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Displaying drugs 201 - 225 of 14664 in total

Cholesterol

The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
Approved
Investigational
Matched Description: … cord, and in animal fats and oils. ... The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal …

Ergosterol

A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS break a bond to result in ERGOCALCIFEROL.
Approved
Experimental
Matched Description: … of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and …
Matched Categories: … Diet, Food, and Nutrition …

Pefloxacin

A synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria.
Approved
Matched Description: … A synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and …
Matched Categories: … Metabolic Side Effects of Drugs and Substances …

Finafloxacin

Finafloxacin is a fluoroquinolone antibiotic indicated in the treatment of acute otitis externa (swimmer's ear) caused by the bacteria Pseudomonas aeruginosa and Staphylococcus aureus. Finafloxacin is marketed by Novartis under the brand Xtoro™, and was approved by the FDA in December 2014.
Approved
Investigational
Matched Description: … the treatment of acute otitis externa (swimmer's ear) caused by the bacteria Pseudomonas aeruginosa and ... Finafloxacin is marketed by Novartis under the brand Xtoro™, and was approved by the FDA in December …
Matched Salts name: … finafloxacin hydrochloride …

Flurbiprofen

Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically prior to ocular surgery to prevent or reduce intraoperative miosis....
Approved
Investigational
Matched Description: … Flurbiprofen is structurally and pharmacologically related to fenoprofen, ibuprofen, and ketoprofen. ... Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and ... formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and …
Matched Categories: … Antiinflammatory and Antirheumatic Products ... Topical Products for Joint and Muscular Pain ... Antiinflammatory and Antirheumatic Products, Non-Steroids …
Matched Products: … Strepsils MaxPro Honey and Lemon lozenges 8.75mg …

Tacrolimus

Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis...
Approved
Investigational
Matched Description: … drug whose main use is after organ transplant to reduce the activity of the patient's immune system and ... the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and ... This FKBP12-FK506 complex inhibits calcineurin which inhibits T-lymphocyte signal transduction and IL …
Matched Categories: … Skin and Mucous Membrane Agents ... Antineoplastic and Immunomodulating Agents …

Ethionamide

A second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868)
Approved
Matched Description: … (From Smith and Reynard, Textbook of Pharmacology, 1992, p868) …

Drostanolone propionate

Approved
Illicit
Matched Categories: … Testosterone and derivatives …

Regorafenib

Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in April 2017.
Approved
Matched Description: … used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Etilefrine

Etilefrine is an adrenergic agonist that appears to interact with beta-1 and some alpha-adrenergic receptors. It has been used as a vasoconstrictor agent.
Approved
Withdrawn
Matched Description: … Etilefrine is an adrenergic agonist that appears to interact with beta-1 and some alpha-adrenergic receptors …
Matched Salts name: … Etilefrine hydrochloride …
Matched Categories: … Adrenergic and Dopaminergic Agents …

Rifaximin

Rifaximin is a semisynthetic, rifamycin-based non-systemic antibiotic, meaning that the drug will not pass the gastrointestinal wall into the circulation as is common for other types of orally administered antibiotics. It has multiple indications and is used in treatment of traveller's diarrhea caused by E. coli; reduction in risk of...
Approved
Investigational
Matched Description: … It has multiple indications and is used in treatment of traveller's diarrhea caused by E. coli; reduction ... encephalopathy recurrence; as well as diarrhea-predominant irritable bowel syndrome (IBS-D) in adult women and …
Matched Categories: … Alimentary Tract and Metabolism …

Tepotinib

Tepotinib is a MET tyrosine kinase inhibitor intended to treat a variety of MET-overexpressing solid tumors. It was originally developed in partnership between EMD Serono and the University of Texas M.D. Anderson Cancer Center in 2009 and has since been investigated in the treatment of neuroblastoma, gastric cancers, non-small cell...
Approved
Investigational
Matched Description: … indirectly, in the growth and proliferation of tumors in which it is overexpressed and/or mutated. ... ] gastric cancers,[A228033] non-small cell lung cancer, and hepatocellular carcinoma. ... [A228058] It was originally developed in partnership between EMD Serono and the University of Texas M.D …
Matched Salts name: … Tepotinib hydrochloride …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Doxercalciferol

Doxercalciferol is a synthetic vitamin D2 analog that undergoes metabolic activation in vivo to form 1α,25-dihydroxyvitamin D2 (1α,25-(OH)2D2), a naturally occurring, biologically active form of vitamin D2. Doxercalciferol is indicated for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease on dialysis, as well as for the treatment...
Approved
Matched Description: … Doxercalciferol is marketed under the brand name Hectoral by Genzyme Corporation, and is manufactured …
Matched Categories: … Diet, Food, and Nutrition ... Vitamin D and Analogues ... Sex Hormones and Insulins …

Flavone

Approved
Experimental

Melphalan flufenamide

Melphalan flufenamide, also known as melflufen or J1, is a prodrug of melphalan.[A230123,L32173] Melphalan flufenamide is more readily uptaken by cells than melphalan, and is cleaved to the active metabolite by aminopeptidases. In vitro models show that melphalan is 10 to hundreds of times more potent than melphalan. The increased...
Approved
Withdrawn
Matched Description: … [A230123,L32173] Melphalan flufenamide is more readily uptaken by cells than melphalan, and is cleaved ... which showed a decrease in overall survival in comparison to standard treatment with [pomalidomide] and …
Matched Salts name: … Melphalan flufenamide hydrochloride …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …

