Serotonin 5-HT1A Receptor Antagonists

Name
Serotonin 5-HT1A Receptor Antagonists
Accession Number
DBCAT005166
Description

Entities that are capable of exerting an antagonistic effect on 5-HT1A receptors.

Drugs
DrugDrug Description
ClozapineAn antipsychotic drug used in treatment resistant schizophrenia and to decrease suicide risk in schizophrenic patients.
TrazodoneA serotonin uptake inhibitor used to treat major depressive disorder.
AlprenololFor the treatment of hypertension, angina, and arrhythmia
PindololA beta adrenoceptor antagonist used to treat hypertension, edema, ventricular tachycardias, and atrial fibrillation.
QuetiapineA psychotropic agent used for the management of bipolar disorder, schizophrenia, and major depressive disorder.
AsenapineAn atypical antipsychotic used to treat patients with bipolar I disorder and patients with schizophrenia.
PaliperidoneAn atypical antipsychotic used in the treatment of schizophrenia and other schizoaffective or delusional disorders.
MolindoneAn antipsychotic used to treat schizophrenia.
DoxepinA psychotropic agent used for the treatment of depression, anxiety, manic-depressive disorder, and insomnia.
NefazodoneAn antidepressant used in the treatment of depression.
NortriptylineA tricyclic antidepressant used in the treatment of depression.
TrimipramineA tricyclic antidepressant used to treat depression.
ChlorpromazineA phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children.
AlverineA smooth muscle relaxant used to relieve abdominal pain associated with gastrointestinal conditions like heartburn, flatulence, and Irritable Bowel Syndrome.
AcepromazineAcepromazine was first used in humans in the 1950s as an antipsychotic agent. It is now rarely used in humans. Acepromazine is frequently used in animals as a sedative and...
IloperidoneAn atypical antipsychotic agent used for the acute treatment of schizophrenia in adults.
LurasidoneAn atypical antipsychotic used to treat schizophrenia and depressive episodes associated with bipolar I disorder.
PenbutololA beta-adrenergic antagonist used for the management of mild to moderate arterial hypertension, alone or in combination with other antihypertensive agents.
AmoxapineA tricyclic antidepressant used in the treatment of neurotic or reactive depressive disorders and endogenous or psychotic depression.
DosulepinA tricyclic antidepressant commonly used only in patients for whom alternative therapies are ineffective due to its toxicity potential.
PirlindoleFor the treatment of major depression. It is being studied in the treatment of fibromyalgia pain syndrome. One study determined that the effect of pirlindole on sensorimotor performance while driving...
RisperidoneA second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression.
PipotiazineAn antipsychotic indicated for the management of chronic, non-agitated schizophrenic patients.
Drugs & Drug Targets
DrugTargetType
ClozapineDopamine D4 receptortarget
ClozapineHistamine H1 receptortarget
ClozapineDopamine D2 receptortarget
ClozapineNeuron-specific vesicular protein calcyontarget
ClozapineHistamine H4 receptortarget
Clozapine5-hydroxytryptamine receptor 2Atarget
Clozapine5-hydroxytryptamine receptor 1Atarget
Clozapine5-hydroxytryptamine receptor 2Ctarget
ClozapineDopamine D1 receptortarget
