Oral Hypoglycemics

Name
Oral Hypoglycemics
Accession Number
DBCAT003861
Description

Oral agents for treating diabetes.

Drugs
DrugDrug Description
PhenforminFor the reatment of type II diabetes mellitus.
MetforminA biguanide drug used in conjunction with diet and exercise for glycemic control in type 2 diabetes mellitus and used off-label for insulin resistance in polycystic ovary syndrome (PCOS).
BuforminBuformin is an anti-diabetic drug of the biguanide class, chemically related to metformin and phenformin. It was withdrawn from the market in most countries due to a high risk of...
GlyburideA sulfonylurea used in the treatment of non insulin dependent diabetes mellitus.
ChlorpropamideA sulfonylurea used in the treatment of non insulin dependent diabetes mellitus.
TolbutamideA sulfonylurea used to treat hyperglycemia in patients with type 2 diabetes mellitus.
GlibornurideGlibornuride is a sulfonylurea-type anti-diabetic drug.
TolazamideA sulfonylurea used in the treatment of non insulin dependent diabetes mellitus.
CarbutamideNot Annotated
GlipizideA sulfonylurea medication used in Type 2 Diabetes to sensitize pancreatic beta cells and stimulate insulin release.
GliquidoneA sulfonylurea drug used in the management of diabetes mellitus type 2.
GliclazideA sulfonylurea used to treat hyperglycemia in patients with type 2 diabetes mellitus.
MetahexamideNot Annotated
GlisoxepideFor the treatment of diabetes mellitus type 2.
GlimepirideA sulfonylurea drug used to treat type 2 diabetes mellitus.
AcetohexamideUsed in the management of diabetes mellitus type 2 (adult-onset).
GlymidineGlycodiazine is used concomitantly with insulin for the treatment of noninsulin-dependent (type 2) diabetes mellitus.
AcarboseAn alpha-glucosidase inhibitor used in adjunctly with diet and exercise for the management of glycemic control in patients with type 2 diabetes mellitus.
MiglitolAn oral alpha-glucosidase inhibitor used to improve glycemic control by delaying the digestion of carbohydrates.
VogliboseAn alpha-glucosidase inhibitor indicated in the management of postprandial blood glucose in patients with type II diabetes.
TroglitazoneFor the treatment of Type II diabetes mellitus. It is used alone or in combination with a sulfonylurea, metformin, or insulin as an adjunct to diet and exercise.
RosiglitazoneA thiazolidinedione indicated as an adjunct to diet and exercise to maintain glycemic control in type 2 diabetes.
PioglitazoneA thiazolidinedione used adjunctively with diet and exercise to normalize glycemic levels in adults with type 2 diabetes mellitus.
SitagliptinAn oral dipeptidyl peptidase-4 (DPP-4) inhibitor used for the management of type 2 diabetes mellitus.
VildagliptinA once-daily dipeptidyl peptidase 4 (DPP-4) inhibitor used in the management of type 2 diabetes mellitus.
SaxagliptinAn DPP-4 inhibitor used for the management of type 2 diabetes mellitus.
AlogliptinA dipeptidyl peptidase-4 (DPP-4) inhibitor used to treat hyperglycemia in patients with type 2 diabetes mellitus.
LinagliptinA dipeptidyl peptidase-4 (DPP-4) inhibitor used to manage hyperglycemia in patients with type 2 diabetes mellitus.
GemigliptinA dipeptidyl peptidase-4 (DPP-4) inhibitor used to manage hyperglycemia in patients with type 2 diabetes mellitus.
EvogliptinEvogliptin has been used in trials studying the treatment and screening of Osteoporosis, Renal Impairment, Type 2 Diabetes Mellitus, Diabetes Mellitis Type 2, and Diabetes Mellitus, Type 2.
DapagliflozinA sodium-glucose cotransporter 2 inhibitor used in the management of type 2 diabetes mellitus.
CanagliflozinA sodium-glucose co-transporter 2 (SGLT2) inhibitor used to manage hyperglycemia in type 2 diabetes mellitus (DM). Also used to reduce the risk of major cardiovascular events in patients with established cardiovascular disease and type 2 DM.
EmpagliflozinAn SGLT2 inhibitor used to manage type 2 diabetes mellitus.
RepaglinideA antihyperglycemic used to improve glycemic control in diabetes.
NateglinideA meglitinide used to treat non insulin dependent diabetes mellitus.
BenfluorexBenfluorex is an anorectic and hypolipidemic agent that is structurally related to fenfluramine. It was patented and manufactured by a French pharmaceutical company Servier. The European Medicines Agency (EMA) recommended...
MitiglinideFor the treatment of type 2 diabetes.
