Antipruritics, Incl. Antihistamines, Anesthetics, Etc.

Name
Antipruritics, Incl. Antihistamines, Anesthetics, Etc.
Accession Number
DBCAT002280
Description
Not Available
ATC Classification
Drugs
DrugDrug Description
TripelennamineA histamine H1 antagonist used to treat hypersensitivity reactions, coughs, and the common cold.
OxybuprocaineA local anesthetic used in ophthalmology.
PheniramineAn antihistamine used to treat allergic rhinitis and pruritus.
MepyramineAn antihistamine agent used for the symptomatic treatment of allergy, hypersensitivity reactions, and pruritic skin disorders.
DimetindeneIndicated as symptomatic treatment of allergic reactions: urticaria, allergies of the upper respiratory tract such as hey fever and perennial rhinitis, food and drug allergies; pruritus of various origins, except...
ChlorphenoxamineChlorphenoxamine is marketed under the name Phenoxene. It is an antihistamine and anticholinergic used to treat itching as well as for its antiparkinsonian effect.
PramocaineA local anesthetic and antipruritic agent found in various topical preparations.
TolpropamineNot Annotated
QuinisocaineNot Annotated
LidocaineA local anesthetic used in a wide variety of superficial and invasive procedures.
ClemastineAn antihistamine with sedative and anticholinergic effects used to treat the symptoms of allergic rhinitis.
CinchocaineAn anesthetic used for local or regional anesthesia.
PromethazineA first-generation antihistamine used for the treatment of allergic conditions, nausea and vomiting, and motion sickness.
DiphenhydramineA H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes.
BenzocaineA topical local anesthetic used for the temporary relief of pain and itching associated with minor burns, sunburn, scrapes and insect bites or minor skin irritations.
ThenalidineWithdrawn from the Canadian, US, and UK markets in 1963 due to concerns involving neutropenia.
ChloropyramineFor the treatment of allergic conjunctivitis, allergic rhinitis, bronchial asthma, and other atopic (allergic) conditions.
IsothipendylFor the topical treatment of itching associated with allergic reactions.
TetracaineA local anaesthetic agent used to induce local analgesia in the eyes and skin during medical procedures.
ThonzylamineThozylamine is indicated for use in the symptomatic control of allergic rhinitis or other upper respiratory allergic symptoms [FDA Label]. It is typically a part of combination over the counter...
BamipineNot Annotated
DoxepinA psychotropic agent used for the treatment of depression, anxiety, manic-depressive disorder, and insomnia.
Drugs & Drug Targets
DrugTargetType
TripelennamineHistamine H1 receptortarget
TripelennamineCytochrome P450 2D6enzyme
OxybuprocaineSodium channel protein type 10 subunit alphatarget
OxybuprocaineCholinesteraseenzyme
PheniramineHistamine H1 receptortarget
PheniramineNuclear receptor subfamily 1 group I member 3target
PheniramineHistamine H4 receptortarget
MepyramineCytochrome P450 2D6enzyme
MepyramineHistamine H1 receptortarget
MepyramineSolute carrier family 22 member 4transporter
MepyramineSolute carrier family 22 member 5transporter
DimetindeneMuscarinic acetylcholine receptor M2target
DimetindeneHistamine H1 receptortarget
PramocaineVoltage-gated sodium channel alpha subunittarget
LidocaineSodium channel protein type 5 subunit alphatarget
LidocaineSodium channel protein type 10 subunit alphatarget
LidocaineEpidermal growth factor receptortarget
LidocaineSodium channel protein type 9 subunit alphatarget
LidocaineCytochrome P450 1A2enzyme
LidocaineCytochrome P450 2D6enzyme
LidocaineCytochrome P450 3A4enzyme
LidocaineCytochrome P450 3A5enzyme
LidocaineCytochrome P450 3A7enzyme
LidocaineSolute carrier family 22 member 5transporter