ClozapineCytochrome P450 1A2enzyme
ClozapineCytochrome P450 2D6enzyme
ClozapineDopamine D3 receptortarget
ClozapineMuscarinic acetylcholine receptor M1target
ClozapineMuscarinic acetylcholine receptor M2target
ClozapineMuscarinic acetylcholine receptor M3target
ClozapineMuscarinic acetylcholine receptor M4target
ClozapineMuscarinic acetylcholine receptor M5target
Clozapine5-hydroxytryptamine receptor 1Btarget
Clozapine5-hydroxytryptamine receptor 1Dtarget
Clozapine5-hydroxytryptamine receptor 1Etarget
Clozapine5-hydroxytryptamine receptor 3Atarget
Clozapine5-hydroxytryptamine receptor 6target
Clozapine5-hydroxytryptamine receptor 7target
ClozapineAlpha-1A adrenergic receptortarget
ClozapineAlpha-1B adrenergic receptortarget
ClozapineAlpha-2A adrenergic receptortarget
ClozapineAlpha-2B adrenergic receptortarget
ClozapineAlpha-2C adrenergic receptortarget
ClozapineCytochrome P450 2C9enzyme
ClozapineP-glycoprotein 1transporter
ClozapineCytochrome P450 3A4enzyme
ClozapineCytochrome P450 2C19enzyme
ClozapineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
ClozapineUDP-glucuronosyltransferase 1-4enzyme
ClozapineCytochrome P450 1A1enzyme
ClozapineCytochrome P450 2A6enzyme
ClozapineCytochrome P450 2C8enzyme
ClozapineGlutathione S-transferase Ptarget
Trazodone5-hydroxytryptamine receptor 2Atarget
TrazodoneSodium-dependent serotonin transportertarget
TrazodoneAlpha-1A adrenergic receptortarget
TrazodoneAlpha-2A adrenergic receptortarget
TrazodoneHistamine H1 receptortarget
Trazodone5-hydroxytryptamine receptor 1Atarget
TrazodoneCytochrome P450 2D6enzyme
TrazodoneCytochrome P450 3A4enzyme
Trazodone5-hydroxytryptamine receptor 2Ctarget
TrazodoneCytochrome P450 3A5enzyme
TrazodoneCytochrome P450 3A7enzyme
TrazodoneP-glycoprotein 1transporter
Trazodone5-hydroxytryptamine receptor 1Ctarget
AlprenololBeta-1 adrenergic receptortarget
AlprenololBeta-2 adrenergic receptortarget
Alprenolol5-hydroxytryptamine receptor 1Atarget
AlprenololCytochrome P450 2D6enzyme
AlprenololBeta-3 adrenergic receptortarget
PindololBeta-1 adrenergic receptortarget
PindololBeta-2 adrenergic receptortarget
Pindolol5-hydroxytryptamine receptor 1Atarget
Pindolol5-hydroxytryptamine receptor 1Btarget
PindololCytochrome P450 2D6enzyme
PindololBeta-3 adrenergic receptortarget
PindololBeta adrenergic receptortarget
PindololUDP-glucuronosyltransferases (UGTs)enzyme
PindololSulfotransferaseenzyme
PindololSolute carrier family 22 member 2transporter
Pindololalpha1-acid glycoproteincarrier
Quetiapine5-hydroxytryptamine receptor 2Atarget
Quetiapine5-hydroxytryptamine receptor 2Ctarget
QuetiapineDopamine D2 receptortarget
Quetiapine5-hydroxytryptamine receptor 1Atarget
QuetiapineHistamine H1 receptortarget
QuetiapineCytochrome P450 3A4enzyme
QuetiapineAlpha-1 adrenergic receptorstarget
QuetiapineAlpha-2A adrenergic receptortarget
QuetiapineAlpha-2B adrenergic receptortarget
QuetiapineAlpha-2C adrenergic receptortarget
Quetiapine5-hydroxytryptamine receptor 1Dtarget
QuetiapineMuscarinic acetylcholine receptor M1target
QuetiapineMuscarinic acetylcholine receptor M2target
QuetiapineMuscarinic acetylcholine receptor M3target
QuetiapineMuscarinic acetylcholine receptor M4target
QuetiapineMuscarinic acetylcholine receptor M5target
Quetiapine5-hydroxytryptamine receptor 1Btarget