Drugs & Drug Targets
DrugTargetType
Phenformin5'-AMP-activated protein kinase catalytic subunit alpha-1target
PhenforminCytochrome P450 2D6enzyme
PhenforminSolute carrier family 22 member 2transporter
PhenforminSolute carrier family 22 member 1transporter
PhenforminATP-sensitive inward rectifier potassium channel 8target
Metformin5'-AMP-activated protein kinase subunit beta-1target
MetforminSolute carrier family 22 member 2transporter
MetforminSolute carrier family 22 member 1transporter
MetforminMultidrug and toxin extrusion protein 1transporter
MetforminEquilibrative nucleoside transporter 4transporter
MetforminSolute carrier family 22 member 3transporter
MetforminMultidrug and toxin extrusion protein 2transporter
MetforminElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrialtarget
MetforminGlycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmictarget
BuforminSolute carrier family 22 member 1transporter
GlyburideATP-binding cassette sub-family C member 9target
GlyburideBile salt export pumptarget
GlyburideATP-binding cassette sub-family A member 1target
GlyburideCystic fibrosis transmembrane conductance regulatortarget
GlyburideSulfonylurea receptor 1, Kir6.2target
GlyburideCytochrome P450 2C9enzyme
GlyburideCanalicular multispecific organic anion transporter 2transporter
GlyburideBile salt export pumptransporter
GlyburideP-glycoprotein 1transporter
GlyburideMultidrug resistance-associated protein 1transporter
GlyburideSolute carrier family 15 member 1transporter
GlyburideSolute carrier organic anion transporter family member 1A2transporter
GlyburideSolute carrier family 15 member 2transporter
GlyburideSolute carrier family 22 member 6transporter
GlyburideCanalicular multispecific organic anion transporter 1transporter
GlyburideATP-binding cassette sub-family G member 2transporter
GlyburideSolute carrier family 22 member 7transporter
GlyburideSolute carrier organic anion transporter family member 2B1transporter
GlyburideCytochrome P450 2C19enzyme
GlyburideCytochrome P450 3A4enzyme
GlyburideSerum albumincarrier
GlyburideMitochondrial ATP-sensitive potassium channeltarget
GlyburideCarnitine O-palmitoyltransferase 1, liver isoformtarget
GlyburideCytochrome P450 3A7enzyme
GlyburideCytochrome P450 3A5enzyme
GlyburideTransient receptor potential cation channel subfamily M member 4target
ChlorpropamideATP-binding cassette sub-family C member 8target
ChlorpropamideSolute carrier family 15 member 1transporter
ChlorpropamideSolute carrier family 15 member 2transporter
ChlorpropamideSolute carrier family 22 member 6transporter
ChlorpropamideCytochrome P450 2C9enzyme
ChlorpropamideCytochrome P450 2C19enzyme
ChlorpropamideProstaglandin G/H synthase 1enzyme
TolbutamideATP-sensitive inward rectifier potassium channel 1target
TolbutamideCytochrome P450 2C19enzyme
TolbutamideCytochrome P450 2C9enzyme
TolbutamideCytochrome P450 2C8enzyme
TolbutamideATP-binding cassette sub-family C member 8target
TolbutamideSolute carrier family 15 member 1transporter
TolbutamideSolute carrier organic anion transporter family member 1A2transporter
TolbutamideSolute carrier family 15 member 2transporter
TolbutamideSolute carrier family 22 member 6transporter
TolbutamideSolute carrier organic anion transporter family member 2B1transporter
TolbutamideCytochrome P450 2C18enzyme
TolbutamideSerum albumincarrier
GlibornurideCytochrome P450 2C9enzyme
TolazamideSulfonylurea receptor 1, Kir6.2target
TolazamideCytochrome P450 2C9enzyme
CarbutamideCytochrome P450 2C9enzyme
GlipizideCytochrome P450 2C9enzyme
GlipizidePeroxisome proliferator-activated receptor gammatarget
GlipizideATP-binding cassette sub-family C member 8target
GlipizideUDP-glucuronosyltransferase 1-1enzyme
GlipizideBile salt export pumptransporter
GlipizideSerum albumincarrier
GliquidoneATP-binding cassette sub-family C member 8target
GliquidoneATP-sensitive inward rectifier potassium channel 8target
GliquidoneCytochrome P450 2C9enzyme
GliclazideATP-binding cassette sub-family C member 8target
