON 100MG/10ML İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 3 ADET ... İNFÜZYONLUK ÇÖZELTİ İÇİN KONSANTRE, 2 FLAKON ... RİXATHON 100MG/10ML İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 2 ADET …
Matched Products: … RİXATHON 100MG/10ML İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 3 ADET ... İNFÜZYONLUK ÇÖZELTİ İÇİN KONSANTRE, 2 FLAKON ... RİXATHON 100MG/10ML İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 2 ADET …
Water
Water (chemical formula: H2O) is a transparent fluid which forms the world's streams, lakes, oceans and rain, and is the major constituent of the fluids of organisms. As a chemical compound, a water molecule contains one oxygen and two hydrogen atoms that are connected by covalent bonds. Water is a...
Approved
Matched Description: … As a chemical compound, a water molecule contains one oxygen and two hydrogen atoms that are connected ... Water (chemical formula: H2O) is a transparent fluid which forms the world's streams, lakes, oceans and ... Water is a liquid at standard ambient temperature and pressure, but it often co-exists on Earth with …
Matched Mixtures name: … Je-vax 1 Dose ... Measles Virus Vaccine, Live, Attenuated (dried) ... Intron A …
Matched Products: … N/A ... A-Med ... Sterile Diluent for Merck Sharp & Dohme Llc Live, Attenuated, Virus Vaccines …
Matched Mixtures name: … Je-vax 1 Dose ... Measles Virus Vaccine, Live, Attenuated (dried) ... Intron A …
Matched Products: … N/A ... A-Med ... Sterile Diluent for Merck Sharp & Dohme Llc Live, Attenuated, Virus Vaccines …
Ibrexafungerp
Ibrexafungerp, also known as SCY-078 or MK-3118, is a novel enfumafungin derivative oral triterpene antifungal approved for the treatment of vulvovaginal candidiasis (VVC), also known as a vaginal yeast infection.[A235384,L34349] It was developed out of a need to treat fungal infections that may have become resistant to echinocandins or azole...
Approved
Investigational
Matched Synonyms: … -8- ((2R)-3-METHYLBUTAN-2-YL)-14-(5-(PYRIDIN-4-YL)-1H-1,2,4- TRIAZOL-1-YL)-1,6,6A,7,8,9,10,10A,10B,11,12,12A-DODECAHYDRO ... enfumafungin derivative B-(1,3)-D-glucan synthestis inhibitor ... (1S,4AR,6AS,7R,8R,10AR,10BR,12AR,14R,15R)-15-((2R)- 2-AMINO-2,3,3-TRIMETHYLBUTOXY)-1,6A,8,10A-TETRAMETHYL …
Matched Iupac: … -[(2R)-3-methylbutan-2-yl]-20-[5-(pyridin-4-yl)-1H-1,2,4-triazol-1-yl]-17-oxapentacyclo[13.3.3.0^{1,14 ... }.0^{2,11}.0^{5,10}]henicos-2-ene-6-carboxylic acid ... (1R,5S,6R,7R,10R,11R,14R,15S,20R,21R)-21-[(2R)-2-amino-2,3,3-trimethylbutoxy]-5,7,10,15-tetramethyl-7 …
Matched Description: … [A235414,L34349] Ibrexafungerp was granted FDA approval on 1 June 2021.[L34349] ... approved for the treatment of vulvovaginal candidiasis (VVC), also known as a vaginal yeast infection ... Ibrexafungerp, also known as SCY-078 or MK-3118, is a novel enfumafungin derivative oral triterpene antifungal …
Matched Iupac: … -[(2R)-3-methylbutan-2-yl]-20-[5-(pyridin-4-yl)-1H-1,2,4-triazol-1-yl]-17-oxapentacyclo[13.3.3.0^{1,14 ... }.0^{2,11}.0^{5,10}]henicos-2-ene-6-carboxylic acid ... (1R,5S,6R,7R,10R,11R,14R,15S,20R,21R)-21-[(2R)-2-amino-2,3,3-trimethylbutoxy]-5,7,10,15-tetramethyl-7 …
Matched Description: … [A235414,L34349] Ibrexafungerp was granted FDA approval on 1 June 2021.[L34349] ... approved for the treatment of vulvovaginal candidiasis (VVC), also known as a vaginal yeast infection ... Ibrexafungerp, also known as SCY-078 or MK-3118, is a novel enfumafungin derivative oral triterpene antifungal …
Dronabinol
Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effects of smoking cannabis such as increased appetite, reduced pain, and...