Quetiapine5-hydroxytryptamine receptor 1Etarget
Quetiapine5-hydroxytryptamine receptor 3Atarget
Quetiapine5-hydroxytryptamine receptor 6target
Quetiapine5-hydroxytryptamine receptor 7target
QuetiapineDopamine D5 receptortarget
QuetiapineDopamine D1 receptortarget
QuetiapineDopamine D3 receptortarget
QuetiapineDopamine D4 receptortarget
QuetiapineCytochrome P450 3A5enzyme
QuetiapineP-glycoprotein 1transporter
QuetiapineCytochrome P450 2C19enzyme
QuetiapineCytochrome P450 2D6enzyme
QuetiapineCytochrome P450 3A7enzyme
Asenapine5-hydroxytryptamine receptor 1Atarget
Asenapine5-hydroxytryptamine receptor 1Btarget
Asenapine5-hydroxytryptamine receptor 2Atarget
Asenapine5-hydroxytryptamine receptor 2Btarget
Asenapine5-hydroxytryptamine receptor 2Ctarget
Asenapine5-hydroxytryptamine receptor 6target
Asenapine5-hydroxytryptamine receptor 7target
AsenapineAlpha-2A adrenergic receptortarget
AsenapineAlpha-2B adrenergic receptortarget
AsenapineAlpha-2C adrenergic receptortarget
AsenapineAlpha-1A adrenergic receptortarget
AsenapineDopamine D1 receptortarget
AsenapineDopamine D2 receptortarget
AsenapineDopamine D3 receptortarget
AsenapineDopamine D4 receptortarget
AsenapineHistamine H1 receptortarget
AsenapineHistamine H2 receptortarget
AsenapineCytochrome P450 1A2enzyme
AsenapineCytochrome P450 2D6enzyme
Asenapine5-hydroxytryptamine receptor 5Atarget
AsenapineUDP-glucuronosyltransferase 1-4enzyme
AsenapineCytochrome P450 3A4enzyme
AsenapineBeta-1 adrenergic receptortarget
AsenapineBeta-2 adrenergic receptortarget
AsenapineSerum albumincarrier
Asenapinealpha1-acid glycoproteincarrier
PaliperidoneDopamine D2 receptortarget
Paliperidone5-hydroxytryptamine receptor 2Atarget
PaliperidoneHistamine H1 receptortarget
PaliperidoneAlpha-1A adrenergic receptortarget
PaliperidoneAlpha-1B adrenergic receptortarget
PaliperidoneDopamine D3 receptortarget
PaliperidoneDopamine D4 receptortarget
PaliperidoneDopamine D1 receptortarget
PaliperidoneAlpha-2A adrenergic receptortarget
PaliperidoneAlpha-2B adrenergic receptortarget
PaliperidoneAlpha-2C adrenergic receptortarget
Paliperidone5-hydroxytryptamine receptor 1Atarget
Paliperidone5-hydroxytryptamine receptor 1Dtarget
Paliperidone5-hydroxytryptamine receptor 2Ctarget
Paliperidone5-hydroxytryptamine receptor 7target
PaliperidoneCytochrome P450 3A4enzyme
PaliperidoneCytochrome P450 2D6enzyme
PaliperidoneCytochrome P450 3A5enzyme
PaliperidoneP-glycoprotein 1transporter
MolindoneDopamine D2 receptortarget
Molindone5-hydroxytryptamine receptor 1Atarget
Molindone5-hydroxytryptamine receptor 2Atarget
MolindoneMuscarinic acetylcholine receptor M1target
DoxepinSodium-dependent serotonin transportertarget
DoxepinSodium-dependent noradrenaline transportertarget
DoxepinHistamine H1 receptortarget
DoxepinHistamine H2 receptortarget
DoxepinCytochrome P450 2D6enzyme
DoxepinMuscarinic acetylcholine receptor M1target
DoxepinMuscarinic acetylcholine receptor M2target
DoxepinMuscarinic acetylcholine receptor M3target
DoxepinMuscarinic acetylcholine receptor M4target
DoxepinMuscarinic acetylcholine receptor M5target
DoxepinAlpha-1A adrenergic receptortarget
Doxepin5-hydroxytryptamine receptor 1Atarget
Doxepin5-hydroxytryptamine receptor 2Atarget
DoxepinCytochrome P450 2C19enzyme
DoxepinCytochrome P450 2C9enzyme
DoxepinCytochrome P450 1A2enzyme