GliclazideSerum albumincarrier
GliclazideVascular endothelial growth factor Atarget
GliclazideCytochrome P450 2C9enzyme
GliclazideCytochrome P450 2C19enzyme
MetahexamideCytochrome P450 2C9enzyme
GlisoxepideATP-sensitive inward rectifier potassium channel 8target
GlisoxepideCytochrome P450 2C9enzyme
GlimepirideATP-sensitive inward rectifier potassium channel 1target
GlimepirideATP-sensitive inward rectifier potassium channel 11target
GlimepirideCytochrome P450 2C9enzyme
GlimepirideATP-binding cassette sub-family C member 8target
GlimepirideBile salt export pumptransporter
AcetohexamideATP-sensitive inward rectifier potassium channel 1target
AcetohexamideCarbonyl reductase [NADPH] 1enzyme
AcetohexamideSerum albumincarrier
AcetohexamideCytochrome P450 2C9enzyme
GlymidineATP-sensitive inward rectifier potassium channel 1target
GlymidineATP-binding cassette sub-family C member 8target
AcarboseMaltase-glucoamylase, intestinaltarget
AcarboseLysosomal alpha-glucosidasetarget
AcarboseSucrase-isomaltase, intestinaltarget
AcarbosePancreatic alpha-amylasetarget
MiglitolMaltase-glucoamylase, intestinaltarget
MiglitolPancreatic alpha-amylaseenzyme
MiglitolLysosomal alpha-glucosidasetarget
MiglitolNeutral alpha-glucosidase ABtarget
MiglitolNeutral alpha-glucosidase Ctarget
VogliboseMaltase-glucoamylase, intestinaltarget
TroglitazonePeroxisome proliferator-activated receptor gammatarget
TroglitazoneLong-chain-fatty-acid--CoA ligase 4target
TroglitazonePlasminogen activator inhibitor 1target
TroglitazoneEquilibrative nucleoside transporter 1target
TroglitazoneCytochrome P450 3A4enzyme
TroglitazoneCytochrome P450 2C19enzyme
TroglitazoneUDP-glucuronosyltransferase 1-1enzyme
TroglitazoneCytochrome P450 2C8enzyme
TroglitazoneBile salt export pumptransporter
TroglitazoneSolute carrier organic anion transporter family member 1B1transporter
TroglitazoneEstrogen-related receptor gammatarget
TroglitazoneSteroid hormone receptor ERR1target
TroglitazoneCytochrome P450 19A1enzyme
TroglitazoneCytochrome P450 1A1enzyme
TroglitazoneCytochrome P450 2B6enzyme
TroglitazoneCytochrome P450 2C9enzyme
TroglitazoneCytochrome P450 3A5enzyme
TroglitazoneCytochrome P450 3A7enzyme
TroglitazoneUDP-glucuronosyltransferase 1-3enzyme
TroglitazoneUDP-glucuronosyltransferase 1-4enzyme
TroglitazoneUDP-glucuronosyltransferase 1-6enzyme
TroglitazoneUDP-glucuronosyltransferase 1-7enzyme
TroglitazoneUDP-glucuronosyltransferase 1-8enzyme
TroglitazoneUDP-glucuronosyltransferase 1-9enzyme
TroglitazoneUDP-glucuronosyltransferase 1-10enzyme
TroglitazoneUDP-glucuronosyltransferase 2B7enzyme
TroglitazoneUDP-glucuronosyltransferase 2B15enzyme
TroglitazonePeroxisome proliferator-activated receptor deltatarget
TroglitazonePeroxisome proliferator-activated receptor alphatarget
TroglitazoneGlutathione S-transferase Ptarget
RosiglitazonePeroxisome proliferator-activated receptor gammatarget
RosiglitazoneCytochrome P450 2C8enzyme
RosiglitazoneCytochrome P450 2C9enzyme
RosiglitazoneLong-chain-fatty-acid--CoA ligase 4target
RosiglitazoneSolute carrier organic anion transporter family member 1B1transporter
RosiglitazoneProstaglandin G/H synthase 1enzyme
RosiglitazoneCytochrome P450 1A2enzyme
RosiglitazoneCytochrome P450 2D6enzyme
RosiglitazoneSerum albumincarrier
RosiglitazonePeroxisome proliferator-activated receptor alphatarget
RosiglitazonePeroxisome proliferator-activated receptor deltatarget
RosiglitazoneRetinoic acid receptor RXR-alphatarget
RosiglitazoneRetinoic acid receptor RXR-betatarget
RosiglitazoneRetinoic acid receptor RXR-gammatarget
RosiglitazoneCytochrome P450 3A4enzyme
RosiglitazoneBile salt export pumptransporter
RosiglitazoneCytochrome P450 2B6enzyme
RosiglitazoneCytochrome P450 2E1enzyme
PioglitazonePeroxisome proliferator-activated receptor gammatarget
PioglitazoneCytochrome P450 2C8enzyme
PioglitazoneCytochrome P450 3A4enzyme
PioglitazoneSolute carrier organic anion transporter family member 1B3transporter
PioglitazoneSolute carrier organic anion transporter family member 1B1transporter
