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Displaying drugs 2401 - 2425 of 14983 in total

Encorafenib

Encorafenib, also known as BRAFTOVI, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and secretion. Mutations in this gene,...
Approved
Investigational
Matched Description: … [L3344] On June 27, 2018, the Food and Drug Administration approved encorafenib and [binimetinib] ... role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Fostemsavir

Fostemsavir is the phosphonooxymethyl prodrug of temsavir, a novel HIV-1 attachment inhibitor. It binds to and inhibits the activity of gp120, a subunit within the HIV-1 gp160 envelope glycoprotein that facilitates the attachment of HIV-1 to host cell CD4 receptors - in doing so, temsavir prevents the first step in...
Approved
Investigational
Matched Iupac: … oxoacetyl]-4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-1-yl}methoxy)phosphonic acid …
Matched Description: … of gp120 as a potential target of interest in the treatment of HIV-1 infection is relatively recent, and ... [L14867,L14917] Targeting gp120 subunits is a new and novel therapeutic approach to HIV-1 infection, ... [L14867] It binds to and inhibits the activity of gp120, a subunit within the HIV-1 gp160 envelope glycoprotein …

Metyrapone

An inhibitor of the enzyme steroid 11-beta-monooxygenase. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of cushing syndrome.
Approved
Investigational

Tedizolid phosphate

Drug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and penicillin-resistant Streptococcus penumoniae, represent a massive public health threat.[A199086, A199131] Tedizolid is a member of the oxazolidinone class of antibiotics, which includes the previously approved linezolid and is generally effective against multidrug-resistant Gram-positive bacteria. Tedizolid is indicated for the...
Approved
Matched Iupac: … 2-methyl-2H-1,2,3,4-tetrazol-5-yl)pyridin-3-yl]phenyl}-2-oxo-1,3-oxazolidin-5-yl]methoxy}phosphonic acid …
Matched Description: … ) and is generally more effective and more tolerable than [linezolid]. ... such as methicillin-resistant _Staphylococcus aureus_, vancomycin-resistant _Enterococcus faecium_, and ... member of the oxazolidinone class of antibiotics, which includes the previously approved [linezolid] and …

Finerenone

Finerenone, or BAY 94-8862, is a mineralocorticoid receptor antagonist indicated to reduce the risk of sustained decline in glomerular filtration rate, end stage kidney disease, cardiovascular death, heart attacks, and hospitalization due to heart failure in adults with chronic kidney disease associated with type II diabetes mellitus.[A236519,L34739] Patients with kidney...
Approved
Investigational
Matched Description: … [A236544] Spironolactone has low selectivity and affinity for the receptor; it dissociates quickly and ... [A236544] Eplerenone is more selective and has longer lasting effects. ... can also have effects at the androgen, progesterone, and glucocorticoid receptors. …

Agkistrodon piscivorus antivenin

Agkistrodon piscivorus antivenin is derived and purified immunoglobulin fragments obtained from other domestic animals such as sheep previously immunized with Agkistrodon piscivorus (Cottonmouth or Water Moccasin snake). The final purified antivenin product is obtained by mixing other different monospecific snake antivenins and isolating the antivenin of interest through fractionation and...
Approved
Experimental
Matched Description: … Sistrurus spp.) and the copperheads and cottonmouth water moccasins (Agkistrodon spp.) ... isolating the antivenin of interest through fractionation and chromatography techniques. ... Agkistrodon piscivorus antivenin is derived and purified immunoglobulin fragments obtained from other …

Poloxamer 188

Poloxamer 188 (P188) is a nonionic block linear copolymer that exhibits rheologic, anti-thrombotic, anti-inflammatory, and cytoprotective activities in various tissue injury models . Composed of two hydrophilic side-chains attached to a hydrophobic center core , its average molecular weight is 8400 Daltons. P188 was originally approved by the FDA in...
Approved
Investigational
Matched Description: … mouthwash, and used in various cosmetic, industrial and pharmaceutical applications. ... of _in vivo_ and _in vitro_ models [A27218]. ... ) is a nonionic block linear copolymer that exhibits rheologic, anti-thrombotic, anti-inflammatory, and …

Menadiol diphosphate

Approved
Nutraceutical
Matched Iupac: … {[3-methyl-4-(phosphonooxy)naphthalen-1-yl]oxy}phosphonic acid …

Sertraline

Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as Citalopram and Fluoxetine. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before...
Approved
Matched Description: … is similar to drugs such as [Citalopram] and [Fluoxetine]. ... popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and ... classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and …
Matched Categories: … Medications that increase serum magnesium …

Human papillomavirus type 6 L1 capsid protein antigen

Human papillomavirus type 6 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus...
Approved
Investigational
Matched Description: … by Human Papillomavirus (HPV) types 6, 11, 16 and 18. ... antigen is contained in Gardasil, or a recombinant Human Papillomavirus Quadrivalent (Types 6, 11, 16, and ... It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused …

Esketamine

Major depressive disorder (MDD) is a significant cause of disability worldwide and the most common illness preceding suicide.[L5596,A175462] On March 5, 2019, the nasal spray drug, esketamine, also known as Spravato (by Janssen Pharmaceuticals), was approved by the FDA for treatment-resistant major depression. Esketamine is the s-enantiomer of Ketamine. Ketamine...
Approved
Investigational
Matched Description: … Major depressive disorder (MDD) is a significant cause of disability worldwide and the most common illness ... The intranasal route of administration for this drug allows for easy administration and a fast onset ... disorder who have not experienced an improvement in symptoms despite treatment with various medications and …