DoxepinP-glycoprotein 1transporter
Doxepin5-hydroxytryptamine receptor 2Btarget
Doxepin5-hydroxytryptamine receptor 2Ctarget
DoxepinAlpha-1B adrenergic receptortarget
DoxepinAlpha-1D adrenergic receptortarget
DoxepinCytochrome P450 3A4enzyme
Doxepin5-hydroxytryptamine receptor 6target
DoxepinHistamine H4 receptortarget
DoxepinPotassium voltage-gated channel subfamily H member 2target
DoxepinSerum albumincarrier
DoxepinAlpha-1-acid glycoprotein 1carrier
Nefazodone5-hydroxytryptamine receptor 2Atarget
NefazodoneSodium-dependent serotonin transportertarget
NefazodoneSodium-dependent noradrenaline transportertarget
NefazodoneAlpha-1A adrenergic receptortarget
NefazodoneAlpha-1B adrenergic receptortarget
NefazodoneCytochrome P450 3A4enzyme
NefazodoneCytochrome P450 2D6enzyme
NefazodoneSodium-dependent dopamine transportertarget
NefazodoneAlpha-2A adrenergic receptortarget
Nefazodone5-hydroxytryptamine receptor 1Atarget
NefazodoneCYP2B proteinenzyme
NefazodoneP-glycoprotein 1transporter
Nefazodone5-hydroxytryptamine receptor 2Ctarget
NefazodonePotassium voltage-gated channel subfamily H member 2target
NefazodoneCytochrome P450 3A Subfamilyenzyme
NefazodoneSolute carrier organic anion transporter family member 1B3transporter
NefazodoneSolute carrier organic anion transporter family member 2B1transporter
NefazodoneBile salt export pumptransporter
NortriptylineSodium-dependent serotonin transportertarget
NortriptylineSodium-dependent noradrenaline transportertarget
NortriptylineCytochrome P450 1A2enzyme
NortriptylineCytochrome P450 2D6enzyme
NortriptylineSerum albumincarrier
NortriptylineAlpha-1-acid glycoprotein 1carrier
NortriptylineHistamine H1 receptortarget
Nortriptyline5-hydroxytryptamine receptor 2Atarget
NortriptylineAlpha-1A adrenergic receptortarget
Nortriptyline5-hydroxytryptamine receptor 1Atarget
NortriptylineCytochrome P450 3A4enzyme
NortriptylineCytochrome P450 3A5enzyme
NortriptylineAlpha-1D adrenergic receptortarget
NortriptylineCytochrome P450 2C19enzyme
NortriptylineCytochrome P450 2E1enzyme
Nortriptyline5-hydroxytryptamine receptor 2Ctarget
NortriptylineAlpha-1B adrenergic receptortarget
NortriptylineAlpha-2 adrenergic receptorstarget
NortriptylineBeta adrenergic receptortarget
NortriptylineDopamine D2 receptortarget
NortriptylineSigma receptortarget
Nortriptyline5-hydroxytryptamine receptor 1Ctarget
NortriptylineSodium-dependent noradrenaline transportertransporter
NortriptylineMuscarinic acetylcholine receptortarget
NortriptylineP-glycoprotein 1transporter
TrimipramineSodium-dependent serotonin transportertarget
TrimipramineSodium-dependent noradrenaline transportertarget
TrimipramineCytochrome P450 2D6enzyme
TrimipramineSodium-dependent dopamine transportertarget
Trimipramine5-hydroxytryptamine receptor 2Atarget
Trimipramine5-hydroxytryptamine receptor 1Atarget
TrimipramineAlpha-1A adrenergic receptortarget
TrimipramineAlpha-1B adrenergic receptortarget
TrimipramineDopamine D2 receptortarget
TrimipramineAlpha-2B adrenergic receptortarget
TrimipramineHistamine H1 receptortarget
TrimipramineCytochrome P450 2C19enzyme
TrimipramineP-glycoprotein 1transporter
TrimipramineCytochrome P450 2C9enzyme
Trimipramine5-hydroxytryptamine receptor 2Ctarget
Trimipramine5-hydroxytryptamine receptor 3Atarget
Trimipramine5-hydroxytryptamine receptor 1Dtarget