Approved
Illicit
Matched Synonyms: … 3-Pentyl-6,6,9-trimethyl-6a,7,8,10a-tetrahydro-6H-dibenzo(b,d)pyran-1-ol ... 6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol ... .DELTA.1-THC …
Matched Iupac: … (6aR,10aR)-6,6,9-trimethyl-3-pentyl-6H,6aH,7H,8H,10aH-benzo[c]isochromen-1-ol …
Matched Description: … THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid ... -2 (CB2R) receptors, which results in the well-known effects of smoking cannabis such as increased appetite ... for such a wide variety of medical conditions. …
Matched Iupac: … (6aR,10aR)-6,6,9-trimethyl-3-pentyl-6H,6aH,7H,8H,10aH-benzo[c]isochromen-1-ol …
Matched Description: … THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid ... -2 (CB2R) receptors, which results in the well-known effects of smoking cannabis such as increased appetite ... for such a wide variety of medical conditions. …
Ixazomib
Ixazomib is a reversible proteasome inhibitor. Because it is a modified peptide boronic acid with one chiral center, it is considered a boronate proteasome inhibitor. More than 99% of the drug compound is the R-enantiomer. Ixazomib was approved by the FDA on November 20, 2015, making it the first oral...
Approved
Investigational
Matched Synonyms: … BORONIC ACID, B-((1R)-1-((2-((2,5-DICHLOROBENZOYL)AMINO)ACETYL)AMINO)-3-METHYLBUTYL)- ... 2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-5-oxo-1,3,2-dioxaborolane-4,4- ... ((1R)-1-((2,5-DICHLOROBENZAMIDO)ACETAMIDO)-3-METHYLBUTYL)BORONIC ACID …
Matched Iupac: … [(1R)-1-{2-[(2,5-dichlorophenyl)formamido]acetamido}-3-methylbutyl]boronic acid …
Matched Description: … [A264319] It was later approved by Health Canada on August 3, 2016,[L51239] and by the EMA on November ... Because it is a modified peptide boronic acid with one chiral center,[A264329] it is considered a boronate ... Ixazomib is a reversible proteasome inhibitor. …
Matched Salts cas: … 1239908-20-3 …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2B6 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index …
Matched Products: … NİNLARO 3 MG KAPSÜL, 3 ADET ... NINLARO (3 MG) CAPSULE ... NİNLARO 4 MG KAPSÜL, 3 ADET …
Matched Iupac: … [(1R)-1-{2-[(2,5-dichlorophenyl)formamido]acetamido}-3-methylbutyl]boronic acid …
Matched Description: … [A264319] It was later approved by Health Canada on August 3, 2016,[L51239] and by the EMA on November ... Because it is a modified peptide boronic acid with one chiral center,[A264329] it is considered a boronate ... Ixazomib is a reversible proteasome inhibitor. …
Matched Salts cas: … 1239908-20-3 …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2B6 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index …
Matched Products: … NİNLARO 3 MG KAPSÜL, 3 ADET ... NINLARO (3 MG) CAPSULE ... NİNLARO 4 MG KAPSÜL, 3 ADET …
Lisocabtagene maraleucel
Lisocabtagene maraleucel is a chimeric antigen receptor (CAR) T-cell therapy, similar to brexucabtagene autoleucel and axicabtagene ciloleucel.[A228493,L31588] Lisocabtagene maraleucel is a genetically modified autologous T-cell therapy that targets CD19, the B-lymphocyte surface antigen B4. CAR T-cell therapy has changed the treatment of B-cell lymphomas, significantly increasing survival rates over standard...
Approved
Matched Description: … CD19, the B-lymphocyte surface antigen B4. ... 1 year period. ... Lisocabtagene maraleucel is a chimeric antigen receptor (CAR) T-cell therapy, similar to [brexucabtagene …
Buprenorphine
Buprenorphine is a weak partial mu-opioid receptor agonist and a weak kappa-opioid receptor antagonist used for the treatment of severe pain.[A186283,A186292] It is also commonly used as an alternative to methadone for the treatment of severe opioid addiction. Buprenorphine is commercially available as the brand name product Suboxone which is...