Ferumoxytol

Ferumoxytol is an intravenously administered iron preparation indicated in the EU and the US for the treatment of iron deficiency anemia in adult patients with chronic kidney disease (CKD) . It is comprised of superparamagnetic iron oxide nanoparticles which are coated by a semi-synthetic carbohydrate shell in an isotonic, neutral...
Approved
Investigational
Matched Description: … Ferumoxytol is an intravenously administered iron preparation indicated in the EU and the US for the …

Anisindione

Anisindione is a synthetic anticoagulant and an indanedione derivative. Its anticoagulant action is mediated through the inhibition of the vitamin K-mediated gamma-carboxylation of precursor proteins that are critical in forming the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagulant proteins C and S,...
Approved
Matched Description: … Anisindione is a synthetic anticoagulant and an indanedione derivative. ... X, as well as the anticoagulant proteins C and S, in the liver. ... precursor proteins that are critical in forming the formation of active procoagulation factors II, VII, IX, and …

Isoxicam

Isoxicam is a non-steroidal anti-inflammatory drug that is not marketed in the United States.
Approved
Withdrawn

Polyvinyl alcohol

Polyvinyl alcohol is a water-soluble synthetic polymer obtained by polymerization of vinyl alcohol. It has varying roles in commercial and industrial applications such as papermaking, textiles, and printing. Polyvinyl alcohol is found in ophthalmic solutions as a lubricant to prevent irritation or to relieve dryness of the eyes .
Approved
Matched Description: … It has varying roles in commercial and industrial applications such as papermaking, textiles, and printing …

Povidone K30

A polyvinyl polymer of variable molecular weight; used as suspending and dispersing agent and vehicle for pharmaceuticals; also used as blood volume expander. See povidone for full details.
Approved
Experimental
Matched Description: … A polyvinyl polymer of variable molecular weight; used as suspending and dispersing agent and vehicle …

Pazopanib

Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009.
Approved
Matched Description: … It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Voxelotor

Voxelotor is a novel hemoglobin S polymerization inhibitor for the treatment of sickle cell disease. This is a genetically inherited condition most prevalent in the Middle East, Africa, and certain parts of India. Sickle cell disease can lead to excruciating pain, stroke, infection, and various other complications arising from the...
Approved
Investigational
Matched Description: … ], and [crizanlizumab][A188135,A188138] due to its novel mechanism of action. ... This is a genetically inherited condition most prevalent in the Middle East, Africa, and certain parts ... Sickle cell disease can lead to excruciating pain, stroke, infection, and various other complications …
Matched Categories: … Blood and Blood Forming Organs …

Iodide I-131

Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of...
Approved
Investigational
Matched Description: … Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of ... Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its ... As a result of beta decay, approximately 10% of its energy and radiation dose is via gamma radiation, …

Flortaucipir F-18

Flortaucipir F-18, also known as 18F-T807 and 18F-AV-1451, is a small indole molecule synthesized with a radioactive fluorine isotope. It is used as a marker in positron emission tomography (PET) imaging of patients suspected of having Alzheimer's disease. After crossing the blood-brain barrier, flortaucipir F-18 binds to aggregated tau protein,...
Approved
Investigational
Matched Description: … MAO-B, as well as to regions containing high levels of melanin, neuromelanin, and iron. ... Flortaucipir F-18, also known as 18F-T807 and 18F-AV-1451, is a small indole molecule ... binding throughout the brain,[A203936] it does display off-target binding to monoamine oxidase MAO-A and …

Pyridostigmine

Myasthenia gravis is an autoimmune disease involving dysfunction at the neuromuscular junction, most commonly due to autoantibodies directed against the acetylcholine receptor (AChR), which results in muscle tone loss, muscle weakness, and fatigue. Acetylcholinesterase inhibitors have been the symptomatic treatment of choice in myasthenia gravis since the 1930s with the...
Approved
Investigational
Matched Description: … under various brand and generic names. ... directed against the acetylcholine receptor (AChR), which results in muscle tone loss, muscle weakness, and ... By inhibiting the breakdown of acetylcholine in the neuromuscular junction, they increase signalling and …

Phendimetrazine

Phendimetrazine is a weight loss medication. Phendimetrazine is chemically related to amphetamines and is a Schedule III drug under the Convention on Psychotropic Substances and in the US since 1970.
Approved
Illicit
Matched Description: … on Psychotropic Substances and in the US since 1970. ... Phendimetrazine is chemically related to amphetamines and is a Schedule III drug under the Convention …

Indium In-111 oxyquinoline

Indium In 111 oxyquinoline (oxine) is a diagnostic radiopharmaceutical intended for radiolabeling of autologous leukocytes. It is composed of a 3:1 saturated complex of In-111 isotope and oxyquinoline. Indium-111 decays by isomeric transition and electron capture to cadmium-111, emitting a gamma ray that can be detected with a gamma ray...
Approved
Matched Description: … The degree of accuracy may vary with labeling techniques and with the size, location and nature of the ... It is composed of a 3:1 saturated complex of In-111 isotope and oxyquinoline. ... Indium-111 decays by isomeric transition and electron capture to cadmium-111, emitting a gamma ray that …

Ethosuximide

An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures.
Approved

Fluoride ion F-18

Sodium Fluoride F 18 Injection is a positron emitting radiopharmaceutical, no-carrier added. It contains radioactive fluoride F 18 that is used for diagnostic purposes in conjunction with positron emission tomography (PET) imaging and is administered by intravenous injection. Its primary indication is for bone imaging. Increased deposition around joints can...
Approved
Matched Description: … Increased deposition around joints can occur in arthritis and following trauma and increased deposition ... that is used for diagnostic purposes in conjunction with positron emission tomography (PET) imaging and ... has been noted around fracture sites, in osteomyelitis, fibrous dysplasia, spondylitis tuberculosa, and …
Displaying drugs 2401 - 2425 of 14983 in total