TrimipramineAlpha-2A adrenergic receptortarget
TrimipramineD(1) dopamine receptortarget
TrimipramineBeta adrenergic receptortarget
TrimipramineMuscarinic acetylcholine receptortarget
Trimipramine5-hydroxytryptamine receptor 1Ctarget
ChlorpromazineDopamine D2 receptortarget
Chlorpromazine5-hydroxytryptamine receptor 2Atarget
ChlorpromazineCytochrome P450 2D6enzyme
ChlorpromazineCholinesteraseenzyme
ChlorpromazineCytochrome P450 1A2enzyme
ChlorpromazineSerum albumincarrier
ChlorpromazineP-glycoprotein 1transporter
ChlorpromazineDopamine D1 receptortarget
Chlorpromazine5-hydroxytryptamine receptor 1Atarget
ChlorpromazineAlpha-1A adrenergic receptortarget
ChlorpromazineAlpha-1B adrenergic receptortarget
ChlorpromazineCytochrome P450 2E1enzyme
ChlorpromazineCytochrome P450 3A4enzyme
ChlorpromazineHistamine H1 receptortarget
ChlorpromazinePotassium voltage-gated channel subfamily H member 2target
ChlorpromazineD(1) dopamine receptortarget
ChlorpromazineDopamine D3 receptortarget
ChlorpromazineDopamine D4 receptortarget
ChlorpromazineDopamine D5 receptortarget
Chlorpromazine5-hydroxytryptamine receptor 2Ctarget
Chlorpromazine5-hydroxytryptamine 2 receptortarget
ChlorpromazineAlpha-1 adrenergic receptorstarget
ChlorpromazineAlpha-2 adrenergic receptorstarget
ChlorpromazineMuscarinic acetylcholine receptor M1target
ChlorpromazineMuscarinic acetylcholine receptor M3target
ChlorpromazineSphingomyelin phosphodiesterasetarget
ChlorpromazineCalmodulintarget
Chlorpromazinealpha1-acid glycoproteintarget
Chlorpromazine5-hydroxytryptamine receptor 6target
Chlorpromazine5-hydroxytryptamine receptor 7target
ChlorpromazineHistamine H4 receptortarget
ChlorpromazineBile salt export pumptransporter
Alverine5-hydroxytryptamine receptor 1Atarget
AcepromazineDopamine D2 receptortarget
AcepromazineDopamine D1 receptortarget
Acepromazine5-hydroxytryptamine receptor 2Atarget
Acepromazine5-hydroxytryptamine receptor 1Atarget
AcepromazineAlpha-1A adrenergic receptortarget
AcepromazineAlpha-1B adrenergic receptortarget
AcepromazineSerum albumincarrier
IloperidoneDopamine D2 receptortarget
Iloperidone5-hydroxytryptamine receptor 2Atarget
IloperidoneCytochrome P450 2D6enzyme
IloperidoneCytochrome P450 3A4enzyme
IloperidoneCytochrome P450 3A5enzyme
IloperidoneCytochrome P450 3A7enzyme
IloperidoneCytochrome P450 2E1enzyme
IloperidoneDopamine D3 receptortarget
IloperidoneAlpha-1A adrenergic receptortarget
IloperidoneDopamine D4 receptortarget
Iloperidone5-hydroxytryptamine receptor 6target
Iloperidone5-hydroxytryptamine receptor 7target
IloperidoneHistamine H1 receptortarget
IloperidoneDopamine D1 receptortarget
Iloperidone5-hydroxytryptamine receptor 1Atarget
IloperidoneAlpha-2C adrenergic receptortarget
LurasidoneCytochrome P450 3A4enzyme
LurasidoneDopamine D2 receptortarget
Lurasidone5-hydroxytryptamine receptor 2Atarget
Lurasidone5-hydroxytryptamine receptor 7target
Lurasidone5-hydroxytryptamine receptor 1Atarget
LurasidoneAlpha-2C adrenergic receptortarget
LurasidoneAlpha-2A adrenergic receptortarget
PenbutololAlpha-1-acid glycoprotein 1carrier
PenbutololBeta-1 adrenergic receptortarget
PenbutololBeta-2 adrenergic receptortarget
Penbutolol5-hydroxytryptamine receptor 1Atarget
Penbutolol5-hydroxytryptamine receptor 1Btarget
PenbutololCytochrome P450 2D6enzyme
