This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Melitracen is a thioxanthene neuroleptic indicated in the treatment of anxiety, depression, and asthenia.
- Generic Name
- Melitracen
- DrugBank Accession Number
- DB13384
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental, Investigational
- Structure
Structure for Melitracen (DB13384)
- Weight
- Average: 291.438
Monoisotopic: 291.198699809 - Chemical Formula
- C21H25N
- Synonyms
- Melitracen
- Melitraceno
Pharmacology
- Indication
Not Available
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- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your software1,2-Benzodiazepine The risk or severity of CNS depression can be increased when 1,2-Benzodiazepine is combined with Melitracen. Acarbose Melitracen may decrease the hypoglycemic activities of Acarbose. Acebutolol Melitracen may decrease the antihypertensive activities of Acebutolol. Aceclofenac The risk or severity of gastrointestinal bleeding can be increased when Melitracen is combined with Aceclofenac. Acemetacin The risk or severity of gastrointestinal bleeding can be increased when Melitracen is combined with Acemetacin. Acenocoumarol The risk or severity of bleeding can be increased when Melitracen is combined with Acenocoumarol. Acetazolamide The risk or severity of CNS depression can be increased when Acetazolamide is combined with Melitracen. Acetohexamide Melitracen may decrease the hypoglycemic activities of Acetohexamide. Acetophenazine The serum concentration of Melitracen can be increased when it is combined with Acetophenazine. Acetylsalicylic acid The risk or severity of gastrointestinal bleeding can be increased when Melitracen is combined with Acetylsalicylic acid. 
Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more - Food Interactions
- Not Available
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image ANXISET Melitracen (10 MG) + Flupentixol (0.5 MG) Tablet, film coated Oral บริษัท ยูเนียนเมดดิคอล (ประเทศไทย) จำกัด 2014-06-13 Not applicable Thailand 
DEANXIT Melitracen (10 MG) + Flupentixol (0.5 MG) Tablet, sugar coated Oral บริษัท บี.เอ็ล.ฮั้ว จำกัด 1985-02-13 Not applicable Thailand Deanxit - Filmtabletten Melitracen (10 mg) + Flupentixol (0.5 mg) Tablet, film coated Oral Lundbeck Austria Gmb H 1971-01-13 Not applicable Austria 
DEANXIT TABLET Melitracen (10 mg) + Flupentixol (0.5 mg) Tablet, film coated Oral LUNDBECK SINGAPORE PTE. LTD. 1988-09-05 Not applicable Singapore DORMIR TABLET, 20 ADET Melitracen (10 mg) + Flupentixol (0.5 mg) Tablet OSEL İLAÇ SAN. VE TİC. A.Ş. 2020-08-14 Not applicable Turkey 
ดิพรีซอล Melitracen (10 MG) + Flupentixol (0.5 MG) Tablet, film coated Oral บริษัท เภสัชกรรมศรีประสิทธิ์ จำกัด 2018-02-09 Not applicable Thailand ฟลูเทรส Melitracen (10 MG) + Flupentixol (0.5 MG) Tablet, film coated Oral บริษัท ยูนีซัน จำกัด 2016-12-29 Not applicable Thailand
Categories
- ATC Codes
- N06CA02 — Melitracen and psycholeptics
- N06CA — Antidepressants in combination with psycholeptics
- N06C — PSYCHOLEPTICS AND PSYCHOANALEPTICS IN COMBINATION
- N06 — PSYCHOANALEPTICS
- N — NERVOUS SYSTEM
- Drug Categories
- Agents that produce hypertension
- Agents that reduce seizure threshold
- Antidepressive Agents
- Antidepressive Agents, Tricyclic
- Central Nervous System Agents
- Central Nervous System Depressants
- Narrow Therapeutic Index Drugs
- Nervous System
- Neurotoxic agents
- Non-Selective Monoamine Reuptake Inhibitors
- Psychoanaleptics
- Psychotropic Drugs
- Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as anthracenes. These are organic compounds containing a system of three linearly fused benzene rings.
- Kingdom
- Organic compounds
- Super Class
- Benzenoids
- Class
- Anthracenes
- Sub Class
- Not Available
- Direct Parent
- Anthracenes
- Alternative Parents
- Trialkylamines / Organopnictogen compounds / Hydrocarbon derivatives
- Substituents
- Amine / Anthracene / Aromatic homopolycyclic compound / Hydrocarbon derivative / Organic nitrogen compound / Organonitrogen compound / Organopnictogen compound / Tertiary aliphatic amine / Tertiary amine
- Molecular Framework
- Aromatic homopolycyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- Q7T0Y1109Z
- CAS number
- 5118-29-6
- InChI Key
- GWWLWDURRGNSRS-UHFFFAOYSA-N
- InChI
- InChI=1S/C21H25N/c1-21(2)19-13-7-5-10-17(19)16(12-9-15-22(3)4)18-11-6-8-14-20(18)21/h5-8,10-14H,9,15H2,1-4H3
- IUPAC Name
- [3-(10,10-dimethyl-9,10-dihydroanthracen-9-ylidene)propyl]dimethylamine
- SMILES
- CN(C)CCC=C1C2=CC=CC=C2C(C)(C)C2=CC=CC=C12
References
- General References
- FDA Thailand Product Information: Anxiset (melitracen/flupentixol) film-coated tablets [Link]
- External Links
- ChemSpider
- 23697
- BindingDB
- 112783
- 446248
- ChEBI
- 135214
- ChEMBL
- CHEMBL110094
- ZINC
- ZINC000001482101
- Wikipedia
- Melitracen
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Treatment Compliance / Depression / Dyspepsia 1 4 Completed Treatment Emotional Disorders / Neurological Disorders 1 4 Completed Treatment Tinnitus 1 3 Completed Treatment Globus 1 1 Completed Treatment Healthy Men and Women 1 1 Completed Treatment Healthy Subjects (HS) 1 1, 2 Unknown Status Treatment Syndrome X 1 Not Available Recruiting Treatment Antidepressant Discontinuation Syndrome / Antidepressant Drug Adverse Reaction / Dyspepsia / Functional Gastrointestinal Disorders (FGID) 1 Not Available Unknown Status Not Available Gastro-esophageal Reflux Disease (GERD) 1 Not Available Unknown Status Not Available Somatic Symptom Disorders 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet, sugar coated Oral Tablet Tablet Tablet, film coated Oral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.00318 mg/mL ALOGPS logP 5.4 ALOGPS logP 4.95 Chemaxon logS -5 ALOGPS pKa (Strongest Basic) 9.76 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 1 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 3.24 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 116.42 m3·mol-1 Chemaxon Polarizability 36.16 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS Not Available Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
Drug created at June 23, 2017 20:41 / Updated at June 02, 2021 20:04