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Displaying drugs 2001 - 2025 of 15401 in total

Leucovorin

Folinic Acid (also known as 5-formyl tetrahydrofolic acid or leucovorin) is the 5-formyl derivative of tetrahydrofolic acid, a necessary co-factor in the body. Commercially available leucovorin is composed of a 1:1 racemic mixture of the dextrorotary and levorotary isomers, while levoleucovorin contains only the pharmacologically active levo-isomer. In vitro, the...
Approved
Matched Iupac: … (2S)-2-[(4-{[(2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido …
Matched Description: … In vitro, the levo-isomer has been shown to be rapidly converted to the biologically available methyl-tetrahydrofolate ... Commercially available leucovorin is composed of a 1:1 racemic mixture of the dextrorotary and levorotary ... activity, the two commercially available forms have been shown to be pharmacokinetically identical and …
Matched Categories: … Enzymes and Coenzymes ... Folic Acid and Derivatives …

Prazepam

Prazepam is a benzodiazepine that is used in the treatment of anxiety disorders. It is a schedule IV drug in the U.S.
Approved
Illicit
Matched Categories: … Benzodiazepines and benzodiazepine derivatives …

Vamorolone

Vamorolone is a novel and fully synthetic glucocorticoid developed by Santhera Pharmaceuticals. It is used to manage inflammation and immune dysregulation in patients with Duchenne muscular dystrophy (DMD), a neuromuscular disorder characterized by the insidious regression of neuromuscular function and the most common form of muscular dystrophy in the United...
Approved
Investigational
Matched Description: … Vamorolone is a novel and fully synthetic glucocorticoid developed by Santhera Pharmaceuticals. ... It is used to manage inflammation and immune dysregulation in patients with Duchenne muscular dystrophy ... (DMD), a neuromuscular disorder characterized by the insidious regression of neuromuscular function and …
Matched Categories: … Sex Hormones and Insulins …

Secobarbital

Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom.
Approved
Vet approved
Matched Description: … Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate ... derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. …
Matched Categories: … Hypnotics and Sedatives …

Temazepam

Temazepam, like many other similar and related benzodiazepines, acts as a gamma-aminobutyric acid (GABA) modulator and is capable of eliciting a variety of actions including sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action [A175207, A175210, F3718, F3721]. Although the chemical synthesis of temazepam was established by 1965 ,...
Approved
Investigational
Matched Iupac: … 7-chloro-3-hydroxy-1-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one …
Matched Description: … capable of developing drug tolerance, physical dependence, and addiction in users. ... Temazepam, like many other similar and related benzodiazepines, acts as a gamma-aminobutyric acid (GABA ... relaxation, anticonvulsant activity, and anxiolytic action [A175207, A175210, F3718, F3721]. …
Matched Categories: … Hypnotics and Sedatives ... Benzodiazepine hypnotics and sedatives ... Benzodiazepines and benzodiazepine derivatives …

Tofacitinib

Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant to methotrexate....
Approved
Investigational
Matched Iupac: … 3-[(3R,4R)-4-methyl-3-[methyl({7H-pyrrolo[2,3-d]pyrimidin-4-yl})amino]piperidin-1-yl]-3-oxopropanenitrile …
Matched Description: … Known adverse effects include nausea and headache as well as more serious immunologic and hematological ... kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and ... tofacitinib has also been studied in clinical trials for the prevention of organ transplant rejection, and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Amobarbital

A barbiturate with hypnotic and sedative properties (but not antianxiety). Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with continued use is high. (From Martindale, The Extra Pharmacopoeia, 30th ed, p565)
Approved
Illicit
Matched Description: … A barbiturate with hypnotic and sedative properties (but not antianxiety). ... Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with …
Matched Categories: … Hypnotics and Sedatives …

Mumps virus strain B level jeryl lynn live antigen

Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease.
Approved
Investigational
Matched Mixtures name: … PROQUAD® ( Measles, Mumps, Rubella AND Varicella (Oka/Merck) Virus Vaccine Live, MSD) LYOPHILIZED VACCINE …

Pirbuterol

Pirbuterol is a beta-2 adrenergic bronchodilator. In vitro studies and in vivo pharmacologic studies have demonstrated that pirbuterol has a preferential effect on beta-2 Adrenergic receptors compared with isoproterenol. While it is recognized that beta-2 adrenergic receptors are the predominant receptors in bronchial smooth muscle, data indicate that there is...
Approved
Matched Description: … In vitro studies and in vivo pharmacologic studies have demonstrated that pirbuterol has a preferential ... Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release …
Matched Salts name: … Pirbuterol acetate …

Bendazac

Bendazac is an oxyacetic acid [A39863, A39869]. Despite possessing anti-inflammatory, anti-necrotic, choleretic, and anti-lipidemic characteristics, most research has revolved around studying and demonstrating the agent's principal action in inhibiting the denaturation of proteins - an effect that has primarily proven useful in managing and delaying the progression of ocular cataracts...
Approved
Withdrawn
Matched Description: … Despite possessing anti-inflammatory, anti-necrotic, choleretic, and anti-lipidemic characteristics, ... most research has revolved around studying and demonstrating the agent's principal action in inhibiting ... the denaturation of proteins - an effect that has primarily proven useful in managing and delaying the …
Matched Categories: … Topical Products for Joint and Muscular Pain …