PioglitazoneAmine oxidase [flavin-containing] Btarget
PioglitazoneSerum albumincarrier
PioglitazoneCytochrome P450 1A1enzyme
SitagliptinDipeptidyl peptidase 4target
SitagliptinCytochrome P450 3A4enzyme
SitagliptinCytochrome P450 2C8enzyme
SitagliptinP-glycoprotein 1transporter
SitagliptinSolute carrier family 22 member 8transporter
VildagliptinDipeptidyl peptidase 4target
VildagliptinP-glycoprotein 1transporter
SaxagliptinDipeptidyl peptidase 4target
SaxagliptinCytochrome P450 3A4enzyme
SaxagliptinCytochrome P450 3A5enzyme
SaxagliptinMultidrug resistance-associated protein 1transporter
SaxagliptinSolute carrier organic anion transporter family member 4C1transporter
SaxagliptinSolute carrier family 22 member 8transporter
AlogliptinDipeptidyl peptidase 4target
AlogliptinCytochrome P450 3A4enzyme
AlogliptinCytochrome P450 2D6enzyme
LinagliptinDipeptidyl peptidase 4target
LinagliptinCytochrome P450 3A4enzyme
LinagliptinP-glycoprotein 1transporter
LinagliptinSolute carrier family 22 member 1transporter
LinagliptinSolute carrier family 22 member 2transporter
LinagliptinSolute carrier family 22 member 3transporter
DapagliflozinSodium/glucose cotransporter 2target
DapagliflozinCytochrome P450 1A1enzyme
DapagliflozinCytochrome P450 1A2enzyme
DapagliflozinCytochrome P450 2A6enzyme
DapagliflozinCytochrome P450 2C9enzyme
DapagliflozinCytochrome P450 2D6enzyme
DapagliflozinCytochrome P450 3A4enzyme
DapagliflozinUDP-glucuronosyltransferase 1-9enzyme
DapagliflozinUDP-glucuronosyltransferase 2B4enzyme
DapagliflozinUDP-glucuronosyltransferase 2B7enzyme
DapagliflozinP-glycoprotein 1transporter
CanagliflozinUDP-glucuronosyltransferase 1-9enzyme
CanagliflozinUDP-glucuronosyltransferase 2B4enzyme
CanagliflozinCytochrome P450 3A4enzyme
CanagliflozinSodium/glucose cotransporter 2target
CanagliflozinP-glycoprotein 1transporter
CanagliflozinCanalicular multispecific organic anion transporter 1transporter
CanagliflozinAlpha-1-acid glycoprotein 1carrier
CanagliflozinATP-binding cassette sub-family G member 2transporter
EmpagliflozinSodium/glucose cotransporter 2target
EmpagliflozinUDP-glucuronosyltransferase 2B7enzyme
EmpagliflozinUDP-glucuronosyltransferase 1-3enzyme
EmpagliflozinUDP-glucuronosyltransferase 1-8enzyme
EmpagliflozinUDP-glucuronosyltransferase 1-9enzyme
EmpagliflozinP-glycoprotein 1transporter
EmpagliflozinATP-binding cassette sub-family G member 2transporter
EmpagliflozinSolute carrier family 22 member 8transporter
EmpagliflozinSolute carrier organic anion transporter family member 1B1transporter
EmpagliflozinSolute carrier organic anion transporter family member 1B3transporter
RepaglinideATP-binding cassette sub-family C member 8target
RepaglinideCytochrome P450 2C8enzyme
RepaglinidePeroxisome proliferator-activated receptor gammatarget
RepaglinideCytochrome P450 3A4enzyme
RepaglinideSerum albumincarrier
RepaglinideSolute carrier organic anion transporter family member 1B1transporter
RepaglinideBile salt export pumptransporter
NateglinideATP-binding cassette sub-family C member 8target
NateglinideCytochrome P450 3A4enzyme
NateglinideCytochrome P450 2C9enzyme
NateglinidePeroxisome proliferator-activated receptor gammatarget
NateglinideCytochrome P450 3A5enzyme
NateglinideCytochrome P450 3A7enzyme
NateglinideSolute carrier family 15 member 1transporter
NateglinideSolute carrier family 15 member 2transporter
NateglinideSolute carrier family 22 member 6transporter
NateglinideMonocarboxylate transporter 1transporter
NateglinideProstaglandin G/H synthase 1enzyme
NateglinideUDP-glucuronosyltransferase 1-9enzyme
NateglinideCytochrome P450 2D6enzyme
NateglinideMultidrug resistance-associated protein 4transporter
NateglinideSerum albumincarrier
NateglinideAlpha-1-acid glycoprotein 1carrier
MitiglinideATP-binding cassette sub-family C member 8target
MitiglinidePeroxisome proliferator-activated receptor gammatarget
MitiglinideUDP-glucuronosyltransferase 1-3enzyme
MitiglinideUDP-glucuronosyltransferase 2B7enzyme