Isothipendyl

DB08802InvestigationalSmall molecule

Isothipendyl is a 1st generation histamine H1 antagonist primarily applied topically as an antipruritic. Isothipendyl is an antihistamine and anticholinergic used as an antipruritic.

Mechanism: Isothipendyl is a selective histamine H1 antagonist and binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
Curator reviewed
Primary indication: For the topical treatment of itching associated with allergic reactions.Curator reviewed · 1 structured indication
Formula / weight: C₁₆H₁₉N₃S · 285.407 g/mol (avg)
Code names: AY-56012 · D-201

Resolves to

Compound

UNIIWVZ7K9P0JYCAS482-15-5ChEMBLCHEMBL2111066ChEBI135183PubChem3781KEGGD08091

Clinical / RWD

RxNorm28012ATCD04AA22ATCR06AD09PharmGKBPA165958421

Structure

InChIKeyOQJBSDFFQWMKBQ-UHFFFAOYSA-NSMILESCC(CN1C2=CC=CC=C2SC2=C1N=CC=C2)N(C)C

Targets

P35367HRH1

What you can answer from here — as of September 13, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

36Drug interactionsStructured to mechanism, not free text

1Structured indicationCondition, population, route and combination as fields, not prose

5Marketed productsAcross 2 countries and 2 labellers

2ATC codesIncluding every combination product, plus 10 drug categories

2+ReferencesStructured and connected to the statements they support

Which drugs share a target with Isothipendyl, and which of those have an active Phase 3 trial?

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