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Displaying drugs 2226 - 2250 of 15095 in total

Elosulfase alfa

Elosulfase alfa is a synthetic version of the enzyme N-acetylgalactosamine-6-sulfatase. It was approved by the FDA in 2014 for the treatment of Morquio syndrome. Elosulfase alfa was developed by BioMarin Pharmaceutical Inc. and is marketed under the brand Vimizim™. The recommended dose is 2 mg per kg given intravenously over...
Approved
Investigational
Matched Description: … Elosulfase alfa was developed by BioMarin Pharmaceutical Inc. and is marketed under the brand Vimizim …
Matched Categories: … Enzymes and Coenzymes ... Alimentary Tract and Metabolism ... Chondroitinases and Chondroitin Lyases …

NADH

NADH is the reduced form of NAD+, and NAD+ is the oxidized form of NADH, a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by...
Approved
Nutraceutical
Matched Iupac: … [(2R,3S,4R,5R)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy})phosphinic acid …
Matched Description: … electron carrier by being alternately oxidized (NAD+) and reduced (NADH). ... It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an ... NADH is the reduced form of NAD+, and NAD+ is the oxidized form of NADH, a coenzyme composed of ribosylnicotinamide …
Matched Categories: … Enzymes and Coenzymes ... Nucleic Acids, Nucleotides, and Nucleosides …

Pegvisomant

Pegvisomant is a highly selective growth hormone (GH) receptor antagonist. It is used to treat acromegaly. Unlike dopamine or somatostatin analogs (which inhibit growth hormone secretion), this drug actually blocks the hepatic (GH-mediated) production of insulin like growth factor (IGF-1), which is the main mediator of growth hormone activity.
Approved
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins ... Anterior Pituitary Lobe Hormones and Analogues ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Insulin icodec

Insulin icodec is an ultra long-acting basal insulin analogue.
Approved
Investigational
Matched Categories: … Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Tibolone

Tibolone is a synthetic steroid hormone drug, which is mainly non-selective in its binding profile, acting as an agonist primarily at estrogen receptors (ER), with a preference for ER alpha . Tibolone (Livial, Org OD 14), produced by Organon (West Orange, NJ), is a synthetic steroid that possesses estrogenic, androgenic...
Approved
Investigational
Matched Description: … produced by Organon (West Orange, NJ), is a synthetic steroid that possesses estrogenic, androgenic and ... Tibolone is approved in 90 countries to manage menopausal symptoms and in 45 countries to prevent the ... been used in Europe for almost 2 decades, primarily for the prevention of postmenopausal osteoporosis and …
Matched Categories: … Genito Urinary System and Sex Hormones ... Sex Hormones and Modulators of the Genital System ... Hormones, Hormone Substitutes, and Hormone Antagonists ... Estrogens, Antiestrogens, and Estrogen Agonist-Antagonists …

Amivantamab

Amivantamab, also known as JNJ-61186372, is an anti-EGFR-MET bispecific antibody, derived from Chinese hamster ovary cells, approved for the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 20 insertion mutations, as detected by an FDA-approved test, whose...
Approved
Investigational
Matched Description: … FDA approval on 21 May 2021,[L34193] followed by the approval by the EMA on 9 December 2021 [L41474] and ... [A235103,L34193] Patients with NSCLC often develop resistance to drugs that target EGFR and MET individually ... Patients with NSCLC with exon 20 insertion mutations in EGFR do not respond to tyrosine kinase inhibitors, and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …

Somapacitan

Somapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency.[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily. Somapacitan was granted FDA approval...
Approved
Investigational
Matched Description: … A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and …
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins ... Somatropin and Somatropin Agonists ... Anterior Pituitary Lobe Hormones and Analogues …

Pixantrone

Pixantrone is an aza-anthracenedione and DNA intercalator which inhibits topoisomerase II. It is similar in structure to anthracyclines such as mitoxantrone, but exerts fewer toxic effects on cardiac tissue. [2] The lower cardio-toxic effects of pixantrone may be explained, in part, by its redox inactivity [3]. Pixantrone does not bind...
Approved
Investigational
Matched Description: … Pixantrone is an aza-anthracenedione and DNA intercalator which inhibits topoisomerase II. ... Pixantrone does not bind iron and promotes the formation of reactive oxygen species to a lesser degree ... that it resulted in significantly higher complete response rate and progression free survival in comparison …
Matched Categories: … Anthracyclines and Related Substances ... Antineoplastic and Immunomodulating Agents ... Cytotoxic Antibiotics and Related Substances …