AmoxapineSodium-dependent serotonin transportertarget
AmoxapineSodium-dependent noradrenaline transportertarget
AmoxapineAlpha-2A adrenergic receptortarget
AmoxapineDopamine D2 receptortarget
AmoxapineAlpha-1A adrenergic receptortarget
AmoxapineDopamine D1 receptortarget
AmoxapineMuscarinic acetylcholine receptor M1target
AmoxapineGamma-aminobutyric acid receptor subunit alpha-1target
AmoxapineAlpha-1-acid glycoprotein 1carrier
AmoxapineCytochrome P450 2D6enzyme
Amoxapine5-hydroxytryptamine receptor 2Atarget
Amoxapine5-hydroxytryptamine receptor 2Ctarget
Amoxapine5-hydroxytryptamine receptor 6target
Amoxapine5-hydroxytryptamine receptor 7target
AmoxapineDopamine D3 receptortarget
AmoxapineDopamine D4 receptortarget
AmoxapineHistamine H1 receptortarget
AmoxapineAlpha-1 adrenergic receptorstarget
AmoxapineMuscarinic acetylcholine receptortarget
Amoxapine5-hydroxytryptamine receptor 2Btarget
Amoxapine5-hydroxytryptamine receptor 3Atarget
Amoxapine5-hydroxytryptamine receptor 1Atarget
Amoxapine5-hydroxytryptamine receptor 1Btarget
AmoxapineAlpha-2 adrenergic receptorstarget
AmoxapineHistamine H4 receptortarget
AmoxapineGABA(A) Receptortarget
AmoxapineSodium-dependent dopamine transportertarget
Dosulepin5-hydroxytryptamine receptor 1Atarget
Dosulepin5-hydroxytryptamine receptor 2Atarget
DosulepinCytochrome P450 2D6enzyme
DosulepinCytochrome P450 1A2enzyme
DosulepinCytochrome P450 2C19enzyme
DosulepinCytochrome P450 2C9enzyme
DosulepinHistamine H1 receptortarget
DosulepinMuscarinic acetylcholine receptor M1target
DosulepinMuscarinic acetylcholine receptor M2target
DosulepinMuscarinic acetylcholine receptor M3target
DosulepinMuscarinic acetylcholine receptor M4target
DosulepinMuscarinic acetylcholine receptor M5target
DosulepinSodium-dependent noradrenaline transportertarget
DosulepinSodium-dependent serotonin transportertarget
DosulepinAlpha-1 adrenergic receptorstarget
DosulepinAlpha-2 adrenergic receptorstarget
PirlindoleAmine oxidase [flavin-containing] Atarget
Pirlindole5-hydroxytryptamine receptor 1Atarget
PirlindoleAlpha-2A adrenergic receptortarget
PirlindoleAmine oxidase [flavin-containing] Aenzyme
RisperidoneCytochrome P450 2D6enzyme
RisperidoneCytochrome P450 3A4enzyme
RisperidoneP-glycoprotein 1transporter
RisperidoneSerum albumincarrier
RisperidoneAlpha-1-acid glycoprotein 1carrier
Risperidone5-hydroxytryptamine receptor 2Atarget
RisperidoneDopamine D2 receptortarget
RisperidoneAlpha-1B adrenergic receptortarget
RisperidoneAlpha-2B adrenergic receptortarget
RisperidoneAlpha-1A adrenergic receptortarget
RisperidoneAlpha-2C adrenergic receptortarget
RisperidoneHistamine H1 receptortarget
Risperidone5-hydroxytryptamine receptor 2Ctarget
Risperidone5-hydroxytryptamine receptor 1Dtarget
Risperidone5-hydroxytryptamine receptor 1Atarget
Risperidone5-hydroxytryptamine receptor 7target
RisperidoneD(2L) dopamine receptortarget
RisperidoneDopamine D1 receptortarget
PipotiazineCytochrome P450 2D6enzyme
PipotiazineCytochrome P450 3A4enzyme
PipotiazineDopamine D2 receptortarget
PipotiazineDopamine D1 receptortarget
Pipotiazine5-hydroxytryptamine receptor 2Atarget
Pipotiazine5-hydroxytryptamine receptor 1Atarget
PipotiazineSolute carrier family 22 member 1transporter
PipotiazineSerum albumincarrier
PipotiazineCytochrome P450 2C19enzyme