Approved
Illicit
Investigational
Vet approved
Matched Synonyms: … 2-(N-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6-methoxy-6,14-endo-ethanomorphinan-6α-yl)-3,3-dimethyl-2 ... 2-[3-cyclopropylmethyl-11-hydroxy-15-methoxy-(14R)-13-oxa-3-azahexacyclo[13.2.2.12,8.01,6.06,14.07,12 ... -3-ol …
Matched Iupac: … -oxa-3-azahexacyclo[13.2.2.1^{2,8}.0^{1,6}.0^{6,14}.0^{7,12}]icosa-7,9,11-trien-11-ol ... (1S,2R,6S,14R,15R,16R)-3-(cyclopropylmethyl)-16-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-15-methoxy-13 …
Matched Description: … 4:1 fixed-dose combination product along with [naloxone], a non-selective competitive opioid receptor ... Buprenorphine is a weak partial mu-opioid receptor agonist and a weak kappa-opioid receptor antagonist ... Buprenorphine has a number of unique pharmacokinetic and pharmacodynamic properties that make it a preferred …
Matched Mixtures name: … Bupensan Duo 4 mg/1 mg-Sublingualtabletten ... Suboxone 8 mg/2 mg sublingual tablets ... Suboxone 2 mg/0.5 mg sublingual tablets …
Matched Products: … Bupensan 1 mg-Sublingualtabletten ... BUPENSAN 2 MG ... BUPRENORPHIN-NEURAX 2 MG …
Matched Iupac: … -oxa-3-azahexacyclo[13.2.2.1^{2,8}.0^{1,6}.0^{6,14}.0^{7,12}]icosa-7,9,11-trien-11-ol ... (1S,2R,6S,14R,15R,16R)-3-(cyclopropylmethyl)-16-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-15-methoxy-13 …
Matched Description: … 4:1 fixed-dose combination product along with [naloxone], a non-selective competitive opioid receptor ... Buprenorphine is a weak partial mu-opioid receptor agonist and a weak kappa-opioid receptor antagonist ... Buprenorphine has a number of unique pharmacokinetic and pharmacodynamic properties that make it a preferred …
Matched Mixtures name: … Bupensan Duo 4 mg/1 mg-Sublingualtabletten ... Suboxone 8 mg/2 mg sublingual tablets ... Suboxone 2 mg/0.5 mg sublingual tablets …
Matched Products: … Bupensan 1 mg-Sublingualtabletten ... BUPENSAN 2 MG ... BUPRENORPHIN-NEURAX 2 MG …
Teclistamab
Teclistamab is an IgG4-PAA bispecific antibody that targets the CD3 receptor expressed on the surface of T cells and B cell maturation antigen (BCMA) expressed on malignant multiple myeloma cells. Teclistamab consists of an anti-BCMA arm and an anti-CD3 arm connected via two interchain disulfide bonds,[A253587, L43622] allowing the drug...
Approved
Investigational
Matched Description: … cell maturation antigen (BCMA) expressed on malignant multiple myeloma cells. ... IgG4-PAA bispecific antibody that targets the CD3 receptor expressed on the surface of T cells and B …
Matched Categories: … Bispecific B-cell maturation antigen (BCMA)-directed CD3 T-cell engager …
Matched Categories: … Bispecific B-cell maturation antigen (BCMA)-directed CD3 T-cell engager …
Ublituximab
CD20, an antigen expressed by various B and T cells, is an attractive therapeutic target in various cancers and autoimmune conditions.[A244195, A244200, A244205] Monoclonal antibodies for B cell depletion rely on their binding affinity and ability to clear bound cells through mechanisms such as antibody-dependent cellular cytotoxicity (ADCC), mediated by...
Approved
Investigational
Matched Description: … CD20, an antigen expressed by various B and T cells, is an attractive therapeutic target in various cancers ... one-hour infusion twice-a-year following the starting dose. ... [A244195, A244200, A244205] Monoclonal antibodies for B cell depletion rely on their binding affinity …
Matched Categories: … Leukemia, Lymphocytic, Chronic, B-Cell, drug therapy …
Matched Categories: … Leukemia, Lymphocytic, Chronic, B-Cell, drug therapy …
Talquetamab
Talquetamab is a IgG4-PAA bispecific G protein-coupled receptor class C group 5 member D (GPRC5D)-directed CD3 T-cell engager. It consists of two arms - anti-GPRC5D and anti-CD3 arms - linked by two interchain disulfide bonds, each arm comprising a heavy and light chain. Talquetamab binds to GPRC5D, a cell surface...
Approved
Investigational
Matched Synonyms: … IMMUNOGLOBULIN G4 (233-PROLINE,239-ALANINE,240-ALANINE,410-LEUCINE,414-LYSINE), ANTI-(HUMAN CD3 ANTIGEN …
Matched Description: … Talquetamab is a IgG4-PAA bispecific G protein-coupled receptor class C group 5 member D (GPRC5D)-directed ... arms - anti-GPRC5D and anti-CD3 arms - linked by two interchain disulfide bonds, each arm comprising a ... [L47765] Talquetamab binds to GPRC5D, a cell surface receptor expressed predominantly on multiple myeloma …
Matched Description: … Talquetamab is a IgG4-PAA bispecific G protein-coupled receptor class C group 5 member D (GPRC5D)-directed ... arms - anti-GPRC5D and anti-CD3 arms - linked by two interchain disulfide bonds, each arm comprising a ... [L47765] Talquetamab binds to GPRC5D, a cell surface receptor expressed predominantly on multiple myeloma …
Displaying drugs 176 - 200 of 6577 in total