Bazedoxifene

Bazedoxifene is a third generation selective estrogen receptor modulator (SERM), developed by Pfizer following the completion of their takeover of Wyeth Pharmaceuticals. In late 2013, Pfizer received approval for bazedoxifene as part of the combination drug DUAVEE in the prevention (not treatment) of postmenopausal osteoporosis. It is approved in the...
Approved
Investigational
Matched Description: … It is approved in the European Union (marketed in Italy and Spain) and Japan as monotherapy. ... In 2013, the combination product containing conjugated estrogens and bazedoxifene was approved by the …
Matched Categories: … Genito Urinary System and Sex Hormones ... conjugated estrogens and bazedoxifene ... Sex Hormones and Modulators of the Genital System ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Catumaxomab

Catumaxumab is a trifunctional monoclonal antibody developed for use in cancer treatment. It has affinity for T-cells, accessory immune cells, and cancer cells. Catumaxumab was initially authorized for market by the European Medicines Agency in April 2009 for the treatment of malignant ascites . Its market authorization was withdrawn in...
Approved
Investigational
Withdrawn
Matched Description: … It has affinity for T-cells, accessory immune cells, and cancer cells. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …

Hydroxyethyl Starch

Hydroxyethyl starch (HES/HAES) is a nonionic starch derivative. Hydroxyethyl starches (HES) are synthetic colloids commonly used for fluid resuscitation to replace intravascular volume. HES is a general term and can be sub-classified according to average molecular weight, molar substitution, concentration, C2/C6 ratio and Maximum Daily Dose.
Approved
Matched Description: … , concentration, C2/C6 ratio and Maximum Daily Dose. ... HES is a general term and can be sub-classified according to average molecular weight, molar substitution …
Matched Categories: … Blood and Related Products ... Blood and Blood Forming Organs ... Blood Substitutes and Perfusion Solutions ... Blood Substitutes and Plasma Protein Fractions …

Etranacogene dezaparvovec

Hemophilia B - also called factor IX deficiency or Christmas disease - is an X-linked genetic disorder resulting in an absence or deficiency of clotting factor IX. Clotting factors, including factor IX, are necessary components of the signaling cascade responsible for blood clotting and subsequent wound healing. Symptoms of hemophilia...
Approved
Investigational
Matched Description: … including factor IX, are necessary components of the signaling cascade responsible for blood clotting and ... recommended etranacogene dezaparvovec be granted marketing authorization for the treatment of severe and ... [L45255] Etranacogene dezaparvovec was approved by the EMA in February 2023[L45439,L45444] and by Health …
Matched Categories: … Cellular and Gene Therapy ... Blood and Blood Forming Organs …

Eptotermin alfa

A bone morphogenetic protein that is widely expressed during EMBRYONIC DEVELOPMENT. It is both a potent osteogenic factor and a specific regulator of nephrogenesis. Eptotermin alfa is an ingredient in the EMA-withdrawn product Osigraft.
Approved
Investigational
Withdrawn
Matched Description: … It is both a potent osteogenic factor and a specific regulator of nephrogenesis. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Intercellular Signaling Peptides and Proteins ... Drugs Affecting Bone Structure and Mineralization …

Dibotermin alfa

Dibotermin alfa is a recombinant human bone morphogenetic protein-2 (rhBMP-2) derived from a recombinant Chinese Hamster Ovary (CHO) cell line [FDA Label]. It is implanted in patients undergoing bone surgeries or those with fractures. BMPs are subfamily of the transforming growth factor-β (TGF-β) superfamily that have different actions on the...
Approved
Investigational
Matched Description: … In 2004, it was approved by the FDA and is marketed as Infuse. ... critical role in the differentiation of osteoprogenitor cells into osteoblasts, thus promoting bone and ... at the site of implantation, dibotermin alfa accelerates the healing of open tibial shaft fractures and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Intercellular Signaling Peptides and Proteins ... Drugs Affecting Bone Structure and Mineralization …

