Did you mean bitopertin of ro 493838 of r 168 of ビトペルチン?
Displaying drugs 2076 - 2100 of 9627 in total
Capivasertib
Hormone receptor (HR) positive, especially estrogen receptor-positive, HER2-negative breast cancer is the most common subtype of metastatic breast cancer, resulting in more than 400,000 deaths annually. Although endocrine-based therapy is the first line of treatment, resistance eventually emerges, leaving chemotherapy the only but often ineffective treatment left. Therefore, significant research...
Approved
Investigational
Matched Description: … of the PIK3/AKT pathway, or PIK3CA mutations. ... , leading to the development of capivasertib, a pan-AKT kinase inhibitor. ... positive, especially estrogen receptor-positive, HER2-negative breast cancer is the most common subtype of …
Levosimendan
Levosimendan increases calcium sensitivity to myocytes by binding to troponin C in a calcium dependent manner. This increases contractility without raising calcium levels. It also relaxes vascular smooth muscle by opening adenosine triphosphate sensitive potassium channels. Levosimendan is used to manage acutely decompensated congestive heart failure.
Approved
Investigational
Panobinostat
Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress of being conducted. Panobinostat...
Approved
Investigational
Matched Description: … trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress of ... Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of …
Teplizumab
Teplizumab (teplizumab-mzwv) is a humanized IgG1 kappa CD3-directed monoclonal antibody used to delay the onset of type 1 diabetes (T1D).[A241480,A241045,A241475,L44091] T1D is an autoimmune condition in which T cell-mediated destruction of pancreatic β cells leads to loss of insulin production, impaired glycemic control, and reliance on exogenous insulin. Anti-CD3 therapy...
Approved
Investigational
Matched Description: … Although the mechanism of action of teplizumab has not been fully elucidated, it may involve partial ... agonistic signaling and deactivation of pancreatic beta cell autoreactive T lymphocytes. ... teplizumab-mzwv) is a humanized IgG1 kappa CD3-directed monoclonal antibody used to delay the onset of …
Ferric cation
Iron is a transition metal with a symbol Fe and atomic number 26. By mass, it is the most common element on Earth. Iron is an essential element involved in various metabolic processes, including oxygen transport, deoxyribonucleic acid (DNA) synthesis, and energy production in electron transport . Resulting from inadequate...
Approved
Matched Description: … Resulting from inadequate supply of iron to cells due to depletion of stores, iron deficiency is the ... most common nutritional deficiency worldwide, particularly affecting children, women of childbearing ... Iron deficiency may be characterized without the development of anemia, and may result in functional …
Nedosiran
Nedosiran is an RNA interference targeting hepatic lactate dehydrogenase, the enzyme responsible for the conversion of glyoxylate to oxalate. Oxalate, particularly calcium oxalate, precipitation is the main cause of kidney stones formation; therefore, blocking the production of oxalate can help alleviate renal symptoms. Nedosiran was approved by the FDA on...
Approved
Investigational
Matched Description: … ; therefore, blocking the production of oxalate can help alleviate renal symptoms. ... RNA interference targeting hepatic lactate dehydrogenase, the enzyme responsible for the conversion of ... [A261690] Oxalate, particularly calcium oxalate, precipitation is the main cause of kidney stones formation …
Hydroxycitronellal
Hydroxycitronellal is a synthetic fragrance that is widely used in many cosmetics and hygiene products such as deodorants, soaps, antiseptics, and other household items. It has the smell of lilac, lily, and lily of the valley . Hydroxycitronellal has also been shown to be a dermatologic irritant and allergen, and...
Approved
Experimental
Matched Description: … It has the smell of lilac, lily, and lily of the valley [A34269]. …
Sulindac
Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) of the arylalkanoic acid class that is marketed by Merck under the brand name Clinoril. Like other NSAIDs, it may be used in the treatment of acute or chronic inflammatory conditions. Sulindac is a prodrug, derived from sulfinylindene, that is converted in vivo...
Approved
Investigational
Matched Description: … Like other NSAIDs, it may be used in the treatment of acute or chronic inflammatory conditions. ... Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) of the arylalkanoic acid class that is marketed ... the sulfide metabolite undergoing enterohepatic circulation thus maintaining constant blood levels of …
Chloral hydrate
A hypnotic and sedative used in the treatment of insomnia. The safety margin is too narrow for chloral hydrate to be used as a general anesthetic in humans, but it is commonly used for that purpose in animal experiments. It is no longer considered useful as an anti-anxiety medication.
Approved
Illicit
Investigational
Vet approved
Matched Description: … A hypnotic and sedative used in the treatment of insomnia. …
Colfosceril palmitate
Colfosceril palmitate is a synthetic pulmonary surfactant administered in infants with respiratory distress syndrome. It was part of the first generation of commercially available artificial surfactants. It was developed by Burroughs Wellcome and it was FDA approved on August 6, 1990. Nowadays colfosceril palmitate is under the state of canceled...
Approved
Investigational
Withdrawn
Matched Description: … [A31510] It was part of the first generation of commercially available artificial surfactants. ... [L1109] Nowadays colfosceril palmitate is under the state of canceled post-marketing. …
Carboprost tromethamine
A nonsteroidal abortifacient agent that is effective in both the first and second trimesters of pregnancy.
