Noscapine

DB06174ApprovedSmall molecule

Noscapine is a non-sedating isoquinoline alkaloid used primarily for its antitussive properties. A type of medication used to prevent coughing.

Mechanism: Noscapine's antitussive effects appear to be primarily mediated by its sigma receptor agonist activity. Evidence for this mechanism is suggested by experimental evidence in rats. Pretreatment with rimcazole, a sigma specific antagonist, causes a dose-dependent reduction in antitussive activity of noscapine.
Curator reviewed
Primary indication: Investigated for use/treatment in lymphoma (non-hodgkin's), leukemia (lymphoid), cancer/tumors (unspecified), and multiple myeloma.Curator reviewed · 4 structured indications
Formula / weight: C₂₂H₂₃NO₇ · 413.4205 g/mol (avg)
Also known as: alpha-Narcotine
Code names: CB3304 · NSC-5366

Resolves to

Compound

UNII8V32U4AOQUCAS128-62-1ChEMBLCHEMBL364713ChEBI73237KEGGC09592

Clinical / RWD

RxNorm7533ATCR05DA07

Structure

InChIKeyAKNNEGZIBPJZJG-MSOLQXFVSA-NSMILES[H][C@@]1(OC(=O)C2=C1C=CC(OC)=C2OC)[C@]1([H])N(C)CCC2=CC3=C(OCO3)C(OC)=C12

Targets

Q99720SIGMAR1

What you can answer from here — as of September 23, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

356Drug interactionsStructured to mechanism, not free text

2Clinical trialsPhase, status and sponsor resolved per trial

4Structured indicationsCondition, population, route and combination as fields, not prose

11ContraindicationsEach with its own population and attribute set

22Marketed productsAcross 7 countries and 13 labellers

1ATC codeIncluding every combination product, plus 15 drug categories

5+ReferencesStructured and connected to the statements they support

Which drugs share a target with Noscapine, and which of those have an active Phase 3 trial?

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