Fosphenytoin

Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repetitive firing of action potentials.
Approved
Investigational
Matched Description: … channels, and therefore limit repetitive firing of action potentials. ... Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium …
Matched Categories: … Phenytoin and Prodrugs …

Ornithine

Produced during the urea cycle, ornithine is an amino acid produced from the splitting off of urea from arginine. L-Ornithine allows for the disposal of excess nitrogen and acts as a precursor of citrulline and arginine.
Approved
Nutraceutical
Matched Description: … L-Ornithine allows for the disposal of excess nitrogen and acts as a precursor of citrulline and arginine …
Matched Categories: … Bile and Liver Therapy ... Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins …

Valrubicin

Valrubicin (N-trifluoroacetyladriamycin-14-valerate) is a chemotherapy drug commonly marketed under the trade name VALSTAR. It is a semisynthetic analog of the doxorubicin, which is an anthracycline drug. Used in the treatment of the bladder cancer, valrubicin is administered by direct infusion into the bladder.
Approved
Matched Iupac: … 2-oxo-2-[(2S,4S)-2,5,12-trihydroxy-4-{[(2R,4S,5S,6S)-5-hydroxy-6-methyl-4-(2,2,2-trifluoroacetamido)oxan …
Matched Categories: … Anthracyclines and Related Substances ... Antineoplastic and Immunomodulating Agents ... Cytotoxic Antibiotics and Related Substances …

Magnesium glycinate

Magnesium glycinate is a magnesium salt of glycine that is available as dietary supplements as a source of magnesium. It is used in the treatment of magnesium deficiency.
Approved

Voclosporin

Lupus nephritis (LN) is a type of glomerulonephritis occurring in patients with systemic lupus erythematosus (SLE). LN is a significant cause of renal failure, morbidity, and death in patients with SLE. Within 10 years of being diagnosed with SLE, 5-20% of those suffering from LN develop end-stage kidney disease, a...
Approved
Investigational
Matched Description: … Early and accurate intervention for LN is important in improving clinical outcomes. ... LN is a significant cause of renal failure, morbidity, and death in patients with SLE. ... [L31208] Voclosporin has demonstrated a more stable pharmacokinetic and pharmacodynamic relationship …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …

Difluocortolone

Difluocortolone is a potent topical corticosteroid. It is commonly used in dermatology for the reduction of inflammation and itching. It was submitted to the FDA in July 1984 by the pharmaceutical company Schering AG.
Approved
Investigational
Withdrawn
Matched Description: … It is commonly used in dermatology for the reduction of inflammation and itching. …
Matched Categories: … diflucortolone and antiseptics ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Raltitrexed

Raltitrexed (brand name Tomudex®) is a chemotherapy drug manufactured AstraZeneca Company, is an antimetabolite used in chemotherapy. It is an inhibitor of thymidylate synthase.
Approved
Investigational
Matched Iupac: … (2S)-2-[(5-{methyl[(2-methyl-4-oxo-1,4-dihydroquinazolin-6-yl)methyl]amino}thiophen-2-yl)formamido]pentanedioic …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Calcium glucoheptonate

Calcium supplements such as calcium gluceptate are taken by individuals who are unable to get enough calcium in their regular diet or who have a need for more calcium. They are used to prevent or treat several conditions that may cause hypocalcemia (not enough calcium in the blood). The body...
Approved
Matched Description: … Calcium is also needed for the heart, muscles, and nervous system to work properly. …
Matched Categories: … Alimentary Tract and Metabolism …

Phenylbutazone

A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit considerations indicate that this drug should not be employed for this...
Approved
Vet approved
Matched Description: … A drug that has anti-inflammatory, antipyretic, and analgesic activities. ... It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). …
Matched Categories: … phenylbutazone and corticosteroids ... Antiinflammatory and Antirheumatic Products ... Topical Products for Joint and Muscular Pain ... Antiinflammatory and Antirheumatic Products, Non-Steroids …

Edrophonium

A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.
Approved
Matched Description: … A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis …

Deslanoside

Deacetyllanatoside C. A cardiotonic glycoside from the leaves of Digitalis lanata.
Approved
Matched Iupac: … ,11-dihydroxy-7-{[(2R,4S,5S,6R)-4-hydroxy-5-{[(2S,4S,5S,6R)-4-hydroxy-5-{[(2S,4S,5S,6R)-4-hydroxy-6-methyl …

Iodixanol

Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents.
Approved

Berberine

An alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal infections and as antidiarrheal.
Approved
Investigational
Matched Description: … and as antidiarrheal. ... It is relatively toxic parenterally, but has been used orally for various parasitic and fungal infections …

Nialamide

Withdrawn from the Canadian, US, and UK markets in 1963 due to interactions with food products containing tyrosine.
Approved
Withdrawn
Matched Description: … Withdrawn from the Canadian, US, and UK markets in 1963 due to interactions with food products containing …

Urethane

Urethane, formerly marketed as an inactive ingredient in Profenil injection, was determined to be carcinogenic and was removed from the Canadian, US, and UK markets in 1963.
Approved
Withdrawn
Matched Description: … was removed from the Canadian, US, and UK markets in 1963. ... formerly marketed as an inactive ingredient in Profenil injection, was determined to be carcinogenic and …
Displaying drugs 2001 - 2025 of 15401 in total