Approved
Matched Description: … A nonsteroidal abortifacient agent that is effective in both the first and second trimesters of pregnancy …
Lomustine
An alkylating agent of value against both hematologic malignancies and solid tumors.
Approved
Investigational
Matched Description: … An alkylating agent of value against both hematologic malignancies and solid tumors. …
Unoprostone
Unoprostone isopropyl is a prostaglandin analogue. Ophthalmic Solution 0.15% is a synthetic docosanoid. Unoprostone isopropyl has the chemical name isopropyl (+)-(Z)-7-[(1R,2R,3R,5S)-3,5 dihydroxy-2-(3-oxodecyl)cyclopentyl]-5-heptenoate.
The main indication of Unoprostane is treatment of glucoma.
Approved
Investigational
Matched Description: … The main indication of Unoprostane is treatment of glucoma. …
Influenza B virus B/Wisconsin/1/2010 recombinant hemagglutinin antigen
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … memory B cells) and of cell-mediated immunity through the production of T-lymphocytes. ... This defence includes the production of humoral immunity through the development of antibodies (through ... A seasonally-specific component of the influenza vaccine. …
Influenza B virus B/Brisbane/60/2008 recombinant hemagglutinin antigen
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … memory B cells) and of cell-mediated immunity through the production of T-lymphocytes. ... This defence includes the production of humoral immunity through the development of antibodies (through ... A seasonally-specific component of the influenza vaccine. …
Levobetaxolol
Levobetaxolol is a beta-blocker used to lower the pressure in the eye to treat conditions such as glaucoma. It was marketed as a 0.5% ophthalmic solution of levobetaxolol hydrochloride under the trade name Betaxon but has been discontinued.
Approved
Investigational
Matched Description: … It was marketed as a 0.5% ophthalmic solution of levobetaxolol hydrochloride under the trade name Betaxon …
Calcium levulinate
The relatively new calcium levulinate is produced from a direct reaction between L- or levulinic acid levulose and calcium hydroxide . The resultant calcium levulinate formulation, when used as a calcium supplement, possesses a high calcium content that is observed to be 14.8% higher than the content typically found in...
Approved
Experimental
Matched Description: … This new application of calcium is intended for use as a food fortifier, to fortify foods like sauces …
Paclitaxel
Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as...
Approved
Vet approved
Matched Description: … for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of …
Ketoprofen
Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.
Approved
Vet approved
Pegcetacoplan
Pegcetacoplan is a complement inhibitor indicated in the treatment of paroxysmal nocturnal hemoglobinuria (PNH).[A235000,L34095] Prior to its FDA approval, patients with PNH were typically treated with the C5 inhibiting monoclonal antibody eculizumab. Patients given eculizumab experienced less hemolysis caused by the membrane attack complex, but were still somewhat susceptible to...
Approved
Matched Description: … further upstream of C5. ... [A235000,A235005] Pegcetacoplan was developed out of a need for an inhibitor of complement mediated hemolysis ... Pegcetacoplan is a complement inhibitor indicated in the treatment of paroxysmal nocturnal hemoglobinuria …
Undecylenic acid
Undecylenate, or undecylenic acid, is an unsaturated fatty acid with a terminal double bond that is derived from castor oil. Undecylenic acid is also found naturally in the human sweat. It is used as a precursor in the manufacture of aromatic chemicals, polymers or modified silicones . Undecylenic acid was...
Approved
Investigational
Matched Description: … Undecylenic acid was first isolated from the products of distillation of castor oil in 1877 via pyrolysis ... of ricinoleic acid, and has been polymerized for vinyl production [A32281]. ... It is used as a precursor in the manufacture of aromatic chemicals, polymers or modified silicones [L1891 …
Chlorprothixene
Chlorprothixene is a typical antipsychotic drug of the thioxanthene (tricyclic) class. Chlorprothixene exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors.
Approved
Experimental
Investigational
Withdrawn
Matched Description: … Chlorprothixene is a typical antipsychotic drug of the thioxanthene (tricyclic) class. …
Ancrod
Ancrod, marketed as Viprinex, is a defibrinogenating agent derived from Malayan pit viper venom. The defribrinogenation of blood results in an anticoagulant effect. Currently, Viprinex®/ancrod is not approved or marketed in any country, but is being investigated as a stroke treatment in worldwide clinical trials. In January 2005, the U.S....
Approved
Investigational
Matched Description: … The defribrinogenation of blood results in an anticoagulant effect. ... to portions of the brain, for which phase III trials are currently being conducted. ... stroke, a life threatening condition caused by the blockage of blood vessels supplying blood and oxygen …
Tafluprost
A prostaglandin analogue ester prodrug used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. Chemically, tafluprost is a fluorinated analog of prostaglandin F2-alpha. Tafluprost was approved for use in the U.S. on February 10, 2012.
Approved
Matched Description: … and in the management of ocular hypertension. ... Chemically, tafluprost is a fluorinated analog of prostaglandin F2-alpha. ... A prostaglandin analogue ester prodrug used topically (as eye drops) to control the progression of glaucoma …
Displaying drugs 2076 - 2100 of 9627 in total