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Displaying drugs 176 - 200 of 8039 in total

Oliceridine

Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid receptor subtype is predominantly targeted by and is responsible for...
Approved
Investigational
Matched Description: … ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of ... [A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which ... the μ-opioid receptor subtype is predominantly targeted by and is responsible for the effects of opioid …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Thiamine

Thiamine or thiamin, also known as vitamin B1, is a colorless compound with the chemical formula C12H17N4OS. It is soluble in water and insoluble in alcohol. Thiamine decomposes if heated. Thiamine was first discovered by Umetaro Suzuki in Japan when researching how rice bran cured patients of Beriberi. Thiamine plays...
Approved
Investigational
Nutraceutical
Vet approved
Matched Description: … a key role in intracellular glucose metabolism and it is thought that thiamine inhibits the effect of ... Thiamine was first discovered by Umetaro Suzuki in Japan when researching how rice bran cured patients of ... It is essential for normal growth and development and helps to maintain proper functioning of the heart …
Matched Mixtures name: … Harvest Of Values All B Complex Tab ... Herbs of Gold B Complex Plus Softgel …

Efavirenz

Efavirenz (brand names Sustiva® and Stocrin®) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and is used as part of highly active antiretroviral therapy (HAART) for the treatment of a human immunodeficiency virus (HIV) type 1. For HIV infection that has not previously been treated, efavirenz and lamivudine in combination with...
Approved
Investigational
Matched Description: … Sustiva® and Stocrin®) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and is used as part of ... highly active antiretroviral therapy (HAART) for the treatment of a human immunodeficiency virus (HIV ... Efavirenz is also used in combination with other antiretroviral agents as part of an expanded postexposure …
Matched Categories: … Inducers of Drug Clearance ... Metabolic Side Effects of Drugs and Substances ... Antivirals used in combination for the treatment of HIV infections …

Rifampin

Rifampin, also known as rifampicin, is a broad-spectrum antimicrobial that was first discovered in 1965 and clinically used in 1968. Rifampin is used to treat tuberculosis and works by inhibiting the microbial DNA-dependent RNA polymerase (RNAP).
Approved
Matched Categories: … Drugs for Treatment of Lepra ... Drugs for Treatment of Tuberculosis ... Metabolic Side Effects of Drugs and Substances …

Magnesium carbonate

Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label].
Approved
Investigational
Matched Description: … magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of …
Matched Categories: … Drugs for Treatment of Hyperkalemia and Hyperphosphatemia …

Sufentanil

Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as Dsuvia, the sublingual form is used for the management of acute pain in adults that...
Approved
Investigational
Matched Description: … Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is ... severe to warrant the use of an opioid analgesic in certified medically supervised healthcare settings ... Consideration may be made in the future for the use of the sublingual form in the US military in cases …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Acetazolamide

One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is...
Approved
Vet approved
Matched Description: … However, its usefulness is transient often because of rapid development of tolerance. ... (From Smith and Reynard, Textbook of Pharmacology, 1991, p337) ... One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. …
Matched Categories: … combinations of sulfonamides …

Dosulepin

Dosulepin (INN, BAN) formerly known as dothiepin (USAN), is a tricyclic antidepressant with anxiolytic properties that is used in several European and South Asian countries, as well as Australia, South Africa, and New Zealand. It is not FDA-approved due to low therpeutic index and significant toxicity in overdose. Dosulepin inhibits...
Approved
Matched Description: … Dosulepsin is a thio derivative of [DB00321] with a similar efficacy to that of [DB00321], and also exhibits ... Dosulepin inhibits the reuptake of biogenic amines, increasing available neurotransmitter levels at the ... The use of dosulepsin is only recommended in patients who are intolerant or unresponsive to alternative …
Matched Categories: … Combined Inhibitors of Serotonin/Norepinephrine Reuptake ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Duloxetine

Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval for a...
Approved
Matched Description: … [L6454] It has since received approval for a variety of indications including the treatment of neuropathic ... Duloxetine continues to be investigated for the treatment of pain in cancer, surgery, and more. ... A178741] Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of …
Matched Categories: … Combined Inhibitors of Serotonin/Norepinephrine Reuptake ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Pilocarpine

A naturally occurring alkaloid derived from the Pilocarpus plants, pilocarpine is a muscarinic acetylcholine agonist.[A262016, A262036] Pilocarpine is associated with parasympathomimetic effects by selectively working on muscarinic receptors. Pilocarpine is used to treat dry mouth and various ophthalmic conditions, including elevated intraocular pressure and glaucoma. The usage of glaucoma by...
Approved
Investigational
Matched Description: … The usage of glaucoma by pilocarpine dates back to 1875.[A262041] …

Inotuzumab ozogamicin

Inotuzumab ozogamicin is an antibody-drug conjugate consisting of a humanized IgG4 kappa CD22-targeting monoclonal antibody covalently attached to calicheamicin derivative, N-acetyl-gamma-calicheamicin dimethylhydrazide. The antibody portion of the drug binds to CD22 receptors expressed on leukemic B cells and intracellularly releases N-acetyl-gamma-calicheamicin dimethylhydrazide, which produces cytotoxic effects. Inotuzumab ozogamicin was first...
Approved
Investigational
Matched Description: … Inotuzumab ozogamicin is an antibody-drug conjugate consisting of a humanized IgG4 kappa CD22-targeting ... Inotuzumab ozogamicin was first approved by the European Commission in June 2017 for the treatment of ... [A20352] The antibody portion of the drug binds to CD22 receptors expressed on leukemic B cells and intracellularly …
Matched Categories: … CD22 (Clusters of Differentiation 22) inhibitors …

