Advanced Filter

Filter by Group

Filter by Market Availability

Clear
Did you mean chloroxylenol and emetine acid and propylene glycol?
Displaying drugs 2351 - 2375 of 15109 in total

Vismodegib

Vismodegib is an orally active small molecule that inhibits the hedgehog signaling pathway by binding to and inhibiting the transmembrane protein smoothened homologue (SMO).[A258613,A258618,L45803] It was discovered by high-throughput screening of a library of small-molecule compounds and subsequent optimization through medicinal chemistry. Since it targets the hedgehog signaling pathway, vismodegib...
Approved
Investigational
Matched Description: … Afterwards, it is silenced in all cells and tissues, except for hair, skin and stem cells. ... Vismodegib is an orally active small molecule that inhibits the hedgehog signaling pathway by binding to and ... The Hedgehog signaling pathway plays an important role in the development of organs and tissues during …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Golimumab

Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate treatment in patients with...
Approved
Matched Description: … Golimumab binds and inhibits soluble and transmembrane human TNFα. ... Additionally in children and adolescents taking golimumab, there have been lymphoma and other malignancies ... In the U.S. and Canada, golimumab is marketed under the brand name Simponi®. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …

Efgartigimod alfa

Myasthenia gravis (MG) is an autoimmune disorder characterized by significant muscle weakness - particularly in the eye, throat, and extremities - caused by autoantibodies attacking the neuromuscular junction. The production of IgG autoantibodies against acetylcholine receptors (AChRs) is one of the more common pathophysiological mechanisms behind MG, and results in...
Approved
Investigational
Matched Description: … results in the destruction of these receptors and a reduction in electrical nerve impulses. ... autoimmune disorder characterized by significant muscle weakness - particularly in the eye, throat, and ... acetylcholine receptors (AChRs) is one of the more common pathophysiological mechanisms behind MG, and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Fluoroestradiol F-18

Fluoroestradiol F-18 is an imaging agent used with positron emission tomography (PET) to detect estrogen receptor-positive breast cancer lesions. The ability to image ER-positive tumors in vivo is advantageous in that, while helping to visualize tumor progression/regression, it may also be used to assess for heterogeneity in ER expression across...
Approved
Matched Description: … PETNET Solutions, Inc. and Zionexa USA under the brand name Cerianna. ... [A203912] Fluoroestradiol F-18 was first granted FDA approval in May 2020, and will be developed by …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …

Pexidartinib

Pexidartinib is a selective tyrosine kinase inhibitor that works by inhibiting the colony-stimulating factor (CSF1)/CSF1 receptor pathway. Pexidartinib was originally developed by Daiichi Sankyo, Inc. and it was approved by the FDA in August 2019 as the first systemic therapy for adult patients with symptomatic tenosynovial giant cell tumor. Tenosynovial...
Approved
Investigational
Matched Description: … tendon sheaths to thicken and overgrow, leading to damage in surrounding joint tissue. ... Pexidartinib was originally developed by Daiichi Sankyo, Inc. and it was approved by the FDA in August ... [A182243] Pexidartinib is available in oral formulations and it is commonly marketed as Turalio. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Roflumilast

Roflumilast is a highly selective phosphodiesterase-4 (PDE4) inhibitor. PDE4 is a major cyclic-3',5′-adenosinemonophosphate (cyclic AMP, cAMP)-metabolizing enzyme expressed on nearly all immune and pro-inflammatory cells, in addition to structural cells like those of the smooth muscle or epithelium. The resultant increase in intracellular cAMP induced by roflumilast's inhibition of PDE4...
Approved
Matched Description: … [L46546] It was first approved by the EMA in July 2010, and by the FDA in January 2018. ... adenosinemonophosphate (cyclic AMP, cAMP)-metabolizing enzyme [L37564] expressed on nearly all immune and ... The cream formulation was first approved by the FDA in July 2022 [L42580] and by Health Canada in April …

Bisoctrizole

Bisoctrizole, or methylene bis-benzotriazolyl tetramethylbutylphenol, is a broad-spectrum organic UV filter that is marketed as Tinosorb M . It is a benzotriazole-based organic compound that absorbs, reflects, and scatters both UV-A and UV-B rays. Bisoctrizole is not approved by the FDA, but is approved in the EU and other parts...
Approved
Matched Description: … It is a benzotriazole-based organic compound that absorbs, reflects, and scatters both UV-A and UV-B ... Bisoctrizole is not approved by the FDA, but is approved in the EU and other parts of the world as a ... UV-filter in sunscreens, day care products and skin lightening products at a maximum concentration of …