Chlorquinaldol

Chlorquinaldol was used historically as a topical antiseptic under the trade name Sterosan. It was marketed in the 1950s as an iodine-free alternative which was also unrelated to sulfa drugs or hormones. Chlorquinaldol is currently approved by the European Medicines Agency as a combination tablet with promestriene for the treatment...
Approved
Matched Categories: … Antiseptics and Disinfectants ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics ... Antiparasitic Products, Insecticides and Repellents …

Etelcalcetide

Etelcalcetide is a calcimimetic drug for the treatment of secondary hyperparathyroidism in patients undergoing hemodialysis. Etelcalcetide was approved (trade name Parsabiv) for the treatment of secondary hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) on hemodialysis in February, 2017.
Approved
Investigational
Matched Salts name: … Etelcalcetide hydrochloride …
Matched Categories: … Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins …

Daridorexant

Daridorexant, formerly known as nemorexant, is a selective dual orexin receptor antagonist used to treat insomnia. Insomnia is characterized by difficulties with sleep onset and/or sleep maintenance and impairment of daytime functioning. It chronically affects the person's daily functioning and long-term health effects, as insomnia is often associated with comorbidities...
Approved
Matched Description: … Insomnia is characterized by difficulties with sleep onset and/or sleep maintenance and impairment of ... associated with comorbidities such as hypertension, diabetes, and depression. ... are wake-promoting neuropeptides and endogenous ligands to these receptors. …
Matched Salts name: … Daridorexant hydrochloride …
Matched Categories: … Hypnotics and Sedatives …

Oxyquinoline

Oxyquinoline is a heterocyclic phenol and derivative of quinoline with antiseptic, disinfectant, and pesticide properties. It is used as a stabilizer for hydrogen peroxide, where it is sometimes added in cosmetic products.
Approved
Vet approved
Matched Description: … Oxyquinoline is a heterocyclic phenol and derivative of quinoline with antiseptic, disinfectant, and …
Matched Salts name: … 8-Hydroxyquinoline hydrochloride …
Matched Categories: … Alimentary Tract and Metabolism ... Antiseptics and Disinfectants ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics ... Antiinfectives and Antiseptics for Local Oral Treatment …

Rupatadine

Rupatadine is a dual histamine H1 receptor and platelet activating factor receptor antagonist that is used for symptomatic relief in seasonal and perennial rhinitis as well as chronic spontaneous urticaria. It was approved for marketing in Canada under the tradename Rupall and comes in tablet formulation for adult use and...
Approved
Matched Description: … adult use and liquid formulation for pediatric use. ... Rupatadine is a dual histamine H1 receptor and platelet activating factor receptor antagonist that is ... used for symptomatic relief in seasonal and perennial rhinitis as well as chronic spontaneous urticaria …

Lynestrenol

Lynestrenol is a progestin and prodrug of norethisterone.
Approved
Investigational
Matched Description: … Lynestrenol is a progestin and prodrug of [norethisterone]. …
Matched Categories: … lynestrenol and estrogen ... lynestrenol and estrogen ... lynestrenol and ethinylestradiol ... lynestrenol and ethinylestradiol ... Genito Urinary System and Sex Hormones …

Ursodeoxycholic acid

Ursodeoxycholic acid (UDCA), also known as ursodiol, is a naturally-occurring bile acid that constitutes a minor fraction of the human bile acid pool.[A256272,A256277] UDCA has been used to treat liver disease for decades: its first use in traditional medicine dates back more than a hundred years.[A256267,A256463] UDCA was first characterized...
Approved
Investigational
Matched Description: … [A256267,A256463] UDCA was first characterized in the bile of the Chinese black bear and is formed by ... [A256272] UDCA was first approved by the FDA in 1987 for dissolution of gallstones and for primary …
Matched Categories: … Bile Acids and Salts ... Bile and Liver Therapy ... Bile acids and derivatives ... Alimentary Tract and Metabolism ... Cholagogues and Choleretics …

Diiodohydroxyquinoline

Diiodohydroxyquinoline, also known as uidoquinol and iodoquinol, is a quinoline derivative that can be used in the treatment of amoebiasis. The exact mechanism of action is unknown. Iodoquinol is not currently available in any FDA-approved products.
Approved
Matched Description: … Diiodohydroxyquinoline, also known as uidoquinol and iodoquinol, is a quinoline derivative that can be …
Matched Categories: … Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Flutamide

An antiandrogen with about the same potency as cyproterone in rodent and canine species.
Approved
Investigational
Matched Description: … An antiandrogen with about the same potency as cyproterone in rodent and canine species. …
Matched Categories: … Hormone Antagonists and Related Agents ... Antineoplastic and Immunomodulating Agents ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Tivozanib

Renal cell carcinoma (RCC) is responsible for 3% of cancer cases and is one of the 10 most common cancers in adults. The average age of diagnosis is between age 65 to 74. Tivozanib, also known as FOTIVDA, is a kinase inhibitor developed to treat adult patients with relapsed or...
Approved
Investigational
Matched Description: … Renal cell carcinoma (RCC) is responsible for 3% of cancer cases[A231314] and is one of the 10 most common …
Matched Salts name: … Tivozanib hydrochloride …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Displaying drugs 201 - 225 of 14664 in total