Alatrofloxacin

Alatrofloxacin is a fluoroquinolone antibiotic developed by Pfizer, delivered as a mesylate salt. It was withdrawn from the U.S. market in 2001.
Approved
Withdrawn
Matched Iupac: … [3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid …

Cefamandole nafate

Approved
Matched Iupac: … methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid …

Carboprost tromethamine

A nonsteroidal abortifacient agent that is effective in both the first and second trimesters of pregnancy.
Approved
Matched Iupac: … -7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-3-methyloct-1-en-1-yl]cyclopentyl]hept-5-enoic acid …
Matched Description: … A nonsteroidal abortifacient agent that is effective in both the first and second trimesters of pregnancy …
Matched Categories: … Genito Urinary System and Sex Hormones …

Brivudine

Brivudine is used in the treatment of herpes zoster. Although not approved in the U.S. or Canada, it is approved in several European countries.
Approved
Investigational
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides ... Nucleosides and Nucleotides Excl. Reverse Transcriptase Inhibitors …

Magnesium glycinate

Magnesium glycinate is a magnesium salt of glycine that is available as dietary supplements as a source of magnesium. It is used in the treatment of magnesium deficiency.
Approved

Cladribine

Cladribine is a purine analogue or a chlorinated derivative of adenine that causes apoptosis of B and T lymphocytes. Cladribine was first approved in the United States in 1993 initially as a treatment for a number of hematological malignancies; currently, it is approved for the treatment of hairy cell leukemia....
Approved
Investigational
Matched Description: … Cladribine is a purine analogue or a chlorinated derivative of adenine [A263733] that causes apoptosis of B and ... [A263733] In 2017 in Europe and in 2019 in the United States, cladribine was also approved for the treatment …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Nucleic Acids, Nucleotides, and Nucleosides …

Colistin

Cyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes. Colistin is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used orally.
Approved
Matched Description: … It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes …
Matched Categories: … Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins …

Lomustine

An alkylating agent of value against both hematologic malignancies and solid tumors.
Approved
Investigational
Matched Description: … An alkylating agent of value against both hematologic malignancies and solid tumors. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Anistreplase

Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl group is chemically conjugated to a complex of bacterial-derived streptokinase and human Plasma-derived...
Approved
Matched Description: … A p-anisoyl group is chemically conjugated to a complex of bacterial-derived streptokinase and human ... derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and …
Matched Categories: … Enzymes and Coenzymes ... Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …

Tisagenlecleucel

Tisagenlecleucel is a CD19-directed genetically modified autologous T cell immunotherapy, or a CAR-T cell therapy for B-cell acute lymphoblastic leukemia. It was granted approval by FDA in August 2017 under the market name Kymriah. Tisagenlecleucel is an immunocellular therapy that involves autologous T cells that are collected from each individual...
Approved
Investigational
Matched Description: … These CD19-directed chimeric antigen receptors (CD19 CAR-T cells) direct the T cells to target and kill ... immunocellular therapy that involves autologous T cells that are collected from each individual patient and ... In a multicenter clinical trial involving pediatric and young adult patients with relapsed or refractory …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic cell and gene therapy ... Antineoplastic and Immunomodulating Agents …

Bemiparin

Bemiparin is an antithrombotic and belongs to the group of drugs known as the low molecular weight heparins (LMWH). Like semuloparin, bemiparin is classified as an ultra-LMH because of its low mean molecular mass of 3600 daltons, which is a unique property of this class . These heparins have lower...
Approved
Investigational
Matched Description: … Bemiparin is an antithrombotic and belongs to the group of drugs known as the low molecular weight heparins ... These heparins have lower anti-thrombin activity than the traditional low molecular weight heparins and ... Interestingly, current research is underway for the potential benefit of bemiparin in the treatment of tumors and …
Matched Categories: … Heparin and similars ... Blood and Blood Forming Organs …
Displaying drugs 2226 - 2250 of 15095 in total