Pargyline

Pargyline is a monoamine oxidase inhibitor with antihypertensive properties.
Approved
Matched Categories: … pargyline and diuretics ... MAO Inhibitors and Diuretics …

Udenafil

Udenafil is a new phosphodiesterase type 5 (PDE5) inhibitor used to treat erectile dysfunction (ED). It has been approved in South Korea and will be marketed under the brand name Zydena. It is not yet approved for use in the U.S., E.U., or Canada.
Approved
Investigational
Matched Description: … It has been approved in South Korea and will be marketed under the brand name Zydena. …
Matched Categories: … Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Cobalt

A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis. Except for radioactive forms...
Approved
Experimental
Withdrawn
Matched Description: … It is used in nuclear weapons, alloys, and pigments. ... It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. ... Except for radioactive forms of cobalt and cobalamin, the FDA withdrew its approval for the use of drug …
Matched Categories: … Diet, Food, and Nutrition …

Segesterone acetate

Segesterone acetate is a steroidal progestin or synthetic progesterone and a 19-norprogesterone derivative with no CH3 group radical in position 6 . In animal studies, segesterone acetate was shown to be one of the most potent progestins . It mediates progestational activity 100 times higher than that of progesterone ....
Approved
Experimental
Investigational
Matched Description: … low-birth-weight infants, and physical and mental health risks [L4246]. ... It is commonly sold under the brand names Nestorone and Elcometrine and serves as an active component ... Food and Drug Administration (FDA) as the first and only contraceptive that provides an entire year of …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …

Ritlecitinib

Ritlecitinib (PF-06651600) is a highly selective inhibitor of Janus kinase 3 (JAK3) and the tyrosine kinase expressed in hepatocellular carcinoma (TEC) kinase family. In June 2023, it was approved by the FDA for the treatment of severe alopecia areata in adults and adolescents 12 years and older.[L47092,L47127] It was further...
Approved
Investigational
Matched Description: … 12 years and older. ... This makes ritlecitinib a highly selective and irreversible JAK3 inhibitor. ... [L48181] Ritlecitinib is administered orally and is the first member of its class. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Oteseconazole

Oteseconazole is an azole metalloenzyme inhibitor that targets fungal CYP51. CYP51, also known as 14α demethylase, participates in the formation of ergosterol, a compound that plays a vital role in the integrity of cell membranes.[L41635,A247020] By binding and inhibiting CYP51, oteseconazole is active against most microorganisms associated with recurrent vulvovaginal...
Approved
Investigational
Matched Description: … [L41635,A247020] By binding and inhibiting CYP51, oteseconazole is active against most microorganisms ... Candida glabrata_, _Candida krusei_, _Candida parapsilosis_, _Candida tropicalis_, _Candida lusitaniae_ and ... L41635] Unlike previous-generation azole antifungals, oteseconazole has a high selectivity for CYP51 and …
Matched Categories: … Triazole and tetrazole derivatives …

Belumosudil

Belumosudil is used in the treatment of chronic graft-versus-host disease (GVHD) and has been investigated for the treatment of pulmonary arterial hypertension. It is an inhibitor of rho-associated coiled-coil-containing protein kinases (ROCK), with significantly more selectivity for ROCK2 as compared to ROCK1 (IC50 100 nM vs. 3 μM, respectively). In...
Approved
Investigational
Matched Description: … Belumosudil is used in the treatment of chronic graft-versus-host disease (GVHD) and has been investigated ... HSCT), belumosudil helps to resolve immune dysregulation by shifting the balance between Th17 cells and ... July 2021, under the brand name Rezurock, for the treatment of chronic GVHD in patients who have tried and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Stiripentol

Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzymes. However, its clinical efficacy as...
Approved
Matched Description: … [A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the ... [A19739] Approved in the US, Canada, and Europe, stiripentol is used to treat seizures associated …

Attapulgite

Attapulgite is a magnesium aluminium phyllosilicate which occurs in a type of clay soil common to the Southeastern United States. When used in medicine, it physically binds to acids and toxic substances in the stomach and digestive tract. For that reason, it has often been used in antidiarrheal medications. Until...
Approved
Vet approved
Matched Description: … When used in medicine, it physically binds to acids and toxic substances in the stomach and digestive …
Matched Categories: … Alimentary Tract and Metabolism …

