Human chromosome 7: DNA sequence and biology.

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Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, Carson AR, Parker-Katiraee L, Skaug J, Khaja R, Zhang J, Hudek AK, Li M, Haddad M, Duggan GE, Fernandez BA, Kanematsu E, Gentles S, Christopoulos CC, Choufani S, Kwasnicka D, Zheng XH, Lai Z, Nusskern D, Zhang Q, Gu Z, Lu F, Zeesman S, Nowaczyk MJ, Teshima I, Chitayat D, Shuman C, Weksberg R, Zackai EH, Grebe TA, Cox SR, Kirkpatrick SJ, Rahman N, Friedman JM, Heng HH, Pelicci PG, Lo-Coco F, Belloni E, Shaffer LG, Pober B, Morton CC, Gusella JF, Bruns GA, Korf BR, Quade BJ, Ligon AH, Ferguson H, Higgins AW, Leach NT, Herrick SR, Lemyre E, Farra CG, Kim HG, Summers AM, Gripp KW, Roberts W, Szatmari P, Winsor EJ, Grzeschik KH, Teebi A, Minassian BA, Kere J, Armengol L, Pujana MA, Estivill X, Wilson MD, Koop BF, Tosi S, Moore GE, Boright AP, Zlotorynski E, Kerem B, Kroisel PM, Petek E, Oscier DG, Mould SJ, Dohner H, Dohner K, Rommens JM, Vincent JB, Venter JC, Li PW, Mural RJ, Adams MD, Tsui LC

Human chromosome 7: DNA sequence and biology.

Science. 2003 May 2;300(5620):767-72. Epub 2003 Apr 10.

PubMed ID
12690205 [ View in PubMed
]
Abstract

DNA sequence and annotation of the entire human chromosome 7, encompassing nearly 158 million nucleotides of DNA and 1917 gene structures, are presented. To generate a higher order description, additional structural features such as imprinted genes, fragile sites, and segmental duplications were integrated at the level of the DNA sequence with medical genetic data, including 440 chromosome rearrangement breakpoints associated with disease. This approach enabled the discovery of candidate genes for developmental diseases including autism.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Cytochrome c oxidase subunit NDUFA4O00483Details
Asparagine synthetase [glutamine-hydrolyzing]P08243Details
Adenylate cyclase type 1Q08828Details
Peroxisomal carnitine O-octanoyltransferaseQ9UKG9Details
Calcitonin receptorP30988Details
Serine/threonine-protein kinase B-rafP15056Details
Dihydrolipoyl dehydrogenase, mitochondrialP09622Details
Aldose reductaseP15121Details
Inosine-5'-monophosphate dehydrogenase 1P20839Details
Niemann-Pick C1-like protein 1Q9UHC9Details
Lanosterol 14-alpha demethylaseQ16850Details
Hepatocyte growth factor receptorP08581Details
Serum paraoxonase/arylesterase 1P27169Details
Insulin-like growth factor-binding protein 3P17936Details
Beta-glucuronidaseP08236Details
Cytochrome cP99999Details
GlucokinaseP35557Details
Hepatocyte growth factorP14210Details
Cystic fibrosis transmembrane conductance regulatorP13569Details
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformP48736Details
Trypsin-1P07477Details
Laminin subunit beta-1P07942Details
Cyclin-dependent kinase 6Q00534Details
Cytochrome P450 3A5P20815Details
ATP-binding cassette sub-family B member 5Q2M3G0Details
Nicotinamide phosphoribosyltransferaseP43490Details
Zinc-alpha-2-glycoproteinP25311Details
G-protein coupled estrogen receptor 1Q99527Details
Transmembrane glycoprotein NMBQ14956Details
Serum paraoxonase/lactonase 3Q15166Details
3-oxo-5-beta-steroid 4-dehydrogenaseP51857Details
Cytochrome P450 3A7P24462Details
Phosphatidylcholine translocator ABCB4P21439Details
Aryl hydrocarbon receptorP35869Details
Carboxypeptidase A1P15085Details
Calcium/calmodulin-dependent protein kinase type II subunit betaQ13554Details
Proteasome subunit alpha type-2P25787Details
Aldo-keto reductase family 1 member B10O60218Details
Cytohesin-3O43739Details
Homeobox protein engrailed-2P19622Details
cAMP-dependent protein kinase type II-beta regulatory subunitP31323Details
Ras-related protein Ral-AP11233Details
Smoothened homologQ99835Details
Transient receptor potential cation channel subfamily V member 6Q9H1D0Details
Transient receptor potential cation channel subfamily V member 5Q9NQA5Details
Calcium-dependent secretion activator 2Q86UW7Details
Taste receptor type 2 member 16Q9NYV7Details
Secreted frizzled-related protein 4Q6FHJ7Details
ZyxinQ15942Details
Eukaryotic translation initiation factor 2-alpha kinase 1Q9BQI3Details
Ephrin type-A receptor 1P21709Details
Ephrin type-B receptor 6O15197Details
Serine/threonine-protein kinase 17AQ9UEE5Details
Insulin-like growth factor-binding protein 1P08833Details
Serum paraoxonase/arylesterase 2Q15165Details
Diacylglycerol kinase betaQ9Y6T7Details
Diacylglycerol kinase iotaO75912Details
V-type proton ATPase 116 kDa subunit a isoform 4Q9HBG4Details
Hyaluronidase PH-20P38567Details
Hyaluronidase-4Q2M3T9Details
Protein Wnt-2P09544Details