LidocaineP-glycoprotein 1transporter
LidocaineCytochrome P450 2A6enzyme
LidocaineCytochrome P450 2B6enzyme
LidocaineCytochrome P450 2C8enzyme
LidocaineCytochrome P450 2C9enzyme
LidocaineSodium channel protein type 4 subunit alphatarget
LidocaineAlpha-1-acid glycoprotein 1target
LidocaineAlpha-1-acid glycoprotein 2target
ClemastineHistamine H1 receptortarget
ClemastineCytochrome P450 2D6enzyme
CinchocaineSodium channel protein type 5 subunit alphatarget
CinchocaineSodium channel protein type 10 subunit alphatarget
CinchocaineCalmodulintarget
CinchocaineCholinesteraseenzyme
PromethazineDopamine D2 receptortarget
PromethazineHistamine H1 receptortarget
PromethazineMuscarinic acetylcholine receptor M4target
PromethazineMuscarinic acetylcholine receptor M1target
PromethazineMuscarinic acetylcholine receptor M5target
PromethazineMuscarinic acetylcholine receptor M2target
PromethazineMuscarinic acetylcholine receptor M3target
PromethazineCalmodulintarget
PromethazineCytochrome P450 2D6enzyme
PromethazineCytochrome P450 2B6enzyme
PromethazineP-glycoprotein 1transporter
PromethazineCytochrome P450 2C9enzyme
PromethazineHistamine H2 receptortarget
PromethazineAlpha adrenergic receptortarget
PromethazineP2 Purinoceptorstarget
PromethazineVoltage-gated sodium channel alpha subunittarget
PromethazineVoltage-gated Potassium Channelstarget
PromethazineCanalicular multispecific organic anion transporter 2transporter
PromethazineMultidrug resistance-associated protein 4transporter
PromethazineSerum albumincarrier
DiphenhydramineHistamine H1 receptortarget
DiphenhydramineCytochrome P450 2D6enzyme
DiphenhydramineCytochrome P450 2C9enzyme
DiphenhydramineCytochrome P450 2C19enzyme
DiphenhydramineSolute carrier family 22 member 2transporter
DiphenhydramineSolute carrier family 22 member 5transporter
DiphenhydramineProstaglandin G/H synthase 1enzyme
DiphenhydramineMuscarinic acetylcholine receptor M2target
BenzocaineSodium channel protein type 10 subunit alphatarget
BenzocaineP-glycoprotein 1transporter
BenzocaineLiver carboxylesterase 1enzyme
ChloropyramineHistamine H1 receptortarget
IsothipendylHistamine H1 receptortarget
TetracaineRyanodine receptor 1target
TetracaineRyanodine receptor 2target
TetracaineVoltage-gated sodium channel alpha subunittarget
ThonzylamineHistamine H1 receptortarget
ThonzylamineMuscarinic acetylcholine receptor M1target
ThonzylamineMuscarinic acetylcholine receptor M2target
ThonzylamineMuscarinic acetylcholine receptor M3target
ThonzylamineMuscarinic acetylcholine receptor M4target
ThonzylamineMuscarinic acetylcholine receptor M5target
DoxepinSodium-dependent serotonin transportertarget
DoxepinSodium-dependent noradrenaline transportertarget
DoxepinHistamine H1 receptortarget
DoxepinHistamine H2 receptortarget
DoxepinCytochrome P450 2D6enzyme
DoxepinMuscarinic acetylcholine receptor M1target
DoxepinMuscarinic acetylcholine receptor M2target
DoxepinMuscarinic acetylcholine receptor M3target
DoxepinMuscarinic acetylcholine receptor M4target
DoxepinMuscarinic acetylcholine receptor M5target
DoxepinAlpha-1A adrenergic receptortarget
Doxepin5-hydroxytryptamine receptor 1Atarget
Doxepin5-hydroxytryptamine receptor 2Atarget
DoxepinCytochrome P450 2C19enzyme
DoxepinCytochrome P450 2C9enzyme
DoxepinCytochrome P450 1A2enzyme
DoxepinP-glycoprotein 1transporter
Doxepin5-hydroxytryptamine receptor 2Btarget
Doxepin5-hydroxytryptamine receptor 2Ctarget
DoxepinAlpha-1B adrenergic receptortarget
DoxepinAlpha-1D adrenergic receptortarget
DoxepinCytochrome P450 3A4enzyme
Doxepin5-hydroxytryptamine receptor 6target
DoxepinHistamine H4 receptortarget
DoxepinPotassium voltage-gated channel subfamily H member 2target
DoxepinSerum albumincarrier
DoxepinAlpha-1-acid glycoprotein 1carrier