Lebrikizumab

Lebrikizumab is a monoclonal antibody against IL-13 that binds to a different epitope compared tralokinumab.[A262874,A262879] On November 17, 2023, lebrikizumab was approved by the EMA under the brand name EBGLYSS for the treatment of moderate-to-severe atopic dermatitis in adult and adolescent patients 12 years and older with a body weight...
Approved
Investigational
Matched Description: … adolescent patients 12 years and older with a body weight of at least 40 kg. ... EMA under the brand name EBGLYSS for the treatment of moderate-to-severe atopic dermatitis in adult and ... This approval is based on the positive results obtained from the Phase 3 studies ADvocate 1 and ADvocate …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Lorcaserin

Lorcaserin (previously APD-356), a highly selective 5HT2C receptor agonist, is used for the treatment of obesity. It has been shown to reduce body weight and food intake in animal models of obesity, and it is thought that targeting the 5HT2C receptor may alter body weight by regulating satiety. Lorcaserin is...
Approved
Withdrawn
Matched Description: … It has been shown to reduce body weight and food intake in animal models of obesity, and it is thought ... Safety Communication requesting the manufacturer of Belviq (lorcaserin hydrochloride tablets, 10 mg) and ... hydrochloride extended-release tablets, 20 mg) to voluntarily withdraw these products from the U.S. market, and …
Matched Categories: … Alimentary Tract and Metabolism …

Suvorexant

Suvorexant is a selective dual antagonist of orexin receptors OX1R and OX2R that promotes sleep by reducing wakefulness and arousal. It has been approved for the treatment of insomnia.
Approved
Investigational
Matched Description: … wakefulness and arousal. ... Suvorexant is a selective dual antagonist of orexin receptors OX1R and OX2R that promotes sleep by reducing …
Matched Categories: … Hypnotics and Sedatives ... Miscellaneous Anxiolytics Sedatives and Hypnotics …

Pyrvinium

Pyrvinium is an anthelmintic effective for pinworms. Several forms of pyrvinium have been prepared with variable counter anions, such as halides, tosylate, triflate and pamoate. Pyrvinum's anti-cancer properties are currently under investigation.
Approved
Matched Description: … forms of pyrvinium have been prepared with variable counter anions, such as halides, tosylate, triflate and …
Matched Categories: … Antiparasitic Products, Insecticides and Repellents …

Iloperidone

Iloperidone is a benzisoxazole and an atypical antipsychotic agent that was first approved by the FDA on May 6, 2009. It is considered to be a second-generation antipsychotic drug with multiple receptor binding profile, although it shows high affinity towards 5-HT2A and dopamine D2 receptors. Iloperidone is currently used to...
Approved
Matched Description: … Iloperidone is a benzisoxazole [A263557] and an atypical antipsychotic agent that was first approved ... ] with multiple receptor binding profile, although it shows high affinity towards 5-HT2A and ... [A263547] Iloperidone is currently used to treat schizophrenia and manic or mixed episodes associated …

Gadopiclenol

Gadopiclenol is a gadolinium-based contrast agent (GBCA) based on a pyclen macrocyclic structure. It is indicated for use with magnetic resonance imaging (MRI) to detect and visualize lesions with abnormal vascularity in the central nervous system and the body. In 2006, the use of GBCAs was associated with the development...
Approved
Matched Description: … hardening of skin and subcutaneous tissues. ... vascularity in the central nervous system and the body. ... It is indicated for use with magnetic resonance imaging (MRI) to detect and visualize lesions with abnormal …

Naftifine

Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative for the topical treatment of tinea pedis, tinea cruris, and tinea corporis caused by the organisms Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans and Epidermophyton floccosum.
Approved
Matched Description: … , Trichophyton mentagrophytes, Trichophyton tonsurans and Epidermophyton floccosum. ... Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative for the topical ... treatment of tinea pedis, tinea cruris, and tinea corporis caused by the organisms Trichophyton rubrum …

Voriconazole

Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increased affinity of voriconazole for 14-alpha sterol demethylase...
Approved
Matched Description: … These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. …
Matched Categories: … Triazole and tetrazole derivatives ... Metabolic Side Effects of Drugs and Substances …

Phenindione

An indandione that has been used as an anticoagulant. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higher incidence of severe adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p234)
Approved
Investigational
Matched Categories: … Blood and Blood Forming Organs …
Displaying drugs 2351 - 2375 of 15109 in total