Synopsis of some recent tactical application of bioisosteres in drug design.

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Meanwell NA

Synopsis of some recent tactical application of bioisosteres in drug design.

J Med Chem. 2011 Apr 28;54(8):2529-91. doi: 10.1021/jm1013693. Epub 2011 Mar 17.

PubMed ID
21413808 [ View in PubMed
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DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
HaloperidolDopamine D1 receptorKi (nM)107N/AN/ADetails
HaloperidolDopamine D2 receptorKi (nM)2.84N/AN/ADetails
HaloperidolDopamine D3 receptorKi (nM)10.4N/AN/ADetails
NimesulideProstaglandin G/H synthase 2IC 50 (nM)700N/AN/ADetails
VenlafaxineSodium-dependent dopamine transporterIC 50 (nM)6670N/AN/ADetails
VenlafaxineSodium-dependent dopamine transporterIC 50 (nM)19600N/AN/ADetails
VenlafaxineSodium-dependent dopamine transporterIC 50 (nM)4430N/AN/ADetails
VenlafaxineSodium-dependent noradrenaline transporterIC 50 (nM)754N/AN/ADetails
VenlafaxineSodium-dependent noradrenaline transporterIC 50 (nM)61N/AN/ADetails
VenlafaxineSodium-dependent noradrenaline transporterIC 50 (nM)149N/AN/ADetails
VenlafaxineSodium-dependent serotonin transporterIC 50 (nM)7N/AN/ADetails
VenlafaxineSodium-dependent serotonin transporterIC 50 (nM)30N/AN/ADetails
VenlafaxineSodium-dependent serotonin transporterIC 50 (nM)20N/AN/ADetails