Frovatriptan

Frovatriptan is a triptan drug developed by Vernalis for the treatment of migraine headaches, in particular those associated with menstruation. Frovatriptan causes vasoconstriction of arteries and veins that supply blood to the head.
Approved
Investigational
Matched Description: … Frovatriptan causes vasoconstriction of arteries and veins that supply blood to the head. ... Frovatriptan is a triptan drug developed by Vernalis for the treatment of migraine headaches, in particular …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Ergoloid mesylate

Ergoloid Mesylate is an equiproportional preparation of three different ergotamantriones: dihydroergocornine, dihydroergocristine, and dihydroergocryptine. All these components are produced by the fungus Claviceps purpurea and are all derivatives of the tetracyclic compound 6-methylergonovine. The derivatives of this fungus are identified to be about 350 different substances from which the components...
Approved
Matched Description: … components of the ergoloid mesylate mixture are composed of the dihydrogenated ergot alkaloid derivatives ... Ergoloid Mesylate is an equiproportional preparation of three different ergotamantriones: dihydroergocornine ... A32912] All these components are produced by the fungus _Claviceps purpurea_ and are all derivatives of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Rasagiline

Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases.
Approved
Matched Description: … Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Levacetylmethadol

Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased...
Approved
Investigational
Withdrawn
Matched Description: … It is used mainly in the treatment of narcotic dependence. ... Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. ... The production of levacetylmethadol in the US has ceased as well.[L44052,T862] …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Dihydrocodeine

Dihydrocodeine is an opioid analgesic used as an alternative or adjunct to codeine to treat moderate to severe pain, severe dyspnea, and cough. It is semi-synthetic, and was developed in Germany in 1908 during an international search to find a more effective antitussive agent to help reduce the spread of...
Approved
Illicit
Matched Description: … during an international search to find a more effective antitussive agent to help reduce the spread of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Telaprevir

Telaprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common...
Approved
Withdrawn
Matched Description: … alter the affinity of the drug for NS3/4A or the activity of the enzyme itself. ... another class of DAAs [A19593]. ... The barrier for develoment of resistance to NS3/4A inhibitors is lower than that of NS5B inhibitors, …
Matched Categories: … Antivirals for treatment of HCV infections …

Butriptyline

Butriptyline is a tricyclic antidepressant which has been used in Europe since 1974. It is the isobutyl side chain homologue of amitriptyline.
Approved
Withdrawn
Matched Description: … It is the isobutyl side chain homologue of amitriptyline. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Sulfisoxazole

A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms.
Approved
Vet approved
Matched Description: … A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive …
Matched Categories: … combinations of sulfonamides …

Chlorthalidone

Chlorthalidone is a thiazide-like diuretic used for the treatment of hypertension and for management of edema caused by conditions such as heart failure or renal impairment. Chlorthalidone improves blood pressure and swelling by preventing water absorption from the kidneys through inhibition of the Na+/Cl− symporter in the distal convoluted tubule...
Approved
Matched Description: … of edema caused by conditions such as heart failure or renal impairment. ... Chlorthalidone is a thiazide-like diuretic used for the treatment of hypertension and for management ... improves blood pressure and swelling by preventing water absorption from the kidneys through inhibition of …
Matched Categories: … combinations of sulfonamides …

Stavudine

A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.
Approved
Investigational
Matched Categories: … Antivirals used in combination for the treatment of HIV infections …

Naltrexone

Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.
Approved
Investigational
Vet approved
Matched Description: … Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. ... The FDA has approved naltrexone for the treatment of alcohol dependence. ... effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Dasabuvir

Dasabuvir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common...
Approved
Matched Description: … reduced liver-related damage, improved quality of life, reduced incidence of Hepatocellular Carcinoma ... Dasabuvir is a direct acting antiviral medication used as part of combination therapy to treat chronic ... nine distinct genotypes, with genotype 1 being the most common in the United States, and affecting 72% of …
Matched Categories: … Antivirals for treatment of HCV infections …

Fluoxetine

Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies.
Approved
Vet approved
Matched Description: … [A181673] It gained FDA approval in 1987 and although it was initially intended for the treatment of …
Matched Categories: … Metabolic Side Effects of Drugs and Substances ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Miconazole

Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-based products are available.[L14021, L14024, L14027,...
Approved
Investigational
Vet approved
Matched Description: … oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of ... L14021, L14024, L14027, L14033, L14396] Miconazole is thought to act primarily through the inhibition of ... [A214523, L14021] It is currently available as a variety of prescription and over the counter products …
Matched Categories: … combinations of imidazole derivatives ... Metabolic Side Effects of Drugs and Substances …
Displaying drugs 176 - 200 of 8039 in total